Article
Medicine, Research & Experimental
Teresa Mezza, Pietro Manuel Ferraro, Gianfranco Di Giuseppe, Simona Moffa, Chiara M. A. Cefalo, Francesca Cinti, Flavia Impronta, Umberto Capece, Giuseppe Quero, Alfredo Pontecorvi, Andrea Mari, Sergio Alfieri, Andrea Giaccari
Summary: This study aimed to verify the acute effect of reduced beta cell mass on the development of hyperglycemia. The research found that reduced first-phase insulin secretion and glucose sensitivity were predictors of eventual development of impaired glucose tolerance and diabetes. Thus, these functional alterations may play a key role in the pathogenesis of type 2 diabetes (T2DM).
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Jun Bae Bang, Chang-Kwon Oh, Yu Seun Kim, Sung Hoon Kim, Hee Chul Yu, Chan-Duck Kim, Man Ki Ju, Byung Jun So, Sang Ho Lee, Sang Youb Han, Cheol Woong Jung, Joong Kyung Kim, Hyung Joon Ahn, Su Hyung Lee, Ja Young Jeon
Summary: In this study, the changes in glucose metabolism after kidney transplantation were investigated. It was found that some patients with pre-transplant diabetes experienced diabetes remission one year after transplantation. The newly diagnosed diabetes before transplantation and baseline insulinogenic index (IGI(30)) were associated with diabetes remission.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Gary J. Farkas, Phillip S. Gordon, Nareka Trewick, Ashraf S. Gorgey, David R. Dolbow, Eduard Tiozzo, Arthur S. Berg, David R. Gater
Summary: This study shows that QUICKI has the highest agreement with insulin sensitivity in individuals with chronic motor complete SCI. HbA1C and FPG have poor agreement with Si.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ravi Retnakaran, Jiajie Pu, Alexandra Emery, Stewart B. Harris, Sonja M. Reichert, Hertzel C. Gerstein, Natalia McInnes, Caroline K. Kramer, Bernard Zinman
Summary: Induction with short-term insulin therapy followed by maintenance with metformin can stabilize beta-cell function in early type 2 diabetes. The study found that initial reversibility of beta-cell dysfunction and preserved hepatic insulin sensitivity are associated with sustained stabilization of beta-cell function.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Shihao Hu, Yuzhi Lu, Andrea Tura, Giovanni Pacini, David Z. D'Argenio
Summary: Glucose effectiveness, the ability of glucose to regulate glucose utilization and production in the body, plays a significant role in maintaining normal blood sugar levels. Hierarchical statistical analysis revealed that individuals with type 2 diabetes had a decreased glucose effectiveness compared to non-diabetic individuals. This finding suggests that glucose effectiveness could be a potential marker for glucose metabolism disorders and a target for diabetes treatment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Benedikt Dietz, Juergen Machann, Vaibhav Agrawal, Martin Heni, Patrick Schwab, Julia Dienes, Steffen Reichert, Andreas L. Birkenfeld, Hans-Ulrich Haering, Fritz Schick, Norbert Stefan, Andreas Fritsche, Hubert Preissl, Bernhard Schoelkopf, Stefan Bauer, Robert Wagner
Summary: The study indicated that diabetes can be detected through whole-body MRI without additional data, with visceral fat playing a crucial role in diabetes classification. The model identified a high-risk group with increased risk for future diabetes and microalbuminuria.
Article
Physiology
Ping Luo, Yaoquan Cao, Pengzhou Li, Guohui Wang, Zhi Song, Weizheng Li, Zhihong Su, Hui Zhou, Xianhao Yi, Zhibing Fu, Xulong Sun, Haibo Tang, Beibei Cui, Qianqian Yu, Liyong Zhu, Shaihong Zhu
Summary: Both LRYGB and LSG effectively induced remission of insulin resistance in patients with T2DM and a BMI of 27.5-32.5 kg/m(2). LRYGB group had a higher percentage of patients achieving the target composite endpoint compared to LSG group.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Kristin Kallner, Rasmus Krook, Ann-Sofie Sandberg, Lena Hulthen, Ulrika Andersson-Hall, Agneta Holmang
Summary: A diagnosis of gestational diabetes mellitus (GDM) during pregnancy increases the risk of developing type 2 diabetes later in life. This study aimed to investigate the relationship between iron parameters, individual fatty acids (FAs), and desaturases in the development of impaired glucose metabolism (IGM) in women after GDM. The results showed that soluble transferrin receptor levels were higher in the IGM group compared to the normal glucose tolerance (NGT) group and were associated with saturated FAs and monounsaturated FAs in the IGM group. Iron and transferrin saturation were positively associated with monounsaturated fatty acids (MUFAs) and desaturase activity. These associations were not observed in the NGT group.
Article
Food Science & Technology
Mai Hijikata, Mariko Higa, Takamasa Ichijo, Takahisa Hirose
Summary: This study compared plasma glucose levels in MTT and 75-g OGTT to identify factors predicting a need for insulin therapy in GDM. It found that PG levels at 30 min after MTT may be useful for identifying patients who need insulin therapy.
FOOD & NUTRITION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Lihui Zhang, Yunliang Zhang, Sheng'ai Shen, Xueying Wang, Luling Dong, Qiuyun Li, Weidong Ren, Yufeng Li, Jianling Bai, Qiuhong Gong, Hongyu Kuang, Lin Qi, Qiang Lu, Wenli Cheng, Yanjie Liu, Shuang Yan, Donghong Wu, Hui Fang, Fang Hou, Yingju Wang, Zhixia Yang, Xu Lian, Jianling Du, Ningling Sun, Linong Ji, Guangwei Li
Summary: Metformin plus lifestyle intervention is more effective than lifestyle intervention alone in preventing the development of diabetes in Chinese individuals with impaired glucose regulation, without new safety concerns.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Tao Yuan, Shuoning Song, Tianyi Zhao, Yanbei Duo, Shihan Wang, Junxiang Gao, Shixuan Liu, Yingyue Dong, Rui Li, Yong Fu, Weigang Zhao
Summary: The study identified two different patterns of FPIS among subjects with normal glucose tolerance, indicating that individuals with later time to glucose peak during FPIS may have a lower risk of developing type 2 diabetes in the future.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Bernice Man, Alan Schwartz, Oksana Pugach, Yinglin Xia, Ben Gerber
Summary: A clinical prediction model was developed for personalized treatment decisions for prediabetes in women with a history of gestational diabetes mellitus. The study found that higher levels of fasting glucose and hemoglobin A1C were associated with an increased risk of developing diabetes, and metformin was more effective for individuals with higher BMI.
Review
Nanoscience & Nanotechnology
Milad Ashrafizadeh, Alan Prem Kumar, Amir Reza Aref, Ali Zarrabi, Ebrahim Mostafavi
Summary: Exosomes have great potential in the treatment of diabetes mellitus, as they can regulate glucose and lipid metabolism, ameliorate apoptosis and endoplasmic reticulum stress in beta cells, and influence insulin resistance/sensitivity.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Nutrition & Dietetics
Wanbao Yang, Wen Jiang, Shaodong Guo
Summary: This article reviews the effects of different components of macronutrients on insulin sensitivity and their underlying mechanisms, highlighting the importance of adjusting the intake of beneficial food compounds for the prevention of insulin resistance and type 2 diabetes.
Article
Multidisciplinary Sciences
Fan Chen, Li Ge, Xinyong Jiang, Yuting Lai, Pingping Huang, Jinghe Hua, Yuzheng Lin, Yan Lin, Xiumin Jiang
Summary: This study compared different methods for modeling gestational diabetes mellitus (GDM) in rats and found that a combination of a high-fat and high-sugar (HFHS) diet with intraperitoneal injection of 25 mg/kg STZ was the best method. The GDM model constructed using this method exhibited pathological characteristics similar to human GDM patients.
Article
Genetics & Heredity
Jingcheng Wu, Wenfan Chen, Yuxuan Zhou, Ying Chi, Xiansheng Hua, Jian Wu, Xun Gu, Shuqing Chen, Zhan Zhou
Summary: In this study, the authors present an updated version, TSNAdb v2.0, of the tumor-specific neoantigen database (TSNAdb). This version offers new features, including stricter criteria for neoantigen identification, predicted neoantigens derived from three types of somatic mutations, and the collection of experimentally validated neoantigens categorized according to experimental level.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2023)
Review
Biochemistry & Molecular Biology
Muhammad Sajid Hamid Akash, Sumbal Rasheed, Kanwal Rehman, Muhammad Ibrahim, Muhammad Imran, Mohammed A. Assiri
Summary: Krupple-Like family of transcription factor-14 (KLF14) is a crucial gene involved in various biological functions and pathological mechanisms. It controls the expression of multiple genes and influences lipid metabolism, glucose regulation, insulin sensitivity, as well as cell apoptosis, proliferation, and differentiation. KLF14 has also been used as an epigenetic biomarker for estimating chronological age. Genetic variations in KLF14, especially in adipose tissues, are associated with dyslipidemia, insulin resistance, and glucose intolerance. The prevalence of these genetic polymorphisms varies among different populations due to ethnic differences and epigenetic modifications, and they can be influenced by environmental and physiological factors such as diet, age, gender, and obesity.
Article
Medicine, Research & Experimental
Muhammad Tariq, Nadia Hussain, Kanwal Rehman, Muhammad Sajid Hamid Akash, Amal H. I. Al Haddad, Amira S. A. Said, Adel Al Fateasej, Ali Alamri, Awaji Y. Safhi, Fahad Y. Sabei, Ahmed Abdullah Al Awad, Musaddique Hussain
Summary: In this study, it was found that lapatinib effectively suppressed the expression of IL_13-induced M2 polarized macrophages surface markers and downregulated M2 genes related to tumor progression. Lapatinib also inhibited the invasion and migration of cancer cells mediated by M2 polarized macrophages. Mechanistically, lapatinib inhibited IL-13 triggered STAT6 phosphorylation. In the mouse model, lapatinib significantly reduced tumorigenesis and downregulated M2 markers in the tumor.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Francis Victor, Kanwal Rehman, Muhammad Sajid Hamid Akash, Sumbal Rasheed, Muhammad Imran, Mohammed Ali Assiri
Summary: Omega-3 fatty acids are important dietary components necessary for normal growth and development. They possess therapeutic activities against various diseases but are prone to oxidation, reducing their efficacy. To overcome this problem, novel drug delivery approaches have been developed to enhance stability and maximize therapeutic potential of omega-3 fatty acids.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Endocrinology & Metabolism
Abdullah Salah Alanazi, Sumbal Rasheed, Kanwal Rehman, Tauqeer Hussain Mallhi, Muhammad Sajid Hamid Akash, Nasser Hadal Alotaibi, Abdulaziz Ibrahim Alzarea, Nida Tanveer, Yusra Habib Khan
Summary: This study investigates the relationship between KLF14 rs4731702 single nucleotide polymorphism (SNP) and the risk of type 2 diabetes mellitus (T2DM) and dyslipidemia in different ethnic populations. The findings suggest that individuals with the C allele of KLF14 rs4731702 exhibit compromised insulin sensitivity, decreased HDL-C and ApoA1 levels, and increased serum glucose, TG, and LDL-C concentrations in T2DM patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tauqeer Hussain Mallhi, Momina Shahid, Kanwal Rehman, Yusra Habib Khan, Abdullah Salah Alanazi, Nasser Hadal Alotaibi, Muhammad Sajid Hamid Akash, Muhammad Hammad Butt
Summary: Myocardial infarction (MI) is a cardiovascular disease caused by coronary artery blockage, leading to cardiac muscle death. The etiology of MI involves environmental, occupational, and genetic factors. Previous studies have shown that different variants of the MTHFR gene are responsible for MI by impacting folate and homocysteine metabolism. This study focuses on investigating the genetic polymorphism of MTHFR C677T (rs1801133) and its association with MI in the presence of diabetes mellitus (DM) as a risk factor. The study found that the T/T homozygous genotype of MTHFR C677T (rs1801133) was significantly associated with MI in patients with DM as a risk factor.
Article
Biochemistry & Molecular Biology
Muhammad Sajid Hamid Akash, Mutayyba Fatima, Kanwal Rehman, Qudsia Rehman, Zunera Chauhdary, Ahmed Nadeem, Tahir Maqbool Mir
Summary: The aim of this study was to investigate the disruptions of metabolic pathways induced by bisphenol A (BPA) and explore the potential therapeutic intervention provided by resveratrol (RSV) in mitigating these disruptions through the modulation of biochemical pathways. The results revealed that BPA exposure significantly increased the serum levels of various biomarkers and gene expressions associated with metabolic disorders, while RSV treatment effectively reduced these alterations and restored normal metabolic function. The findings suggest that RSV shows promise as a therapeutic intervention for BPA-induced metabolic disorders.
Article
Biochemistry & Molecular Biology
Syed Muhammad Shoaib, Samina Afzal, Ali Feezan, Muhammad Sajid Hamid Akash, Ahmed Nadeem, Tahir Maqbool Mir
Summary: Our study investigated the effects of arsenic-induced metabolic disorders, specifically disruptions in lipid metabolism, amino acid metabolism, and carbohydrate metabolism. We also assessed the potential therapeutic effects of resveratrol as a remedy for arsenic-induced diabetes. The findings showed significant changes in glucose levels, insulin resistance, inflammatory biomarkers, and liver and kidney function in mice exposed to arsenic. Additionally, enzyme levels related to carbohydrate metabolism and oxidative stress biomarkers were reduced in the arsenic-exposed group. The study also observed alterations in gene expression related to lipid and carbohydrate metabolism, as well as decreases in certain amino acids in arsenic-exposed mice. Metabolomics analysis identified disruptions in lipid metabolomes, amino acids, and arsenic metabolites. Histopathological observations revealed significant changes in liver architecture in the arsenic-exposed group.
Review
Biochemistry & Molecular Biology
Muhammad Sajid Hamid Akash, Azka Yaqoob, Kanwal Rehman, Muhammad Imran, Mohammed A. A. Assiri, Fatema Al-Rashed, Fahd Al-Mulla, Rasheed Ahmad, Sardar Sindhu
Summary: Heavy metals are highly toxic compounds found in the earth's crust. Their environmental levels are consistently rising above permissible limits, causing disruption of metabolism and altered gene or protein expression. Metabolomics, a state-of-the-art analytical tool, is used to investigate the mechanisms of metabolic impairment caused by heavy metal toxicities. It plays a key role in identifying perturbations in lipid and amino acid metabolism and oxidative stress in metabolic impairment. The applications of metabolomics in meeting emerging needs are discussed.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Komal Jabeen, Kanwal Rehman, Muhammad Sajid Hamid Akash, Ahmed Nadeem, Tahir Maqbool Mir
Summary: This study aimed to investigate the potential protective effects of metformin and vitamin E against AlCl3-induced neuroinflammation and cardiometabolic disturbances. The results showed that the combination therapy of metformin and vitamin E significantly reduced glucose, cholesterol, and triglyceride levels and increased insulin and high-density lipoprotein levels. Moreover, the combination therapy preserved neuronal structures and normal morphology in brain, heart, and pancreatic tissues.
Article
Chemistry, Multidisciplinary
Mohammed A. Assiri, Akbar Ali, Muhammad Ibrahim, Muhammad Usman Khan, Khalid Ahmed, Muhammad Sajid Hamid Akash, Muhammad Akhtar Abbas, Athar Javed, Muhammad Suleman, Muhammad Khalid, Ishtiaq Hussain
Summary: The synthesis of three lauric acid-based hydrazones was carried out and their antioxidant and anticancer activities were evaluated. The results showed that NBDH exhibited the highest antioxidant activity, while FBDH showed the highest anticancer activity. Molecular simulation analysis confirmed the potential of these compounds for biological, electronic, and nonlinear optical applications.
Review
Chemistry, Multidisciplinary
Muhammad Sajid Hamid Akash, Sumbal Rasheed, Kanwal Rehman, Muhammad Imran, Mohammed A. Assiri
Summary: This article discusses the harmful effects of bisphenols on various body systems and mechanisms, as well as their biotransformation processes in organisms and ecosystems. It emphasizes preventive measures to avoid bisphenol exposure and highlights the potential use of plant-based bioactive compounds as therapeutic strategies. The findings contribute to a better understanding of bisphenol research and the development of safer practices and interventions to safeguard public health.
Article
Environmental Sciences
Muhammad Sajid Hamid Akash, Moazzama Akbar, Kanwal Rehman, Muhammad Ajmal Shah, Pharkphoom Panichayupakaranant, Muhammad Imran, Mohammed A. Assiri
Summary: Currently, only a few cholinesterase inhibitor drugs are effective in relieving symptoms of Alzheimer's disease (AD), but they do not treat the underlying causes and have adverse effects. Berberine has shown therapeutic potential against AD, and this study evaluated its activity in an AD rat model. The results showed that both pure berberine (PB) and berberine-enriched extract (BEE) had neuroprotective effects and improved cognitive function in the rats, suggesting their potential as treatments for AD. However, further clinical trials are needed to assess their efficacy and safety.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biology
Kanwal Rehman, Ammara Afzaal, Muhammad Sajid Hamid Akash, Muhammad Imran, Mohammed A. Assiri
Summary: The self-regulation mechanism of the cytokine channel involves the synthesis of antagonistic cytokines that connect to receptors and release soluble cytokine receptors. Interleukin-1 receptor antagonist (IL-1Ra) is the first naturally occurring receptor antagonist of cytokine. IL-1Ra protein is obtained from cultured monocyte supernatants. IL-1 family includes IL-1a, IL-1β, and IL-1Ra. IL-Ra is involved in normal physiological functions and acts as an anti-inflammatory agent. IL-Ra is synthesized in tissues during active disease and can be measured or estimated. Maintenance of IL-Ra and IL-1 levels is crucial for host resistance during diseased conditions. This article focuses on the synthesis and functions of IL-Ra in activated inflammatory responses.
Article
Biology
Momina Shahid, Kanwal Rehman, Muhammad Sajid Hamid Akash, Haleem Suhail, Sumbal Rasheed, Muhammad Imran, Mohammed A. Assiri
Summary: Genetic polymorphism plays a vital role in the pathogenesis and development of myocardial infarction (MI), as a single nucleotide polymorphism in an amino acid sequence can lead to a diseased state. Multiple positions within a single gene can exhibit genetic polymorphism, resulting in different variants. Genetic polymorphisms of AGT M235T, AGT T174M, ACE I/D, eNOS, and MTHFR can be risk factors for MI. However, it is crucial to investigate the prevalence of these genetic polymorphisms in different populations.
