Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 578, Issue 2-3, Pages 137-141Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2007.09.022
Keywords
cannabinoid CB1 receptor; serotonin; dopamine; neuron
Categories
Ask authors/readers for more resources
The endocannabinoid system is involved in memory, cognition, and pain perception by the presynaptic cannabinoid CB1 receptor, which is expressed at high levels in many brain regions. Functional studies have shown that activation of cannabinoid CB1 receptors inhibits the synaptic release of many neurotransmitters such as gamma-aminobutyric acid, glutamate, acetylcholine and monoamines. Monoamines, however, are known not only to be released from and taken back up at nerve terminals but also at extrasynaptic axonal and somatodendritic sites. Here we present immunocytochemical data documenting cannabinoid CB1 receptor expression on neurite extensions and over cell bodies of serotonergic and dopaminergic neurons. (C) 2007 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available