Article
Chemistry, Medicinal
Savina Malancona, Mattia Mori, Paola Fezzardi, Marisabella Santoriello, Andreina Basta, Martina Nibbio, Lesia Kovalenko, Roberto Speziale, Maria Rosaria Battista, Antonella Cellucci, Nadia Gennari, Edith Monteagudo, Annalise Di Marco, Alessia Giannini, Rajhans Sharma, Manuel Pires, Eleonore Real, Maurizio Zazzi, Maria Chiara Dasso Lang, Davide De Forni, Francesco Saladini, Yves Mely, Vincenzo Summa, Steven Harper, Maurizio Botta
ACS MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Multidisciplinary Sciences
Robin Oz, Sean M. Howard, Rajhans Sharma, Hanna Tornkvist, Ilaria Ceppi, K. K. Sriram, Erik Kristiansson, Petr Cejka, Fredrik Westerlund
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biophysics
Dipanjan Mukherjee, Tatini Rakshit, Priya Singh, Suman Mondal, Debashish Paul, Manisha Ahir, Arghya Adhikari, Theja P. Puthiyapurayil, Praveen Kumar Vemula, Dulal Senapati, Ranjan Das, Samir Kumar Pal
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Article
Biochemistry & Molecular Biology
Robin Oz, Jing L. Wang, Raphael Guerois, Gaurav Goyal, Sriram Kk, Virginie Ropars, Rajhans Sharma, Firat Koca, Jean-Baptiste Charbonnier, Mauro Modesti, Terence R. Strick, Fredrik Westerlund
Summary: In this study, single-molecule techniques were used to characterize the dynamics of prokaryotic DNA repair by non-homologous end-joining (NHEJ). The findings suggest differences in the mechanisms of bacterial NHEJ compared to human NHEJ, with bacterial Ku playing a significant role in the process. The study also proposes evolutionary similarities between bacterial and eukaryotic NHEJ mechanisms.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Dipanjan Mukherjee, Priya Singh, Soumendra Singh, Debanjona Singh Roy, Subhankar Singha, Uttam Pal, Jhimli Sengupta, Rami J. Obaid, Saleh A. Ahmed, Tanusri Saha Dasgupta, Ranjan Das, Samir Kumar Pal
Summary: The study investigates the molecular recognition and binding process between CD1 and HSA, revealing that different host vehicles can impact the rate of drug binding to the protein, thereby modulating the release rate of the drug mimic.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Arpan Bera, Md Nur Hasan, Uttam Pal, Damayanti Bagchi, Tuhin Kumar Maji, Tanusri Saha-Dasgupta, Ranjan Das, Samir Kumar Pal
Summary: The application of NIR active drugs like ICG in PDT shows potential, but limitations in ROS generation exist due to aggregation. A solution is the fabrication of ICG-ZnO nanohybrid, which enhances ROS production and prevents aggregation, showing remarkable antimicrobial activity.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Physical
Dipanjan Mukherjee, Md Nur Hasan, Ria Ghosh, Gourab Ghosh, Arpan Bera, Sujanthi Easwara Prasad, Ankita Hiwale, Praveen K. Vemula, Ranjan Das, Samir Kumar Pal
Summary: Complexes of cationic liposomes with DNA have shown promise as nonviral vectors for gene therapy. This study examines the kinetics of liposome/DNA complex formation and reveals two different kinetic processes using novel cationic lipids. The observed difference in kinetics is likely due to variations in the lipid/DNA complex structures.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Pritam Biswas, Uttam Pal, Aniruddha Adhikari, Susmita Mondal, Ria Ghosh, Dipanjan Mukherjee, Tanusri Saha-Dasgupta, Sudeshna Shyam Choudhury, Ranjan Das, Samir Kumar Pal
Summary: This study investigates the conformational dynamics and catalytic activity of alpha-chymotrypsin using optical spectroscopy and molecular dynamics simulations. The enzyme shows highest catalytic efficiency at the optimum temperature of 308 K. It is found that the flexibility of the enzyme increases with temperature. Principal component analysis reveals the essential dynamics and gatekeeping role of loop regions surrounding the catalytic pocket.
Article
Biochemistry & Molecular Biology
Ria Ghosh, Soumendra Singh, Dipanjan Mukherjee, Susmita Mondal, Monojit Das, Uttam Pal, Aniruddha Adhikari, Aman Bhushan, Surajit Bose, Siddharth Sankar Bhattacharyya, Debasish Pal, Tanusri Saha-Dasgupta, Maitree Bhattacharyya, Debasis Bhattacharyya, Asim Kumar Mallick, Ranjan Das, Samir Kumar Pal
Summary: This study investigates the efficacy of SDS surfactant in delivering a model drug from micellar cavity to DNA in both monomer and micellar stages. The results show that the concentration of SDS has a significant impact on the encapsulation and delivery of the drug.
Article
Chemistry, Analytical
Nivedita Pan, Lopamudra Roy, Md. Nur Hasan, Amrita Banerjee, Ria Ghosh, Meshari A. Alsharif, Basim H. Asghar, Rami J. Obaid, Arpita Chattopadhyay, Ranjan Das, Saleh A. Ahmed, Samir Kumar Pal
Summary: We have synthesized a nanohybrid combining TiO2 nanoparticle and organic molecule RK1, which has the potential for solar light harvesting applications. We have performed detailed structural characterization and studied the ultrafast dynamics of RK1 in different environments. The attachment of RK1 to the surface of semiconductor nanoparticles results in fast electron transfer, which is crucial for efficient light harvesting. The generation of reactive oxygen species as a result of photoinduced electron injection in the aqueous medium is also investigated for potential redox-active micromachines.
Article
Nanoscience & Nanotechnology
Dipanjan Mukherjee, Debashish Paul, Sushmita Sarker, Md Nur Hasan, Ria Ghosh, Sujanthi Easwara Prasad, Praveen K. Vemula, Ranjan Das, Arghya Adhikary, Samir Kumar Pal, Tatini Rakshit
Summary: The fusion of cell-derived extracellular vesicles (EVs) with synthetic liposomes using polyethylene glycol (PEG) can enhance the cellular delivery efficiency of siRNA molecules to breast cancer cells, potentially providing clinically viable delivery solutions.
ACS APPLIED BIO MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Rajhans Sharma, K. K. Sriram, Erik D. Holmstrom, Fredrik Westerlund
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Chemistry, Physical
Dipanjan Mukherjee, Priya Singh, Tatini Rakshit, Theja P. Puthiya-Purayil, Praveen Kumar Vemula, Jhimli Sengupta, Ranjan Das, Samir Kumar Pal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2020)
Article
Chemistry, Multidisciplinary
Priya Singh, Dipanjan Mukherjee, Subhankar Singha, V. K. Sharma, Ismail I. Althagafi, Saleh A. Ahmed, R. Mukhopadhyay, Ranjan Das, Samir Kumar Pal
Article
Chemistry, Physical
Pritam Biswas, Aniruddha Adhikari, Uttam Pal, Priya Singh, Monojit Das, Tanusri Saha-Dasgupta, Sudeshna Shyam Choudhury, Ranjan Das, Samir Kumar Pal