Article
Cardiac & Cardiovascular Systems
Mostafa Rezaeitaleshmahalleh, Nan Mu, Zonghan Lyu, Weihua Zhou, Xiaoming Zhang, Todd E. Rasmussen, Robert D. McBane III, Jingfeng Jiang
Summary: The objective is to predict the growth status of abdominal aortic aneurysms (AAA) using the structural information of intraluminal thrombus (ILT) through an automated workflow. Deep-learning image segmentation models were used to generate 3D geometrical AAA models, followed by automated analysis and classification using a support vector machine. The most accurate predictive model considered four geometrical parameters, two parameters quantifying the constitution of ILT, antihypertensive medication, and the presence of co-existing coronary artery disease, achieving an AUROC of 0.89 and a total accuracy of 83%.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eva Aalbregt, Reza Indrakusuma, Hamid Jalalzadeh, R. Nils Planken, Joost van Schuppen, Lilian Meijboom, Ron Balm, Aart J. Nederveen, Kak Khee Yeung, Pim van Ooij
Summary: 4D flow MRI is a reliable method for assessing the hemodynamics within AAA, but there is no correlation between hemodynamic parameters and maximum diameter, ILT volume and growth rate.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Biophysics
Alexis Throop, Martina Bukac, Rana Zakerzadeh
Summary: This study investigates the biomechanical role of intraluminal thrombus (ILT) in abdominal aortic aneurysm (AAA). The results demonstrate that while ILT can reduce wall stress, it significantly decreases oxygen transport within the tissue, leading to wall hypoxia.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Surgery
Regent Lee, Ismail Cassimjee, Honglei Huang, Pierfrancesco Lapolla, Elisha Ngetich, Anirudh Chandrashekar, Philip Charles, Benedikt Kessler, Roman Fischer, Ashok Handa
Summary: This study discovered novel biomarkers for predicting AAA growth using a mass spectrometry proteomics pipeline. These biomarkers, including Attractin, showed significant correlation with future AAA growth and could be used to predict the growth of AAA.
Article
Chemistry, Multidisciplinary
Mohammed Almijalli
Summary: This research utilized computer modeling to study the impact of intraluminal thrombus (ILT) on abdominal aortic aneurysm (AAA) rupture, and found that ILT does not lead to local hypoxia as previously theorized.
APPLIED SCIENCES-BASEL
(2021)
Review
Medicine, General & Internal
Andres Schanzer, Gustavo S. Oderich
Summary: Repair of abdominal aortic aneurysm is recommended in men with an aneurysm of 5.5 cm or more and in women with an aneurysm of 5.0 cm or more. Endovascular aortic aneurysm repair has lower risk of perioperative complications and death compared to open surgical repair, but there is no long-term survival advantage. Long-term imaging surveillance is recommended after endovascular repair.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Aldona Siennicka, Monika Adamowicz, Natalie Grzesch, Magdalena Klysz, Jaroslaw Wozniak, Miloslaw Cnotliwy, Katarzyna Galant, Maria Jastrzebska
Summary: This study compared the levels of inflammatory mediators in different thicknesses of intraluminal thrombus (ILT) and adjacent abdominal aortic aneurysm (AAA) walls. The results showed that neutrophil elastase, TNF-a, and IL-6 levels were significantly higher in thick ILT and aneurysmal walls covered by thick ILT. Positive correlations were also found between thick ILT and the adjacent wall, as well as thin ILT and the adjacent wall. These findings suggest that neutrophil mediators and inflammatory cytokines may accumulate differently in AAA tissues based on ILT thickness, potentially weakening the AAA wall.
Article
Surgery
Arjet Helena Margaretha Nievergeld, Esther Jorien Maas, Joerik de Ruijter, Judith Helena Cornelia Fonken, Marcus Rodolph Henricus Maria van Sambeekan, Richard Godfried Paulus Lopata
Summary: This study proposed a semi-automatic segmentation method for abdominal aortic aneurysms and their intraluminal thrombus based on 3D ultrasound, and validated the results with computed tomography. The study found strong correlations between vessel and lumen distensibility with blood pressure, and also a correlation between lumen distensibility and ILT thickness.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Mechanics
Martina Bukac, Shawn C. Shadden
Summary: In this study, a poroelastic model for intraluminal thrombus (ILT) was introduced to investigate its impact on the risk of abdominal aortic aneurysm (AAA) rupture. Numerical simulations were performed on three different patient-specific geometries, indicating that the presence of ILT may reduce wall stress in AAA. However, the permeability of ILT has little effect on the Peak Wall Stress (PWS) of AAA, with similar values obtained for both porous and nonporous ILT models.
ARCHIVE OF APPLIED MECHANICS
(2022)
Article
Engineering, Mechanical
Alp Kalipcilar, Huseyin Enes Salman
Summary: Abdominal aortic aneurysm (AAA) is a widely prevalent condition characterized by the dilatation of the abdominal aorta. Computational fluid dynamics (CFD) simulations play an important role in studying AAA hemodynamics. This study investigates the effect of intraluminal thrombus (ILT) burden on AAA hemodynamics using CFD simulations, revealing that ILT significantly alters the biomechanical environment by influencing wall shear stress distribution.
JOURNAL OF THE BRAZILIAN SOCIETY OF MECHANICAL SCIENCES AND ENGINEERING
(2023)
Review
Cardiac & Cardiovascular Systems
John Anagnostakos, Brajesh K. Lal
Summary: Abdominal aortic aneurysms (AAA) are common in older adults and can lead to serious morbidity and mortality if not treated promptly. The causes include trauma, infection, and inflammatory disorders, with risk factors such as smoking, advanced age, dyslipidemia, hypertension, and coronary artery disease. The pathophysiology involves arterial insult leading to inflammation and weakening of the arterial wall, requiring monitoring of size and growth rate to prevent rupture. Management options include controlling risk factors, surgical intervention based on risk assessment, and post-operative monitoring for complications. Advancements in technology have improved the diagnosis and treatment of AAA in recent years.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Aykut Can Arslan, Huseyin Enes Salman
Summary: Abdominal aortic aneurysm (AAA) is a serious health condition characterized by the enlargement of the abdominal aorta beyond its normal diameter. The risk of rupture in AAA can be determined using computational techniques such as computational fluid dynamics (CFD) and fluid-structure interaction (FSI). This study investigates the effect of intraluminal thrombus (ILT) and arterial material properties on the mechanical stresses in AAA using CFD simulations and FSI analysis.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Christiana Lowis, Aurellia Ramara Winaya, Puja Kumari, Cristobal F. Rivera, John Vlahos, Rio Hermantara, Muhammad Yogi Pratama, Bhama Ramkhelawon
Summary: Cumulative evidence supports the idea that mechanical and frictional forces have distinct effects in the aortic layers and contribute to the development of abdominal aortic aneurysms (AAA). Mechanosensory cellular hubs play a crucial role in triggering signaling cascades that lead to the degradation of the extracellular matrix (ECM), resulting in aortic rupture. This review provides an overview of the current understanding of the mechanotransduction networks in different cell types during AAA development, focusing on the mechanosensors and stressors that accumulate in the AAA sac and their effects on inflammation, oxidative stress, remodeling, and ECM degradation. Manipulating this mechano-machinery could be a promising direction for future AAA research.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Xiaoying Ma, Shibo Xia, Guangqin Liu, Chao Song
Summary: Abdominal aortic aneurysm is a common cardiovascular disease with a need for improved treatment options. The role of intraluminal thrombus and platelets in the growth and rupture of AAA has been recognized. Pharmaceutical interventions, such as anti-platelet therapies, are being explored as potential strategies for early AAA.
Review
Medicine, Research & Experimental
Lauren M. Weaver, Charles D. Loftin, Chang-Guo Zhan
Summary: This article discusses drugs for the treatment of abdominal aortic aneurysms (AAA) that have been studied in clinical trials. It examines the drug targets and their ability to regulate the three key pathways involved in AAA progression. The article highlights the historical use of repurposed therapeutics in interventional clinical trials and the need for novel treatments to reach the clinic. It emphasizes the importance of centralized anti-inflammatory drug targets and translatability in AAA treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Surgery
Ross Naylor, Barbara Rantner, Stefano Ancetti, Gert J. de Borst, Marco De Carlo, Alison Halliday, Stavros K. Kakkos, Hugh S. Markus, Dominick J. H. McCabe, Henrik Sillesen, Jos C. van den Berg, Melina Vega de Ceniga, Maarit A. Venermo, Frank E. G. Vermassen
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Surgery
Bijan Modarai, Stephan Haulon, Elizabeth Ainsbury, Dittmar Bockler, Eliseo Vano-Carruana, Joseph Dawson, Mark Farber, Isabelle Van Herzeele, Adrien Hertault, Joost van Herwaarden, Ashish Patel, Anders Wanhainen, Salome Weiss, Frederico Bastos Goncalves, Martin Bjorck, Nabil Chakfe, Gert J. de Borst, Raphael Coscas, Nuno V. Dias, Florian Dick, Robert J. Hinchliffe, Stavros K. Kakkos, Igor B. Koncar, Philippe Kolh, Jes S. Lindholt, Santi Trimarchi, Riikka Tulamo, Christopher P. Twine, Frank Vermassen, Klaus Bacher, Elias Brountzos, Fabrizio Fanelli, Liliana A. Fidalgo Domingos, Mauro Gargiulo, Kevin Mani, Tara M. Mastracci, Blandine Maurel, Robert A. Morgan, Peter Schneider
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Surgery
Joachim S. S. Kristensen, Lasse M. Obel, Marie Dahl, Annette Hogh, Jes S. Lindholt
Summary: This study investigated the impact of a relative-size-index of the abdominal aortic diameter on the prevalence estimates of abdominal aortic dilatations compared to absolute diameters. Two gender-specific prediction equations were developed based on body-surface area and age. The results showed that the prevalence of abdominal aortic dilatations, abdominal aortic aneurysms, and repair-recommendable abdominal aortic aneurysms defined by absolute size and relative size index were significantly higher in males than females.
ANNALS OF VASCULAR SURGERY
(2023)
Review
Dermatology
Susanne Friis Sondergaard, Else Godsk Vestergaard, Anne Bendix Andersen, Raymond Kolbaek, Marie Dahl, Annette Hogh
Summary: Diabetic foot ulcer (DFU) is a severe complication of diabetes that greatly impacts patients' quality of life. Treatment requires a multi-sectoral approach and telemedicine (TM) can be an effective tool for communication and follow-up care. This review examines the literature on patients' experiences and views regarding the use of TM solutions for DFUs and highlights the importance of further investigation from both patients' and caregivers' perspectives.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Katrine Lawaetz Larsen, Egle Kavaliunaite, Lars Melholt Rasmussen, Jesper Hallas, Axel Diederichsen, Flemming Hald Steffensen, Martin Busk, Lars Frost, Grazina Urbonaviciene, Jess Lambrechtsen, Kenneth Egstrup, Jes Sanddal Lindholt
Summary: A paradoxical protective effect of diabetes on the development and progression of abdominal aortic aneurysms (AAA) has been investigated through a cross-sectional study, systematic review, and meta-analysis. The results suggest a potential change in the association between diabetes and AAA over time.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Zhaojie Meng, Shuya Zhang, Wei Li, Yunzhe Wang, Minjie Wang, Xin Liu, Cong-Lin Liu, Sha Liao, Tianxiao Liu, Chongzhe Yang, Jes S. Lindholt, Lars M. Rasmussen, Lasse M. Obel, Jane Stubbe, Axel C. Diederichsen, Yong Sun, Yabing Chen, Paul B. Yu, Peter Libby, Guo-Ping Shi, Junli Guo
Summary: In this study, it was found that blood eosinophil count and eosinophil cationic protein (ECP) concentration are risk factors for cardiovascular diseases. Eosinophils and ECP were shown to contribute to vascular calcification and atherogenesis through the BMPR-1A/1B-Smad-1/5/8-Runx2 signaling pathway.
EUROPEAN HEART JOURNAL
(2023)
Article
Surgery
Marie Dahl, Jes Lindholt, Rikke Sogaard, Jens Refsgaard, Dorthe Svenstrup, Niels-Jorgen Moeslund, Mette Bredsgaard, Annette Hogh
Summary: This is a study on cardiovascular disease screening among 67-year-olds in Denmark. The results showed that men had more positive screening results than women, but the proportion of initiating prophylactic medicine was equal in both sexes.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Health Care Sciences & Services
Marie Dahl, Susanne F. Sondergaard, Rafel Salman Al-Allaq, Axel Diederichsen, Jes S. Lindholt
Summary: This study explores the perceptions of Arabic-speaking male immigrants on preventive initiatives, particularly for cardiovascular diseases. The findings reveal that preventive initiatives are ethically and culturally acceptable, and are considered important for the participants' health and self-determination. However, Arabic-speaking men may face barriers in engaging in prevention due to their basic assumptions and limited capabilities. Therefore, a person-centred approach and efforts to improve health literacy can help address inequality in accessibility and acceptability of preventive measures.
HEALTH EXPECTATIONS
(2023)
Article
Medicine, General & Internal
Annette Hogh, Jes Sanddal Lindholt, Rikke Sogaard, Jens Refsgaard, Dorte Svenstrup, Niels-Jorgen Moeslund, Mette Bredsgaard, Marie Dahl
Summary: The study aims to evaluate the health benefits, harms, and cost-effectiveness of a population-based screening program for cardiovascular diseases and explore the perspectives of the participants.
Article
Cardiac & Cardiovascular Systems
Johanna Larsson, Soren Auscher, Andre Shamoun, Gokulan Pararajasingam, Laurits Juhl Heinsen, Thomas Rueskov Andersen, Jes Sanddal Lindholt, Axel Cosmus Pyndt Diederichsen, Jess Lambrechtsen, Kenneth Egstrup
Summary: This study found an association between insulin resistance and necrotic plaque volume in asymptomatic non-diabetic men.
Article
Cardiac & Cardiovascular Systems
Anton Danholt Lautrup, Tobias Hyrup, Anna Schneider-Kamp, Marie Dahl, Jes Sanddal Lindholt, Peter Schneider-Kamp
Summary: This study aims to evaluate the ability of ChatGPT to provide health advice related to cardiovascular diseases and identifies both strengths and weaknesses in its responses.
