Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 38, Pages 12191-12194Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b05832
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Funding
- Hoansha Foundation
- Akiyama Life Science Foundation
- Shimadzu Science Foundation
- Innovation COE Project for Future Medicine and Medicinal Research
- [26702034]
- [24310151]
- [15H03111]
- Grants-in-Aid for Scientific Research [26702034, 15H03111] Funding Source: KAKEN
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The stereochemistry of glycerophospholipids (GPLs) has been of interest for its roles in the evolution of life and in their biological activity. However, because of their structural complexity, no convenient method to determine their configuration has been reported. In this work, through the first systematic application of vibrational circular dichroism (VCD) spectroscopy to various diacylated GPLs, we have revealed that their chirality can be assigned by the sign of a VCD exciton couplet generated by the interaction of two carbonyl groups. This paper also presents spectroscopic evidence for the stereochemistry of GPLs isolated from bacteria, eukaryotes, and mitochondria.
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