4.8 Article

Domino Aryne Precursor: Efficient Construction of 2,4-Disubstituted Benzothiazoles

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 17, Pages 5670-5673

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b02566

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Funding

  1. NSFC [21372268]
  2. 100 Young Plan by Chongqing University

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An aryne precursor with a potential to perform domino aryne chemistry was proposed and synthesized. The reaction of this reagent with benzothioamide derivatives could afford 2,4-disubstituted benzothiazole with sequential incorporation of C-S, C-N, and C-C bonds on the consecutive three positions of the aryne precursor.

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