Article
Peripheral Vascular Disease
Yang Chen, Seethalakshmi R. Iyer, Viacheslav O. Nikolaev, Fabio Naro, Manuela Pellegrini, Silvia Cardarelli, Xiao Ma, Hon-Chi Lee, John C. Burnett
Summary: This study demonstrated that pGC-A mediates aldosterone inhibition, MANP inhibits aldosterone via PDE2, and the inhibitory effect is mediated by a reduction of intracellular Ca2+ levels.
Article
Biochemistry & Molecular Biology
Jacopo Pieroni, Yuto Yamazaki, Xin Gao, Yuta Tezuka, Hiroko Ogata, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hironobu Sasano
Summary: The study revealed that in aldosterone-producing adenomas and idiopathic hyperaldosteronism, cells in the zona glomerulosa exhibited significantly higher levels of senescence compared to other regions. Additionally, laboratory findings of primary aldosteronism were significantly correlated with specific gene mutations.
Review
Biochemistry & Molecular Biology
Rocco V. Carsia, Patrick J. Mcilroy, Henry B. John-Alder
Summary: This review summarizes the research on dispersed adrenocortical cells of various lizard species and discusses their steroidogenic function. The findings suggest that both sex and life stage have an impact on the steroidogenic budget and function of adrenocortical cells. The study also reveals the existence of multiple, labile subpopulations of these cells, with potential implications for the cortisol profile of lizard species. These findings highlight the importance of further research on the effects of climate change and environmental pollutants on adrenocortical cell populations.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hiroki Shimada, Shuko Hata, Yuto Yamazaki, Yuri Otsubo, Ikuko Sato, Kazue Ise, Atsushi Yokoyama, Takashi Suzuki, Hironobu Sasano, Akira Sugawara, Yasuhiro Nakamura
Summary: YM750, an ACAT inhibitor, suppresses CYP11B2 gene expression and aldosterone secretion by inhibiting intracellular signaling activated by depolarization. ACAT1 is suggested to play a significant role in steroidogenesis in the zona glomerulosa (ZG). Therefore, YM750 has the potential to be a therapeutic agent for primary aldosteronism (PA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Ye Yang, Chunlei Wang, Hong Shen, Hongliang Fan, Jing Liu, Nanxiang Wu
Summary: This study investigated the effects of cis-bifenthrin on the biosynthesis of adrenal steroids in human adrenocortical carcinoma cells. It was found that cis-bifenthrin can decrease the production of cortisol and aldosterone by disrupting cAMP signaling pathway.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Yuhong Yang, Martina Tetti, Twinkle Vohra, Christian Adolf, Jochen Seissler, Michael Hristov, Alexia Belavgeni, Martin Bidlingmaier, Andreas Linkermann, Paolo Mulatero, Felix Beuschlein, Martin Reincke, Tracy Ann Williams
Summary: APAs exhibit transcriptome differences of different sizes, with BEX1 showing higher expression in micro-APAs compared to macro-APAs, negatively correlated with APA diameter, and promoting cell survival by regulating ferroptosis.
Article
Endocrinology & Metabolism
Benjamin M. Dungar, Chad D. Schupbach, Jessie R. Jacobson, Phillip G. Kopf
Summary: The study found that BDE-47 significantly increases adrenal corticosteroid secretion and upregulates gene expression of enzymes involved in corticosteroid synthesis and mitochondrial metabolism. In the rat experiment, adrenal weight and plasma corticosterone levels were significantly increased in the BDE-47 treatment groups, suggesting a potential disruption in corticosteroid regulation and supporting the role of PBDEs as endocrine disruptors.
Article
Endocrinology & Metabolism
Benjamin M. Dungar, Chad D. Schupbach, Jessie R. Jacobson, Phillip G. Kopf
Summary: The study found that BDE-47 significantly increased aldosterone and cortisol secretion in HAC15 cells, as well as gene expression related to corticosteroid synthesis and mitochondrial metabolism. In Sprague Dawley rats, adrenal weight was significantly increased in BDE-47 treatment groups, with a notable rise in plasma corticosterone levels in the 100 μg BDE-47/kg treatment group. These results indicate that BDE-47 disrupts corticosteroid secretion and supports the notion that PBDEs could act as endocrine disruptors.
Article
Endocrinology & Metabolism
Liling Zhao, Jinjing Wan, Yujun Wang, Wenjun Yang, Qi Liang, Jinrong Wang, Ping Jin
Summary: This study presents a rare case of co-existing Cushing's syndrome and primary aldosteronism caused by bilateral adrenocortical adenomas secreting aldosterone and cortisol. Through clinical examinations and pathological analysis, it was found that the heterogeneity of tumor cell compositions and a mutation in the KCNJ5 gene may have led to different hormone secretions in the bilateral adrenal adenomas.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yusuf Ali, Elise P. Gomez-Sanchez, Celso E. Gomez-Sanchez
Summary: The mTOR signaling pathway plays a crucial role in transducing the AngII signal initiating aldosterone and cortisol synthesis in HAC15 cells.
Article
Endocrinology & Metabolism
Guido Zavatta, Guido Di Dalmazi, Paola Altieri, Carla Pelusi, Rita Golfieri, Cristina Mosconi, Caterina Balacchi, Claudio Borghi, Eugenio Roberto Cosentino, Ilaria Di Cintio, Jennifer Malandra, Uberto Pagotto, Valentina Vicennati
Summary: This study aimed to assess the relationship between aldosterone levels and the PTH-vitamin D-calcium axis in patients with primary aldosteronism (PA) compared to patients with nonsecreting adrenocortical tumors. The results showed a positive association between aldosterone and PTH levels, possibly independent of 25(OH) vitamin D levels and urinary calcium. Further research is needed to determine if aldosterone directly interacts with the parathyroid glands.
ENDOCRINE PRACTICE
(2022)
Review
Biochemistry & Molecular Biology
Hiroki Shimada, Yuto Yamazaki, Akira Sugawara, Hironobu Sasano, Yasuhiro Nakamura
Summary: The adrenal cortex produces essential steroid hormones, but tumors can disrupt hormone balance and homeostasis in the body. Genetic abnormalities can impact hormone secretion and tumor pathogenesis.
Article
Biochemistry & Molecular Biology
Michael Gekle, Sigrid Mildenberger
Summary: Mineralocorticoid aldosterone induces cytosolic alkalization in rat glomerular mesangial cells through NHE and ERK1/2 activation, promoting cell proliferation and collagen secretion.
Review
Endocrinology & Metabolism
Xin Gao, Yuto Yamazaki, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hironobu Sasano
Summary: PA is the most common cause of secondary hypertension, classified into unilateral and bilateral types. APMs may be precursors of APAs, and aging plays a pivotal role in the development of aldosterone-producing lesions.
ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Endocrinology & Metabolism
Fatin Athirah Pauzi, Elena Aisha Azizan
Summary: Primary aldosteronism is a common curable form of secondary hypertension, often caused by the overproduction of aldosterone in the adrenal glands. The detection of aldosterone synthase through immunohistochemistry can identify aldosterone-producing cell clusters, potentially contributing to hyperaldosteronism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Keiichi Ikeda, Kouki Fujioka, Toshiaki Tachibana, Seung U. Kim, Katsuyoshi Tojo, Yoshinobu Manome
Article
Chemistry, Analytical
Kouki Fujioka, Yasuko Tomizawa, Nobuo Shimizu, Keiichi Ikeda, Yoshinobu Manome
Article
Clinical Neurology
Yuta Suzuki, Kouki Fujioka, Keiichi Ikeda, Yuichi Murayama, Yoshinobu Manome
JOURNAL OF CLINICAL NEUROSCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Saulo J. A. Felizola, Takashi Maekawa, Yasuhiro Nakamura, Fumitoshi Satoh, Yoshikiyo Oho, Kumi Kikuchi, Shizuka Aritomi, Keiichi Ikeda, Michihiro Yoshimura, Katsuyoshi Tojo, Hironobu Sasano
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2014)
Article
Oncology
Kohei Akiyoshi, Minori Kamada, Nobutake Akiyama, Masafumi Suzuki, Michiko Watanabe, Kouki Fujioka, Keiichi Ikeda, Shuichi Mizuno, Yoshinobu Manome
MOLECULAR MEDICINE REPORTS
(2014)
Article
Oncology
Minori Kamada, Kohei Akiyoshi, Nobutake Akiyama, Naotake Funamizu, Michiko Watanabe, Kouki Fujioka, Kei-Ichi Ikeda, Yoshinobu Manome
Article
Chemistry, Analytical
Kouki Fujioka, Mika Shirasu, Yoshinobu Manome, Nobuo Ito, Satoshi Kakishima, Tomohiro Minami, Tadashi Tominaga, Fumio Shimozono, Takeo Iwamoto, Keiichi Ikeda, Kenji Yamamoto, Jin Murata, Yasuko Tomizawa
Article
Chemistry, Analytical
Kouki Fujioka, Eiji Arakawa, Jun-ichi Kita, Yoshihiro Aoyama, Yoshinobu Manome, Keiichi Ikeda, Kenji Yamamoto
Article
Chemistry, Analytical
Kouki Fujioka, Nobuo Shimizu, Yoshinobu Manome, Keiichi Ikeda, Kenji Yamamoto, Yasuko Tomizawa
Review
Endocrinology & Metabolism
Keiichi Ikeda, Kouki Fujioka, Yoshinobu Manome, Katsuyoshi Tojo
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2012)
Review
Endocrinology & Metabolism
Keiichi Ikeda, Tsuyoshi Isaka, Kouki Fujioka, Yoshinobu Manome, Katsuyoshi Tojo
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2012)
Article
Multidisciplinary Sciences
Keiichi Ikeda, Toshiaki Tachibana, Yuta Suzuki, Kouki Fujioka, Hiroshi Takeyama, Yoshinobu Manome
Article
Oncology
Toshiaki Tachibana, Yuta Suzuki, Kouki Fujioka, Keiichi Ikeda, Yuriko Inoue, Yoshifumi Tada, Takashi Kei Saito, Yoshinobu Manome
ANTICANCER RESEARCH
(2015)
Article
Oncology
Kohei Akiyoshi, Minori Kamada, Kouki Fujioka, Keiichi Ikeda, Katsuyoshi Tojo, Yoshinobu Manome
ANTICANCER RESEARCH
(2013)
Article
Oncology
Minori Kamada, Keiichi Ikeda, Kouki Fujioka, Noibutake Akiyama, Kouhei Akiyoshi, Yuriko Inoue, Sanshiro Hanada, Kenji Yamamoto, Katsuyoshi Tojo, Yoshinobu Manome
ANTICANCER RESEARCH
(2012)
