Article
Cardiac & Cardiovascular Systems
Christoph Beyer, Lyudmyla Tokarska, Markus Stuhlinger, Gudrun Feuchtner, Florian Hintringer, Sarah Honold, Lukas Fiedler, Marie-Sophie Schonbauer, Robert Schonbauer, Fabian Plank
Summary: Atrial wall thickness, epicardial fat volume, and attenuation are associated with AF recurrence in patients undergoing ablation therapy.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Medicine, General & Internal
Nathalie Noirclerc, Olivier Huttin, Christian de Chillou, Christine Selton-Suty, Laura Fillipetti, Jean Marc Sellal, Erwan Bozec, Erwan Donal, Zohra Lamiral, Masatake Kobayashi, Joao Pedro Ferreira, Patrick Rossignol, Nicolas Girerd
Summary: The study found that patients with paroxysmal atrial fibrillation exhibit early cardiac remodeling, characterized by increased left ventricular mass and left atrial enlargement. Although less than 10% of patients show diastolic dysfunction, there is a significant association with atrial fibrillation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Michelle L. Munro, Isabelle van Hout, Hamish M. Aitken-Buck, Ramanen Sugunesegran, Krishna Bhagwat, Philip J. Davis, Regis R. Lamberts, Sean Coffey, Christian Soeller, Peter P. Jones
Summary: The clustering properties of RyR2 were found to be largely unchanged in AF patients, unlike significant differences observed in atrial dilation and cardiomyocyte hypertrophy between patient groups. This suggests that RyR2 cluster remodeling is not a contributing factor to altered channel function and arrhythmogenesis in human AF.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Physiology
Yajun Yao, Mei Yang, Dishiwen Liu, Qingyan Zhao
Summary: Immune remodeling is a new direction for research and therapeutic strategies for atrial fibrillation (AF) as it has complex relationships with atrial electrical, structural, and neural remodeling. It may provide effective therapies for AF.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Plant Sciences
Jin Ma, Miao Ren, Jinxin Li, Chaoyang Zheng, Qiuxiong Chen, Shiyu Ma
Summary: The study demonstrated that DQ reduces the risk of atrial fibrillation in post-myocardial infarction heart failure rats by inhibiting the functions of cardiac fibroblasts, thus ameliorating left atrial arrhythmogenic substrate.
Article
Immunology
Jie Liao, Shaoshao Zhang, Shuaitao Yang, Yang Lu, Kai Lu, Yuwei Wu, Qiongfeng Wu, Ning Zhao, Qian Dong, Lei Chen, Yimei Du
Summary: IL-6 neutralization improved atrial inflammation and fibrosis, as well as atrial fibrillation susceptibility in ST rats, which is associated with Ca2+ handling abnormalities and RyR2 dysfunction.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Laurie Soulat-Dufour, Sylvie Lang, Karima Addetia, Stephane Ederhy, Saroumadi Adavane-Scheuble, Marion Chauvet-Droit, Marie-Liesse Jean, Pascal Nhan, Rim Ben Said, Iris Kamami, Pauline Issaurat, Elodie Capderou, Camille Arnaud, Franck Boccara, Roberto M. Lang, Ariel Cohen
Summary: Restoration of sinus rhythm in atrial fibrillation patients can improve cardiac cavity remodeling and functional regurgitation, reducing the severity of regurgitation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Cell Biology
Abhijit Takawale, Martin Aguilar, Yasmina Bouchrit, Roddy Hiram
Summary: This article explores the association between thyroid disease and atrial fibrillation, highlighting the impact of thyroid hormone dysregulation on the development of atrial arrhythmogenic substrate. It also reviews the available therapeutic strategies for treating atrial fibrillation in the context of thyroid disease.
Article
Pharmacology & Pharmacy
Guang Zhong Liu, Wei Xu, Yan Xiang Zang, Qi Lou, Peng Zhou Hang, Qiang Gao, Hang Shi, Qi Yun Liu, Hong Wang, Xin Sun, Cheng Liu, Peng Zhang, Hua Dong Liu, Shao Hong Dong
Summary: The study revealed that Sirt3 was significantly down-regulated in AF patients and models, but restored by HL treatment. Sirt3 could regulate the acetylated modification of key metabolic enzymes, and increasing Sirt3 levels rescued AF-induced atrial metabolic remodeling.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Angelica Perna, Carmine Sellitto, Klara Komici, Eleonora Hay, Aldo Rocca, Paolo De Blasiis, Angela Lucariello, Francesco Moccia, Germano Guerra
Summary: Tumor diseases spread quickly and studies have focused on the role of ion channels, particularly the Transient Receptor Potential (TRP) channels, in tumor vessel formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Yung-Lung Chen, Hui-Ting Wang, Pei-Ting Lin, Jiin-Haur Chuang, Ming-Yu Yang
Summary: This study revealed a significant association between higher MIP-1 alpha levels and LA remodeling, suggesting the potential for predicting LA remodeling with larger LA volumes. Circadian gene derangement may also impact the expression of MIP-1 alpha.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Ryo Nishinarita, Shinichi Niwano, Hiroe Niwano, Hironori Nakamura, Daiki Saito, Tetsuro Sato, Gen Matsuura, Yuki Arakawa, Shuhei Kobayashi, Yuki Shirakawa, Ai Horiguchi, Naruya Ishizue, Tazuru Igarashi, Tomoharu Yoshizawa, Jun Oikawa, Yoshinobu Hara, Takafumi Katsumura, Jun Kishihara, Akira Satoh, Hidehira Fukaya, Hiroyuki Sakagami, Junya Ako
Summary: This study found that the SGLT2 inhibitor canagliflozin may be beneficial for preventing atrial fibrillation and suppressing atrial remodeling, by reducing atrial effective refractory period, decreasing conduction velocity, and inhibiting the inducibility of AF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Laura Amores-Bonet, Ralf Kleene, Thomas Theis, Melitta Schachner
Summary: The interaction between NCAM and TRPC1, -4, and -5 is important for the NCAM-stimulated and PSA-dependent Ca2+ entry into neurons, influencing essential neural functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Dengyue Xu, Chennian Xu, Xiaodong Xue, Yinli Xu, Jikai Zhao, Tao Huang, Zhishang Wang, Qiusheng Zhao, Zijun Zhou, Yuting Huang, Liming Yu, Huishan Wang
Summary: The activation of CB2R has a protective effect against atrial fibrillation (AF) by preventing oxidative stress. CB2R can serve as a potential therapeutic target for treating AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yoshiko Murakata, Fumi Yamagami, Nobuyuki Murakoshi, DongZhu Xu, Zhonghu Song, Siqi Li, Yuta Okabe, Kazuhiro Aonuma, ZiXun Yuan, Haruka Mori, Kazutaka Aonuma, Kazuko Tajiri, Masaki Ieda
Summary: Inflammatory atrial cardiomyopathy can lead to atrial fibrillation, characterized by enlarged atria, infiltration of inflammatory cells, and fibrosis. These changes increase susceptibility to arrhythmias by affecting electrical conduction, genetic factors, and autonomic regulation. Therefore, reducing inflammation is important in preventing atrial fibrillation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)