Article
Medicine, Research & Experimental
Biao Wu, Jie Shang, Shiyuan Lin, Ning Jiang, Baizhou Xing, Rong Peng, Xianghe Xu, Huading Lu
Summary: Increased bone resorption caused by excessive osteoclasts is the main cause of osteoporosis. The expression of RILP, a protein, is induced by receptor activator of NF-KB ligand, and its inhibition decreases the number and function of osteoclasts. Inhibition of RILP also reduces preosteoclast migration and bone resorption. The study suggests that RILP plays a crucial role in osteoclast formation and bone resorption, and could be a therapeutic target for bone diseases caused by excessive osteoclasts.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Hye Jung Ihn, Jiwon Lim, Kiryeong Kim, Sang-Hyeon Nam, Soomin Lim, Su Jeong Lee, Jong-Sup Bae, Tae Hoon Kim, Jung-Eun Kim, Moon-Chang Baek, Yong Chul Bae, Eui Kyun Park
Summary: Ciclopirox effectively inhibits osteoclast differentiation and bone resorption both in vitro and in vivo, making it a potential candidate for preventing osteoporosis and other osteoclast-related bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Chenhui Cai, Wenhui Hu, Ying Zhang, Xu Hu, Sizhen Yang, Hao Qiu, Rujie Wang, Min Ma, Yiyun Qiu, Tongwei Chu
Summary: BCI treatment attenuates osteoclast differentiation and alleviates osteoporosis by inhibiting STAT3 and NF-kappa B signaling pathways, suggesting a potential effective approach for treating osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yin Cheng, Haixia Liu, Jing Li, Yujie Ma, Changheng Song, Yuhan Wang, Pei Li, Yanjing Chen, Zhiguo Zhang
Summary: Monascin was found to inhibit osteoclastogenesis in RANKL-induced RAW264.7 cells by suppressing MAPKs signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Kazuki Inoue, Courtney Ng, Yuhan Xia, Baohong Zhao
Summary: The translation discusses the role of osteoclasts in bone development and remodeling, as well as the significance of epigenetic regulation and microRNAs in gene expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Shicheng Huo, Xuesong Liu, Shutao Zhang, Zhuocheng Lyu, Jue Zhang, You Wang, Bin'en Nie, Bing Yue
Summary: Our study shows that A-485 has a protective effect in osteoporosis and can inhibit RANKL-induced osteoclast differentiation while reducing the expression of genes associated with osteoporosis. Additionally, A-485 also attenuated OVX-induced bone loss in a mouse model by inhibiting MAPK pathway phosphorylation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Cell Biology
Zhong-Hua Chen, Jun-Jie Wu, Dan-Yang Guo, Yue-Yue Li, Meng-Nan Chen, Zhen-Yu Zhang, Zheng-Dong Yuan, Kai-Wen Zhang, Wei-Wei Chen, Fan Tian, Jun-Xing Ye, Xia Li, Feng-Lai Yuan
Summary: With aging, bone tissue undergoes significant changes, leading to senile osteoporosis, a common bone disease characterized by reduced bone mass and increased fracture risk. These changes are primarily due to the disorder in the formation and resorption of bone cells, osteoblasts and osteoclasts. Osteoclasts, as bone-resorbing cells, have unique cytoskeletal structures called podosomes, which play a vital role in the degradation of mineralized bone matrix. This review summarizes recent advancements in understanding the architecture and functions of podosomes and discusses their regulatory pathways, providing insights for future research and potential therapeutic interventions for inhibiting bone resorption.
AGEING RESEARCH REVIEWS
(2023)
Article
Medicine, Research & Experimental
Seong Cheol Kim, Hyeon Jeong Kim, Gi Eun Park, Ramesh Prasad Pandey, Jisun Lee, Jae Kyung Sohng, Yong Il Park
Summary: This study demonstrated that Tri inhibits osteoclastic cell differentiation and bone resorption by down-regulating the expression of osteoclastogenic marker genes and signalling proteins, bone resorptive proteins, and by augmenting serum OPG/RANKL ratio, suggesting that Tri can be a novel anti-osteoporotic compound for treating senile and postmenopausal OP.
Article
Biochemistry & Molecular Biology
Gyeong Do Park, Yoon-Hee Cheon, So Young Eun, Chang Hoon Lee, Myeung Su Lee, Ju-Young Kim, Hae Joong Cho
Summary: Osteoporosis is a systemic metabolic bone disorder characterized by excessive bone resorption by osteoclasts. Beta-boswellic acid (β-BA) derived from Boswellia serrata shows anti-resorptive effects by inhibiting osteoclast differentiation and bone resorption, suggesting its potential as a therapeutic candidate for bone diseases like osteoporosis.
Article
Biology
Shumin Wang, Eri O. Maruyama, John Martinez, Justin Lopes, Trunee Hsu, Wencheng Wu, Wei Hsu, Takamitsu Maruyama, Ritu Trivedi
Summary: miRNA is an ideal master regulator for organogenesis due to its ability to simultaneously modulate a set of genes for lineage-specific development. However, the lack of obvious phenotypic defects in most miRNA deletions may be attributed to functional redundancy. Our study identifies MIR27a as a specific miRNA essential for bone homeostasis, as its loss causes severe osteoporosis in mice. MIR27a affects bone resorption by osteoclasts and not bone formation by osteoblasts, and its effects are mediated through the regulation of Squstm1/p62.
Article
Biochemistry & Molecular Biology
Perry C. Caviness, Dongzheng Gai, Oxana P. Lazarenko, Michael L. Blackburn, Fenghuang Zhan, Jin-Ran Chen
Summary: Osteoclasts derived from hematopoietic stem cells play a crucial role in bone resorption. Identifying new molecules that can epigenetically regulate osteoclastogenesis is essential for the development of novel treatments for bone deterioration disorders like osteoporosis. The protein Ezh2 has been found to be associated with the epigenetic regulation of various cellular processes, but its role in bone cell development is still not fully understood.
Article
Biochemistry & Molecular Biology
Guochun Zhu, Wei Chen, Chen-Yi Tang, Abigail McVicar, Diep Edwards, Jinwen Wang, Matthew McConnell, Shuying Yang, Yang Li, Zhijie Chang, Yi-Ping Li
Summary: Cathepsin K plays a role in epigenetic regulation in osteoclasts, regulating gene expression and maintaining bone homeostasis through protein proteolysis. This finding provides new insights into the treatment of osteolytic diseases such as osteoporosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Guochun Zhu, Wei Chen, Chen-Yi Tang, Abigail McVicar, Diep Edwards, Jinwen Wang, Matthew McConnell, Shuying Yang, Yang Li, Zhijie Chang, Yi-Ping Li
Summary: This study reveals the important role of Ctsk as an epigenetic regulator in osteoclasts, orchestrating multiple signaling pathways and proteolysis mechanisms to maintain bone homeostasis and prevent bone loss.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Meghan Craven, Mary Ellen Vajravelu, Karuna V. Shekdar, Michael A. Levine, Steven Mumm, Michael P. Whyte, Edna E. Mancilla
Summary: This article presents a case study of a 12-year-old girl who was found to have a 12-bp duplication in the TNFRSF11A gene. She exhibited tooth root resorption and hearing loss, but with a relatively milder clinical phenotype. After receiving treatment with bisphosphonates, her skeletal condition improved.
Article
Cell Biology
Hirohito Hirata, Asana Kamohara, Masatoshi Murayama, Kenichi Nishioka, Hiroaki Honda, Yasuteru Urano, Hidenobu Soejima, Shinya Oki, Toshio Kukita, Shunsuke Kawano, Masaaki Mawatari, Akiko Kukita
Summary: Bhlhe40 is a crucial regulator of osteoclast differentiation and function, and its deficiency leads to increased bone volume and reduced bone resorption activity. Analysis of potential target genes reveals their association with proton transport and intracellular vesicle acidification.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Food Science & Technology
Young-Sil Lee, Sun-Sil Choi, Takayuki Yonezawa, Toshiaki Teruya, Je-Tae Woo, Hyo Jung Kim, Byung-Yoon Cha
FOOD SCIENCE AND BIOTECHNOLOGY
(2015)
Article
Food Science & Technology
Ji-Won Lee, Midori Asai, Sang-Kyung Jeon, Tadahiro Iimura, Takayuki Yonezawa, Byung-Yoon Cha, Je-Tae Woo, Akira Yamaguchi
MOLECULAR NUTRITION & FOOD RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Hyo Jung Kim, Takayuki Yonezawa, Toshiaki Teruya, Je-Tae Woo, Byung-Yoon Cha
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2015)
Article
Chemistry, Medicinal
Motoyasu Minami, Takako Mori, Takayuki Yonezawa, Yukiko Saito, Toshiaki Teruya, Je-Tae Woo
JOURNAL OF NATURAL MEDICINES
(2018)
Article
Immunology
Yan Weng, Natsumi Mizuno, Jiangxu Dong, Ryosuke Segawa, Takayuki Yonezawa, Byung Yoon Cha, Je-Tae Woo, Takahiro Moriya, Masahiro Hiratsuka, Noriyasu Hirasawa
INTERNATIONAL IMMUNOPHARMACOLOGY
(2018)
Article
Plant Sciences
Yuji Mitani, Kazuhiro Satake, Megumi Tsukamoto, Ichiro Nakamura, Onat Kadioglu, Toshiaki Teruya, Takayuki Yonezawa, Cha Byung-Yoon, Thomas Efferth, Woo Je-Tae, Hiroshi Nakagawa
Article
Biochemistry & Molecular Biology
Sun Hee Cheong, Keisuke Furuhashi, Katsuki Ito, Masato Nagaoka, Takayuki Yonezawa, Yutaka Miura, Kazumi Yagasaki
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2014)
Article
Food Science & Technology
Sun Hee Cheong, Keisuke Furuhashi, Katsuki Ito, Masato Nagaoka, Takayuki Yonezawa, Yutaka Miura, Kazumi Yagasaki
MOLECULAR NUTRITION & FOOD RESEARCH
(2014)
Article
Cell Biology
Yan Weng, Jingwen Wang, Zhifu Yang, Miaomiao Xi, Jialin Duan, Chao Guo, Ying Yin, Ryosuke Segawa, Takahiro Moriya, Takayuki Yonezawa, Byung Yoon Cha, Je-Tae Woo, Aidong Wen, Noriyasu Hirasawa
CELLULAR SIGNALLING
(2019)
Article
Chemistry, Multidisciplinary
Haruhisa Kikuchi, Kosuke Kawai, Yota Nakashiro, Takayuki Yonezawa, Kumi Kawaji, Eiichi. N. Kodama, Yoshiteru Oshima
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Article
Pharmacology & Pharmacy
Ryosuke Segawa, Mika Shiraki, Shiori Sudo, Kenichi Shigeeda, Taiji Saito, Natsumi Mizuno, Takahiro Moriya, Takayuki Yonezawa, Je-Tae Woo, Masahiro Hiratsuka, Noriyasu Hirasawa
EUROPEAN JOURNAL OF PHARMACOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Tomoe Tsuboi, Rui Lu, Takayuki Yonezawa, Akio Watanabe, Je-Tae Woo, Sumiko Abe-Dohmae, Shinji Yokoyama
Article
Biotechnology & Applied Microbiology
Noriyuki Natsume, Takayuki Yonezawa, Je-Tae Woo, Toshiaki Teruya
Summary: Pinocembrin isolated from the traditional plant Alpinia zerumbet in Okinawa, Japan, showed enhanced ALP activity and mineralization, and increased mRNA expression of osteoblast-related genes. Pinocembrin may increase BMP-2 expression via ER, promoting osteoblast specific genes expression and mineralization through Smad-dependent and independent pathways. This suggests that pinocembrin has bone anabolic effects and may be useful for the prevention and treatment of bone metabolic diseases such as osteoporosis.
Article
Biochemistry & Molecular Biology
Akio Watanabe, Marilia Oliveira de Almeida, Yusuke Deguchi, Ryuzo Kozuka, Caroline Arruda, Andresa Aparecida Berretta, Jairo Kenupp Bastos, Je-Tae Woo, Takayuki Yonezawa
Summary: Baccharin, a major component of Brazilian green propolis, promotes adipocyte differentiation by increasing lipid accumulation and glucose uptake through activation of PPAR gamma. In diabetic ob/ob mice, intraperitoneal administration of baccharin significantly improved blood glucose levels. These results suggest that baccharin has a hypoglycemic effect on glucose metabolic disorders, such as type 2 diabetes mellitus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Noriyuki Natsume, Takayuki Yonezawa, Yukiko Saito, Je-Tae Woo, Toshiaki Teruya
Summary: The study revealed that isonymphaeol B and 3'-geranyl naringenin promote glucose uptake and AMPK phosphorylation in skeletal muscle cells, leading to increased levels of GLUT1 protein, indicating potential benefits for glucose metabolism and suggesting their potential as lead candidates for antidiabetic drug development.
JOURNAL OF NATURAL MEDICINES
(2021)