Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 68, Issue 3, Pages 453-466Publisher
ELSEVIER
DOI: 10.1016/j.ejpb.2007.08.007
Keywords
topical glucocorticoids; bioavailability; bioequivalence; percutaneous absorption; side-effects; vehicle effects; potency
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Dermatological therapy depends significantly upon the use of topical glucocorticoids (TG). While effective, and often remarkably so, their delivery into the skin is sometimes rather inefficient. The factors which determine drug efficacy, and the various methodologies, by which the rate and extent of TG transport to their sites of action may be assessed, are the foci of this review. (C) 2007 Elsevier B.V. All rights reserved.
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