Article
Multidisciplinary Sciences
Thanh Tan Vo, Geun Ho Im, Kayoung Han, Minah Suh, Patrick J. Drew, Seong-Gi Kim
Summary: In this study, the hemodynamic responses elicited by optogenetic stimulation of PV interneurons were investigated using electrophysiology, fMRI, OIS, and pharmacological applications. The findings showed that activation of PV neurons induced an early vasoconstrictive response and a later ultraslow vasodilation response. The ultraslow response was mediated by neuropeptide substance P released from PV neurons and was dependent on the brain state.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Medicine, General & Internal
Alan L. Peterson, Tabatha H. Blount, Edna B. Foa, Lily A. Brown, Carmen P. McLean, Jim Mintz, Richard P. Schobitz, Bryann R. DeBeer, Joseph Mignogna, Brooke A. Fina, Wyatt R. Evans, Samantha Synett, Brittany N. Hall-Clark, Timothy O. Rentz, Christian Schrader, Jeffrey S. Yarvis, Katherine A. Dondanville, Hunter Hansen, Vanessa M. Jacoby, Jose Lara-Ruiz, Casey L. Straud, Willie J. Hale, Dhiya Shah, Lauren M. Koch, Kelsi M. Gerwell, Stacey Young-McCaughan, Brett T. Litz, Eric C. Meyer, Abby E. Blankenship, Douglas E. Williamson, John D. Roache, Martin A. Javors, Allah-Fard M. Sharrieff, Barbara L. Niles, Terence M. Keane
Summary: This study aimed to determine the efficacy of two compressed prolonged exposure therapy treatments for combat-related PTSD. The findings suggest that both treatments effectively reduce PTSD symptoms and maintain treatment gains.
Article
Health Care Sciences & Services
Kyle Possemato, Emily Johnson, Kimberly Barrie, Sharfun Ghaus, Delilah Noronha, Michael Wade, Mark A. Greenbaum, Craig Rosen, Marylene Cloitre, Jason Owen, Shaili Jain, Gregory Beehler, Annabel Prins, Karen Seal, Eric Kuhn
Summary: This study tested the effectiveness of a brief primary care-based treatment in reducing the severity of PTSD and improving patient satisfaction. The results showed that the treatment resulted in more patient-reported symptom relief and higher treatment satisfaction, but did not show a significant improvement in clinician-rated PTSD severity.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Youjia Yu, Yan Li, Dan Han, Chuhao Gong, Liwei Wang, Beiping Li, Rui Yao, Yangzi Zhu
Summary: In this study, the effects of intraoperative and postoperative low-dose intravenous pumping dexmedetomidine on PTSD among patients with trauma undergoing emergency surgery were evaluated. A total of 310 trauma patients participated in the analysis. The results showed that the incidence of PTSD was significantly lower in the dexmedetomidine group compared to the control group, and the CAPS-5 score was also lower. Therefore, dexmedetomidine can effectively reduce the risk of PTSD in trauma patients.
Article
Multidisciplinary Sciences
Tracy L. Simpson, Debra L. Kaysen, Charles B. Fleming, Isaac C. Rhew, Anna E. Jaffe, Sruti Desai, Denise A. Hien, Lucy Berliner, Dennis Donovan, Patricia A. Resick
Summary: This study compared the effectiveness of Cognitive Processing Therapy (CPT), Relapse Prevention (RP), and assessment-only (AO) for individuals with PTSD and AUD. The results showed that CPT significantly improved PTSD symptom severity compared to AO, while RP did not show significant differences in PTSD symptoms compared to AO. Both active treatments reduced heavy drinking days compared to AO. In the follow-up period, both treatment conditions showed significant improvements in PTSD symptoms and drinking, with RP demonstrating an advantage in reducing heavy drinking days.
Article
Medicine, General & Internal
E. Jennifer Edelman, Geliang Gan, James Dziura, Denise Esserman, Elizabeth Porter, William C. Becker, Philip A. Chan, Deborah H. Cornman, Christian D. Helfrich, Jesse Reynolds, Jessica E. Yager, Kenneth L. Morford, Srinivas B. Muvvala, David A. Fiellin
Summary: The study evaluated the impact of implementation facilitation on the provision of medications for addiction treatment in HIV clinics. The results showed that facilitation increased the provision of treatment for tobacco use disorder, while the provision for alcohol and opioid use disorders did not immediately improve, and there was no improvement in opioid use disorder provision.
Article
Psychiatry
Zhiying Zhao, Or Duek, Rebecca Seidemann, Charles Gordon, Christopher Walsh, Emma Romaker, William N. Koller, Mark Horvath, Jitendra Awasthi, Yao Wang, Erin O'Brien, Harlan Fichtenholtz, Michelle Hampson, Ilan Harpaz-Rotem
Summary: In this study, the efficacy of real-time fMRI neurofeedback intervention for training control over amygdala activity after trauma recall was evaluated. The active group showed significantly greater improvements in control over amygdala activity 30 days after the intervention, suggesting potential clinical application of neurofeedback in PTSD treatment.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Marcel O. Bonn-Miller, Sue Sisley, Paula Riggs, Berra Yazar-Klosinski, Julie B. Wang, Mallory J. E. Loflin, Benjamin Shechet, Colin Hennigan, Rebecca Matthews, Amy Emerson, Rick Doblin
Summary: There is a growing interest in using medical cannabis for the treatment of PTSD, but this study found no significant difference in symptom improvement between active cannabis concentrations and placebo. Further studies are needed to determine whether smoked cannabis can effectively alleviate symptoms of PTSD.
Article
Public, Environmental & Occupational Health
Brittain L. Mahaffey, Daniel M. Mackin, Jonathan Rosen, Rebecca M. Schwartz, Emanuela Taioliz, Adam Gonzalez
Summary: Disaster workers are at higher risk for mental health problems, but participating in a resilience training program has been shown to improve healthy behaviors and reduce mental health symptoms, especially when administered prior to repeat trauma exposure. Further research is needed to evaluate the long-term effects of participation in the program.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2021)
Article
Medicine, General & Internal
Paula P. Schnurr, Kathleen M. Chard, Josef I. Ruzek, Bruce K. Chow, Patricia A. Resick, Edna B. Foa, Brian P. Marx, Matthew J. Friedman, Michelle J. Bovin, Kristina L. Caudle, Diane Castillo, Kyle T. Curry, Michael Hollifield, Grant D. Huang, Christine L. Chee, Millie C. Astin, Benjamin Dickstein, Kerry Renner, Carolina P. Clancy, Claire Collie, Kelly Maieritsch, Su Bailey, Karin Thompson, Michael Messina, Laurel Franklin, Steve Lindley, Karen Kattar, Brandi Luedtke, Jennifer Romesser, John McQuaid, Patrick Sylvers, Ruth Varkovitzky, Lori Davis, David MacVicar, Mei-Chiung Shih
Summary: This randomized clinical trial compared the effectiveness of prolonged exposure (PE) and cognitive processing therapy (CPT) for treating PTSD in veterans. The study found that while PE was statistically more effective than CPT, the difference was not clinically significant, and both treatments showed meaningful improvements in PTSD.
Article
Psychiatry
Alan L. Peterson, Jim Mintz, John C. Moring, Casey L. Straud, Stacey Young-McCaughan, Cindy A. McGeary, Donald D. McGeary, Brett T. Litz, Dawn Velligan, Alexandra Macdonald, Emma Mata-Galan, Stephen L. Holliday, Kirsten H. Dillon, John D. Roache, Lindsay M. Bira, Paul S. Nabity, Elisa M. Medellin, Willie J. Hale, Patricia A. Resick
Summary: The study compares the outcomes of cognitive processing therapy (CPT) for posttraumatic stress disorder (PTSD) among military veterans and active duty personnel when delivered in-home or through telehealth compared to in-office treatment. The results show that in-home and telehealth delivery formats are more acceptable, have lower dropout rates, and result in better treatment outcomes.
Article
Clinical Neurology
Wesley R. Cole, Catherine L. Tegeler, Y. Sammy Choi, Tyler E. Harris, Nora Rachels, Paula G. Bellini, Thaddeus J. Haight, Lee Gerdes, Charles H. Tegeler, Michael J. Roy
Summary: This study found that the use of Cereset Research(TM) Standard Operating Procedures (CR-SOP) auditory stimulation neurotechnology can improve symptoms after a concussion. However, linking the tones to brainwave activity did not reduce symptoms more than random tones.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Chadi G. Abdallah, John D. Roache, Ralitza Gueorguieva, Lynnette A. Averill, Stacey Young-McCaughan, Paulo R. Shiroma, Prerana Purohit, Antoinette Brundige, William Murff, Kyung-Heup Ahn, Mohamed A. Sherif, Eric J. Baltutis, Mohini Ranganathan, Deepak D'Souza, Brenda Martini, Steven M. Southwick, Ismene L. Petrakis, Rebecca R. Burson, Kevin B. Guthmiller, Argelio L. Lopez-Roca, Karl A. Lautenschlager, John P. McCallin, Matthew B. Hoch, Alexandar Timchenko, Sergio E. Souza, Charles E. Bryant, Jim Mintz, Brett T. Litz, Douglas E. Williamson, Terence M. Keane, Alan L. Peterson, John H. Krystal
Summary: This study examined the efficacy of intravenous ketamine doses in reducing symptoms of posttraumatic stress disorder (PTSD). The results showed that ketamine did not have a dose-related effect on PTSD symptoms, but the standard dose had rapid antidepressant effects.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Gregory A. Fonzo, Madeleine S. Goodkind, Desmond J. Oathes, Yevgeniya Zaiko, Meredith Harvey, Kathy K. Peng, M. Elizabeth Weiss, Allison L. Thompson, Sanno E. Zack, Steven E. Lindley, Bruce A. Arnow, Booil Jo, Barbara O. Rothbaum, Amit Etkin
Summary: Exposure-based psychotherapy for PTSD patients has been shown to induce changes in brain activity patterns, including increased connectivity between the amygdala and insula, expanded connectivity with other brain regions, and weakened connections in certain areas. These changes in brain activity may serve as potential mechanisms of recovery.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychology, Clinical
Josh M. Cisler, Joseph E. Dunsmoor, Anthony A. Privratsky, G. Andrew James
Summary: Laboratory paradigms are used to study fear learning in PTSD, showing that neuronal activity patterns for conditioned stimuli can reinstate patterns for unconditioned stimuli, quantifying fear memory strength. Dopaminergic neurotransmission impacts fear memory strength, with dopamine influencing the consolidation of fear extinction memories.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Adam Bayes, Brooke Short, Carlos A. Zarate, Lawrence Park, James W. Murrough, Declan M. McLoughlin, Patricio Riva-Posse, Robert Schoevers, Jolien Veraart, Sagar Parikh, Paul Glue, Johnson Fam, Rupert McShane, Veronica Galvez, Donel Martin, Phern-Chern Tor, Andre R. Brunoni, Colleen K. Loo
Summary: The safety monitoring of ketamine and esketamine presents knowledge gaps, with no standard monitoring for off-label generic ketamine and varying regulations for intranasal esketamine. The Ketamine Side Effect Tool (KSET) is recommended for comprehensive safety monitoring of acute and longer term side effects.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Lorig Kachadourian, James Murrough, Carly Kaplan, Sabrina Kaplan, Jordyn Feingold, Adriana Feder, Dennis Charney, Steven Southwick, Lauren Peccoralo, Jonathan DePierro, Jonathan Ripp, Robert Pietrzak
Summary: This study examined the association between acute COVID-19-related PTSD, MDD, and GAD symptoms and burnout and functional difficulties in frontline healthcare workers. The results suggest that early interventions targeting transdiagnostic symptoms of MDD, PTSD, and GAD may help mitigate the risk of burnout and functional difficulties in this population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yentl Y. van der Zee, Lars M. T. Eijssen, Philipp Mews, Aarthi Ramakrishnan, Kelvin Alvarez, Casey K. Lardner, Hannah M. Cates, Deena M. Walker, Angelica Torres-Berrio, Caleb J. Browne, Ashley Cunningham, Flurin Cathomas, Hope Kronman, Eric M. Parise, Laurence de Nijs, Li Shen, James W. Murrough, Bart P. F. Rutten, Eric J. Nestler, Orna Issler
Summary: This study explored the potential use of miRNAs as biomarkers for MDD and its treatment. The findings showed that there were significant differences in blood miRNA signatures between stress-resilient and stress-susceptible mice after an incubation period. Additionally, ketamine treatment was more effective than imipramine at re-establishing baseline miRNA expression levels in mice that responded behaviorally to the drug. The study also identified miR-144-3p as a candidate biomarker for depression diagnosis and predicting ketamine treatment response.
MOLECULAR PSYCHIATRY
(2022)
Article
Behavioral Sciences
Daniel L. Ranti, Andrew J. Warburton, John W. Rutland, Jonathan T. Dullea, Matthew Markowitz, Derek A. Smith, Sophie Z. Karwoska Kligler, Sarah Rutter, Mackenzie Langan, Annie Arrighi-Allisan, Ilena George, Gaurav Verma, James W. Murrough, Bradley N. Delman, Priti Balchandani, Laurel S. Morris
Summary: Emerging evidence suggests a relationship between blood-brain barrier breakdown and elevated inflammatory cytokines in depression. This study used ultra-high field MRI to explore the link between glymphatic system dysfunction and psychological trauma in patients with major depressive disorder (MDD) and healthy controls. The results showed that trauma experience was positively correlated with glymphatic neuroanatomy in MDD patients and the overall population. Age also correlated positively with glymphatic parameters in all participants. These findings suggest a potential role of glymphatic impairment in trauma-related symptomatology.
BRAIN AND BEHAVIOR
(2022)
Review
Psychiatry
Audrey G. Evers, James W. Murrough, Dennis S. Charney, Sara Costi
Summary: Stress exposure is a major risk factor for psychiatric illnesses. This review explores the potential pro-resilience effect of ketamine in rodents and its preliminary evidence as a prophylactic treatment for postpartum depression in humans. Animal studies have shown that ketamine given prior to a stressor can protect against depressive-like behavior. Similar protective effects have been observed against PTSD-like behavior. Recent research also found that ketamine administration immediately after caesarian-section significantly reduced the prevalence of postpartum depression.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Bartholt Bloomfield-Clagett, Elizabeth D. Ballard, Deanna K. Greenstein, Samuel T. Wilkinson, Michael F. Grunebaum, James W. Murrough, Sanjay J. Mathew, Jennifer L. Phillips, Maurizio Fava, Gerard Sanacora, Carlos A. Zarate
Summary: This study investigates the differential placebo response for suicidal ideation compared to other depressive symptoms in clinical trials of IV ketamine. The findings suggest that placebo response for suicidal ideation may be different from other symptoms, which may explain the less prominent effect of IV ketamine on suicidal ideation compared to overall depression.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Judy Alper, Rui Feng, Gaurav Verma, Sarah Rutter, Kuang-han Huang, Long Xie, Paul Yushkevich, Yael Jacob, Stephanie Brown, Marin Kautz, Molly Schneider, Hung-Mo Lin, Lazar Fleysher, Bradley N. Delman, Patrick R. Hof, James W. Murrough, Priti Balchandani
Summary: This study aimed to assess volumetric differences in hippocampal subfields between patients with major depressive disorder (MDD), treatment-resistant depression (TRD) and healthy controls (HC) using high-resolution MRI data. The results showed that MDD and TRD patients had reduced volume in the right-hemisphere CA2/3 subfield compared to HC. Negative correlations between subfield volumes and life-stressor checklist scores were also found. This study provides valuable insights into the pathophysiology of depression.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Sara Costi, Audrey Evers, Manish K. Jha, Matthew Klein, Jessica R. Overbey, Ki A. Goosens, JoColl Burgess, Kelvin Alvarez, Adriana Feder, Dennis S. Charney, James W. Murrough
Summary: Stress exposure is a key risk factor for the development of major depressive disorder and posttraumatic stress disorder. Enhancing stress resilience in at-risk populations could potentially protect against stress-induced disorders. The administration of ketamine one week prior to an acute stressor prevents the development of stress-induced depressive-like behavior in rodents. This study aimed to test if the prophylactic effect of ketamine against stress also applies to humans.
NEUROBIOLOGY OF STRESS
(2023)
Article
Neurosciences
Sagar V. Parikh, Scott T. Aaronson, Sanjay J. Mathew, Gustavo Alva, Charles Debattista, Stephen Kanes, Robert Lasser, Amy Bullock, Mona Kotecha, Jungah Jung, Fiona Forrestal, Jeff Jonas, Theresa Vera, Bridgette Leclair, James Doherty
Summary: Major depressive disorder (MDD) is a debilitating mental health disorder that can be difficult to treat with standard therapies. A study found that zuranolone+ADT led to faster improvement in depressive symptoms compared to placebo+ADT in MDD patients, with a good safety profile.
NEUROPSYCHOPHARMACOLOGY
(2023)
Meeting Abstract
Neurosciences
Benedetta Bigio, Olivia Barnhill, Josh Dobbin, Paolo de Angelis, Marin Kautz, Francis Lee, James Murrough, Natalie Rasgon, Carla Nasca
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Yael Jacob, Gaurav Verma, Sarah Rutter, Laurel Morris, Priti Balchandani, James Murrough
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Laurel Morris, Marishka Mehta, Christopher Ahn, Morgan Corniquel, Gaurav Verma, Yael Jacob, Priti Balchandani, James Murrough
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
James Murrough, Sarah Boukezzi, Sara Costi, Flurin Cathomas, Lisa Shin, Scott Russo, Laurel Morris
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Flurin Cathomas, Hsiao-Yun Lin, Kenny Chan, Long Li, Romain Durand-de Cuttoli, Lyonna Parise, Aarthi Ramakrishnan, Antonio Aubry, Samer Muhareb, Eric Parise, Sara Costi, Jun Wang, Fiona Desland, Eric Nestler, Miriam Merad, Li Shen, James Murrough, Scott Russo
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Jungho Cha, Ki Sueng Choi, Juna Khang, Justin Rajendra, Matthew Klein, James Murrough, Boadie Dunlop, Helen Mayberg
BIOLOGICAL PSYCHIATRY
(2022)