Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 699, Issue 1-3, Pages 118-123Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2012.11.043
Keywords
Auraptene; Global cerebral ischemia; Hippocampus; Anti-inflammation; COX-2; Neuroprotection
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Funding
- Japan Society for the Promotion of Science [23700941]
- The Science Research Promotion Fund of The Promotion and Mutual Aid Corporation for Private Schools of Japan
- The Research Promotion Fund of Ehime Industrial Promotion Foundation
- Grants-in-Aid for Scientific Research [23659699, 23700941] Funding Source: KAKEN
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Cerebral ischemia causes delayed neuronal cell death in the hippocampus resulting in sequential cognitive impairments. Hyper-activated inflammation following ischemia is one of the etiologies for delayed neuronal cell death. In the present study, using a transient global ischemia mouse model, we showed that auraptene (AUR), a citrus coumarin, effectively inhibited microglia activation, cyclooxygenase-2 expression by astrocytes, and neuronal cell death in the hippocampus following ischemic insults. These results suggest that AUR acts as a neuroprotective agent in the ischemic brain, which may be mediated by suppression of the inflammatory response. (C) 2012 Elsevier B.V. All rights reserved.
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