Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 18, Issue -, Pages S108-S114Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.euroneuro.2008.02.004
Keywords
hyperprolactinaemia; Antipsychotics; schizophrenia; physical health
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Elevations in serum prolactin levels (hyperprolactinaemia) are a common side effect of Schizophrenia; conventional and some atypical antipsychotic treatments. In patients with schizophrenia, the Physical health adverse effects of anti psychotic-induced hyperprolactinaemia on physical health (e.g. fertility problems, sexual dysfunction and reduced bone mineral density) are gaining attention. Accumulating evidence shows consistent 'prolactin-raising' effects of conventional antipsychotics and risperidone compared with other current atypical antipsychotics, which are more likely to have 'prolactin-sparing' properties. Prolactin-sparing antipsychotics (for example, aripiprazole and quetiapine) tend to show lower frequencies of hyperprolactinaemia-associated side effects. In recent studies, aripiprazote-treated patients have demonstrated lower prolactin levels compared with patients receiving other protactin-sparing antipsychotics. There is a lack of robust recommendations for monitoring prolactin elevation among patients receiving antipsychotics. Decreasing the antipsychotic dose or switching to a prolactin-sparing medication are possible management options for antipsychotic-induced hyperprolactinaemia. There is a need to increase awareness and understanding of the impact of anti psychotic-induced hyperprolactinaemia on physical health in schizophrenia. (c) 2008 Elsevier B.V. and ECNP. All rights reserved.
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