Review
Biochemistry & Molecular Biology
Jaromir Myslivecek
Summary: There are tight interactions between dopamine and acetylcholine signaling in the striatum, affecting neurotransmitter release and movement regulation. Both neurotransmitters and their receptors show diurnal variations, with research indicating that reward function is also influenced by the circadian system.
Article
Biochemistry & Molecular Biology
Subramaniam Jayanthi, Bruce Ladenheim, Patricia Sullivan, Michael T. McCoy, Irina N. Krasnova, David S. Goldstein, Jean Lud Cadet
Summary: Perturbations in striatal dopamine homeostasis may contribute to METH use disorder. Rats exposed to footshocks after long-term METH intake showed decreased intake when given a DA D1 receptor antagonist. Compulsive METH takers exhibited abnormal DA metabolism and decreased protein levels. These findings are consistent with studies on human METH users.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Artem Savchenko, Giorgia Targa, Zoia Fesenko, Damiana Leo, Raul R. Gainetdinov, Ilya Sukhanov
Summary: The key element of dopamine neurotransmission is the dopamine transporter (DAT), responsible for the synaptic reuptake of dopamine. Changes in DAT function can be a mechanism of pathological conditions associated with high dopamine levels. Rodents lacking DAT exhibit increased levels of dopamine, resulting in hyperactivity, stereotypic behaviors, cognitive deficits, and other behavioral abnormalities. Pharmacological studies and the use of dopaminergic agents can alleviate these abnormalities. This review aims to analyze known data on changes in DAT expression in experimental animals, pharmacological studies in these animals, and evaluate the validity of DAT-deficient animals as models for discovering new treatments for dopamine-related disorders.
Article
Neurosciences
Carla L. Busceti, Roxana P. Ginerete, Luisa Di Menna, Giovanna D'Errico, Francesca Cisani, Paola Di Pietro, Tiziana Imbriglio, Valeria Bruno, Giuseppe Battaglia, Francesco Fornai, James A. Monn, Anna Pittaluga, Ferdinando Nicoletti
Summary: Genetic knockout of mGlu2 and mGlu3 receptors affects mice's preference and motor responses to methamphetamine, indicating different roles of these two receptors in methamphetamine addiction. mGlu3(-/-) mice show increased sensitization and elevated levels of phospho-ERK1/2 and free radicals in relevant brain areas, while mGlu2(-/-) mice exhibit reduced motor response to the first methamphetamine injection.
Article
Medicine, General & Internal
Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Xiaopei Xu, Ling Hu, Peiyu Huang, Xiaojun Xu, Minming Zhang
Summary: This study found that current coffee consumption is associated with decreased striatal dopamine transporter availability in the caudate. However, the effects of caffeine on dopamine transporter may fade and disappear after quitting coffee consumption.
Article
Psychiatry
Akhil Sharma, Arman Harutyunyan, Bernard L. Schneider, Anna Moszczynska
Summary: The study found that rats overexpressing PARKIN gene have stronger self-administration ability for METH, while rats with PARKIN knockout are more prone to self-administer METH. This result provides useful models for studying the neural substrates underlying resilience or vulnerability to METH use disorder and identifies PARKIN as a novel potential drug target for treating heavy use of METH.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Liang Xu, Liao Y. Chen
Summary: This study characterizes the interactions between METH, sigma 1R, and DAT at a molecular level, finding that METH is more likely to act as an agonist for sigma 1R, with antagonists reducing its binding. Additionally, it demonstrates that sigma 1R can bind to dDAT through specific helix interactions, decreasing the binding affinity of METH to dDAT.
CHEMICAL BIOLOGY & DRUG DESIGN
(2021)
Article
Chemistry, Multidisciplinary
Peng-ju Yan, Zhao-xiang Ren, Zhi-feng Shi, Chun-lei Wan, Chao-jun Han, Liu-shuai Zhu, Ning-ning Li, John L. Waddington, Xue-chu Zhen
Summary: This study reveals that deficiency of Clk1 suppresses METH-induced conditioned place preference (CPP) and increases DAT expression on the cell membrane of striatum and hippocampus. The decrease in iron content in the brain regions is due to elevated expression of iron exporter ferroportin 1 (FPN1) associated with increased expression of hypoxia-inducible factor-1 alpha (HIF-1 alpha) in response to Clk1 deficiency. Iron plays a critical role in mediating Clk1 deficiency-induced alterations in DAT expression via upstream HIF-1 alpha.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Hwan Kim, Jonghu Jeon, Young Lee, Seung Min Kim, Miju Cheon, Jun Yup Kim
Summary: This study aimed to understand the development of dysphagia in patients with Parkinson's disease (PD) and identify potential target regions for neuromodulation by analyzing the distribution of dopamine transporter availability in the striatum. The results showed that decreased dopamine transporter availability in specific subregions of the striatum may explain the dysphagia in PD, particularly in the pharyngeal phase.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Samuel Hogarth, Emily J. Jaehne, Xiangjun Xu, Quenten Schwarz, Maarten van den Buuse
Summary: The aim of this study was to investigate the role of BDNF and dopamine D3 receptors in the effects of chronic methamphetamine on prepulse inhibition (PPI), an endophenotype of psychosis. The results showed that chronic methamphetamine disrupted PPI regulation in male mice with BDNF haploinsufficiency, regardless of D3 receptor knockout. However, there were no effects of BDNF heterozygosity or D3 knockout on PPI regulation in female mice. These findings suggest a significant involvement of BDNF in the long-term effects of methamphetamine on PPI, particularly in male mice.
Review
Clinical Neurology
Monika Vrajova, Romana Slamberova, Cyril Hoschl, Saak Ovsepian
Summary: Methamphetamine is a powerful and highly addictive psychostimulant with detrimental effects on mental and physical health. It poses a significant challenge in terms of sleep impairments and addiction relapse, calling for targeted interventions. Understanding the mechanisms behind methamphetamine-related sleep disruption is crucial for translational and clinical psychiatry, highlighting the need for further research and therapeutic approaches.
Article
Biochemistry & Molecular Biology
Min Liu, Shouhong Mu, Weikai Han, Xu Tan, E. Liu, Zhaofang Hang, Shaowei Zhu, Qingwei Yue, Jinhao Sun
Summary: The study demonstrated that methamphetamine (MA) increases c-Fos expression and synaptic plasticity in the orbitofrontal cortex (OFC) and dorsal striatum (DS). MA activates projection neurons from the OFC to the DS and affects conditioned place preference (CPP) scores. The study also showed that DA release in the OFC is increased in the MA group, and D1R neurons in the OFC-DS pathway play a role in MA addiction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Neurosciences
Vindhya Nawaratne, Sean P. McLaughlin, Felix P. Mayer, Zayna Gichi, Alyssa Mastriano, Lucia Carvelli
Summary: The dopamine 2 receptors (D2R) play an important role in mediating the effects of amphetamine, which primarily rely on the ability of amphetamine to increase extracellular dopamine. This study found that prolonged exposure to amphetamine can decrease or increase endogenous hD2R at the cellular membrane in HEK293 cells. Moreover, the effects of amphetamine on D2R expression may occur independently of dopamine and DAT.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Hirotaka Sekiguchi, Geoff Pavey, Brian Dean
Summary: Dopamine dysregulation is known to have a major role in the pathophysiology of major depressive disorders (MDD) and bipolar disorders (BD). The dopamine transporter (DAT) plays a critical role in regulating dopamine concentration at the synaptic cleft and may be selectively affecting dopamine homeostasis in patients with MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Sanghoon Choi, Yijuan Du, David L. Wokosin, Steven M. Graves
Summary: This study found that repeated meth use resulted in dysfunction of the indirect pathway neurons in the dorsomedial striatum, with the severity of dysfunction dependent on the duration of abstinence. These findings have important implications for understanding the neurobiological mechanisms of meth addiction.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Hannah Meijs, Helena Voetterl, Alexander T. Sack, Hanneke van Dijk, Bieke De Wilde, Jan Van Hecke, Peter Niemegeers, Evian Gordon, Jurjen J. Luykx, Martijn Arns
Summary: This study used a polygenic score (PGS) and electroencephalography (EEG) data analysis to identify potential predictors for treatment outcomes in major depressive disorder (MDD). The results suggest the existence of a stable EEG network related to antidepressant-response that has potential as a predictor for MDD treatment, particularly in the case of venlafaxine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2024)
