Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 24, Issue 1, Pages 86-94Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.euroneuro.2013.07.003
Keywords
Obsessive-compulsive disorder; HTR3A; HTR3B; HTR3C; HTR3D; HTR3E; 5-HT3; Serotonin; Symptom dimensions; Endophenotype
Funding
- German Research Foundation DFG [Fa 731/6-1, DFG-FK D0620/3-1]
- German Federal Ministry for Education and Research BMBF [01GV0907, NGFN+MooDs PNM-01GS08146-3]
- 7th Framework Programme of the European Union [HEALTH-F4-2009-242257]
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A role of the HTR3A-E genes in obsessive-compulsive disorder (OCD) can be expected based on promising effects of 5-HT3 receptor antagonists as adjunctive treatment of OCD. We therefore genotyped six common coding or promoter variants within the HTR3A-E genes in a case-control-sample consisting of N=236 OCD patients and N=310 control subjects and in N=58 parent-child-trios. Given the heterogeneous OCD phenotype, we also investigated OCD symptom dimensions and cognitive endophenotypes in subsamples. OCD patients scoring high for the washing subtype were significantly more likely to carry the c.256G-allele of the HTR3E variant rs7627615 (p=0.0001) as compared to OCD patients low for this symptom dimension. Visual organization was impaired in OCD patients and unaffected relatives as compared to healthy control subjects and carriers of the HTR3E c.256G/c.256G-genotype performed significantly
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