Article
Immunology
Archana Bharti Sonkar, Pranesh Kumar, Anand Kumar, Anurag Kumar Gautam, Abhishek Verma, Amita Singh, Umesh Kumar, Dinesh Kumar, Tarun Mahata, Bolay Bhattacharya, Amit K. Keshari, Biswanath Maity, Sudipta Saha
Summary: This study reveals the role of vinpocetine, a synthetic derivative of vincamine, in DMH-induced colon carcinogenesis. Rats were induced with DMH for four weeks and then treated with vinpocetine for 15 days. The results show that vinpocetine can attenuate altered plasma parameters, suppress COX-2 stimulation, and decrease IL-10, IL-2, IL-6, and IL-10 levels. Vinpocetine has anti-inflammatory and antioxidant potential, making it a potential anticancer agent for CRC treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ferenc Zador, Samia Joca, Gabor Nagy-Grocz, Szabolcs Dvoracsko, Edina Szucs, Csaba Tomboly, Sandor Benyhe, Laszlo Vecsei
Summary: Substance use/abuse is a major cause of depression, potentially leading to inflammatory reactions triggering depressive symptoms, and increased pro-inflammatory cytokines may affect tryptophan metabolism, resulting in reduced serotonin levels, and subsequently inducing depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Ciprian Rezus, Alexandra Maria Burlui, Elena Rezus
Summary: Cardiovascular diseases are a leading cause of high mortality in SLE patients, and traditional risk factors are insufficient in predicting their risk. Inflammation has been found to play a crucial role in the development of atherosclerosis in SLE, highlighting the need for new biomarkers to assess subclinical CVD risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Psychiatry
Maria Lourdes Garcia-Garcia, Carlos Alfonso Tovilla-Zarate, Mario Villar-Soto, Isela Esther Juarez-Rojop, Thelma Beatriz Gonzalez-Castro, Alma Delia Genis-Mendoza, Miguel Angel Ramos-Mendez, Maria Lilia Lopez-Narvaez, Angelica Selene Saucedo-Osti, Jesus Arturo Ruiz-Quinones, Jose Jaime Martinez-Magana
Summary: The meta-analysis and systematic review indicates that fluoxetine treatment can improve symptoms of major depressive disorder by reducing levels of inflammatory cytokines such as IL-1 beta, IL-6, and TNF-alpha.
PSYCHIATRY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ivan K. Domingo, Asna Latif, Amit P. Bhavsar
Summary: Cisplatin, a widely used chemotherapeutic drug, is effective against various solid cancers but limited by its adverse drug reactions. The most common reactions include nephrotoxicity, peripheral neuropathy, and ototoxicity. Previous studies focused on oxidative stress as the cause of these toxicities, but recent evidence suggests that inflammation may be the main driving force. This review summarizes the common and distinct inflammation characteristics among different adverse reactions, as well as current treatments targeting pro-inflammatory signaling pathways to improve the use of cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Piotr Szpakowski, Dominika Ksiazek-Winiarek, Malgorzata Turniak-Kusy, Ilona Pacan, Andrzej Glabinski
Summary: Astrocytes, once considered passive brain cells, have been found to play a more active role in the central nervous system. This study aimed to evaluate the production of inflammatory chemokines and neurotrophic factors by primary human astrocytes after inflammatory or anti-inflammatory stimulation. The results showed that only astrocytes induced by inflammatory mediators produced certain chemokines, and pro-inflammatory conditions decreased the release of a neurotrophic factor while anti-inflammatory cytokines increased its production.
Article
Biochemistry & Molecular Biology
Rafael Cardoso Maciel Costa Silva, Luis Tan, Danielle Aparecida Rodrigues, Elisa Beatriz Prestes, Caroline Pereira Gomes, Andreza Moreira Gama, Pedro Lagerblad de Oliveira, Claudia Neto Paiva, Benedicte Manoury, Marcelo Torres Bozza
Summary: The study indicates that chloroquine may be used as a supportive therapy to control heme-induced deleterious inflammation in different hemolytic diseases by inhibiting inflammatory effects induced by heme.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Wei-Chia Lee, Hong-Ren Yu, You-Lin Tain, Kay L. H. Wu, Yao-Chi Chuang, Julie Y. H. Chan
Summary: The study investigates the effects of vinpocetine and celecoxib on metabolic syndrome-associated bladder overactivity. It finds that vinpocetine can alleviate bladder overactivity by restoring detrusor cAMP production and exerting anti-inflammatory effects.
Article
Biochemistry & Molecular Biology
Jiebo Zhu, Min Joung Lee, Jong Hun An, Eungseok Oh, Woosuk Chung, Jun Young Heo
Summary: Microglial activation is correlated with the unfolded protein response (UPRmt) in mitochondria, which acts as a protective mechanism during neuroinflammation and may be a potential therapeutic target for reducing inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Dorina Lauritano, Filiberto Mastrangelo, Cristian D'Ovidio, Gianpaolo Ronconi, Alessandro Caraffa, Carla E. Gallenga, Ilias Frydas, Spyros K. Kritas, Matteo Trimarchi, Francesco Carinci, Pio Conti
Summary: Mast cells (MCs) are tissue cells derived from bone marrow stem cells and play a role in various diseases and disorders. They communicate with microglia in the brain through the production of mediators and can have pathological effects. MCs release preformed chemical mediators and cytokines, and can interact with neuropeptides, leading to inflammation in the central nervous system. This article explores the activation of MCs by neuropeptides and the therapeutic potential of anti-inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Natalia Lehman, Wioleta Kowalska, Michal Zarobkiewicz, Marek Mazurek, Karolina Mrozowska, Agnieszka Bojarska-Junak, Radoslaw Rola
Summary: Monocyte subpopulations in glioma patients' peripheral blood were analyzed based on CD14, CD16, and SLAN expression. The study found different profiles of monocytes with varying cytokine expression. The presence of these different profiles might hinder the effectiveness of immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Mengwei Li, Limei Zhang, Xinyan Liu, Guoqiang Wang, Jian Lu, Jifeng Guo, Hongjie Wang, Jinpeng Xu, Yi Zhang, Na Li, You Zhou
Summary: This study found that low-intensity exercise training can improve the heart function and structure of spontaneously hypertensive rats by inhibiting the RhoA/ROCK signaling pathway, providing further evidence for this protective effect.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Roberto Gramignoli, Aarati R. Ranade, Raman Venkataramanan, Stephen C. Strom
Summary: Pro-inflammatory cytokines can affect liver cell functions, particularly ammonia and drug metabolism, but do not necessarily indicate rejection or loss of cell graft.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Biao Dai, Xiaoping Wu, Fanfan Yan, Yang Chen, Yayun Xu, Qingrong Xia, Xulai Zhang, Xuefeng Xie
Summary: This study aimed to investigate the effects of MECT on elderly patients with TRD, and found that MECT could alleviate depressive symptoms while having adverse effects on cognition, with no significant impact on serum cortisol, nesfatin-1, and pro-inflammatory cytokine levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Asma Ahmed, Himanshu Tripathi, Krista E. van Meijgaarden, Nirutha Chetan Kumar, Vasista Adiga, Srabanti Rakshit, Chaitra Parthiban, J. Sharon D'Souza, George D'Souza, Mary Dias, Tom H. M. Ottenhoff, Mihai G. Netea, Simone A. Joosten, Annapurna Vyakarnam
Summary: This study characterized the mechanisms of BCG revaccination-induced trained immunity in India and found that revaccination can induce immune responses but does not enhance control of mycobacterial growth. After vaccination, enhanced immune responses to fungal, bacterial, and viral stimuli were observed.
Article
Obstetrics & Gynecology
Andrzej Wrobel, Izabela Winkler, Tomasz Rechberger, Katarzyna Skorupska, Pawel Miotla
Summary: This study assessed the efficacy of collagen patches in preventing lymphoceles, and found that patients with TachoSil patches had lower drainage volume and a decreased tendency of lymphocele occurrence after completion of adjuvant therapy.
GINEKOLOGIA POLSKA
(2022)
Article
Environmental Sciences
Beata Kulik-Rechberger, Maria Trojanowska-Szostek
Summary: This article examines the relationship between the concentration of C-type natriuretic peptide (CNP) and growth velocity and bone markers in healthy school-age children. The study finds that NTproCNP concentration is associated with growth velocity in children, highlighting the importance of understanding CNP biology in bone growth mechanisms.
ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Ewa Rechberger, Andrzej Wrobel, Beata Kulik-Rechberger, Pawel Miotla, Tomasz Rechberger
Summary: This study aimed to investigate the non-inferiority of Femistina compared with Canephron in reducing symptomatic urinary tract infections (UTI) in the first six months following midurethral sling surgery. The results showed that Femistina was not inferior to Canephron in preventing lower urinary tract infections after the surgery.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Behavioral Sciences
Gabriela Bielecka-Papierz, Anna Serefko, Aleksandra Szopa, Sylwia Talarek, Andrzej Wrobel, Bernadeta Szewczyk, Maria Radziwon-Zaleska, Malgorzata Koltun-Jasion, Ewa Poleszak
Summary: This study investigated the potential involvement of the L-arginine-NO-cGMP pathway in the development of sensitization to mephedrone-induced hyperlocomotion. The results showed that inhibition of neuronal nitric oxide synthase (NOS) effectively prevented this process, while non-selective inhibition of NOS may have a dual effect.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Aleksandra Szopa, Mariola Herbet, Anna Pachuta-Stec, Joanna Lachowicz, Kamil Pawlowski, Magdalena Iwan, Dominika Jarecka-Florek, Oliwia Krasinska, Anna Serefko, Ewa Poleszak, Monika Pitucha
Summary: The aim of the studies was to evaluate the antiproliferative potential of new derivatives containing 4-nitrophenyl group against human tumor cell lines and its impact on developmental toxicity in zebrafish model. The results showed that APS-1 and APS-18 compounds reduced the viability of human tumor lines, with APS-18 showing strong and selective antiproliferative activity against all neoplastic cell lines, particularly glioblastoma. The fish embryo acute toxicity test demonstrated that APS-1 and APS-18 did not cause morphological abnormalities in zebrafish embryos, indicating their potential for further research and development of safer drugs with better anticancer properties.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Microbiology
Sara Wawrysiuk, Tomasz Rechberger, Agnieszka Kubik-Komar, Aleksandra Kolodynska, Kurt Naber, Pawel Miotla
Summary: Urinary tract infections (UTIs) are common complications of urogynecological surgeries, and current preventive methods using antibiotics are becoming less effective due to increasing antibiotic resistance. This study aimed to compare the effectiveness of Canephron, a phytotherapeutic drug, with antibiotic prophylaxis in preventing postoperative UTIs. The results showed that Canephron was noninferior to antibiotic prophylaxis in preventing UTIs, suggesting its potential as an alternative method to decrease antibiotic consumption and combat antibiotic resistance.
Article
Biochemistry & Molecular Biology
Lukasz Zapala, Grzegorz Niemczyk, Piotr Zapala, Artur Wdowiak, Iwona Bojar, Tomasz Kluz, Aleksandra Szopa, Anna Serefko, Piotr Radziszewski, Andrzej Wrobel
Summary: This paper aimed to investigate whether the selective cannabinoid CB1 receptor agonist ACEA could reverse the effects of corticosterone (CORT) on depressive and overactive bladder potential. Through experiments on 48 female rats, it was found that ACEA could restore CORT-induced bladder dysfunction and depressive behavior, as well as regulate urine and other biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Lukasz Nowakowski, Krzysztof Galczynski, Michal Dybowski, Rafal Typek, Andrzej Dawidowicz, Pawel Miotla, Piotr Olcha, Tomasz Rechberger
Summary: The objective of this study was to develop intravaginal vaginal suppositories containing DHEA and compare the clinical effects of vaginal topical therapy with DHEA, estradiol, or antibiotic after POP surgery. It was found that both DHEA and estradiol topical therapy improved maturation index, vaginal pH, and vaginal symptoms. Topical therapy with DHEA after pelvic organ prolapse repair brings similar results as estradiol, without potential systemic exposure to increased concentrations of sex steroids above levels observed in postmenopausal women.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Review
Pathology
Marta Monist, Dorota Lewkowicz, Patrycja Pietak, Anna Pilewska-Kozak, Yan-Gao Man, Andrzej Semczuk
Summary: The occurrence of synchronous carcinomas originating from the uterine corpus and uterine cervix, of the same histological subtype, is extremely rare. This case study presents a synchronous early stage G1 adenocarcinoma of the uterine corpus with cervical G2 endometrioid adenocarcinoma. The tumors differ in histological grading and clinical stage, and are preceded by different precancerous lesions, atypical endometrial hyperplasia and foci of endometriosis localized within the uterine cervix.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Oncology
Andrea Romano, Tea Lanisnik Rizner, Henrica Maria Johanna Werner, Andrzej Semczuk, Camille Lowy, Christoph Schroeder, Anne Griesbeck, Jerzy Adamski, Dmytro Fishman, Janina Tokarz
Summary: Endometrial cancer, the most common gynaecological malignancy, has a high incidence and mortality rate in developed countries. There is a need for non/minimally invasive tools for diagnosis and prognosis to manage the increasing number of women at risk. Biomarkers from proteomics and metabolomics can be used to develop such tools, and this review explores the current research in this field. A systematic review of published studies using proteomics and/or metabolomics for biomarker discovery in endometrial cancer is provided, along with recommendations for future studies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Szopa, Mariola Herbet, Ewa Poleszak, Anna Serefko, Agnieszka Czylkowska, Iwona Piatkowska-Chmiel, Kamila Kasperek, Andrzej Wrobel, Paulina Prewencka, Bernadeta Szewczyk
Summary: The study evaluated the antidepressant-like effects of an IMI-Zn complex compound on mice and compared its efficacy with separate administration of imipramine and zinc. The results showed that the IMI-Zn complex exhibited dose-dependent antidepressant potential similar to individual treatments of imipramine and zinc. The study also found that acute stress did not significantly affect oxidative stress parameters. Developing the IMI-Zn complex could simplify treatment and improve patient compliance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Danuta Vasilevska, Andrzej Semczuk, Dominika Vasilevska, Artiomas Sirvys, Vilius Rudaitis
Summary: The management of early-stage cervical cancer in young women poses challenges in preserving fertility and achieving optimal oncological outcomes. Insufficient data hinder proper counseling for this vulnerable patient group. This report presents a case of successful treatment outcome in a young woman with early-stage cervical cancer who desired fertility preservation, using neoadjuvant chemotherapy followed by laparoscopic radical trachelectomy. Ongoing prospective trials are expected to provide stronger evidence in this area.
MEDICINA-LITHUANIA
(2022)