Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 70, Issue 1, Pages 234-238Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejpb.2008.02.024
Keywords
follicle penetration; in vivo; in vitro skin model; hair follicle reservoir; elastic fibres
Categories
Funding
- German Science and Humanities
Ask authors/readers for more resources
Penetration studies are commonly performed on in vitro models. presumably due to a lack of non-invasive in vivo methods. To date, it is not clear whether in vitro models are suitable to reflect the in vivo conditions for percutaneous penetration. Apart froth inter and intraspecies skin differences, the excision of a skin sample may influence the penetration rate inter alia as a result of the contraction of the elastic fibres in the skin during excision. Therefore. the aim of the present study was to investigate the follicular reservoir of the hair follicles of human skin in vivo and in vitro utilizing the method of differential stripping. The results obtained revealed a significantly reduced follicular reservoir in vitro, which was only 9.5 +/- 10.6% of the in vivo reservoir. These results are important for the interpretation of earlier Mid future penetration investigations. It can thus be assumed that excised skin models are suitable for penetration studies only to a limited extent, as follicular penetration is greatly diminished due to the contraction of the elastic fibres of the skin. (C) 2008 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available