Article
Medicine, Research & Experimental
Patrick Graff, Stefan Honzke, Aaroh Anand Joshi, Guy Yealland, Emanuel Fleige, Michael Unbehauen, Monika Schafer-Korting, Andreas Hocke, Rainer Haag, Sarah Hedtrich
Summary: Human skin equivalents are useful tools in preclinical dermatological research. In this study, researchers investigated the suitability of inflammatory skin equivalents for testing the anti-inflammatory effects of dexamethasone. The results showed that topical application of dexamethasone reduced the expression of proinflammatory cytokines, increased the expression of skin barrier proteins, and facilitated the translocation of glucocorticoid receptors. The study also found that dexamethasone inhibited the gene expression of extracellular matrix components.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Stefano Piazza, Giulia Martinelli, Urska Vrhovsek, Domenico Masuero, Marco Fumagalli, Andrea Magnavacca, Carola Pozzoli, Luisa Canilli, Massimo Terno, Marco Angarano, Mario Dell'Agli, Enrico Sangiovanni
Summary: Cutibacterium acnes (C. acnes) is one of the main triggers of acne vulgaris, and this study investigated the effect of a extract from Hamamelis virginiana bark on C. acnes-induced inflammation in human keratinocytes. The extract showed anti-inflammatory activity and partially impaired NF-kappa B activation, but had no antibacterial or antibiofilm activities. Further investigations are needed to explore the potential of this extract in other inflammatory-based skin diseases.
Article
Biochemistry & Molecular Biology
Valentina Andretto, Giuseppe Taurino, Giulia Guerriero, Hanae Guerin, Emmanuelle G. Laine, Massimiliano Bianchi, Geraldine Agusti, Stephanie Briancon, Ovidio Bussolati, Alexandra Clayer-Montembault, Giovanna Lollo
Summary: Oral administration of nanoparticles (NPs) faces challenges in the gastrointestinal environment, hindering their efficacy. To tackle this issue, nanocomposites with bio- and mucoadhesive matrixes were developed to improve the retention time of NPs in the intestine. Tailored nanoemulsions (NEs) were produced using a microfluidic-based approach and successfully encapsulated small hydrophobic drugs. These NEs demonstrated effective internalization into human intestinal cells and targeted delivery of drugs, offering potential for intestinal disease treatment.
Article
Biotechnology & Applied Microbiology
Camila Folle, Ana M. Marques, Natalia Diaz-Garrido, Marta Espina, Elena Sanchez-Lopez, Josefa Badia, Laura Baldoma, Ana Cristina Calpena, Maria Luisa Garcia
Summary: Thymol nanoparticles (TH-NPs) with suitable particle size, surface charge, and high encapsulation efficiency demonstrated sustained release of thymol, potent antimicrobial activity against Cutibacterium acnes, and minor effect towards Staphylococcus epidermis. TH-NPs showed promise as an alternative treatment for skin acne infection, avoiding antibiotic administration and preventing microbial drug resistance, while maintaining stability and sterility during storage. Additionally, TH-NPs enhanced thymol's antioxidant activity, offering a natural, preservative-free approach for acne treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qingqing Deng, Lu Zhang, Xuemeng Liu, Lihua Kang, Jiadai Yi, Jinsong Ren, Xiaogang Qu
Summary: Conventional strategies for treating inflammatory bowel disease focus on relieving inflammation but fail to address the underlying causes of the disease. Natural probiotics have shown potential for IBD treatment, but are not recommended due to potential risks. This study introduces artificial probiotics (Aprobiotics) based on artificial enzyme-dispersed covalent organic frameworks (COFs) and a yeast shell as a new approach for IBD management. These COF-based Aprobiotics can effectively relieve inflammation and regulate the gut microbiota, offering a promising solution for IBD treatment and inspiring the development of artificial systems for other diseases.
Article
Pharmacology & Pharmacy
Yubin Xu, Saizhen Chen, Lingling Zhang, Guirong Chen, Jinguang Chen
Summary: The study indicates that Huanglian Jiedu decoction can treat atopic dermatitis by regulating the antigen presentation function of dendritic cells, weakening T-lymphocyte activation, and subsequently exerting anti-inflammatory and anti-pruritus effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Giorgia Condro, Marta Guerini, Michela Castello, Paola Perugini
Summary: The skin microbiota plays an important role in maintaining healthy skin, but its balance can be disrupted by various factors, leading to the development of skin diseases. The correlation between diseases like acne vulgaris, atopic dermatitis, rosacea and the skin microbiota is still unclear, and more research is needed to explore the specific subspecies and strains involved.
Article
Biochemistry & Molecular Biology
William R. Swindell, Krzysztof Bojanowski, Ratan K. Chaudhuri
Summary: This study evaluated the efficacy and mechanisms of two plant-derived oil derivatives in AD-like tissue culture models. The findings showed that these compounds can prevent cytokine-induced disruption of the epidermal barrier and have anti-inflammatory and anti-itching effects. Additionally, they can regulate the expression of differentiation genes in skin cells. These results support further research and development of IDL and IDC as therapeutic candidates for AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Daniela Placha, Josef Jampilek
Summary: Inflammatory diseases are becoming a significant issue, causing damage to affected tissues as a physiological response to harmful agents. There is ongoing research to develop new drugs to modulate inflammatory responses, as well as exploring the use of nanodrug delivery systems for targeted treatment.
Article
Agriculture, Multidisciplinary
Yu Xiong, Yan-Xia Feng, Min Chang, Qian Wang, Sheng-Nan Yin, Liu-Yu Jian, Di-Feng Ren
Summary: In this study, ellagic acid (EA) and anti-inflammatory peptide (FPL) loaded chitosan nanoparticles (FPL/EA NPs) were prepared using the ionic gelation method. The synthesized nanoparticles had a spherical shape, with an average size of 308.33 +/- 4.61 nm, a high encapsulation capacity, and sustainable release of EA/FPL. The stability of the nanoparticles was evaluated and significant anti-inflammatory activity was observed.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biotechnology & Applied Microbiology
Zhihui Fu, Xiaohui Wang, Xuan Lu, Ying Yang, Lingling Zhao, Lin Zhou, Kaikai Wang, Hanlin Fu
Summary: In this study, a modified bovine serum albumin carrier was successfully developed to improve the therapeutic efficacy of Ginsenoside Rb1. By enhancing the solubility and cellular uptake of Rb1, the anti-inflammatory effects were significantly enhanced. The results indicate that the developed carrier plays a crucial role in inhibiting inflammatory reactions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chang-Woo Ha, Eun-Hwa Sohn, Sung-Hyeok Kim, Sohee Jang, Myung-Rye Park, Youn-Kyu Kim, In-Young Bae
Summary: The fermented root of Angelicae tenussimae (FAT) has been found to have anti-melanogenic and anti-photogenic effects. This study aimed to determine the efficacy of FAT on the skin barrier and inflammatory response in atopic dermatitis (AD). The results showed that FAT promoted skin barrier formation and downregulated inflammatory mediators, suggesting its potential as a functional cosmetic material for the care and management of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
M. Veronica Rivas, Daniel Musikant, Rocio Diaz Pena, Daniela Alvarez, Luciana Pelazzo, Ezequiel Rossi, Karina D. Martinez, Maria I. Errea, Oscar E. Perez, Oscar Varela, Adriana A. Kolender
Summary: Polymeric nanoparticles synthesized from D-galactose were used to efficiently encapsulate cilostazol and showed enhanced anti-inflammatory activity, holding great promise for improving its therapeutic administration.
Article
Pharmacology & Pharmacy
Valentina Di Francesco, Martina Di Francesco, Roberto Palomba, Sayanti Brahmachari, Paolo Decuzzi, Miguel Ferreira
Summary: Inflammation plays a crucial role in the initiation, progression, and thrombotic manifestations of atherosclerosis. While previous studies have used anti-inflammatory drugs, such as MTX and COL, the results have been limited. To overcome these limitations, this study explores a combination therapy using liposomes co-encapsulating MTX and COL. In vitro experiments showed that these combination liposomes effectively reduced inflammation and inhibited the accumulation of oxidized LDL in macrophages, suggesting their potential in mitigating cell inflammation and halting the progression of atherosclerosis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Ming-Jun Tsai, Cheng-Yu Lin, Jiri Trousil, Calvin Sung, Mei-Hua Lee, Jia-You Fang, Shih-Chun Yang
Summary: In this study, novel anti-acne nanovesicles based on liposomes loaded with proteinase K (PK), retinoic acid (RA), and soyaethyl morpholinium ethosulfate (SME) were developed for an effective and safe treatment of acne vulgaris.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Markus Ries, Brice Moulari, Maryam A. Shetab Boushehri, Mohamed Ehab Ali, Daniel Molnar, Arnaud Beduneau, Yann Pellequer, Alf Lamprecht
Summary: This study developed a nanoparticle platform for targeted delivery of the anti-TNF-alpha antibody adalimumab (ADA). The binding of ADA to nanoparticles improved stability and showed significant therapeutic effects in a mouse model. Furthermore, immobilization of ADA reduced systemic exposure, enhancing the safety of the treatment.
Article
Pharmacology & Pharmacy
Salma Fereig, Ghada M. El-Zaafarany, Mona Arafa, Mona M. A. Abdel-Mottaleb
Summary: This study aimed to examine the enhanced anti-psoriatic effects of gold-conjugated nanoparticles in vivo. The results showed that the gold-conjugated nanoparticles exhibited promising anti-inflammatory effects and improved skin condition compared to other formulations.
Article
Nanoscience & Nanotechnology
Taghrid Zaiter, Raphael Cornu, Nadine Millot, Michaele Herbst, Yann Pellequer, Georges Moarbess, Helene Martin, Mona Diab-Assaf, Arnaud Beduneau
Summary: The E551 additive is made up of synthetic amorphous silica particles. The current regulation does not specify their size and distribution, allowing the presence of silica nanoparticles despite their potential toxicity. Research found that a size cutoff of 70nm limits the interaction of the E551 additive with intestinal cells.
Article
Ophthalmology
Chloe Carre, Florian Baudin, Benedicte Buteau, Lucy Martine, Stephane Gregoire, Glenda Vasku, Olivier Berdeaux, Arnaud Beduneau, Yann Pellequer, Jasmine Jamoussi, Catherine Desrumeaux, Serge Aho, Alain-Marie Bron, Niyazi Acar, Catherine Creuzot-Garcher, Pierre Henri Gabrielle
Summary: This study evaluated the potential antifibrotic effects of docosahexaenoic acid (DHA) after glaucoma filtration surgery (GFS) in rats. The results showed that DHA had similar effects on intraocular pressure (IOP) and bleb area compared to mitomycin C (MMC). Further investigation is needed to understand the mechanisms of DHA action in rat eye fibroblasts.
ACTA OPHTHALMOLOGICA
(2023)
Review
Toxicology
Raphael Cornu, Arnaud Beduneau, Helene Martin
Summary: Titanium dioxide nanoparticles, commonly used in the food industry, may pose potential health risks when ingested, leading to chronic intestinal inflammation and increased risk of carcinogenesis. Children are particularly vulnerable to exposure, and maternal-foetal transfer during pregnancy and breastfeeding further contribute to offspring exposure. France has suspended the use of E171 as a precautionary measure. Further research is needed to understand the effects of oral exposure to titanium dioxide nanoparticles, especially on the gastrointestinal tract.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Taghrid Zaiter, Raphael Cornu, Wassim El Basset, Helene Martin, Mona Diab, Arnaud Beduneau
Summary: Engineered nanoparticles used in skin products can potentially cause cytotoxicity, oxidative stress, inflammatory response, and genotoxicity. However, the toxicity of nanoparticles applied to healthy skin is still debated due to their inability to reach the viable epidermis.
JOURNAL OF NANOPARTICLE RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Thomas Stalder, Taghrid Zaiter, Wassim El -Basset, Raphael Cornu, Helene Martin, Mona Diab-Assaf, Arnaud Beduneau
Summary: The gastrointestinal tract serves as a primary entry route for many nanomaterials, which are commonly used as food additives and are present in food packaging. Humans can also be orally exposed to nanoparticles in the air or drinking water. Ingested nanoparticles can interact with gastrointestinal fluids, microbiota, mucus layers, and the epithelial barrier, potentially leading to translocation and toxic effects. However, the toxicological profile of ingested nanoparticles remains unclear due to their diverse composition and physicochemical properties, as well as limited research. Understanding the fate and toxicity of ingested nanoparticles in the intestinal lumen is therefore of great importance.
Article
Chemistry, Physical
Mona M. A. Abdel-Mottaleb, Lorenza Boi, Marina Barra, Julie Colin, Luisa Berni, Arnaud Beduneau, Brice Moulari, Yann Pellequer
Summary: Lipoproteins are natural nanostructures that transport cholesterol and lipids in the blood. The protein content has the highest impact on drug entrapment, followed by cholesterol concentration, while triglycerides and phospholipids have negligible effects.
Article
Pharmacology & Pharmacy
Fatma Sa'eed El-Tokhy, Mona M. A. Abdel-Mottaleb, Sherif S. Abdel Mageed, Abdulla M. A. Mahmoud, Elsayed A. El-Ghany, Ahmed S. Geneidi
Summary: In this study, asenapine maleate was successfully encapsulated into biocompatible lipid nanocapsules for transdermal delivery using lavender oil as the oily phase. The LO-LNCs significantly increased the permeation of asenapine across rat skin and showed a fourfold increase in C-max compared to oral suspension in vivo. LO-LNCs also increased the bioavailability of asenapine by up to 52% and provided sustained release for three days.
Article
Biochemistry & Molecular Biology
Khaled E. Abuelella, Hend Abd-Allah, Sara M. Soliman, Mona M. A. Abdel-Mottaleb
Summary: This study aimed to develop polyelectrolyte complex nanoparticles (PENPs) containing chitosan (CS) and hyaluronic acid (HA) as carriers for non-steroidal anti-inflammatory drug etoricoxib (ETX) to treat irritant contact dermatitis (ICD). The optimized ETX-loaded PENPs formulation (N1 0.15%) showed efficient dermal targeting and superior anti-inflammatory properties compared to conventional gel in both ex-vivo and in vivo experiments. These findings suggest that ETX-loaded PENPs could be a promising therapeutic approach for the management of ICD.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Imen Dakhlaoui, Paul J. Bernard, Diana Pietrzak, Alexey Simakov, Maciej Maj, Bernard Refouvelet, Arnaud Beduneau, Raphael Cornu, Krzysztof Jozwiak, Fakher Chabchoub, Isabel Iriepa, Helene Martin, Jose Marco-Contelles, Lhassane Ismaili
Summary: Alzheimer's disease (AD) is a complex neurodegenerative disease without a cure, causing significant social and economic impact. Multitarget-directed ligands (MTDLs) may provide a promising therapeutic strategy for AD treatment. In this study, novel MTDLs were designed and synthesized using simple and cost-efficient methods, targeting calcium channel blockade, cholinesterase inhibition, and antioxidant activity. Two sulfonamide-dihydropyridine hybrids were identified to possess cholinesterase inhibition, calcium channel blockade, antioxidant capacity, and Nrf2-ARE activating effect, suggesting their potential for further investigation in AD therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Andrea Galvan, Enrica Cappellozza, Yann Pellequer, Anita Conti, Edoardo Dalla Pozza, Enrico Vigato, Manuela Malatesta, Laura Calderan
Summary: Skin is a major administration route for drugs and developing reliable skin models is crucial for preclinical studies. Currently, excised human skin is considered the gold standard for in vitro permeation studies. However, the limited life span of skin explants poses a problem. In this study, an innovative bioreactor was used to preserve the structural and functional integrity of explanted human skin for up to 72 hours, allowing for the simulation of inflammatory events observed in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Mohamed Ashraf, Hossam S. El-Sawy, Ghada M. El Zaafarany, Mona M. A. Abdel-Mottaleb
Summary: Although psoriasis has a huge negative impact on patients' quality of life, there is still a need to explore new green treatment approaches. This review focuses on using essential oils and active constituents of herbal botanical origin that have proven to be effective for treating psoriasis. The utilization of nanotechnology-based formulations to enhance the permeation and delivery of these agents is also discussed. The field of natural innovative formulations shows promise in optimizing psoriasis treatment while minimizing adverse effects.
