Review
Cell Biology
Le-Yi Wu, Yu-Juan Song, Cheng-Lin Zhang, Jie Liu
Summary: K-V channel-interacting proteins (KChIP1-4) are Ca2+-binding EF-hand proteins that modulate the excitability of neurons and cardiomyocytes by interacting with the N-terminus of K(V)4 channel α-subunits. They regulate K(V)4 currents by promoting channel translocation, accelerating activation, and inhibiting inactivation. They also regulate other cardiac currents and are involved in the regulation of genes related to pain, memory, endocrine, immune, and inflammatory reactions. Altered expression of KChIPs has been implicated in neurological and cardiovascular diseases. This review summarizes the structural properties, physiological functions, and pathological roles of KChIPs, as well as the small-molecule compounds that regulate their function.
Article
Biochemical Research Methods
Itziar Irigoien, Bru Cormand, Maria Soler-Artigas, Cristina Sanchez-Mora, Josep-Antoni Ramos-Quiroga, Concepcion Arenas
Summary: With the rise of GWAS, the analysis of large-scale SNP data has become crucial in biomedical research. This paper proposes a new method based on genetic distances between individuals to identify disease-related SNPs in case-control studies. By considering population substructure and avoiding multiple testing issues, the method provides ordered lists of SNPs and serves as a useful tool for researchers to focus their attention in the initial stage.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2022)
Article
Biotechnology & Applied Microbiology
Qi Zhang, Tingting Sun, Jiabao Wang, JianBo Fei, Yufu Liu, Lu Liu, Peiwu Wang
Summary: This study conducted a genome-wide association study (GWAS) on the contents of protein and fat in soybeans grown at the experimental base of Jilin Agricultural University from 2019-2021. Four SNP sites were found to be significantly associated with soybean fat content for three consecutive years, while two SNP sites were significantly associated with soybean protein content. Genes related to soybean protein synthesis and lipid metabolism were selected and their expression levels were validated. The results provide a basis for further studying the molecular mechanisms regulating the accumulation of protein and fat in soybean seeds.
Article
Biochemistry & Molecular Biology
Jorim J. Tielbeek, Emil Uffelmann, Benjamin S. Williams, Lucia Colodro-Conde, Eloi Gagnon, Travis T. Mallard, Brandt E. Levitt, Philip R. Jansen, Ada Johansson, Hannah M. Sallis, Giorgio Pistis, Gretchen R. B. Saunders, Andrea G. Allegrini, Kaili Rimfeld, Bettina Konte, Marieke Klein, Annette M. Hartmann, Jessica E. Salvatore, Ilja M. Nolte, Ditte Demontis, Anni L. K. Malmberg, S. Alexandra Burt, Jeanne E. Savage, Karen Sugden, Richie Poulton, Kathleen Mullan Harris, Scott Vrieze, Matt McGue, William G. Iacono, Nina Roth Mota, Jonathan Mill, Joana F. Viana, Brittany L. Mitchell, Jose J. Morosoli, Till F. M. Andlauer, Isabelle Ouellet-Morin, Richard E. Tremblay, Sylvana M. Cote, Jean-Philippe Gouin, Mara R. Brendgen, Ginette Dionne, Frank Vitaro, Michelle K. Lupton, Nicholas G. Martin, Enrique Castelao, Katri Raikkonen, Johan G. Eriksson, Jari Lahti, Catharina A. Hartman, Albertine J. Oldehinkel, Harold Snieder, Hexuan Liu, Martin Preisig, Alyce Whipp, Eero Vuoksimaa, Yi Lu, Patrick Jern, Dan Rujescu, Ina Giegling, Teemu Palviainen, Jaakko Kaprio, Kathryn Paige Harden, Marcus R. Munafo, Genevieve Morneau-Vaillancourt, Robert Plomin, Essi Viding, Brian B. Boutwell, Fazil Aliev, Danielle M. Dick, Arne Popma, Stephen Faraone, Anders D. Borglum, Sarah E. Medland, Barbara Franke, Michel Boivin, Jean-Baptiste Pingault, Jeffrey C. Glennon, J. C. Barnes, Simon E. Fisher, Terrie E. Moffitt, Avshalom Caspi, Tinca J. C. Polderman, Danielle Posthuma
Summary: This study identified significant genetic associations with broad antisocial behavior (ASB) and found that these genetic risks are associated with various antisocial outcomes, as well as mental health, physical health, smoking, cognitive ability, educational attainment, and reproductive traits.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Hyehun Choi, Michael R. Miller, Hong-Ngan Nguyen, Jeffrey C. Rohrbough, Stephen R. Koch, Naoko Boatwright, Michael T. Yarboro, Rajan Sah, W. Hayes McDonald, J. Jeffrey Reese, Ryan J. Stark, Fred S. Lamb
Summary: The LRRC8A volume regulated anion channels can modulate TNFa signaling and vasomotor function. They support extracellular superoxide production and associate with NADPH oxidase 1. Mice lacking LRRC8A in vascular smooth muscle cells show enhanced relaxation and impaired contraction in response to TNFa.
Article
Multidisciplinary Sciences
Satria P. Sajuthi, Jamie L. Everman, Nathan D. Jackson, Benjamin Saef, Cydney L. Rios, Camille M. Moore, Angel C. Y. Mak, Celeste Eng, Ana Fairbanks-Mahnke, Sandra Salazar, Jennifer Elhawary, Scott Huntsman, Vivian Medina, Deborah A. Nickerson, Soren Germer, Michael C. Zody, Goncalo Abecasis, Hyun Min Kang, Kenneth M. Rice, Rajesh Kumar, Noah A. Zaitlen, Sam Oh, Jose Rodriguez-Santana, Esteban G. Burchard, Max A. Seibold
Summary: By performing a transcriptome-wide association study, the researchers identified genetic determinants of airway dysfunction in asthma and discovered genetic mechanisms related to mucus pathobiology.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Frank R. Wendt, Gita A. Pathak, Renato Polimanti
Summary: This study identifies 427 loci with de novo tandem repeat (TR) mutations in a European ancestry population. These loci are enriched for microRNA-184 targets and associated with various body structures, cognition, and cardiovascular, metabolic, psychiatric, and respiratory outcomes.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Pi-Hua Liu, Gwo-Tsann Chuang, Chia-Ni Hsiung, Wei-Shun Yang, Hsiao-Chia Ku, Yi-Ching Lin, Yi-Shun Chen, Yu-Yao Huang, Chia-Hung Lin, Wen-Yi Li, Jou-Wei Lin, Chih-Neng Hsu, Juey-Jen Hwang, Karen Chia-Wen Liao, Meng-Lun Hsieh, Hsiao-Lin Lee, Chen-Yang Shen, Yi-Cheng Chang
Summary: This study conducted a genome-wide association study for melatonin secretion using morning urine samples and identified five candidate genetic loci associated with melatonin level.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Calwing Liao, Veikko Vuokila, Helene Catoire, Fulya Akcimen, Jay P. Ross, Cynthia V. Bourassa, Patrick A. Dion, Inge A. Meijer, Guy A. Rouleau
Summary: This study explores the biology of Tourette's Syndrome (TS) through transcriptome-wide association study and splicing analysis. It reveals increased expression of FLT3 gene in TS and its association with immune-related pathways.
COMMUNICATIONS BIOLOGY
(2022)
Review
Psychiatry
Lorenzo Soldati, Francesco Bianchi-Demicheli, Pauline Schockaert, John Kohl, Mylene Bolmont, Roland Hasler, Nader Perroud
Summary: The literature review examines the association between ADHD, hypersexuality, and paraphilias, finding that individuals with ADHD may report these behaviors but the frequency of hypersexuality and paraphilias in the ADHD population is not definitively established. Conversely, studies suggest a high prevalence of ADHD in individuals with hypersexuality and paraphilias. The review is limited by methodological differences, varying measurement instruments, and small sample sizes in existing studies.
PSYCHIATRY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Monika Mokrzycka, Stefan Stojalowski, Miroslaw Tyrka, Przemyslaw Matysik, Barbara Zmijewska, Rafal Marcinkowski, Urszula Wozna-Pawlak, Roza Martofel, Michal Rokicki, Monika Rakoczy-Trojanowska, Pawel Krajewski
Summary: This study identified markers associated with wheat agronomic traits using genome-wide association analysis. The study also investigated the effects of markers on heterosis and their linkage disequilibrium grouping. The results revealed a large number of single nucleotide polymorphisms with significant effects, predominantly influencing protein translation modification. These findings provide valuable insights for developing new wheat varieties with desirable properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Multidisciplinary
Sarah El Archi, Paul Brunault, Arnaud De Luca, Samuele Cortese, Regis Hankard, Celine Bourbao-Tournois, Nicolas Ballon, Christian Reveillere, Servane Barrault
Summary: This study found a significant association between ADHD and addictive-like eating among bariatric surgery candidates. Emotional factors and personality dimensions play important roles in this association. For individuals with ADHD and obesity, eating may be a way to cope with negative emotions, potentially increasing the risk for addictive-like eating behavior.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Biochemical Research Methods
Zhiyu Hao, Jin Gao, Yuxin Song, Runqing Yang, Di Liu
Summary: In this study, a hierarchical mixed model (Hi-LMM) was proposed to estimate genomic breeding values and infer the association between genotypes and phenotypes, effectively correcting confounding factors and improving the statistical power of association analysis.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Medicine, General & Internal
Edith Lopez-Toro, Casper J. H. Wolf, Rafael A. Gonzalez, Wim van den Brink, Arnt Schellekens, Maria C. Velez-Pastrana
Summary: This study used network analysis to examine the relationships between symptoms of substance use disorders (SUD) and other psychiatric conditions. The findings support the current diagnostic classification system, but also suggest the need for future research to include a broader range of symptoms and explore changes in symptom networks during treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Plant Sciences
Parama Praphasanobol, Putut Rakhmad Purnama, Supaporn Junbuathong, Somsong Chotechuen, Peerapon Moung-Ngam, Waraluk Kasettranan, Chanita Paliyavuth, Luca Comai, Monnat Pongpanich, Teerapong Buaboocha, Supachitra Chadchawan
Summary: Rice is an important source of energy for humans and a staple food for many people worldwide. Rice with highly resistant starch can benefit health and reduce the risk of diseases such as type II diabetes. This study used a genome-wide association study to identify candidate genes that affect starch properties in rice. Three loci on chromosomes 1, 6, and 11 were found to be responsible for starch properties. The identification of these genes will contribute to the understanding of molecular mechanisms affecting starch in rice and aid in the development of rice varieties with improved starch.
Review
Psychology, Developmental
Melissa H. Black, Melissa Scott, Elliot Baker-Young, Craig Thompson, Sarah McGarry, Maya Hayden-Evans, Zelma Snyman, Frank Zimmermann, Viktor Kacic, Torbjorn Falkmer, Marcel Romanos, Sven Boelte, Sonya Girdler, Benjamin Milbourn
Summary: Suicide among post-secondary students is a significant public health concern. While there have been studies on suicide prevention programs, the effective elements of these interventions are still unknown. This study reviewed the literature and identified potential effective elements of suicide prevention programs for post-secondary students. Gatekeeper training programs were found to be the most common type of intervention. These programs have the potential to improve students' engagement with mental health services, knowledge, help-seeking attitudes and behaviors, and gatekeeper-related outcomes.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Simon Foster, Natalia Estevez-Lamorte, Susanne Walitza, Shota Dzemaili, Meichun Mohler-Kuo
Summary: This longitudinal, prospective study examined the relationships between perceived COVID-19-related stress, coping strategies, and mental health status among adolescents in Switzerland during the first wave of the pandemic and one year later. The findings showed that participants reported less COVID-19 related stress one year after the lockdown, but mental health status remained stable. Challenges at home or with others were significantly associated with mental health problems in both genders, while trouble accessing medical care or mental health services was linked to mental health problems in girls. Perceived stress, pre-existing psychiatric problems, and negative coping strategies were associated with worse mental health outcomes.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Sara Bertolin, Pino Alonso, Ignacio Martinez-Zalacain, Jose M. Menchon, Susana Jimenez-Murcia, Justin T. Baker, Nuria Bargallo, Marcelo Camargo Batistuzzo, Premika S. W. Boedhoe, Brian P. Brennan, Jamie D. Feusner, Kate D. Fitzgerald, Martine Fontaine, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Neda Jahanshad, Fern Jaspers-Fayer, Masaru Kuno, Gerd Kvale, Luisa Lazaro, Mafalda Machado-Sousa, Rachel Marsh, Pedro Morgado, Akiko Nakagawa, Luke Norman, Erika L. Nurmi, Joseph O'Neill, Ana E. Ortiz, Chris Perriello, John Piacentini, Maria Pico-Perez, Roseli G. Shavitt, Eiji Shimizu, Helen Blair Simpson, S. Evelyn Stewart, Sophia I. Thomopoulos, Anders Lillevik Thorsen, Susanne Walitza, Lidewij H. Wolters, Paul M. Thompson, Odile A. van den Heuvel, Dan J. Stein, Carles Soriano-Mas
Summary: The results of the study suggest that higher cortical thickness in specific right prefrontal cortex regions may play an important role in the response to cognitive-behavioral therapy in children with OCD.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Christin Scheiner, Andrea Daunke, Alexandra Seidel, Sabrina Mittermeier, Marcel Romanos, Michael Koelch, Arne Buerger
Summary: This study aims to address stress in schools through a short prevention training program that focuses on emotion regulation, mindfulness, and self-compassion. By providing information materials and opportunities for active stress coping, it aims to reduce students' perceived stress levels and develop coping strategies.
Article
Clinical Neurology
Michael A. Strumberger, Isabelle Haeberling, Sophie Emery, Mona Albermann, Noemi Baumgartner, Naima Bucher, Suzanne Erb, Silke Bachmann, Lars Woeckel, Ulrich Mueller-Knapp, Brigitte Contin-Waldvogel, Bruno Rhiner, Susanne Walitza, Gregor Berger, Christian Cajochen, Klaus Schmeck
Summary: This study found a significant association between hypersomnia and middle insomnia symptoms and elevated CRP levels in pediatric depression, which was not linked to alterations in body mass index.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2023)
Article
Clinical Neurology
Cristine Marie Yde Ohki, Natalie Monet Walter, Audrey Bender, Michelle Rickli, Sina Ruhstaller, Susanne Walitza, Edna Grunblatt
Summary: Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental polygenic disorder that affects more than 5% of children and adolescents worldwide. Genetic and environmental factors play important roles in ADHD etiology, leading to diverse clinical outcomes and biological phenotypes. Our study suggests that neural stem cells from ADHD patients with genetic predisposition proliferate less than controls, indicating potential in vitro phenotypic differences that contribute to functional and structural delays observed in patients at a distinct neurodevelopmental stage.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Biochemistry & Molecular Biology
Willem B. Bruin, Yoshinari Abe, Pino Alonso, Alan Anticevic, Lea L. Backhausen, Srinivas Balachander, Nuria Bargallo, Marcelo C. Batistuzzo, Francesco Benedetti, Sara Bertolin Triquell, Silvia Brem, Federico Calesella, Beatriz Couto, Damiaan A. J. P. Denys, Marco A. N. Echevarria, Goi Khia Eng, Sonia Ferreira, Jamie D. Feusner, Rachael G. Grazioplene, Patricia Gruner, Joyce Y. Guo, Kristen Hagen, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q. Hoexter, Neda Jahanshad, Fern Jaspers-Fayer, Selina Kasprzak, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-Shan R. Li, Christine Lochner, Rachel Marsh, Ignacio Martinez-Zalacain, Jose M. Menchon, Pedro S. Moreira, Pedro Morgado, Akiko Nakagawa, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika Nurmi, Jose C. Pariente Zorrilla, John Piacentini, Maria Pico-Perez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Janardhan Y. C. Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Blair H. Simpson, Carles Soriano-Mas, Nuno M. Sousa, Gianfranco Spalletta, Emily R. Stern, S. Evelyn Stewart, Philip Szeszko, Jinsong Tang, Sophia Thomopoulos, Anders L. Thorsen, Yoshida Tokiko, Hirofumi Tomiyama, Benedetta Vai, Ilya M. Veer, Ganesan Venkatasubramanian, Nora C. Vetter, Chris Vriend, Susanne Walitza, Lea Waller, Zhen Wang, Anri Watanabe, Nicole Wolff, Je-Yeon Yun, Qing Zhao, Wieke A. van Leeuwen, Hein J. F. van Marle, Laurens A. van de Mortel, Anouk van der Straten, Ysbrand D. van der Werf, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Guido A. van Wingen
Summary: Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. A mega-analysis of data from 1024 OCD patients and 1028 healthy controls revealed widespread abnormalities in functional connectivity in OCD, including global hypo-connectivity and few hyper-connections mainly with the thalamus. Classification performances based on resting-state connectivity were poor, indicating that it is not an accurate biomarker for identifying individual patients.
MOLECULAR PSYCHIATRY
(2023)
Review
Behavioral Sciences
Samuele Cortese, Katherine McGinn, Mikkel Hojlund, Alan Apter, Celso Arango, Immaculada Baeza, Tobias Banaschewski, Jan Buitelaar, Josefina Castro-Fornieles, David Coghill, David Cohen, Edna Grunblatt, Pieter J. Hoekstra, Anthony James, Pia Jeppesen, Peter Nagy, Anne Katrine Pagsberg, Mara Parellada, Antonio M. Persico, Diane Purper-Ouakil, Veit Roessner, Paramala Santosh, Emily Simonoff, Dejan Stevanovic, Argyris Stringaris, Benedetto Vitiello, Susann Walitza, Abraham Weizman, Tamar Wohlfarth, Ian C. K. Wong, Gil Zalsman, Alessandro Zuddas, Carmen Moreno, Marco Solmi, Christoph U. Correll
Summary: In order to identify potential novel medications for child and adolescent mental health problems, we conducted a systematic search on clinical trial databases from 2010 to 2022. We included phase 2 or 3 randomized controlled trials (RCTs) of medications without regulatory approval in the US, Europe or Asia, and also RCTs of dietary interventions/probiotics. We found 234 ongoing or completed RCTs, with varying results on primary outcomes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Cell & Tissue Engineering
Cristine Marie Yde Ohki, Natalie Monet Walter, Michelle Rickli, Pakita Van Puyenbroeck, Christian Doring, Per Hoffmann, Stefan Herms, Anna Maria Werling, Susanne Walitza, Edna Grunblatt
Summary: Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with a prevalence of over 5% among children and adolescents worldwide, and its incidence has been increasing in recent decades. Although the molecular mechanisms are unknown, both polygenic factors and environmental factors contribute to the development of ADHD. Understanding the pathophysiology of patient-specific cells is crucial for the identification of potential predictive markers and the development of new therapeutic targets. In this study, ADHD patient-derived cell lines were generated using Sendai virus transduction, providing a valuable resource for studying ADHD at the molecular and cellular levels.
STEM CELL RESEARCH
(2023)
Article
Psychiatry
Pritesh Jain, Tyne Miller-Fleming, Apostolia R. Topaloudi, Dongmei K. Yu, Petros Drineas, Marianthi Georgitsi, Zhiyu Yang, Renata Rizzo, Kirsten R. Mueller-Vahl, Zeynep A. Tumer, Nanette Mol Debes, Andreas S. Hartmann, Christel E. Depienne, Yulia S. Worbe, Pablo Mir, Danielle C. Cath, Dorret Boomsma, Veit Roessner, Tomasz Wolanczyk, Piotr Janik, Natalia Szejko, Cezary Zekanowski, Csaba Barta, Zsofia Nemoda, Zsanett Tarnok, Joseph D. Buxbaum, Dorothy Grice, Jeffrey Glennon, Hreinn Stefansson, Bastian Hengerer, Noa Benaroya-Milshtein, Francesco Cardona, Tammy Hedderly, Isobel Heyman, Chaim Huyser, Astrid Morer, Norbert Mueller, Alexander Munchau, Kerstin J. Plessen, Cesare Porcelli, Susanne Walitza, Anette Schrag, Davide Martino, Andrea Dietrich, Carol A. Mathews, Jeremiah M. Scharf, Pieter J. Hoekstra, Lea K. Davis, Peristera Paschou
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychology, Clinical
Ann-Kathrin Thoene, Christina Dose, Michaela Junghaenel, Christopher Hautmann, Lea Teresa Jendreizik, Anne-Katrin Treier, Paula Vetter, Elena von Wirth, Tobias Banaschewski, Katja Becker, Daniel Brandeis, Ute Duerrwaechter, Julia Geissler, Johannes Hebebrand, Sarah Hohmann, Martin Holtmann, Michael Huss, Thomas Jans, Anna Kaiser, Johanna Ketter, Tanja Legenbauer, Sabina Millenet, Luise Poustka, Tobias Renner, Marcel Romanos, Henrik Uebel-von Sandersleben, Priska S. Schneider, Jasmin Wenning, Mirjam Ziegler, Anja Goertz-Dorten, Manfred Doepfner
Summary: This study examines how symptoms of ADHD and disruptive behavior disorders (ODD, CD, CU) relate to functional impairment (FI). The findings reveal the impact of individual symptoms on global FI and identify the strongest associations with FI domains. The study highlights the importance of analyzing individual symptoms and emphasizes the clinical usefulness of symptom-based approaches.
JOURNAL OF PSYCHOPATHOLOGY AND BEHAVIORAL ASSESSMENT
(2023)
Article
Behavioral Sciences
Antonia Tkalcec, Maria Bierlein, Gudrun Seeger-Schneider, Susanne Walitza, Bettina Jenny, Willeke M. Menks, Lynn V. Felhbaum, Reka Borbas, David M. Cole, Nora Raschle, Evelyn Herbrecht, Christina Stadler, Ana Cubillo
Summary: This study compares the cognitive and affective empathy abilities of youth with conduct disorder (CD) and autism spectrum disorder (ASD), and investigates the influence of comorbid Callous-Unemotional (CU) traits on empathy. Results show that the ASD group has lower parent-reported empathy scores and self-reported cognitive empathy scores, while the CD group has lower parent-reported cognitive empathy scores. However, when accounting for the influence of CU traits, deficits in affective empathy for ASD and deficits in cognitive empathy for CD were no longer found.
Article
Clinical Neurology
Ester Osuna, Isabelle Herter-Aeberli, Silvia Probst, Sophie Emery, Mona Albermann, Noemi Baumgartner, Michael Strumberger, Cristian Ricci, Klaus Schmeck, Susanne Walitza, Martin Hersberger, Michael B. Zimmermann, Isabelle Haberling, Gregor Berger, Jeannine Baumgartner
Summary: This study found an association between n-3 polyunsaturated fatty acid (PUFA) status and intake and paediatric major depressive disorder (pMDD) in Swiss adolescents. The composition of red blood cell (RBC) fatty acids showed lower levels of EPA and DHA in pMDD cases, as well as a lower n-3 PUFA index and higher n-6/n-3 PUFA ratio, which were associated with increased risk for pMDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Correction
Biochemistry & Molecular Biology
Willem Bruin, Yoshinari Abe, Pino Alonso, Alan Anticevic, Lea Backhausen, Srinivas Balachander, Nuria Bargallo, Marcelo Batistuzzo, Francesco D. Benedetti, Sara G. Bertolin Triquell, Silvia Brem, Federico Y. Calesella, Beatriz Couto, Damiaan A. J. P. Denys, Marco A. N. Echevarria, Goi Khia Q. Eng, Sonia Ferreira, Jamie Feusner, Rachael Grazioplene, Patricia Gruner, Joyce Guo, Kristen Hagen, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Hoexter, Neda Jahanshad, Fern Jaspers-Fayer, Selina Kasprzak, Minah M. Kim, Kathrin S. Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-Shan R. C. Li, Christine L. Lochner, Rachel Marsh, Ignacio Martinez-Zalacain, Jose Menchon, Pedro Moreira, Pedro Morgado, Akiko Nakagawa, Tomohiro Nakao, Janardhanan Narayanaswamy, Erika Nurmi, Jose C. Pariente Zorrilla, John Piacentini, Maria H. Pico-Perez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Janardhan Y. C. R. Reddy, Daniela Rodriguez-Manrique, Yuki R. Sakai, Eiji Shimizu, Venkataram I. Shivakumar, Blair L. Simpson, Carles Soriano-Mas, Nuno Sousa, Gianfranco Spalletta, Emily M. Stern, S. Evelyn Stewart, Philip C. Szeszko, Jinsong Tang, Sophia Thomopoulos, Anders Thorsen, Tokiko Yoshida, Hirofumi Tomiyama, Benedetta Vai, Ilya Veer, Ganesan Venkatasubramanian, Nora A. Vetter, Chris Vriend, Susanne A. Walitza, Lea Waller, Zhen D. Wang, Anri Watanabe, Nicole Wolff, Je-Yeon Yun, Qing Zhao, Wieke van Leeuwen, Hein J. F. van Marle, Laurens van de Mortel, Anouk van der Straten, Ysbrand van der Werf, Honami C. Arai, Irene Bollettini, Rosa Calvo Escalona, Ana Coelho, Federica Colombo, Leila Darwich, Martine Fontaine, Toshikazu Ikuta, Jonathan Ipser, Asier Juaneda-Segui, Hitomi Kitagawa, Gerd Kvale, Mafalda R. Machado-Sousa, Astrid Morer, Takashi G. Nakamae, Jin J. Narumoto, Joseph O'Neill, Sho A. Okawa, Eva Real, Veit A. Roessner, Joao Sato, Cinto D. Segalas, Roseli A. Shavitt, Dick A. Veltman, Kei M. Yamada, Paul J. Thompson, Dan A. Stein, Odile A. van den Heuvel, Guido van Wingen
MOLECULAR PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Michael Frey, Lukasz Smigielski, Elvira Tini, Stefanie Fekete, Christian Fleischhaker, Christoph Wewetzer, Andreas Karwautz, Christoph U. Correll, Manfred Gerlach, Regina Taurines, Paul L. Plener, Uwe Malzahn, Selina Kornbichler, Laura Weninger, Matthias Brockhaus, Su-Yin Reuter-Dang, Karl Reitzle, Hans Rock, Hartmut Imgart, Peter Heuschmann, Stefan Unterecker, Wolfgang Briegel, Tobias Banaschewski, Joerg M. Fegert, Tobias Hellenschmidt, Michael Kaess, Michael Koelch, Tobias Renner, Christian Rexroth, Susanne Walitza, Gerd Schulte-Koerne, Marcel Romanos, Karin Maria Egberts, Paolo Magni
Summary: This study investigated the relationship between drug dose and serum concentration of fluoxetine in children and adolescents and established the therapeutic serum reference range. The study found a positive correlation between dose and serum concentration of fluoxetine and its metabolite, with higher body weight and female sex associated with lower serum concentrations and therapeutic response. Most patients showed marked or minimal improvements during treatment, with no reported adverse effects.
