Review
Pharmacology & Pharmacy
Fabricio Santiago
Summary: Chronic venous disease negatively affects patients' quality of life, and there is a discrepancy between physicians and patients in understanding its impact. Physicians tend to focus more on physical symptoms while patients are less satisfied with their quality of life. Therefore, physicians should consider the overall aspects of patients' lives, including sleep and quality of life. Additionally, certain medications can improve the quality of life for patients with chronic venous disease.
CLINICAL DRUG INVESTIGATION
(2023)
Article
Surgery
Mohsen Sharifi, R. Curtis Bay, Kaveh Karandish, Farnaz Emrani, Robert Snyder, Siddharth D'Silva, Atlantis Trial
Summary: Aquatic activity shows significant clinical effects and improvements in quality of life for patients with advanced chronic venous insufficiency. The treatment effect is rapidly observed within 3 months of initiating therapy, and continues to slowly improve over time from 3 months to 2 years.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Jurgen H. Prochaska, Natalie Arnold, Andrea Falcke, Sabrina Kopp, Andreas Schulz, Gregor Buch, Sophie Moll, Marina Panova-Noeva, Claus Juenger, Lisa Eggebrecht, Norbert Pfeiffer, Manfred Beutel, Harald Binder, Stephan Grabbe, Karl J. Lackner, Arina Ten Cate-Hoek, Christine Espinola-Klein, Thomas Munzel, Philipp S. Wild
Summary: The study found that chronic venous insufficiency (CVI) is highly prevalent in the population and closely associated with cardiovascular risk factors and disease. Patients with CVI face an increased risk of death, independent of factors such as age, gender, and other cardiovascular risk factors.
EUROPEAN HEART JOURNAL
(2021)
Article
Multidisciplinary Sciences
Janusiya Anajan Muthulingam, Soren Schou Olesen, Tine Maria Hansen, Christina Brock, Asbjorn Mohr Drewes, Jens Brondum Frokjaer
Summary: In this sham-controlled crossover study, we found no evidence that two weeks transcutaneous vagal nerve stimulation induces pain relief in patients with chronic pancreatitis.
Article
Medicine, General & Internal
Hao Zhang, Shao-Hua Guo, Zheng-Kai Xue, Ya-Ru Zhang, Jia-Rui Wang, Jing-Jin Che, Tong Liu, Hua-Yue Tao, Guang-Ping Li, Seung-Woon Rha, Swapnil-Zaman Ashraful-Haque, Kang-Yin Chen
Summary: The study assessed the protective effect of calcium dobesilate against contrast-induced nephropathy in patients with diabetes and CKD, showing no preventive effect. Although there was a slight reduction in SCr levels, no significant differences were observed in CysC and NGAL levels between the experimental and control groups.
Review
Dermatology
Piyush Kumar, Ismat Ara Khan, Anupam Das, Hiral Shah
Summary: Chronic venous disease (CVD), a common condition in dermatology outpatient department, can progress to chronic leg ulcer if left untreated. It affects patients' quality of life and work productivity. The clinical manifestations range from asymptomatic varicose veins to ulceration and scarring. Increased venous hypertension and chronic inflammation play key roles in the development of CVD.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rosario Amato, Vincenzo Dattilo, Carolina Brescia, Lucia D'Antona, Rodolfo Iuliano, Francesco Trapasso, Nicola Perrotti, Davide Costa, Nicola Ielapi, Francesco Aiello, Michele Provenzano, Umberto Marcello Bracale, Michele Andreucci, Raffaele Serra
Summary: This study aimed to validate the correlation between Th17 response and the development of chronic venous disease and chronic venous limb ulcers (CVLUs), and identify Th17 markers as intrinsic risk factors and diagnostic markers for disease development. The results demonstrated that the main expression markers of the CD4 + Th17+ switch were strongly activated in chronic venous insufficiency and advanced ulceration. Th17 markers behaved as empirical risk factors for chronic venous disease development. These findings provide a new hypothesis for the pathogenesis of chronic venous disease and suggest the development of new diagnostic, preventive, and therapeutic approaches.
Article
Respiratory System
Narelle S. Cox, Christine F. McDonald, Ajay Mahal, Jennifer A. Alison, Richard Wootton, Catherine J. Hill, Paolo Zanaboni, Paul O'Halloran, Janet Bondarenko, Heather Macdonald, Kathryn Barker, Hayley Crute, Christie Mellerick, Bruna Wageck, Helen Boursinos, Aroub Lahham, Amanda Nichols, Pawel Czupryn, Monique Corbett, Emma Handley, Angela T. Burge, Anne E. Holland
Summary: The study found no significant differences between center-based pulmonary rehabilitation and telerehabilitation for both primary and secondary outcomes at the end of rehabilitation and at the 12-month follow-up. Although equivalence of telerehabilitation for CRQ-D was not confirmed, it showed equivalence in 6-minute walk distance at the end of rehabilitation and possibly had superiority at 12 months.
Article
Medicine, General & Internal
Jonathan G. Moss, Olivia Wu, Andrew R. Bodenham, Roshan Agarwal, Tobias F. Menne, Brian L. Jones, Robert Heggie, Steve Hill, Judith Dixon-Hughes, Eileen Soulis, Evi Germeni, Susan Dillon, Elaine McCartney
Summary: This study compared complication rates and costs of PICCs, Hickman, and PORTs in patients receiving SACT, finding that PORTs were more effective and safer than both Hickman and PICCs.
Article
Surgery
Erica Menegatti, Stefano Masiero, Paolo Zamboni, Giampiero Avruscio, Mirko Tessari, Anselmo Pagani, Sergio Gianesini
Summary: The study demonstrates that thermal aquatic immersion has a positive impact on the clinical outcomes of patients with chronic venous disease, helping to reduce lower limb volume and improve disease management. Additionally, the research results also show significant improvements in ankle range of motion and quality of life for patients undergoing thermal water immersion.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2021)
Article
Respiratory System
Steven P. Walker, Emma Keenan, Oliver Bintcliffe, Andrew E. Stanton, Mark Roberts, Justin Pepperell, Ian Fairbairn, Edward McKeown, James Goldring, Nadeem Maddekar, James Walters, Alex West, Amrithraj Bhatta, Matthew Knight, Rachel Mercer, Rob Hallifax, Paul White, Robert F. Miller, Najib M. Rahman, Nick A. Maskell
Summary: The study found that in the management of secondary spontaneous pneumothorax (SSP), using Atrium Pneumostat (AP) valve may be safer and more effective than Pleural Vents (PV).
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Plant Sciences
Beatriz Germer Baptista, Susane Fanton, Marcia Ribeiro, Ludmila F. M. F. Cardozo, Bruna Regis, Livia Alvarenga, Marcelo Ribeiro-Alves, Andresa A. Berretta, Paul G. Shiels, Denise Mafra
Summary: The study aimed to evaluate the effects of propolis supplementation on inflammatory markers in peritoneal dialysis patients with chronic kidney disease. The results showed that propolis supplementation significantly reduced tumor necrosis factor-alpha levels and had a trend to increase the expression of nuclear factor erythroid-2-related factor 2.
Article
Gastroenterology & Hepatology
Evan S. Dellon, Kathryn A. Peterson, Benjamin L. Mitlyng, Alina Iuga, Christine E. Bookhout, Lindsay M. Cortright, Kacie B. Walker, Timothy S. Gee, Sarah J. McGee, Brenderia A. Cameron, Joseph A. Galanko, John T. Woosley, Swathi Eluri, Susan E. Moist, Ikuo Hirano
Summary: This study aimed to determine the efficacy of mepolizumab in improving dysphagia symptoms and reducing esophageal eosinophil counts in EoE. The results showed that mepolizumab significantly decreased symptoms and eosinophil counts within 3 months, but longer treatment did not yield additional improvement.
Article
Pharmacology & Pharmacy
Bingyu Du, Yanyan Yin, Yuqing Wang, Hui Fu, Helin Sun, Zhaodi Yue, Shaohong Yu, Zhongwen Zhang
Summary: In this study, the effectiveness of calcium dobesilate (CaD) in diabetic kidney disease (DKD) patients was evaluated. The results showed that CaD treatment significantly reduced the levels of serum creatinine and blood urea nitrogen, while also decreasing the levels of serum cystatin C, urinary molecules reflecting kidney function, and inflammatory factors. Additionally, CaD improved glomerular filtration rate and endothelial function. Network pharmacology analysis indicated that CaD may exert its effects on DKD through the MAPK and chemokine signaling pathways, with AKT1, CASP3, IGF1, MAPK8, and CCL5 identified as potential key targets.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jeroen M. Schuitenmaker, Froukje B. van Hoeij, Marlies P. Schijven, Jan Tack, Jose M. Conchillo, Eric J. Hazebroek, Andre J. P. M. Smout, Albert J. Bredenoord
Summary: The study results indicate that pneumatic dilation with a 35 mm balloon is not superior to sham dilation for the treatment of persistent dysphagia after fundoplication.
Review
Critical Care Medicine
Stefanie Suclupe, Percy Efrain Pantoja Bustillos, Javier Bracchiglione, Carolina Requeijo, Karla Salas-Gama, Ivan Sola, Angela Merchan-Galvis, Jaume Uya Muntana, Gemma Robleda, Maria Jose Martinez-Zapata
Summary: This study provides an overview of the effectiveness of nonpharmacological interventions in preventing adverse events in the intensive care unit. The findings suggest that some interventions, such as subglottic secretion drainage and semirecumbent position, are effective in preventing specific adverse events. However, the low methodological quality of the included reviews should be taken into consideration when interpreting the results. Rating: 7.5/10.
AUSTRALIAN CRITICAL CARE
(2023)
Article
Medicine, General & Internal
Angela Merchan-Galvis, Rafael Anaya, Mireia Rodriguez, Jordi Llorca, Merce Castejon, Jose Maria Gil, Angelica Millan, Veronica Estepa, Elena Cardona, Yaiza Garcia-Sanchez, Ana Ruiz, Maria Jose Martinez-Zapata
Summary: This study evaluated a strategy to shorten the time from admission to surgery in patients with proximal femur fractures on chronic antiplatelet therapy and reported a 12-month follow-up on complications and quality of life. Patients were randomized to either early platelet function-guided surgery or delayed surgery. Surgical wound complications occurred in 5.7% of patients after hospital discharge, and 55.9% had medical complications, with 42.7% experiencing serious adverse events. Quality of life improved significantly after surgery, with the best scores at the six-month follow-up. There were no differences in outcomes between early and delayed surgery groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Javier Bracchiglione, Gerardo Rodriguez-Grijalva, Carolina Requeijo, Marilina Santero, Josefina Salazar, Karla Salas-Gama, Adriana-Gabriela Meade, Alba Antequera, Ariadna Auladell-Rispau, Maria Jesus Quintana, Ivan Sola, Gerard Urrutia, Roberto Acosta-Dighero, Xavier Bonfill Cosp
Summary: Hepatobiliary cancers are usually treated with systemic oncological treatments, but the trade-off between these treatments and supportive care is not clear and other outcomes beyond survival should be considered. This study aimed to assess the effects of systemic oncological treatments versus supportive care for advanced hepatobiliary cancers. The results showed that these treatments tend to improve survival but with greater toxicity, and other patient-important outcomes were not reported.
Editorial Material
Medicine, General & Internal
Xavier Bonfill
BMJ EVIDENCE-BASED MEDICINE
(2023)
Article
Medicine, General & Internal
Maura Marcucci, Thomas W. Painter, David Conen, Vladimir Lomivorotov, Daniel Sessler, Matthew T. V. Chan, Flavia K. Borges, Kate Leslie, Emmanuelle Duceppe, Maria Jose Martinez-Zapata, Chew Yin Wang, Denis Xavier, Sandra N. Ofori, Michael Ke Wang, Sergey Efremov, Giovanni Landoni, Ydo Kleinlugtenbelt, Wojciech Szczeklik, Denis Schmartz, Amit X. Garg, Timothy G. Short, Maria Wittmann, Christian S. Meyhoff, Mohammed Amir, David Torres, Ameen Patel, Kurt Ruetzler, Joel L. Parlow, Vikas Tandon, Edith Fleischmann, Carisi A. Polanczyk, Andre Lamy, Raja Jayaram, Sergey V. Astrakov, William Ka Kei Wu, Chao Chia Cheong, Sabry Ayad, Mikhail Kirov, Miriam de Nadal, Valery V. Likhvantsev, Pilar Paniagua, Hector J. Aguado, Kamal Maheshwari, Richard P. Whitlock, Michael H. McGillion, Jessica Vincent, Ingrid Copland, Kumar Balasubramanian, Bruce M. Biccard, Sadeesh Srinathan, Samandar Ismoilov, Shirley Pettit, David Stillo, Andrea Kurz, Emilie P. Belley-Cote, Jessica Spence, William F. McIntyre, Shrikant Bangdiwala, Gordon Guyatt, Salim Yusuf, P. J. Devereaux
Summary: This study compared the effects of two different blood pressure management strategies, hypotension-avoidance and hypertension-avoidance, on major vascular complications after noncardiac surgery. The results showed that both strategies had similar incidence of major vascular complications.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Francisca Verdugo-Paiva, Xavier Bonfill, Duniel Ortuno, Michael Glick, Alonso Carrasco-Labra
Summary: This study aims to assess policymakers' perceived needs, barriers, and facilitators in using research evidence to inform policies in oral health. The researchers will conduct qualitative interviews with policymakers, and the data will be analyzed using thematic analysis. The findings will be shared with participating organizations, disseminated in conferences, and published in a peer-reviewed journal.
Article
Multidisciplinary Sciences
Angela Maria Merchan-Galvis, David Andres Munoz-Garcia, Felipe Solano, Julian Camilo Velasquez, Nelson Fernando Sotelo, David Alejandro Molina, Juan Pablo Caicedo, Juan Manuel Concha, Jose Andres Calvache, Maria Jose Martinez-Zapata
Summary: This study aimed to identify factors associated with delayed surgery in patients with proximal femoral fracture and evaluate their health-related quality of life (HRQoL) after surgery, including mortality within 6 months. It was a single-center, observational, prospective cohort study that included 163 patients. The main factor associated with delayed surgery was administrative authorization. The HRQoL of patients improved 6 months after surgery.
SCIENTIFIC REPORTS
(2023)
Review
Respiratory System
Karina Mayoral, Catalina Lizano-Barrantes, Victor Zamora, Angels Pont, Carme Miret, Cristina Barrufet, M. Araceli Caballero-Rabasco, Manuel Praena-Crespo, Alberto Bercedo, Laura Valdesoiro-Navarrete, Maria Teresa Guerra, Yolanda Pardo, Ma Jose Martinez Zapata, Olatz Garin, Montse Ferrer
Summary: This study aimed to assess the impact of montelukast on pediatric patients with asthma/allergic rhinitis and found that montelukast was effective in controlling asthma symptoms when compared with placebo, but inhaled corticosteroids were superior in controlling symptoms. These findings are consistent with current asthma treatment guidelines.
EUROPEAN RESPIRATORY REVIEW
(2023)
Review
Oncology
Juan C. Vazquez, Antonio Pinero, Francisco J. de Castro, Ana Lluch, Miguel Martin, Agusti Barnadas, Emilio Alba, Alvaro Rodriguez-Lescure, Federico Rojo, Julia Gimenez, Ivan Sola, Maria J. Quintana, Xavier Bonfill, Gerard Urrutia, Pedro Sanchez-Rovira
Summary: This systematic review analyzed the performance of sentinel lymph-node biopsy (SLNB) in women with node-positive breast cancer at diagnosis and node-negative tumor after neoadjuvant therapy compared to axillary lymph-node dissection. The results showed that SLNB has a low false-negative rate, high lymph-node identification rate, good negative predictive value, and high accuracy. The performance of SLNB can be improved with double mapping and marking the affected node.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Marilina Santero, Julia de Mas, Berta Rifa, Ines Clavero, Irene Rexach, Xavier Bonfill Cosp
Summary: This study evaluated the quality of cancer treatment guidelines from the Spanish Society of Medical Oncology (SEOM) using the AGREE II and AGREE-REX tools. It found that 84.8% of the guidelines were rated as high quality, but there were areas for improvement in terms of clinical applicability and inclusion of patient perspectives.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Review
Oncology
Endre Szigethy, Rosario Dorantes, Miguel Sugranes, Meisser Madera, Ivan Sola, Gerard Urrutia, Xavier Bonfill
Summary: The purpose of this scoping review was to describe the methods and extent of anticancer drug use at the end of life. Through systematic searches, 341 eligible publications were selected, including 69 articles on all cancer types published within the last 5 years. The results showed variability in the frequency of anticancer drug use across different end of life periods.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Josefina Bendersky, Macarena Uribe, Maximiliano Bravo, Juan Pablo Vargas, Julio Villanueva, Gerard Urrutia, Xavier Bonfill
Summary: This systematic mapping review aims to identify, describe, and organize the currently available evidence regarding orthognathic surgery co-interventions and surgical modalities. The quality of the included systematic reviews was generally low, and the study identified several knowledge gaps that need to be addressed in future high-quality research.
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
(2023)
Review
Oncology
Juan Carlos Vazquez, Silvia Antolin, Manuel Ruiz-Borrego, Sonia Servitja, Emilio Alba, Agusti Barnadas, Ana Lluch, Miguel Martin, Alvaro Rodriguez-Lescure, Ivan Sola, Xavier Bonfill, Gerard Urrutia, Pedro Sanchez-Rovira
Summary: Through a systematic review, it was found that dual anti-HER2 blockade had a higher probability of achieving pathological complete response compared to monotherapy. Furthermore, dual treatment may lead to improved survival outcomes and tumor clinical response. For neoadjuvant treatment of HER2-positive breast cancer, the use of dual blockade with trastuzumab and pertuzumab is recommended.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Rehabilitation
Carina Salgueiro, Gerard Urrutia, Rosa Cabanas-Valdes
Summary: This study explores the available apps for Spanish-speaking stroke patients for sensory-motor rehabilitation. The study found that there are few specific apps for stroke rehabilitation and they have important limitations, calling for the development and adaptation of apps for healthcare professionals and users.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2023)
