Article
Metallurgy & Metallurgical Engineering
Jianxin Zhang, Arshe Said, Bing Han, Marjatta Louhi-Kultanen
Summary: This study investigated the semi-batch evaporative crystallization of CoSO4, revealing the impact of solute on boiling underpressure of CoSO4 solutions at various temperatures and concentrations, and the effects of heating power and mixing speed on the particle size distribution of products.
Article
Engineering, Chemical
Yiqian Ma, Michael Svard, Xiong Xiao, Suchithra Ashoka Sahadevan, James Gardner, Richard T. Olsson, Kerstin Forsberg
Summary: This study investigates the recovery of NiSO4 and CoSO4 hydrates from metal sulfate solutions using eutectic freeze crystallization (EFC). Result shows promising potential of EFC as an alternative method for recovering NiSO4 and CoSO4 hydrates.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Construction & Building Technology
Na Li, Xiaoyu Wang, Yuandong Mu, Ronghui Zhang, Lingling Zhu, Guotian Ye
Summary: This study focuses on the strength development and phase transformation of calcium aluminate cement (CAC)-bonded alumina castables during the drying process, revealing that the initial drying period prompts the rapid phase transformation of hydrates, leading to a significant enhancement in the strength of the dried castables compared to demolding strength.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Wanbin Li, Pengcheng Su, Huiyu Tang, Yanshan Lin, Yanqing Yu
Summary: This report presents a one-pot synthesis method for the simultaneous hetero-crystallization and hetero-linker coordination of metal-organic framework (MOF) hollow fiber membranes, leading to precise gas separation. The prepared membranes exhibit improved selectivity and permeance through hetero-linker exchange and framework rigidification.
Article
Pharmacology & Pharmacy
Zunting Pang, Yuanfeng Wei, Hui Chen, Runze Wang, Xin Gao, Jianjun Zhang, Yuan Gao, Shuai Qian
Summary: This study investigated the thermodynamic and kinetic mechanism of the polymorphic transformation of Puerarin, including solvent-mediated and solid-state transformations. The results showed that stirring rate and temperature facilitated the solvent-mediated transformation, while heating led to the formation of different anhydrates from PUEMH and PUEDH. The dehydration rate differed between the two hydrated forms due to varying hydrogen bond interactions, with different rate-limiting steps in the dehydration process.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Optics
Z. U. Rehman, S. Ullah, H. Qayyum, M. Irfan, K. A. Tran, H. Suk, A. Qayyum, K. A. Janulewicz
Summary: Optical breakdown inside a transparent dielectric induced by a tightly focused laser beam leads to extreme thermodynamic conditions and major structural transformations. High-resolution electron microscopy revealed the formation of nano-crystals in the transition area between amorphous and crystalline phases, mainly located near the geometrical focus. Spectral analysis showed material densification through redistribution, spatial segregation, and glass network reorganization pathways.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Chemistry, Physical
Mostapha Dakhchoune, Luis Francisco Villalobos, Rocio Semino, Lingmei Liu, Mojtaba Rezaei, Pascal Schouwink, Claudia Esther Avalos, Paul Baade, Vanessa Wood, Yu Han, Michele Ceriotti, Kumar Varoon Agrawal
Summary: A new method for synthesizing molecular-sieving zeolitic membranes has been developed, which involves exfoliating single layers of zeolite precursor RUB-15 followed by a condensation reaction to produce thin films with high selectivity for gas separation, especially for precombustion carbon capture.
Article
Chemistry, Multidisciplinary
Yuanyuan Sun, Susan M. Reutzel-Edens, Rajni M. Bhardwaj, Michael F. Doherty
Summary: Crystal morphology modeling of organic molecular solvates and hydrates is largely unexplored due to complex intermolecular interactions and growth units. A mechanistic model was presented to predict the crystal morphology of olanzapine-methanol solvate and olanzapine dihydrate, with binding energy calculations identifying the most probable growth unit clusters. The close agreement between experimentally observed and predicted morphologies supports the utility of the model.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Chemistry, Multidisciplinary
Jinjie Liu, Ran Fu, Yanwen Lin, Qiao Shi, Yisi Liu, Tong Li, Zhisen Zhang, Jianyang Wu
Summary: This study investigates the mechanical characteristics of CO2 hydrates with different types of water vacancy defects for the first time through molecular dynamics simulations. The results show that the mechanical properties of CO2 clathrate hydrate vary with the type of water vacancy, and there are various cage structures and cage transformation mechanisms. These findings are crucial for evaluating the formation and mechanical stability of CO2 hydrate-bearing sediments as well as CO2 geological storage by hydrate-based technologies.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Polymer Science
Ioannis Moutsios, Konstantinos Ntetsikas, Gkreti-Maria Manesi, George Liontos, Evgeniia A. Nikitina, Cheng-Yen Chang, Loic Vidal, Nikos Hadjichristidis, Rong-Ming Ho, Dimitri A. Ivanov, Apostolos Avgeropoulos
Summary: This study comprehensively examines structured diblock copolymer liquids composed of soft segments with low glass-transition temperatures, and finds that they have the ability to form well-ordered structures at low temperatures. By manipulating monomer ratios, the molecular and thermal characteristics of the copolymers were studied, and the limits of phase stability were assessed. The diverse molecular characteristics and the ability to design block copolymers with well-ordered phases have great potential for applications in soft electronics.
Article
Chemistry, Medicinal
Lauren A. MacEachern, Rishi Walwyn-Venugopal, Azadeh Kermanshahi-Pour, Mahmoud Mirmehrabi
Summary: The research demonstrated that spray drying is a feasible method for preparing phase pure co-crystals for an incongruently saturating system and simultaneously generating micron size particles.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Physical
Xuanfu Zhu, Gengwu Zhang, Lukman O. Alimi, Basem M. Moosa, Abdul-Hamid Emwas, Fang Fang, Niveen M. Khashab
Summary: This study presents an energy-efficient method for the adsorptive separation of para-halotoluene (PHT) using a TI macrocycle. The selectivity is determined by the specific interactions between the macrocycle and the guest molecules. The results demonstrate the viability of using molecular sieves for sustainable chemical separation processes.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jet Yeo, Ludmila Peeva, Seoyeon Chung, Piers Gaffney, Daeok Kim, Carla Luciani, Sergey Tsukanov, Kevin Seibert, Michael Kopach, Fernando Albericio, Andrew Livingston
Summary: A one-pot liquid phase peptide synthesis was reported, which involved iterative addition of amino acids to a nanostar support and isolation of the growing peptide using organic solvent nanofiltration (OSN) after each synthesis cycle. The use of a three-armed and monodisperse nanostar support enabled efficient nanofiltration and real-time monitoring of each process cycle. This method allowed for more efficient peptide synthesis while maintaining the benefits of liquid phase synthesis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Applied
Andrej Kolarovic, Pavol Jakubec
Summary: Crystallization-induced diastereomer transformations (CIDT) allow for the isolation of target compounds with high enantio- and diastereomeric purities and up to quantitative yields through filtration. This synthetic strategy has been demonstrated in numerous inspiring examples over the past fifteen years, with important considerations discussed for designing CIDT experiments.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Crystallography
Paulo H. B. Brant Carvalho, Amber Mace, Inna Martha Nangoi, Alexandre A. Leitao, Chris A. Tulk, Jamie J. Molaison, Ove Andersson, Alexander P. Lyubartsev, Ulrich Haeussermann
Summary: The high pressure structural behavior of H-2 and Ne clathrate hydrates was investigated, and the transitions of H-2 and Ne hydrates under different pressure and temperature conditions were observed.
Article
Chemistry, Multidisciplinary
Klaus Gast, Anja Schuler, Martin Wolff, Anja Thalhammer, Harald Berchtold, Norbert Nagel, Gudrun Lenherr, Gerrit Hauck, Robert Seckler
PHARMACEUTICAL RESEARCH
(2017)
Article
Pharmacology & Pharmacy
Martin Philipp Feth, Winfried Heyse, Bruno Baumgartner, Norbert Nagel, Christoph Tappertzhofen, Thomas Olpp, Joerg Jurascheck, Joachim Ulrich, Lydia Helmdach, Christine Petzoldt
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2013)
Article
Pharmacology & Pharmacy
Christine Petzoldt, Oliver Bley, Stephen J. Byard, Doris Andert, Bruno Baumgartner, Norbert Nagel, Christoph Tappertzhofen, Martin Philipp Feth
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2014)
Article
Biochemistry & Molecular Biology
Norbert Nagel, Melissa A. Graewert, Mimi Gao, Winfried Heyse, Cy M. Jeffries, Dmitri Svergun, Harald Berchtold
BIOPHYSICAL CHEMISTRY
(2019)
Article
Pharmacology & Pharmacy
Norbert Nagel, Bruno Baumgartner, Harald Berchtold
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Medicine, Research & Experimental
Martin Wolff, Anja Schueler, Klaus Gast, Robert Seckler, Andreas Evers, Stefania Pfeiffer-Marek, Michael Kurz, Norbert Nagel, Torsten Haack, Michael Wagner, Anja Thalhammer
MOLECULAR PHARMACEUTICS
(2020)
Article
Chemistry, Medicinal
Vanessa K. Seiler, Frank Theil, Norbert Nagel, Holger van Lishaut
Summary: Hot-melt-extrusion (HME) is a technology used to improve the bioavailability of poorly soluble pharmaceutical ingredients by embedding them in a polymer carrier. In this study, the dissolution process of crystalline drug compounds in a polymer matrix was investigated using X-Ray Powder Diffraction (XRPD) and Differential Scanning Calorimetry (DSC), and a new temperature-composition phase diagram model was proposed.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biophysics
Joerg Ehrit, Tobias W. Graewert, Hendrik Goeddeke, Petr Konarev, Dmitri I. Svergun, Norbert Nagel
Summary: This study investigated the structural organization of polysorbate micelles, both alone and in the presence of myristic acid. The results showed that the micelles were polydisperse ellipsoidal structures containing about 22-35 molecules per micelle. Addition of myristic acid had minimal effects on the scattering data at low concentrations, but increased the average size of the micelles at high concentrations, indicating penetration of myristic acid into the surfactant micelles. These findings provide insights into the role of polysorbate in preventing or delaying fatty acid particle formation.
BIOPHYSICAL JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Vanessa K. Seiler, Stefan Weber, Markus Boerner, Madeleine Witting, Sarah Ehlers, Norbert Nagel
Summary: Crystalline mannitol is commonly used in antibody formulations to provide structure and prevent collapse during lyophilization. The study aimed to simulate lyophilization processes using X-ray powder diffraction (XRPD) climate chamber to determine optimal process conditions. The emergence of desired anhydrous mannitol forms and the effect of antibodies on excipient crystallization were investigated. The comparison of products obtained in a freeze-dryer and the simulated process showed good accordance, proving the suitability of the method as a tool to identify ideal process conditions.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Inorganic & Nuclear
C Näther, I Jess, Z Havlas, M Bolte, N Nagel, S Nick
SOLID STATE SCIENCES
(2002)
Article
Chemistry, Inorganic & Nuclear
H Bock, E Heigel, N Nagel
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
(2000)
Article
Chemistry, Multidisciplinary
N Nagel, H Bock, P Eller
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS
(2000)
Article
Crystallography
N Nagel, H Bock, P Eller
ZEITSCHRIFT FUR KRISTALLOGRAPHIE
(2000)
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Vito Fodera, Per Larsson, Zarah Schaal, Christel A. S. Bergstrom, Korbinian Lobmann, Aleksei Kabedev
Summary: Our previous work demonstrated that beta-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin remains stable for over 12 months. We further investigated the stabilization mechanisms by testing five other drug molecules and using experimental techniques and molecular dynamics simulations. The results showed that steric confinement, hydrogen bonding, and the glass transition temperature of the drug molecule play important roles in stabilizing ASDs with high drug loadings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Sebastian Schmidt, Ulrike Holzgrabe
Summary: The binding of drugs to plasma proteins, such as human serum albumin (HSA), is crucial for determining pharmacokinetic parameters. This study investigated the enantioselective binding of S- and R-ketamine to HSA. It was found that ketamine has weak affinity to HSA, with no significant differences in binding behavior between the individual enantiomers and the racemate. The aromatic ring and N-methyl group were identified as the most strongly involved structural moieties in the binding of ketamine to HSA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Yuchen Zhao, Han Wang, Lin Jin, Ziwei Zhang, Lianghu Liu, Mengqi Zhou, Xianzheng Zhang, Lingling Zhang
Summary: Interleukins (ILs) are important for communication between immune cells and non-immune cells, but dysregulation of ILs expression is a characteristic of autoinflammatory diseases. Drugs targeting ILs have significant clinical benefits, but may also cause adverse reactions. Fusion protein technology, with its ability to enhance therapeutic efficacy, has been explored for developing anti-inflammatory drugs. This review discusses the efficacy of fusion protein drugs developed with ILs or their receptors in treating autoinflammatory diseases, highlighting the potential of this technology in future anti-inflammatory drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini, Nadia Passerini
Summary: This study investigated the correlation between the structure and release properties of solid lipid microparticles (MPs) with different liquid additives. The additives accelerated the conversion of the unstable alpha-form of tristearin to the stable beta-polymorph and caused structural modifications in the MPs. The presence of additives prolonged the drug release in water and resulted in higher release profiles in biorelevant media. The findings suggest that the release behavior can be influenced by the polymorphism and supramolecular-level structural modification of lipid formulations containing crystal modifiers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Juulia Jarvinen, Ahmed B. Montaser, Santosh Kumar Adla, Jukka Leppanen, Marko Lehtonen, Kati-Sisko Vellonen, Tuomo Laitinen, Aaro Jalkanen, William F. Elmquist, Juri Timonen, Kristiina M. Huttunen, Jarkko Rautio
Summary: This study attempted to alter the brain distribution pattern of Palbociclib by creating and assessing two novel prodrugs. Although the prodrug design did not significantly improve Palbociclib brain delivery, the study provides valuable insights for future prodrug development and drug delivery strategies targeting specific transporters.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Miao Wang, Xinyu Ma, Shiyu Zong, Yaqiong Su, Rui Su, Hong Zhang, Yang Liu, Chunliu Wang, Ye Li
Summary: This article discusses the potential and limitations of nasal administration in central nervous system drug delivery. Nasal gel viscosity can alleviate the impact of nasal mucociliary clearance on drug delivery, and materials such as gellan gum, chitosan, carbomer, cellulose, and poloxamer can be used to prepare nasal gels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Bjarke Strom Larsen, Eric Kissi, Liebert Parreiras Nogueira, Natalja Genina, Ingunn Tho
Summary: This study investigates the influence of drug load and polymer molecular weight on the structure of 3D printed tablets. The results show that drug load and polymer molecular weight have a significant impact on the porosity and size of the tablets, while the effect of drug load on the total porosity of the tablets is minimal.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Zhentao Qiao, Fuhang Wang, Dongjian Han, Yuansong Zhuang, Qingjiao Jiang, Yi Zhang, Miaomiao Liu, Quanxu An, Zhiwei Wang, Deliang Shen
Summary: In this study, it was demonstrated that periadventitial delivery of rapamycin-fibrin glue (RPM-FG) can inhibit intimal hyperplasia (IH) in a rat carotid artery injury model without compromising re-endothelialization. This provides a promising direction for the future development of a safe, effective, and minimally invasive perivascular drug delivery method to treat vascular disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)