Article
Medicine, General & Internal
Amelie L. Behrens, Susanne Dihlmann, Caspar Grond-Ginsbach, Andreas S. Peters, Bernhard Dorweiler, Dittmar Boeckler, Philipp Erhart
Summary: Gene expression profiling reveals the involvement of chronic inflammatory responses, active matrix metalloproteinases, and degradation of the extracellular matrix components in the development and progression of abdominal aortic aneurysms (AAA). The study shows heterogeneous gene expression patterns within the AAA vascular wall. Single biopsy investigations do not provide a comprehensive characterization of the activated molecular processes in AAA disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Daniel Zalewski, Paulina Chmiel, Przemyslaw Kolodziej, Grzegorz Borowski, Marcin Feldo, Janusz Kocki, Anna Bogucka-Kocka
Summary: Abdominal aortic aneurysm (AAA) is a chronic vascular disease with high mortality rate. Abnormal regulation of angiogenesis and inflammation contributes to the disease progression. Dysregulations in key molecular pathways associated with AAA need to be further investigated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Zhen Yuan, Zhijian Heng, Yi Lu, Jia Wei, Zhejun Cai
Summary: The study found that metformin can reduce the growth rate and rupture risk of abdominal aortic aneurysm in type 2 diabetes patients, providing research evidence for related treatment strategies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yubin Chen, Tianyu Ouyang, Cheng Fang, Can-e Tang, Kaibo Lei, Longtan Jiang, Fanyan Luo
Summary: Weakening of the aortic wall and immune response contribute to the development of AAA, and the inflammatory response is closely associated with aortic rupture. Infiltration of immune cells differs significantly between different samples. NFKB1 may be an important transcription factor in AAA and aortic rupture. CD19, SELL, and CCR7 have potential diagnostic value for AAA, while OAS3, IFIT1, and IFI44L may be predictive factors for aortic rupture.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Immunology
Ana Cristina Marquez-Sanchez, Ekaterina K. Koltsova
Summary: This article summarizes the role of immune cells in abdominal aortic aneurysm (AAA) and discusses the regulation of pathogenic immune cell activation in this disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Li Yin, Eric William Kent, Bowen Wang
Summary: Abdominal aortic aneurysm (AAA) is a common focal dilation of the aorta in the elderly population, which can lead to aneurysmal rupture with a mortality rate of around 80%. Despite increased screening efforts, there is currently no cure to halt the expansion of AAA, partly due to incomplete understanding of its pathogenesis. Animal models provide valuable insights into AAA pathophysiology, but no single experimental model fully captures the complexity of the disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biology
Kimberley R. G. Cortenbach, Alexander H. J. Staal, Teske Schoffelen, Mark A. J. Gorris, Lieke L. Van der Woude, Anne F. M. Jansen, Paul Poyck, Robert Jan Van Suylen, Peter C. Wever, Chantal P. Bleeker-Rovers, Mangala Srinivas, Konnie M. Hebeda, Marcel van Deuren, Jos W. Van der Meer, Jolanda M. De Vries, Roland R. J. Van Kimmenade
Summary: This study found that persistent local infection with C. burnetii is associated with an immune-suppressed microenvironment, despite the presence of pro-inflammatory effector cells.
Article
Medicine, General & Internal
Natalia Niklas, Piotr Gutowski, Arkadiusz Kazimierczak, Pawel Rynio
Summary: The current stratification model of aneurysm rupture is inadequate in certain clinical cases. Our study reveals differences in wall structure between ruptured and unruptured aneurysms, with the AFL/ILT surface ratio potentially serving as a predictive factor for aneurysm rupture and symptom occurrence in AAA.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Maciej Jusko, Piotr Kasprzak, Alicja Majos, Waclaw Kuczmik
Summary: Individual anatomical differences may play a crucial role in assessing the risk of rupture for abdominal aortic aneurysms, as shown by the study's findings on diameter ratios and their predictive value for small aneurysms with a high risk of rupture. Further validation of these ratios in larger patient groups is needed.
Review
Endocrinology & Metabolism
Zijia Huang, Huiling Su, Tiejun Zhang, Yuwen Li
Summary: Diabetes mellitus has a negative association with abdominal aortic aneurysm, but is also associated with poorer outcomes following AAA repair. Hypoglycemic medications may have a protective effect against AAA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jianan Huang, Yunlong Jiang, Ruiyuan Ji, Yutian Jia, Saiya Wang, Zhongqiu Zhou, Siying Wang, Jie Wang, Qing Yang, Hui Bai, Xudong Zhu, Bin Jiang, Jingjing Ben, Hanwen Zhang, Xiaoyu Li, Qi Chen
Summary: This study aims to investigate the role of scavenger receptor A1 (SR-A1) in the pathogenesis of abdominal aortic aneurysm (AAA) and found that its deficiency aggravates AAA development by suppressing immunoresponsive gene 1 (IRG1) and increasing inflammatory response. Restoration of macrophage SR-A1 can relieve AAA.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Hematology
Romil R. Parikh, Aaron R. Folsom, Kripa Poudel, Pamela L. Lutsey, Ryan T. Demmer, James S. Pankow, Lin Y. Chen, Weihong Tang
Summary: The study found that higher leukocyte counts in midlife are associated with an increased risk of abdominal aortic aneurysm (AAA), even after considering traditional risk factors. Further research is needed to investigate if immunosuppression is linked to a higher risk of AAA.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Surgery
Katherine M. Reitz, Amanda R. Phillips, Edith Tzeng, Michel S. Makaroun, Christine M. Leeper, Nathan L. Liang
Summary: This study compares immediate and early mortality among patients undergoing ruptured abdominal aortic aneurysm (RAAA) repair and finds that immediate deaths are predominantly related to shock from massive hemorrhage, while early deaths are mainly associated with comorbid conditions leading to multisystem organ failure.
JOURNAL OF VASCULAR SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Jonathan Golledge, Shivshankar Thanigaimani, Janet T. Powell, Phil S. Tsao
Summary: Abdominal aortic aneurysm (AAA) causes a high number of deaths worldwide every year, but no drug therapy has been proven to effectively limit AAA growth in randomized controlled trials. Genome-wide association studies have identified potential drug targets, and treatments to reduce low-density lipoprotein cholesterol and smoking cessation are also being considered. However, previous placebo-controlled randomized trials have not shown convincing evidence of drug efficacy, mainly due to limitations such as small sample sizes and poor participant retention. Further large prospective studies on other targets are needed to address this issue.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Tan Li, Chao Yang, Jingjing Jing, Liping Sun, Yuan Yuan
Summary: Elevated levels of GZMK were found to be associated with the presence of AAA and its rupture risk, suggesting that serum GZMK could serve as a potential non-invasive marker for identifying AAA and assessing its risk of rupture.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Pathology
Karin Leslie, Guy StJ Whitley, Florian Herse, Ralf Dechend, Sandra V. Ashton, Ken Laing, Baskaran Thilaganathan, Judith E. Cartwright
AMERICAN JOURNAL OF PATHOLOGY
(2015)
Article
Physiology
Nicoletta Charolidi, Grisha Pirianov, Evelyn Torsney, Stuart Pearce, Ken Laing, Axel Nohturfft, Gillian W. Cockerill
JOURNAL OF VASCULAR RESEARCH
(2015)
Article
Infectious Diseases
Marcus J. Pond, Achyuta V. Nori, Sheel Patel, Ken Laing, Margarita Ajayi, Andrew J. Copas, Philip D. Butcher, Phillip Hay, Syed Tariq Sadiq
SEXUALLY TRANSMITTED INFECTIONS
(2015)
Article
Infectious Diseases
Marcus J. Pond, Catherine L. Hall, Victoria F. Miari, Michelle Cole, Ken G. Laing, Heena Jagatia, Emma Harding-Esch, Irene M. Monahan, Timothy Planche, Jason Hinds, Catherine A. Ison, Stephanie Chisholm, Philip D. Butcher, Syed Tariq Sadiq
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2016)
Article
Infectious Diseases
Kinga I. Stanczak-Mrozek, Ken G. Laing, Jodi A. Lindsay
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2017)
Article
Infectious Diseases
Mabel Sarpong-Duah, Michael Frimpong, Marcus Beissner, Malkin Saar, Ken Laing, Francisca Sarpong, Aloysius Dzigbordi Loglo, Kabiru Mohammed Abass, Margaret Frempong, Fred Stephen Sarfo, Gisela Bretzel, Mark Wansbrough-Jones, Richard Odame Phillips
PLOS NEGLECTED TROPICAL DISEASES
(2017)
Article
Hematology
Evelyn Torsney, Grisha Pirianov, Nicoletta Charolidi, Azza Shoreim, David Gaze, Slaveia Petrova, Ken Laing, Trevor Meisinger, Wanfen Xiong, B. Timothy Baxter, Gillian W. Cockerill
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2012)
Article
Hematology
Alison E. Wallace, Judith E. Cartwright, Runa Begum, Ken Laing, Baskaran Thilaganathan, Guy S. Whitley
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2013)
Article
Oncology
Catherine T. Choy, Haseong Kim, Ji-Young Lee, David M. Williams, David Palethorpe, Greg Fellows, Alan J. Wright, Ken Laing, Leslie R. Bridges, Franklyn A. Howe, Soo-Hyun Kim
ENDOCRINE-RELATED CANCER
(2014)
Article
Chemistry, Medicinal
Griselda Tudo, Ken Laing, Denis A. Mitchison, Philip D. Butcher, Simon J. Waddell
FUTURE MEDICINAL CHEMISTRY
(2010)
Article
Multidisciplinary Sciences
Louise Hogan, Sabin Bhuju, Des C. Jones, Ken Laing, John Trowsdale, Philip Butcher, Mahavir Singh, Martin Vordermeier, Rachel L. Allen
Article
Infectious Diseases
Michael Frimpong, Hubert Senanu Ahor, Ahmed Abd El Wahed, Bernadette Agbavor, Francisca Naana Sarpong, Kenneth Laing, Mark Wansbrough-Jones, Richard Odame Phillips
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Rheumatology
Anasuya Kuttapitiya, Lena Assi, Ken Laing, Caroline Hing, Philip Mitchell, Guy Whitley, Abiola Harrison, Franklyn A. Howe, Vivian Ejindu, Christine Heron, Nidhi Sofat
ANNALS OF THE RHEUMATIC DISEASES
(2017)
Article
Immunology
Haoua Tall, Berthe-Marie Njanpop-Lafourcade, Didier Mounkoro, Loukoumane Tidjani, Kodjo Agbenoko, Issifou Alassani, Moussa Amidou, Stanislas Tamekloe, Kenneth G. Laing, Adam A. Witney, Jason Hinds, Mark P. G. van der Linden, Bradford D. Gessner, Jennifer C. Moisi
EMERGING INFECTIOUS DISEASES
(2016)