Review
Medicine, General & Internal
Andres Schanzer, Gustavo S. Oderich
Summary: Repair of abdominal aortic aneurysm is recommended in men with an aneurysm of 5.5 cm or more and in women with an aneurysm of 5.0 cm or more. Endovascular aortic aneurysm repair has lower risk of perioperative complications and death compared to open surgical repair, but there is no long-term survival advantage. Long-term imaging surveillance is recommended after endovascular repair.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
John Anagnostakos, Brajesh K. Lal
Summary: Abdominal aortic aneurysms (AAA) are common in older adults and can lead to serious morbidity and mortality if not treated promptly. The causes include trauma, infection, and inflammatory disorders, with risk factors such as smoking, advanced age, dyslipidemia, hypertension, and coronary artery disease. The pathophysiology involves arterial insult leading to inflammation and weakening of the arterial wall, requiring monitoring of size and growth rate to prevent rupture. Management options include controlling risk factors, surgical intervention based on risk assessment, and post-operative monitoring for complications. Advancements in technology have improved the diagnosis and treatment of AAA in recent years.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Haruhito A. Uchida, Tetsuharu Takatsuka, Yoshiko Hada, Ryoko Umebayashi, Hidemi Takeuchi, Kenichi Shikata, Venkateswaran Subramanian, Alan Daugherty, Jun Wada
Summary: The study found that edaravone can attenuate angiotensin II-induced abdominal aortic aneurysms and atherosclerosis through its antioxidant and anti-inflammatory effects.
Article
Mechanics
Pratik M. Panchal, Dev S. Hathi, Niraj K. Shah, Absar M. Lakdawala
Summary: This study numerically analyzes the hemodynamics of Abdominal Aortic Aneurysm (AAA) and proposes hemodynamic indicators for identifying related complications. The results suggest that patients with higher pulse rates are more susceptible to atherosclerosis and mild exercise is recommended for AAA patients. Additionally, pulse rate and flow rate affect the severity of AAA.
Review
Cardiac & Cardiovascular Systems
Christiana Lowis, Aurellia Ramara Winaya, Puja Kumari, Cristobal F. Rivera, John Vlahos, Rio Hermantara, Muhammad Yogi Pratama, Bhama Ramkhelawon
Summary: Cumulative evidence supports the idea that mechanical and frictional forces have distinct effects in the aortic layers and contribute to the development of abdominal aortic aneurysms (AAA). Mechanosensory cellular hubs play a crucial role in triggering signaling cascades that lead to the degradation of the extracellular matrix (ECM), resulting in aortic rupture. This review provides an overview of the current understanding of the mechanotransduction networks in different cell types during AAA development, focusing on the mechanosensors and stressors that accumulate in the AAA sac and their effects on inflammation, oxidative stress, remodeling, and ECM degradation. Manipulating this mechano-machinery could be a promising direction for future AAA research.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, Research & Experimental
Lauren M. Weaver, Charles D. Loftin, Chang-Guo Zhan
Summary: This article discusses drugs for the treatment of abdominal aortic aneurysms (AAA) that have been studied in clinical trials. It examines the drug targets and their ability to regulate the three key pathways involved in AAA progression. The article highlights the historical use of repurposed therapeutics in interventional clinical trials and the need for novel treatments to reach the clinic. It emphasizes the importance of centralized anti-inflammatory drug targets and translatability in AAA treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Daniel Koerfer, Philipp Erhart, Susanne Dihlmann, Maani Hakimi, Dittmar Boeckler, Andreas S. Peters
Summary: The aim of this study was to investigate the histopathological differences in abdominal aortic aneurysms (AAAs) between patients with multiple and single arterial aneurysms. The study found that IL-1 beta was significantly more present in the tunica media in patients with multiple arterial aneurysms compared to those with a single AAA. This suggests that inflammatory processes play a role in aneurysm formation in patients with multiple arterial aneurysms.
Article
Medicine, General & Internal
Amelie L. Behrens, Susanne Dihlmann, Caspar Grond-Ginsbach, Andreas S. Peters, Bernhard Dorweiler, Dittmar Boeckler, Philipp Erhart
Summary: Gene expression profiling reveals the involvement of chronic inflammatory responses, active matrix metalloproteinases, and degradation of the extracellular matrix components in the development and progression of abdominal aortic aneurysms (AAA). The study shows heterogeneous gene expression patterns within the AAA vascular wall. Single biopsy investigations do not provide a comprehensive characterization of the activated molecular processes in AAA disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ang Zhou, Joseph R. Leach, Chengcheng Zhu, Huiming Dong, Fei Jiang, Yoo Jin Lee, James Iannuzzi, Warren Gasper, David Saloner, Michael D. Hope, Dimitrios Mitsouras
Summary: Contrast uptake in lateral aspects of AAA may be increased. Contrast enhancement measurements such as 1-minute slope and 4-minute AUC may be associated with recent AAA growth independent of D-max.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Surgery
Robin Ristl, Johannes Klopf, Andreas Scheuba, Florian Wolf, Martin Funovics, Bernd Gollackner, Anders Wanhainen, Christoph Neumayer, Martin Posch, Christine Brostjan, Wolf Eilenberg
Summary: This study developed a statistical model that takes into account various characteristics of AAA growth and applied it to predict AAA growth. The results demonstrated that the model accurately described the distribution of AAA growth and could be used to predict growth rates and the probability of exceeding a specific threshold for patients.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Immunology
Yu Fu, Haole Liu, Kexin Li, Panpan Wei, Naqash Alam, Jie Deng, Meng Li, Haibin Wu, Xue He, Haiwen Hou, Congcong Xia, Rong Wang, Weirong Wang, Liang Bai, Baohui Xu, Yankui Li, Yi Wu, Enqi Liu, Sihai Zhao
Summary: CRP deficiency suppresses AAA by reducing aneurysmal elastin destruction, macrophage accumulation, and matrix metalloproteinase 2 expression
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Samuel Debono, Jennifer Nash, Andrew L. Tambyraja, David E. Newby, Rachael O. Forsythe
Summary: The management of abdominal aortic aneurysms has been rigorously examined, with traditional open surgical repair improving long-term outcomes but associated with significant morbidity and mortality. Endovascular aneurysm repair has reduced early complications but introduced unique issues like endoleaks. A need for postoperative imaging surveillance and re-intervention arises due to the risks associated with endoleak development, influencing the selection of repair mode for individual patients.
Article
Chemistry, Multidisciplinary
Benjamin T. Ledford, Adam W. Akerman, Kui Sun, David C. Gillis, Jenna M. Weiss, Johnny Vang, Smaranda Willcox, Tristan D. Clemons, Hiroaki Sai, Ruomeng Qiu, Mark R. Karver, Jack D. Griffith, Nick D. Tsihlis, Samuel Stupp, John S. Ikonomidis, Melina R. Kibbe
Summary: This study reports the development of injectable supramolecular nanofibers that target fragmented elastin, matrix metalloproteinase 2, and membrane type 1 matrix metalloproteinase to reduce the risks associated with a ruptured abdominal aortic aneurysm. The results show that one of the nanofibers was able to better localize to the aneurysm tissue and had an optimal dose.
Review
Endocrinology & Metabolism
Tongtong Ye, Guangdong Zhang, Hangyu Liu, Junfeng Shi, Hongyan Qiu, Yongping Liu, Fang Han, Ningning Hou
Summary: PVAT plays a critical role in the development of AAAs and may serve as a therapeutic target.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Peripheral Vascular Disease
Nozomu Otaka, Haruhito A. Uchida, Michihiro Okuyama, Yoshiko Hada, Yasuhiro Onishi, Yuki Kakio, Hidemi Takeuchi, Ryoko Umebayashi, Katsuyuki Tanabe, Venkateswaran Subramanian, Alan Daugherty, Yasufumi Sato, Jun Wada
Summary: Exogenous VASH2 had no significant effect on AngII-induced abdominal aortic aneurysms or atherosclerosis, but increased dilation in the ascending aorta.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
