Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 653, Issue 1-3, Pages 89-94Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2010.11.029
Keywords
Type 2 diabetes; Nephropathy; Inflammation; Oxidative stress; AGE's
Categories
Funding
- Faculty of Medicine, University of Coimbra, Portugal
- Faculty of Medicine, University Hospitals of Coimbra, Portugal
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Type 2 diabetes is increasing at epidemic proportions throughout the world, and diabetic nephropathy is the principal cause of end stage renal failure. Approximately 40% of patients with type 2 diabetes may progress to nephropathy and a good metabolic control can prevent the development of diabetic renal injury. The aim of our study was to evaluate, in young type 2 diabetic Goto-Kakizaki (GK) rats fed with atherogenic diet, the effects of the anti-diabetic compounds insulin, metformin and gliclazide on renal damage. GK rats fed with atherogenic diet showed increased body weight and fasting blood glucose, total cholesterol, triglycerides. C-reactive protein and protein carbonyl levels and lower HDL-cholesterol concentration; renal markers of inflammation and fibrosis were also elevated. All the anti-diabetic agents ameliorated fasting glycaemia and insulin resistance but only insulin and metformin were able to improve glycoxidation, fibrosis and inflammation kidney parameters. Our data suggest that insulin and metformin treatments, improving glicoxidative, inflammatory and fibrotic renal damage markers, play a key role in the prevention of diabetic nephropathy. (C) 2010 Elsevier B.V. All rights reserved.
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