Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Wentao Liang, Li Huang, Xiang Ma, Lijie Dong, Rui Cheng, Marcus Dehdarani, Dimitrios Karamichos, Jian-Xing Ma
Summary: This study found that overexpression of kallistatin in diabetic patients contributes to delayed corneal wound healing by inhibiting the canonical Wnt signaling. Additionally, it was discovered that kallistatin suppresses the activation of Wnt signaling and delays wound healing in the cornea.
Article
Agriculture, Dairy & Animal Science
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Kai Quan, Tesfaye Getachew, Joram M. M. Mwacharo, Aynalem Haile, Yutao Li, Shanhe Wang, Wei Sun
Summary: In our study, we found that CRABP2 was highly expressed in Hu sheep hair follicles, indicating its potential influence on dermal papilla cells (DPCs). Our experiments demonstrated that overexpression of CRABP2 promoted DPC proliferation and activated the Wnt/beta-catenin pathway. These findings highlight the crucial role of CRABP2 in Hu sheep DPC proliferation and shed light on its function in hair follicles.
Article
Cell Biology
Rihao Qu, Khusali Gupta, Danni Dong, Yiqun Jiang, Boris Landa, Charles Saez, Gwendolyn Strickland, Jonathan Levinsohn, Pei-lun Weng, M. Mark Taketo, Yuval Kluger, Peggy Myung
Summary: This study designed a computational approach to resolve signals and cell behaviors in organogenesis, revealing the role of Wnt/β-catenin and SHH signaling gradients in cell proliferation and spatial patterning.
DEVELOPMENTAL CELL
(2022)
Article
Biotechnology & Applied Microbiology
Zhi Fang, Min Zhong, Ling Zhou, Yi Le, Heng Wang, Ziling Fang
Summary: LRP8 is markedly overexpressed in NSCLC tissues and cell lines, correlating with poor clinicopathological characteristics and prognosis. Depletion of LRP8 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of NSCLC cells, partly by inhibiting the Wnt/beta-catenin pathway.
Article
Agriculture, Multidisciplinary
Duoduo Zhang, Xingtao Zhou, Linyuan Liu, Mi Guo, Tongwen Huang, Wengan Zhou, Fang Geng, Steve W. Cui, Shaoping Nie
Summary: The study revealed that glucomannan from Aloe vera gel promoted proliferation and differentiation of intestinal stem cells through the Wnt/β-catenin signaling pathway, facilitating epithelial cell regeneration and alleviating colitis in mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Cell Biology
Xiaoxuan Duan, Yihuan Chen, Kai Zhang, Wei Chen, Jun Zhao, Xiaoshuo Dai, Wenbo Cao, Ziming Dong, Saijun Mo, Jing Lu
Summary: This study found that phosphoglycerate dehydrogenase (PHGDH) was highly expressed in esophageal squamous carcinoma (ESCC), and high expression was associated with poor prognosis. In vitro and in vivo experiments demonstrated that PHGDH knockdown inhibited ESCC progression by suppressing Wnt/beta-catenin signaling pathway. These results indicate that PHGDH may be a potential therapeutic target for ESCC.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Jing-Qiang Huang, Ling-Xin Duan, Qiu-Yu Liu, He-Feng Li, Ao-Ping Hu, Jun-Wei Song, Chuxuan Lin, Bingsheng Huang, Da Yao, Bin Peng, Yehong Sun, Yuxin Wen, Lin Yang, Xingzhi Xu, Li-Yun Gong
Summary: This study found that high expression of SRPK1 was significantly associated with poor progression-free survival (PFS) in patients with advanced non-small cell lung cancer (NSCLC) undergoing gefitinib treatment. SRPK1 reduced the ability of gefitinib to induce apoptosis in NSCLC cells independently of its kinase activity by increasing EGFR expression and promoting the accumulation and phosphorylation of membrane EGFR. The SRPK1/GSK3 beta axis activates the Wnt pathway and promotes gefitinib resistance in NSCLC.
Article
Cell & Tissue Engineering
Huan Jin, Zhengzhi Zou, Haocai Chang, Qi Shen, Lingfeng Liu, Da Xing
Summary: Photobiomodulation therapy (PBMT) promotes hair regeneration by activating ll-CATENIN in hair follicle stem cells (HFSCs) through a synergistic mechanism involving reactive oxygen species (ROS) and WNT secretion from skin-derived precursors (SKPs).
Review
Biochemistry & Molecular Biology
Sandy Winfield Jere, Nicolette Nadene Houreld
Summary: Skin repair after injury is a complex and dynamic process that relies on signaling pathways, including the Wnt/beta-catenin pathway, to restore the skin's protective barrier. Diabetic patients are at a high risk of chronic, non-healing wounds, but photobiomodulation (PBM) can accelerate tissue repair by modulating cellular behavior. This review focuses on key signaling pathways in human skin wound repair and the effects of PBM on chronic wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yanlin Cai, Yi Hu, Furong Yu, Wenjuan Tong, Shufen Wang, Shunliang Sheng, Jiayu Zhu
Summary: Globally, ovarian cancer ranks as the second most common cause of gynecologic-related cancer deaths among women, with a poor prognosis. Research has shown that downregulation of AHNAK in ovarian cancer cells can significantly inhibit cell growth and metastasis, partly by dampening the Canonical Wnt cascade. Therefore, AHNAK may serve as a biomarker and potential treatment target for ovarian cancer.
Article
Medicine, Research & Experimental
Heyu Song, Ricky A. Sontz, Matthew J. Vance, Julia M. Morris, Sulaiman Sheriff, Songli Zhu, Suzann Duan, Jiping Zeng, Erika Koeppe, Ritu Pandey, Curtis A. Thorne, Elena M. Stoffel, Juanita L. Merchant
Summary: The incidence of early-onset colorectal cancer (EO-CRC) is rising, with lifestyle factors and genetic background playing a potential role. The study found a missense mutation, HNF1AA98V, in the Hepatic Nuclear Factor 1α (HNF1A) gene, which reduces DNA binding ability. In mice, introducing the HNF1AA98V variant and feeding a high-fat or high-sugar diet led to an increased formation of colonic polyps. The study also revealed alterations in gene expression and signaling pathways related to metabolism, immunity, and lipid biogenesis.
Article
Pharmacology & Pharmacy
Mattia Tiboni, Enas Elmowafy, Marwa O. El-Derany, Serena Benedetti, Raffaella Campana, Michele Verboni, Lucia Potenza, Francesco Palma, Barbara Citterio, Maurizio Sisti, Andrea Duranti, Simone Lucarini, Mahmoud E. Soliman, Luca Casettari
Summary: Researchers have been exploring innovative green materials made from renewable natural substances, such as chitosans and biosurfactants, for formulation needs. These biopolymers possess biocompatibility, biodegradability, functionality, and cost-effectiveness. They have shown potential for wound dressing to aid in physiological wound healing, which involves oxidative damage, inflammation, and infection risks. The study synthesized different sugar esters in combination with chitosan and sucrose laurate and evaluated their cytocompatibility, anti-inflammatory, antioxidant, and antibacterial activities. The combination showed superior wound healing prospects and restoration of the Wnt/beta-catenin signaling pathway.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Yunok Oh, Chang-Bum Ahn, M. P. C. K. Marasinghe, Jae-Young Je
Summary: Chitosan, a naturally occurring biodegradable polymer, demonstrates osteogenic effects in murine bone marrow-derived mesenchymal stem cells. Grating gallic acid onto chitosan enhances its potential for osteogenesis. Mechanistic study shows that GAC activates the Wnt signaling pathway to promote osteoblast differentiation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Yinan Hu, Qi Wang, Jun Yu, Qing Zhou, Yanhan Deng, Juan Liu, Lei Zhang, Yongjian Xu, Weining Xiong, Yi Wang
Summary: This study reveals the involvement of ACP5 in the initiation and progression of pulmonary fibrosis. Acp5 deficiency protects mice from lung injury and fibrosis, and the upregulation of Acp5 by TGF-beta 1 enhances β-catenin signaling, promoting fibroblast differentiation, proliferation, and migration. Furthermore, treatment with Acp5 siRNA or inhibitor can reverse established lung fibrosis.
NATURE COMMUNICATIONS
(2022)
