Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 79, Issue 3, Pages 544-551Publisher
ELSEVIER
DOI: 10.1016/j.ejpb.2011.07.001
Keywords
3-D ordered macroporous silica; Drug nanoparticles; In vitro dissolution; Gastric damage
Categories
Funding
- National Basic Research Program of China (973 Program) [2009CB930300]
- National Natural Science Foundation of China [81072605]
- Major National Platform for Innovative Pharmaceuticals [2009ZX09301-012]
- Key Laboratory of Drug Preparation Design & Evaluation of Liaoning Provincial Education Department
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In the present study, we exploited for the first time the potential of 3-D ordered macroporous (3DOM) silica as matrix for drug nanoparticles, in order to obtain proper control over drug particle size in the sub-micrometer range, enhance the dissolution rate, and reduce gastric damage. 3DOM silica matrix with 3-D spherical pores of 200 nm was successfully created and then loaded with IMC nanoparticles at various drug-silica ratios. A rapid release profile for IMC nanoparticle formulations was achieved in comparison with microsized IMC and a commercial capsule, which could be attributed to both increase in the specific surface area and decrease in the crystallinity of IMC, as well as the hydrophilic surface and the interconnected pore networks of 3DOM silica. Reduced gastric damage of IMC was demonstrated, and the protective effect may arise from the reduction in drug particle size as well as encapsulation effect of 3DOM silica. (C) 2011 Elsevier B.V. All rights reserved.
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