Article
Pharmacology & Pharmacy
Mohammed Suleiman Alsalhi, K. L. Andrew Chan
Summary: This study investigates the interaction between various amino acids and two model drugs, carbamazepine and indomethacin. The results show that different types of amino acids have different effects on the solubility of the drugs. Additionally, a combination of multiple neutral amino acids can significantly increase the solubility of indomethacin.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Agricultural Engineering
Sharifah Nurfadhlin Afifah Syed Azhar, Siti Efliza Ashari, Jen Kit Tan, Nur Kartinee Kassim, Masriana Hassan, Norhazlin Zainuddin, Rosfarizan Mohamad, Intan Diana Mat Azmi
Summary: Nanostructured lipid carriers (NLC) are effective vehicles for improving the bioavailability of poorly water-soluble drugs. This study investigated the impact of preformulation on different liquid lipids and solid lipids for the quality attributes of Mitragyna speciosa leaves extract-based NLC suitable for drug delivery system.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Engineering, Biomedical
Rachel J. Kulchar, Rahul Singh, Suwan Ding, Elena Alexander, Henry Daniell, Kam W. Leong
Summary: Biologics are often unaffordable due to high costs of fermentation, purification, and cold chain requirements. During the pandemic, limitations in production and delivery systems were evident, with a small percentage of vaccines reaching low-income countries and doses being wasted due to lack of cold-chain infrastructure. Most FDA-approved biologics are delivered invasively, while oral or topical drugs are preferred by patients. However, only a few oral drugs have been approved since 2015. The recent launch of an oral biologic with significantly reduced costs highlights the potential for simplified regulatory processes. Topical delivery offers targeted delivery of high concentration protein drugs, but there are limited FDA-approved options. This review discusses advancements in oral and topical delivery methods and suggests future directions for research.
Article
Pharmacology & Pharmacy
Soad A. Mohamad, Wesam W. Mustafa, Hesham Salem, Mahmoud Elrehany, Remon Roshdy Rofaeil, Hamdy Abdelkader
Summary: Efficient topical drug delivery using phosphodiesterase inhibitors (PDE inhibitors) could potentially revolutionize the treatment of erectile dysfunction. This study investigated the preformulation characteristics and skin permeation of three selected PDE 5 inhibitors. Results showed that the drugs had pH-dependent solubility and lipid solubility. The penetration enhancer Pluronic F127 significantly enhanced the skin permeability of sildenafil. Overall, tadalafil and vardenafil were found to be more viable options for topical penile therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shogo Kawamura, Riku Kawasaki, Shodai Hino, Keita Yamana, Masafumi Okuno, Takuro Eto, Atsushi Ikeda
Summary: Polypeptides can solubilize hydrophobic molecules and prepare highly concentrated water-dispersible complexes with long-term stability and resistance against thermal stress. These complexes show photodynamic activity against cancer cells and improve the dispersibility and storability of guest molecules.
Article
Pharmacology & Pharmacy
Krishna C. Aluri, Kalle Sigfridsson, Aixiang Xue, Niresh Hariparsad, Dermot McGinnity, Diane Ramsden
Summary: Intraperitoneal (i.p.) delivery of poorly soluble compounds with low oral bioavailability can provide efficacy readouts during initial stages of drug discovery. However, the mechanisms of absorption in complex formulations are unclear, limiting the widespread use of i.p. administration. This study investigated the pharmacokinetics of crystalline nano- and microsuspensions administered i.p. and found that smaller particles did not result in higher in vivo exposure, suggesting a potential role of the lymphatic system in absorption.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Adam Juhasz, Laszlo Seres, Norbert Varga, Ditta Ungor, Marek Wojnicki, Edit Csapo
Summary: This study quantitatively investigated the thermodynamic parameters of mixed surfactants, revealing that some mixed micelles have critical micelle concentration lower than predicted by the ideal mixing model, and they exhibit higher solubilization ability for poorly water-soluble model drugs.
Article
Chemistry, Medicinal
Katharina Kapoor, Nicole Graefe, Michael E. Herbig
Summary: Topical film-forming solutions (FFSs) have potential for improving dermal delivery by prolonging substantivity, establishing transient supersaturation, and enhancing solubility. This study successfully developed an FFS composed of tazarotene and polyamide-3 polymers, which demonstrated improved skin delivery and stability. The solid solution films significantly increased the glass transition temperature and enhanced tazarotene penetration compared to a commercial cream. Thus, topical solid solutions may offer an option for enhanced dermal API delivery.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Sabrina Valetti, Hanna Thomsen, Jitendra Wankar, Peter Falkman, Ilse Manet, Adam Feiler, Marica B. Ericson, Johan Engblom
Summary: Research has shown that porous particles of appropriate size and porosity can accumulate in hair follicles and furrows on the skin, providing a potential area for drug delivery. The combination of follicle orifices and furrows can cover up to 20% of the skin surface, making them valuable for optimizing bioavailability of topical formulations. This work highlights the potential of skin furrows for topical drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Nakamwi Akombaetwa, Ange B. B. Ilangala, Lorraine Thom, Patrick B. B. Memvanga, Bwalya Angel Witika, Aristote B. B. Buya
Summary: Skin delivery is a promising approach for effective drug delivery, but low skin permeability is a major challenge. Advances in skin delivery depend on overcoming the challenges associated with drug molecule permeation and skin irritation. Lipid nanosystems offer potential solutions, but their formulation requires careful consideration of factors such as particle size and surface charge.
Review
Pharmacology & Pharmacy
Prashant Agarwal, James Huckle, Jake Newman, Darren L. Reid
Summary: Developability molecule assessment plays a crucial role in the biopharmaceutical industry, helping to screen and rank molecules for successful chemistry manufacturing controls (CMC) development and launch. The impact of physicochemical properties on drug discovery and development is significant, but most publications only focus on medicinal chemistry and fail to consider the influence on CMC development. An analysis of the drug repurposing dataset reveals that the number of hydrogen bond donors is the only physicochemical property consistently preserved in FDA-approved oral molecules over the past century.
DRUG DISCOVERY TODAY
(2022)
Article
Pharmacology & Pharmacy
Kevin McLean, Wenbo Zhan
Summary: Nanoparticle-mediated topical delivery has the potential to significantly improve drug exposure in deep skin tissue. Adequate and long-term drug-skin contact is important for effective drug deposition. The release rate of nanoparticles should be controlled to achieve optimal drug accumulation in different skin layers.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Chando Anita, Momin Munira, Quadros Mural, Lalka Shaily
Summary: Rheumatoid arthritis is a systemic autoimmune disease with a global prevalence of about 0.3%-1%, more prevalent in women. There is no known cure, and current treatment focuses on symptomatic relief with high doses of NSAIDs, but patient compliance is often low due to off-target effects. Researchers are exploring nanosized carriers for topical drug delivery to enhance drug permeation and provide sustained release for effective treatment of RA.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biophysics
Yi Liu, Jingru Zhao, Jing Chen, Xiaoqing Miao
Summary: This review discusses the importance and potential of nanocrystal technology in the cosmetics industry, addressing the issues of high sensitivity and limited drug loading in local delivery. The use of nanocrystalline loaded gel and emulsion improves the stability of the system, and the drug NCs have various beauty efficacy in terms of anti-inflammation, anti-bacterial, lightening, anti-aging, and UV protection. The review also presents the current scenario of stability and safety and discusses the challenges and potential uses of nanocrystals in the cosmetics industry. It serves as a valuable resource for the advancement of nanocrystal technology in cosmetics.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Physics, Applied
Tamas Gera, Tomi Smausz, Tibor Ajtai, Boldizsar Kurilla, Zsolt Homik, Judit Kopniczky, Zoltan Bozoki, Piroska Szabo-Revesz, Rita Ambrus, Bela Hopp
Summary: The study investigated the application of pulsed laser ablation (PLA) for producing magnetic nanoparticles (MNPs)/drug nanocomposites, showing that PLA induced no chemical changes in the pharmaceutical compound and resulted in composite particles with an average size of 100-150 nm. The research demonstrated that PLA offers a simple and chemical-free method for the production of MNPs/drug nanocomposites, with potential applications in future theranostic nanosystems.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Pharmacology & Pharmacy
Michael E. Herbig, Pia Houdek, Sascha Gorissen, Michaela Zorn-Kruppa, Ewa Wladykowski, Thomas Volksdorf, Stephan Grzybowski, Georgios Kolios, Christoph Willers, Henning Mallwitz, Ingrid Moll, Johanna M. Brandner
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2015)
Article
Pharmacology & Pharmacy
Julia Puschmann, Michael E. Herbig, Christel C. Mueller-Goymann
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2018)
Article
Pharmacology & Pharmacy
Melanie Koellmer, Parinaz Mossahebi, Elena Sacharow, Sascha Gorissen, Nicole Graefe, Dirk-Heinrich Evers, Michael E. Herbig
Article
Pharmacology & Pharmacy
Julia Puschmann, Michael E. Herbig, Christel C. Mueller-Goymann
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Biochemical Research Methods
Julia Puschmann, Dirk-H Evers, Christel C. Mueller-Goymann, Michael E. Herbig
JOURNAL OF CHROMATOGRAPHY A
(2019)
Article
Chemistry, Medicinal
Katharina Kapoor, Nicole Graefe, Michael E. Herbig
Summary: Topical film-forming solutions (FFSs) have potential for improving dermal delivery by prolonging substantivity, establishing transient supersaturation, and enhancing solubility. This study successfully developed an FFS composed of tazarotene and polyamide-3 polymers, which demonstrated improved skin delivery and stability. The solid solution films significantly increased the glass transition temperature and enhanced tazarotene penetration compared to a commercial cream. Thus, topical solid solutions may offer an option for enhanced dermal API delivery.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Martin M. Sailer, Melanie Koellmer, Beatrice Masson, Fabio Fais, Ilja P. Hohenfeld, Michael E. Herbig, Assen K. Koitschev, Sven Becker
Summary: This study characterizes the rheological properties of a new bentonite-based thixotropic gel emulsion nasal spray (AM-301), and evaluates its nasal residence time, distribution, safety, and tolerability. The results show that AM-301 provides extended coverage of the nasal mucosa and has a good nasal residence time.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Biochemistry & Molecular Biology
ME Herbig, F Assi, M Textor, HP Merkle
Article
Biophysics
ME Herbig, K Weller, U Krauss, AG Beck-Sickinger, HP Merkle, O Zerbe
BIOPHYSICAL JOURNAL
(2005)
Article
Biochemistry & Molecular Biology
ME Herbig, U Fromm, J Leuenberger, U Krauss, AG Beck-Sickinger, HP Merkle
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2005)