Article
Biochemistry & Molecular Biology
Tsubasa Ochiai, Yuka Sasaki, Hiroshi Kuwata, Yoshihito Nakatani, Chieko Yokoyama, Shuntaro Hara
Summary: The study investigated the roles of mPGES-1 and PGIS in cutaneous immune responses using a contact hypersensitivity (CHS) model. The results indicated that these PG terminal synthases play critical roles in acquired cutaneous immune responses.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Microbiology
W. R. Ribeiro, A. G. Queiroz, E. Mendes, M. B. Casaro, C. M. Nascimento, L. S. S. F. Coelho, F. S. Martins, V. R. Leite-Silva, C. M. Ferreira
Summary: This study demonstrated that the probiotic Bifidobacterium longum 5(1A) has a prophylactic effect on oxazolone-induced allergic contact dermatitis-like skin inflammation in mice, reducing ear and dermal thickness as well as leukocyte infiltration. Additionally, acetate, a byproduct of B. longum 5(1A), was shown to prevent skin thickening, possibly indicating one mechanism of action. However, other factors are likely at play as both probiotic treatment and acetate treatment did not lead to identical results in terms of reducing inflammatory cytokines and chemokines.
BENEFICIAL MICROBES
(2021)
Article
Dermatology
Christopher T. Turner, Matthew R. Zeglinski, Katlyn C. Richardson, Stephanie Santacruz, Sho Hiroyasu, Christine Wang, Hongyan Zhao, Yue Shen, Roma Sehmi, Hermenio Lima, Gail M. Gauvreau, David J. Granville
Summary: Atopic dermatitis (AD) is a common inflammatory skin condition with skin barrier dysfunction playing a crucial role in the disease. Studies have shown elevated levels of GzmB in AD, positively correlated with disease severity and pruritus. The proteolytic activity of GzmB contributes to impaired epidermal barrier function in AD.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Environmental Sciences
Dina Tucovic, Jelena Kulas, Ivana Mirkov, Dusanka Popovic, Lidija Zolotarevski, Marta Despotovic, Milena Kataranovski, Aleksandra Popov Aleksandrov
Summary: The study found that oral cadmium intake intensifies the skin response to sensitizing chemicals, leading to inflammation and injury.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mu-Tzu Chu, Wan-Chun Chang, Shih-Cheng Pao, Shuen-Iu Hung
Summary: Drug hypersensitivity reactions can be immediate or delayed. Delayed drug hypersensitivity is mainly caused by T lymphocyte recognition of drug antigens and cell activation. This type of hypersensitivity can have various clinical presentations ranging from mild reactions to severe cutaneous adverse reactions. Common culprits of delayed drug hypersensitivity include anti-epileptics, antibiotics, anti-gout agents, and anti-viral drugs. The pathogenesis involves molecular recognition, genetic susceptibility, and immune mediators.
Article
Neurosciences
Horacio Villafan, Gabriel Gutierrez-Ospina
Summary: The eyes have immune tolerance and can instruct systemic immune tolerance for organs outside the eyes. Skin inflammatory diseases in young blind people may reflect reduced immune tolerance associated with impaired eye function.
Article
Medicine, General & Internal
Pankaj Gupta, Shivani Mallishery, Nikita Bajaj, K. Banga, Ashna Mehra, Rajiv Desai
Summary: Amalgam has been a popular choice for dental restorations, but concerns about aesthetics, mercury toxicity, and lichenoid lesions have led to a decline in its use. A study of 2000 patients with amalgam restorations found a low prevalence of amalgam-associated lichenoid lesions, with complete resolution of lesions in a few cases after restoration replacement. The presence of lichenoid lesions should not necessarily preclude the use of amalgam in routine dental practice.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Jasdeep S. Bathla, Komalpreet Tur, Zara Sragi, Kyle Sugg
Summary: This case highlights the importance of thorough history taking and clinical suspicion in appropriately diagnosing interface dermatitis, and demonstrates the temporal association between allergic contact dermatitis and autosensitization.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Dermatology
Jamie P. Schlarbaum, Erin M. Warshaw
Summary: The study characterized ingredients and claims of facial moisturizers for men, showing that they commonly contain fragrances, emulsifiers, and glucosides, but relatively few allergenic preservatives.
Article
Surgery
Nawaf Naif Alotaibi, Tawheed Ahmad, Sari Monzer Rabah, Mohammad Tafazul Sheikh
Summary: Among the 60 patients who underwent breast plastic surgery procedures with Dermabond application, 6.6% developed type IV hypersensitivity reaction, presenting with symptoms of itching and skin rash in the second week post-operatively, with no known history of allergies.
Review
Immunology
Yun-Shiuan Olivia Hsu, Kun-Lin Lu, Yun Fu, Chuang-Wei Wang, Chun-Wei Lu, Yu-Fen Lin, Wen-Cheng Chang, Kun-Yun Yeh, Shuen-Iu Hung, Wen-Hung Chung, Chun-Bing Chen
Summary: The immunomodulatory effects of regulatory T cells and co-signaling receptors are important in balancing immunogenic and immunotolerant responses, which may be disrupted in autoimmune and infectious diseases. Drug hypersensitivity has a wide range of manifestations, from mild to severe, and recent studies suggest that insufficient regulation by Tregs may play a role in severe hypersensitivity reactions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Ophthalmology
Grace S. Ahn, Michelle Ting, Catherine Y. Liu, Bobby S. Korn, Don O. Kikkawa
Summary: Microneedling is a skin rejuvenation procedure that involves puncturing the skin with fine needles to stimulate the production of collagen. However, in patients with a history of silicone injections, it may result in severe hypersensitivity and resistance to treatment, requiring long-term medication.
ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY
(2023)
Article
Dermatology
Maggie Holmes, Daim Tabba, Chelsea S. Mockbee, Robert T. Brodell, Vinayak K. Nahar
Summary: This article describes the development of allergic contact dermatitis in a burn patient who applied triple antibiotic cream.
JOURNAL OF THE DERMATOLOGY NURSES ASSOCIATION
(2022)
Article
Allergy
Thomas Rustemeyer
Summary: The understanding of the cellular and molecular pathogenesis of allergic contact dermatitis has significantly improved, with CD4+ and CD8+ T cells being important players, along with natural killer T cells (NKT) and regulatory T cells. Allergic contact dermatitis is a delayed-type hypersensitivity reaction triggered by skin contact with a chemical that individuals were previously sensitized to.
CURRENT TREATMENT OPTIONS IN ALLERGY
(2022)
Article
Cardiac & Cardiovascular Systems
Barbara Kutryb-Zajac, Patrycja Jablonska, Marcin Serocki, Alicja Bulinska, Paulina Mierzejewska, Daniela Friebe, Christina Alter, Agnieszka Jasztal, Romuald Lango, Jan Rogowski, Rafal Bartoszewski, Ewa M. Slominska, Stefan Chlopicki, Juergen Schrader, Magdi H. Yacoub, Ryszard T. Smolenski
CLINICAL RESEARCH IN CARDIOLOGY
(2020)
Review
Immunology
Katarzyna Nazimek, Krzysztof Bryniarski
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Katarzyna Nazimek, Krzysztof Bryniarski
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Katarzyna Nazimek, Krzysztof Bryniarski, Wlodzimierz Ptak, Tom Groot Kormelink, Philip W. Askenase
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Agnieszka Kij, Anna Bar, Kamil Przyborowski, Bartosz Proniewski, Lukasz Mateuszuk, Agnieszka Jasztal, Anna Kieronska-Rudek, Brygida Marczyk, Karolina Matyjaszczyk-Gwarda, Anna Tworzydlo, Camilla Enggaard, Pernille B. Laerkegaard Hansen, Boye Jensen, Maria Walczak, Stefan Chlopicki
Summary: Inhibition of thrombin activity in Ang II-induced hypertension in mice improves the NO-dependent function of vascular endothelium and normalises the 20-HETE-dependent pathway without affecting blood pressure and vascular remodelling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Krzysztof Czamara, Marta Stojak, Marta Z. Pacia, Alicja Zieba, Malgorzata Baranska, Stefan Chlopicki, Agnieszka Kaczor
Summary: Endothelial inflammation induced by LPS is closely related to the formation of LDs, with LD composition depending on LPS incubation time and the presence of serum. This study highlights the spatial association of LPS-induced LDs with nanostructural changes in cell membrane architecture.
Article
Cell Biology
Anna Kieronska-Rudek, Agnieszka Kij, Patrycja Kaczara, Anna Tworzydlo, Marek Napiorkowski, Katarzyna Sidoryk, Stefan Chlopicki
Summary: Vitamins K have anti-inflammatory effects beyond coagulation, with shorter isoprenoid chain vitamins showing stronger potential and being preferred substrates for endogenous MK-4 synthesis, while statins inhibit endogenous MK-4 production. The anti-inflammatory activity of exogenous vitamins K is independent of endogenous MK-4 synthesis.
Article
Cell Biology
Bartosz Proniewski, Anna Bar, Anna Kieronska-Rudek, Joanna Suraj-Prazmowska, Elzbieta Buczek, Krzysztof Czamara, Zuzanna Majka, Izabela Czyzynska-Cichon, Grzegorz Kwiatkowski, Karolina Matyjaszczyk-Gwarda, Stefan Chlopicki
Summary: This study investigated the effects of short-term hyperglycemia induced by administration of the insulin receptor antagonist S961 peptide on endothelium and PVAT in mice. The disruption of systemic insulin signaling led to impaired NO-dependent endothelial function and loss of vasoprotective function of PVAT, indicating a potential contribution of dysfunctional PVAT to vascular pathology in diabetes.
Article
Chemistry, Medicinal
Katarzyna Nazimek, Eugenio Bustos-Moran, Noelia Blas-Rus, Bernadeta Nowak, Justyna Toton-Zuranska, Michal T. Seweryn, Pawel Wolkow, Olga Woznicka, Rafal Szatanek, Maciej Siedlar, Philip W. Askenase, Francisco Sanchez-Madrid, Krzysztof Bryniarski
Summary: This study demonstrates that suppressor T cell-derived EVs carrying miRNA-150 can antigen-specifically downregulate mouse delayed-type hypersensitivity. Pre-incubation with antigen-specific antibodies enhances the inhibitory effect of macrophage-released EVs on effector T cells. The specific binding of EVs to MHC class II-expressing EVs promotes their aggregation and significantly increases their suppressive activity in vivo, potentially offering therapeutic benefits.
Article
Cell Biology
Katarzyna Nazimek, Krzysztof Bryniarski
Summary: EVs as a therapeutic approach face challenges in terms of clearance and distribution, but recent research suggests that utilizing antigen-specific antibodies and light chains can enhance their efficacy and targeting capability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Martyna Cieslik, Katarzyna Nazimek, Krzysztof Bryniarski
Summary: The possibility of orally delivering extracellular vesicles (EVs) and their functional cargos has gained research attention. EVs from various sources have emerged as a platform for miRNA and drug delivery, inducing immune effects after oral administration. This review summarizes research findings on the biological/therapeutic activity of orally administered EVs and their role in cross-species and cross-kingdom signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Krzysztof Bryniarski, Katarzyna Nazimek
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Martyna Cieslik, Krzysztof Bryniarski, Katarzyna Nazimek
Summary: This article discusses the presence of microRNAs (miRNAs) in common foods and their potential use as therapeutics. Oral administration of miRNAs is considered promising due to their protection from gastrointestinal enzymes and ability to affect gastric and intestinal cells. Additionally, miRNAs may have cross-species or cross-kingdom communication and can potentially treat various diseases.
AIMS ALLERGY AND IMMUNOLOGY
(2023)
Meeting Abstract
Immunology
Katarzyna Nazimek, Philip W. Askenase, Krzysztof Bryniarski
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Immunology
Katarzyna Nazimek, Pawel Bryniarski, Hanna Twardowska, Krzysztof Bryniarski
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)