Article
Biochemistry & Molecular Biology
Wei Liu, Hao Zhang, Yun-yi Hou, Rui-yi Hu, Jun-jie Zhang, Xuan Chen, Shuang Wang, Jun-nan Hu, Zi Wang, Wei Li
Summary: This study evaluates the protective effects of arginyl-fructosyl-glucose (AFG), a major Maillard reaction product of red ginseng, against cisplatin-induced intestinal toxicity. The results showed that AFG can alleviate cisplatin-induced gastrointestinal damage and inhibit cell apoptosis by regulating the Wnt/beta-catenin signaling pathway.
Article
Biotechnology & Applied Microbiology
Hui Kang, Hui Yu, Jingxiu Fan, Ge Cao
Summary: Rotigotine shows beneficial effects on Ox-LDL-induced endothelial cell damage, including inhibition of cholesterol accumulation, improvement of monocyte adhesion, reduction of oxidative stress and inflammation. Its potential therapeutic role in cardiovascular diseases is highlighted through these effects.
Article
Immunology
Yue Xiong, Xiaochuan Cui, Yanjun Zhou, Gaoshang Chai, Xiufeng Jiang, Guizhi Ge, Yue Wang, Hongxu Sun, Huilian Che, Yunjuan Nie, Peng Zhao
Summary: DHL treatment effectively alleviated BLM-induced pulmonary fibrosis and inflammation by reducing pro-fibrotic mediators, inhibiting inflammatory cell infiltration, and downregulating IL-33 expression. The mechanism involved the JNK/p38 MAPK-mediated NF-kappa B signaling pathway to suppress macrophage activation and decrease IL-13 and TGF-beta levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Tingting Chen, Shanshan Su, Zhanting Yang, Dejun Zhang, Zhanqiang Li, Dianxiang Lu
Summary: This study aimed to investigate the role of SBT in attenuating pulmonary arterial pressure and vascular remodeling caused by MCT and hypoxia. The study found that SBT reduces pulmonary arterial pressure, vascular remodeling, and levels of inflammatory cytokines in rats. Furthermore, SBT significantly suppresses the MAPK/NF-Kappa B signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Yifeng Shi, Jiaoxiang Chen, Sunlong Li, Yuhao Wu, Caiyu Yu, LiBin Ni, Jian Xiao, Zhenxuan Shao, Huanqing Zhu, Jianshun Wang, Xiangyang Wang, Xiaolei Zhang
Summary: Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.
Review
Chemistry, Medicinal
Saeed Mohammadian Haftcheshmeh, Maliheh Abedi, Kazem Mashayekhi, Mohammad Javad Mousavi, Jamshid Gholizadeh Navashenaq, Asadollah Mohammadi, Amir Abbas Momtazi-Borojeni
Summary: This review discusses the modulatory effects of berberine (BBR) on various inflammatory signaling pathways in the immune system and explores its therapeutic efficacy and anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Mingxin Dong, Xiaohao Zhang, Haotian Yu, Yan Wang, Ying Chang, Chengbiao Sun, Jianxu Zhang, Na Zhao, Kaikai Yu, Guangchao Sun, Guiru Zhao, Na Xu, Wensen Liu
Summary: This study identified circEpc1 as a promoter in RT-induced inflammation, functioning as a miR-5114 sponge to activate NF-kappa B and MAPK signaling pathways. The results provide new insights into the functions of circRNA in innate immunity and suggest potential immunotherapy targets for controlling RT-induced inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Xiaoyu Bao, Jianping Wu
Summary: Ovomucin hydrolysate has been shown to prevent pathogen adhesion to intestinal epithelial cells, and in this study, it was demonstrated to improve intestinal barrier integrity by inhibiting inflammatory responses induced by LPS.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Endocrinology & Metabolism
Zixi Chen, Jinpeng Li, Wenjuan Xu, Xiaomei Wu, Fenfen Xiang, Xiaoxiao Li, Mengzhe Zhang, Jin Zheng, Xiangdong Kang, Rong Wu
Summary: The study found that TLR4 expression on CD14+ maternal blood monocytes was significantly higher in the third trimester compared to the first and second trimesters. Maternal serum concentrations of TLR4 and cytokines were significantly higher in the term labor group compared to the term non-labor group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Wenli Luo, Li Li, Weina Xu, Jing Zhang, Jianxiong Xu
Summary: Treatment of BRL-3A cells with DHA (50, 100, and 200 μM) for 24 hours promotes cell apoptosis and inflammatory response, with involvement of the p38 MAPK, ERK, and NF-kappa B signal pathways.
Article
Immunology
Xiaohe Li, Qing Liang, Shaoyan Gao, Qiuyan Jiang, Fangxia Zhang, Ruiqin Zhang, Hao Ruan, Shuangling Li, Jiaoyan Luan, Ruxia Deng, Honggang Zhou, Hui Huang, Cheng Yang
Summary: Lenalidomide has potential anti-fibrotic effects by suppressing inflammation-related signaling pathways, thereby reducing pulmonary fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wei Liu, Yanghui Ou, Yumeng Yang, Xuemei Zhang, Liqi Huang, Xiaohua Wang, Buling Wu, Mingcheng Huang
Summary: The study demonstrated that punicalagin has a protective effect on HUVECs activation through an endothelial-mediated mechanism, which may be used in the treatment of various disorders such as cancer, rheumatoid arthritis, and cardiovascular disease. This effect is achieved by reducing adhesion of monocyte cells to HUVECs, decreasing expression of ICAM-1 and VCAM-1, and inhibiting permeability, proliferation, migration, and tube formation in VEGF-induced HUVECs. Additionally, punicalagin suppresses IKK-mediated activation of NF-kappa B signaling and inhibits VEGFR2 activation and downstream p-PAK1.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Emad H. M. Hassanein, Mostafa S. Abd El-Maksoud, Islam M. Ibrahim, Esraa K. Abd-alhameed, Hanan S. Althagafy, Nesma M. Mohamed, Samir A. Ross
Summary: Galangin, a naturally occurring flavonoid, has many biological activities including anti-inflammatory effects. Its mechanism of action involves suppressing p38 MAPK, NF-kB, and NLRP3 signaling pathways, which has been confirmed by molecular docking. Clinical translational research is needed to determine if galangin can be used as a safe natural source of anti-inflammatory medication for humans.
PHYTOTHERAPY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jaylen Hudson, Laszlo Farkas
Summary: Pulmonary artery hypertension (PAH) is now recognized as a pulmonary vascular disease with severe endothelial dysfunction, with epigenetic modifications playing a key role in its pathogenesis. Understanding endothelial cell regulation mechanisms and investigating epigenetic changes may lead to future therapeutic advancements in treating PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Integrative & Complementary Medicine
Hyeon Hwa Nam, Li Nan, Byung Kil Choo
Summary: The study demonstrates that Camellia japonica ethanol extract (CJE) possesses strong antioxidant and anti-inflammatory activities, effectively improving symptoms of reflux esophagitis in rats.
Article
Immunology
Ling-tian Ge, Ya-nan Liu, Xi-xi Lin, Hui-juan Shen, Yong-liang Jia, Xin-wei Dong, Yun Sun, Qiang-min Xie
INTERNATIONAL IMMUNOPHARMACOLOGY
(2016)
Article
Oncology
Bo Jiang, Yan Guan, Hui-juan Shen, Lin-hui Zhang, Jun-xia Jiang, Xin-wei Dong, Hua-hao Shen, Qiang-min Xie
Article
Jin-Song Wei, Zhe-Bin Jin, Zhi-Qiang Yin, Qiang-Min Xie, Ji-Qiang Chen, Zi-Gang Li, Hui-Fang Tang
ACTA PHYSIOLOGICA HUNGARICA
(2014)
Article
Biochemistry & Molecular Biology
Hui-juan Shen, Yan-hong Sun, Shui-juan Zhang, Jun-xia Jiang, Xin-wei Dong, Yong-liang Jia, Jian Shen, Yan Guan, Lin-hui Zhang, Fen-fen Li, Xi-xi Lin, Xi-mei Wu, Qiang-min Xie, Xiao-feng Yan
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2014)
Article
Immunology
Liang-liang Shen, Ya-nan Liu, Hui-juan Shen, Chong Wen, Yong-liang Jia, Xin-wei Dong, Fang Jin, Xiao-ping Chen, Yun Sun, Qiang-min Xie
INTERNATIONAL IMMUNOPHARMACOLOGY
(2014)
Article
Plant Sciences
Weizhuo Tang, Qiangmin Xie, Jian Guan, Saihong Jin, Yuqing Zhao
JOURNAL OF ETHNOPHARMACOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Ling-hui Zeng, Hua-dan Zhang, Cai-ju Xu, Yu-jia Bian, Xue-jiao Xu, Qiang-min Xie, Rong-hua Zhang
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2013)
Article
Nutrition & Dietetics
Meng-Jing Bao, Jian Shen, Yong-Liang Jia, Fen-Fen Li, Wen-Jiang Ma, Hui-Juan Shen, Liang-Liang Shen, Xi-Xi Lin, Lin-Hui Zhang, Xin-Wei Dong, Yi-Cheng Xie, Yu-Qing Zhao, Qiang-Min Xie
Article
Cell Biology
Yan Guan, Liucheng Li, Liandi Kan, Qiangmin Xie
Summary: This study demonstrates the protective effects of salvianolic acid B (SalB) inhalation against PM2.5-induced airway inflammation and oxidative stress. SalB treatment reduces inflammatory cell infiltration and damage, and decreases the expression levels of pro-inflammatory proteins and genes. Additionally, SalB reduces oxidative stress levels by inhibiting specific signaling pathways.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Correction
Respiratory System
Ya-nan Liu, Yan Guan, Jian Shen, Yong-liang Jia, Jian-cang Zhou, Yun Sun, Jun-xia Jiang, Hui-juan Shen, Qiang Shu, Qiang-min Xie, Yicheng Xie
RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
Ya-nan Liu, Yan Guan, Jian Shen, Yong-liang Jia, Jian-cang Zhou, Yun Sun, Jun-xia Jiang, Hui-juan Shen, Qiang Shu, Qiang-min Xie, Yicheng Xie
RESPIRATORY RESEARCH
(2020)
Article
Respiratory System
Jun-xia Jiang, Hui-juan Shen, Yan Guan, Yong-liang Jia, Jian Shen, Qi Liu, Qiang-min Xie, Xiao-feng Yan
RESPIRATORY RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Jun-Xia Jiang, Shui-Juan Zhang, Hui-Juan Shen, Yan Guan, Qi Liu, Wei Zhao, Yong-Liang Jia, Jian Shen, Xiao-Feng Yan, Qiang-Min Xie
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2017)
Article
Respiratory System
Ya-Juan Wang, Shun-De Song, Jun-Chun Chen, Xue-Feng Wang, Ya-Li Jiang, Qiang-Min Xie, Ji-Qiang Chen, Zi-Gang Li, Hui-Fang Tang
PULMONARY MEDICINE
(2014)