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Pharmacology & Pharmacy
Xuejun Wang, Li Zhang, Mengwen Feng, Zhongqing Xu, Zijie Cheng, Lingmei Qian
Summary: ELA-11 alleviated heart injury induced by DOX and inhibited apoptosis in cardiac tissues by regulating the PI3K/AKT and ERK/MAPK signaling pathways. It also protected cardiomyocytes from oxidative stress-induced apoptosis by interacting with the APJ receptor.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Suhail Al-Salam, Karthishwaran Kandhan, Manjusha Sudhadevi, Javed Yasin, Saeed Tariq
Summary: Doxorubicin is a commonly used drug for cancer treatment, but its usage is limited due to serious side effects, including cardiotoxicity. This study found that Gal-3, a protein, is upregulated in conditions such as heart failure. The findings suggest that Gal-3 can affect the redox pathways and regulate cell survival and death in acute Doxorubicin-induced cardiotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jie A. Wang, Yufeng Tang, Jingjing Zhang, Jie B. Wang, Mengjie Xiao, Guangping Lu, Jiahao Li, Qingbo Liu, Yuanfang Guo, Junlian Gu
Summary: In this study, the researchers investigated the role of the interaction between SIRT1 and SESN2 in DOX-induced cardiomyopathy. They found that SIRT1 deficiency aggravated cardiac damage, while the activation of SIRT1 had protective effects. Further studies revealed that SIRT1 reduced oxidative damage and apoptosis by attenuating the interaction between SESN2 and MDM2, thereby protecting the heart from DOX-induced toxicity.
Article
Pharmacology & Pharmacy
Zirui Zhao, Shilei Yang, Yawen Deng, Liang Wang, Yifen Zhang, Zhenyu Feng, Han Li, Zhongchao Chi, Yunpeng Xie, Deshi Dong
Summary: The study found that Naringin can prevent DOX-related cardiac injury and inhibit oxidative stress, inflammation, and apoptosis in the heart both in vivo and in vitro. These findings suggest that Naringin may serve as a novel approach to prevent cardiac toxicity induced by anthracycline drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Abdullah F. AlAsmari, Metab Alharbi, Faleh Alqahtani, Fawaz Alasmari, Mohammed AlSwayyed, Sami I. Alzarea, Ibrahim A. Al-Alallah, Adel Alghamdi, Hassan M. Hakami, Meshal K. Alyousef, Youssef Sari, Nemat Ali
Summary: The study showed that diosmin has a protective effect against doxorubicin-induced hepatotoxicity by restoring hepatic antioxidant factors, reducing inflammatory and apoptotic proteins and genes.
Article
Environmental Sciences
Sara Asaad Abdulkareem Aljumaily, Mehmet Demir, Hulya Elbe, Gurkan Yigitturk, Yasemin Bicer, Eyup Altinoz
Summary: The study aimed to investigate the effects of crocin on doxorubicin-induced cardiotoxicity in rats. Results showed that crocin significantly ameliorated lipid profile, cardiac markers, and oxidative stress indices caused by DOX. Additionally, crocin alleviated histopathological damage in myocardium induced by DOX.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Peipei Zhang, Hao Lu, Yuan Wu, Danbo Lu, Chenguang Li, Xiangdong Yang, Zhangwei Chen, Juying Qian, Junbo Ge
Summary: Doxorubicin (DOX) can lead to mitochondrial dysfunction and heart failure. COX5A, an important regulator of mitochondrial energy metabolism, plays a protective role in DOX-induced cardiomyopathy. The expression of COX5A is decreased in patients with dilated cardiomyopathy and after DOX treatment. Overexpression of COX5A improves cardiac function, glucose uptake, mitochondrial morphology, COX activity, and ATP content in DOX-stimulated mice. COX5A protects against oxidative stress, mitochondrial dysfunction, and cardiomyocyte apoptosis via the PI3K/Akt signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Jiang Shan, Ding Xiaoqian, Li Xia, Wang Yu, Zheng Zhilong, Shi Zhihui, Qin Yanjie
Summary: This study investigated the cytotoxicity, molecular function disorder, mitophagy, and apoptosis in loach fin cells exposed to doxycycline (DOX) in vitro. The results showed that DOX could induce the production of reactive oxidative species (ROS) at lower concentrations, leading to reduced cell proliferation, while higher concentrations of DOX induced cell apoptosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
Chun Wang, Ling Hu, Shuang Guo, Qing Yao, Xiufen Liu, Bo Zhang, Xiangwen Meng, Xiaosong Yang
Summary: Myocardial apoptosis and necroptosis are key factors in doxorubicin-induced cardiotoxicity, while phosphocreatine (PCr) has been shown to have cardioprotective effects. PCr can alleviate myocardial cell death induced by DOX by increasing antioxidant activity, and activate the TAK1 signaling pathway to promote myocardial survival.
Article
Physiology
Marina Rankovic, Nevena Draginic, Jovana Jeremic, Andjela Milojevic Samanovic, Svetlana Stojkov, Slobodanka Mitrovic, Nevena Jeremic, Tanja Radonjic, Ivan Srejovic, Sergey Bolevich, Andrey Svistunov, Vladimir Jakovljevic, Tamara Nikolic Turnic
Summary: This study investigated the effects of thiamine on DOX-induced cardiotoxicity in Wistar albino rats. The results demonstrated that thiamine treatment can alleviate oxidative stress, suppress apoptosis, and improve cardiac performance.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chenfei Li, Zhen Guo, Fangyuan Liu, Peng An, Mingyu Wang, Dan Yang, Qizhu Tang
Summary: Doxorubicin (DOX) is a commonly used chemotherapeutic drug in cancer treatment, but its side effects on the heart restrict its clinical application. In this study, researchers found that apoptosis, oxidative stress, and autophagy all play important roles in DOX-induced cardiac injury. They demonstrated that overexpression of PCSK6, a protein involved in cardiovascular diseases, can protect against DOX-induced cardiac damage by promoting autophagy and inhibiting apoptosis and oxidative stress. They also identified the involvement of SIRT1 and FOXO3a in the protective effect of PCSK6.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Toxicology
Chen Zhang, Qinghua Dan, Song Lai, Yutong Zhang, Erer Gao, Haiyan Luo, Liping Yang, Xiaobo Gao, Cailing Lu
Summary: This study investigated the role of Rab10 in doxorubicin (DOX)-induced cardiotoxicity. The results showed that cardiac-specific overexpression of Rab10 alleviated cardiac dysfunction and mitochondrial damage caused by DOX treatment. Rab10 also inhibited apoptosis and oxidative stress in cardiomyocytes. Furthermore, Rab10 inhibited the cleavage of Mst1, a serine-threonine kinase, mediated by DOX treatment.
TOXICOLOGY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Xiaoliang Hu, Cheng Li, Qian Wang, Zhixing Wei, Taizhong Chen, Yuepeng Wang, Yigang Li
Summary: Doxorubicin, a drug with limited clinical application due to its cardiotoxicity, can be alleviated by Dimethyl fumarate (DMF) through reducing oxidative stress and apoptosis via Nrf2 pathway. The study found that DMF significantly improved cell viability and morphology, as well as alleviated DOX-induced cardiac injury, oxidative stress, and apoptosis. Moreover, DMF exerted its protective effects by promoting Nrf2 nuclear translocation and activating downstream antioxidant gene Hmox1. DMF may be a promising candidate to alleviate DOX-related cardiotoxicity in the future.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shanshan Wei, Wanjun Ma, Yuanying Yang, Taoli Sun, Chuanhao Jiang, Jian Liu, Bikui Zhang, Wenqun Li
Summary: This study found that trastuzumab (Tra) in combination with doxorubicin (Dox) leads to more severe cardiotoxicity compared to Dox alone in HER2-positive breast cancer treatment. The results demonstrate that Tra enhances Dox-induced cardiomyocyte apoptosis and cardiac dysfunction through the activation of the NLRP3 inflammasome.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Abdullah F. AlAsmari, Nemat Ali, Metab Alharbi, Faleh Alqahtani, Fawaz Alasmari, Daad Almoqbel, Mohammed AlSwayyed, Abdulrahman Alshammari, Mohammed M. Alanazi, Ali Alhoshani, Naif O. Al-Harbi
Summary: Pre-treatment with geraniol can alleviate doxorubicin-induced kidney damage in rats, improving kidney function, antioxidant parameters, and tissue structure. Geraniol also affects the expression of inflammatory and apoptosis-related genes and proteins, protecting the kidneys from doxorubicin-induced harm.
Article
Medicine, General & Internal
Hui-Chin Lai, Wu-Chien Chien, Chi-Hsiang Chung, Wen-Lieng Lee, Tsu-Juey Wu, Kuo-Yang Wang, Chia-Ning Liu, Tsun-Jui Liu
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2015)
Article
Integrative & Complementary Medicine
Yueh-Chiao Yeh, Tsun-Jui Liu, Hui-Chin Lai
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2015)
Article
Cardiac & Cardiovascular Systems
Hui-Chin Lai, Wu-Chien Chien, Chi-Hsiang Chung, Wen-Lieng Lee, Kuo-Yang Wang, Tsu-Juey Wu, Chia-Ning Liu, Tsun-Jui Liu
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2015)
Article
Anesthesiology
Chieh-Shou Su, Hui-Chin Lai, Chih-Yen Wang, Wen-Lieng Lee, Kuo-Yang Wang, Ya-Ling Yang, Li-Chun Wang, Chia-Ning Liu, Tsun-Jui Liu
BMC ANESTHESIOLOGY
(2016)
Article
Otorhinolaryngology
Yueh-Chiao Yeh, Hung-Rong Yen, Rong-San Jiang, Ren-Ching Wang, Wan-Chun Huang, Shyh-Chang Chen, Bo-Shiou Lin, Kai-Li Liang
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Hui-Chin Lai, Wu-Chien Chien, Chi-Hsiang Chung, Wen-Lieng Lee, Tsu-Juey Wu, Kuo-Yang Wang, Chia-Ning Liu, Tsun-Jui Liu
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Chih-Hung Lai, Keng-Hao Chang, Szu-Ling Chang, Hui-Chih Lai, Wen-Lieng Lee, Tsun-Jui Liu
Article
Cardiac & Cardiovascular Systems
Huan Hsu, Hui-Chin Lai, Tsun-Jui Liu
Article
Integrative & Complementary Medicine
Malcolm Koo, Kai-Li Liang, Rong-San Jiang, Hsin Tsao, Yueh-Chiao Yeh
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2014)
Article
Cardiac & Cardiovascular Systems
H-T. Yi, H. -C. Lai, H. Hsu, W. -L. Lee, K. -Y. Wang, M. -S. Chiang, T. -J. Liu
HEART LUNG AND CIRCULATION
(2014)
Article
Integrative & Complementary Medicine
Malcolm Koo, Hsuan-Pin Chen, Yueh-Chiao Yeh
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Tsun-Jui Liu, Yueh-Chiao Yeh, Wen-Lieng Lee, Li-Chuan Wang, Hsiao-Wei Lee, Miau-Tsz Shiu, Chieh-Shou Su, Hui-Chin Lai
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Medicine, General & Internal
Szu-Ling Chang, Chih-Hung Lai, Guan-Yu Chen, Chia-Man Chou, Sheng-Yang Huang, Yung-Ming Chen, Tsun-Jui Liu, Hui-Chin Lai
Summary: In this study, three infants under one year of age underwent successful uniportal VATS with one-lung ventilation achieved using Fuji 5 Fr Uniblocker bronchial blockers. Challenges encountered during the surgeries included issues with the blockers such as leakage and dislodgement, as well as postoperative complications. However, these were promptly addressed and adjusted to ultimately achieve the surgical goals.
Article
Health Care Sciences & Services
Yo-Yu Liu, Yueh-Chiao Yeh
Summary: This study investigated the factors influencing the use of complementary and alternative medicines (CAMs) for stress management during the COVID-19 pandemic in Taiwan. The results showed that middle-aged adults were more likely to use CAMs, with music therapies, massage, and reading scriptures/The Bible being the most commonly used CAMs. Religion and vegetarian diets were found to be the most important factors influencing participants to use CAMs.
Article
Medicine, General & Internal
Yueh-Chiao Yeh, Tsun-Jui Liu, Hui-Chin Lai
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2020)