Article
Polymer Science
Younghyun Shin, Dajung Kim, Yiluo Hu, Yohan Kim, In Ki Hong, Moo Sung Kim, Seunho Jung
Summary: SG/CMC-based IPN hydrogels with double crosslinking strategy exhibit significantly enhanced mechanical strength and pH-controlled drug release capability, showing potential as biomedical biomaterials for drug delivery in the future.
Article
Chemistry, Applied
Chaiyakarn Pornpitchanarong, Theerasak Rojanarata, Praneet Opanasopit, Tanasait Ngawhirunpat, Mark Bradley, Prasopchai Patrojanasophon
Summary: The objective of this research was to develop a novel mucoadhesive polymer for drug delivery applications based on N-(2-aminoethyl) maleimide-functionalized carboxymethyl cellulose. The weight ratios of the materials were tuned to explore the condition providing the highest maleimide content on the polymer. The synthesized polymer exhibited superior mucoadhesive capability and the ability to control drug release.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Jiwon Park, Seoyoung Kim, Tae-il Kim
Summary: In this study, we synthesized polyethylenimine2k (PEI2k)-conjugated hydroxyethyl cellulose (HECP2k) for the co-delivery of doxorubicin/Bcl-2 siRNA. HECP2ks were successfully synthesized and characterized. The results showed that HECP2ks effectively condensed pDNA into positively charged and nano-sized complexes, exhibiting low cytotoxicity and high transfection efficiency. HECP2k 10X demonstrated superior cellular uptake, endosome escape, and synergistic anti-cancer effects through co-delivery of Dox and Bcl-2 siRNA. Therefore, HECP2k shows great potential as a promising co-delivery carrier for Dox/Bcl-2 siRNA.
Article
Chemistry, Applied
Yanshan Sheng, Jun Gao, Zheng-Zhi Yin, Jing Kang, Yong Kong
Summary: A dual-drug delivery system is proposed for improving chemotherapy efficacy and relieving pain associated with colorectal cancer. This system utilizes hydrogels to protect drugs and achieve dual pH-responsive drug delivery. The findings have significant implications for medical science and pharmaceutics.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Yang Zhou, Zhenghao Zhai, Yimin Yao, John C. Stant, Sarah L. Landrum, Michael J. Bortner, Charles E. Frazier, Kevin J. Edgar
Summary: Polysaccharide-based Schiff base hydrogels prepared by reacting oxidized hydroxypropyl cellulose (Ox-HPC) with carboxymethyl chitosan (CMCS) exhibit pH-responsive, injectable, and self-healing properties. The reversible nature of the imine bonds allows for an injectable and self-healing hydrogel. The incorporation of the model amine-containing drug phenylalanine within the hydrogel showed pH sensitivity, releasing faster in the extracellular space around tumors (pH 6.8) compared to normal tissues (pH 7.4).
CARBOHYDRATE POLYMERS
(2023)
Article
Pharmacology & Pharmacy
Marin Simeonov, Bistra Kostova, Elena Vassileva
Summary: In this study, novel interpenetrating polymer networks (IPNs) were synthesized and studied as potential drug delivery systems for dermal application. The addition of a highly hydrophilic polymer increased the swelling ability of the IPNs, resulting in improved drug entrapment efficiency and drug loading capacity.
Article
Biochemistry & Molecular Biology
Siamak Javanbakht, Malihe Pooresmaeil, Hassan Namazi, Abolfazl Heydari
Summary: In this study, a novel green synthesis route was described for the growth of metal-organic framework (MOF) from zinc metal and 1,4-benzene dicarboxylic acid in the presence of carboxymethyl cellulose (CMC). The synthesized material showed promising characteristics for prolonged drug release, with high drug loading efficiency and better drug release performance compared to the pristine MOF. Overall, the results confirm the functionality of CMC biopolymer for in situ growth of MOF and its cytocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Chemistry, Applied
Malihe Pooresmaeil, Hassan Namazi
Summary: This review discusses the issues with conventional drug administrations and the application of carboxymethyl starch (CMS) in drug delivery. It summarizes the recent advances and prospects of CMS-based drug delivery systems, aiming to provide comprehensive information for overcoming issues with traditional drug delivery systems.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Catalina Anisoara Peptu, Elena Simona a, Corina-Lenuta Savin (Logigan), Marian Lutcanu, Maricel Agop
Summary: New hydrogel films crosslinked with epichlorohydrin, based on alginates and carboxymethyl cellulose, show promise as potential drug delivery systems due to their biocompatibility, water absorption capacity, and controlled drug release potential. A new theoretical model within the Scale Relativity Theory framework offers insights into the microscopic drug release process and simplifies analysis of drug release.
Article
Agricultural Engineering
Mehrab Pourmadadi, Sepehr Darvishan, Majid Abdouss, Fatemeh Yazdian, Abbas Rahdar, Ana M. Diez-Pascual
Summary: A pH-sensitive nanocomposite was synthesized by coating halloysite nanotubes (HNT) with polyacrylic acid (PAA)/carboxymethyl cellulose (CMC) hydrogel for controlled delivery of curcumin (CUR) to MCF-7 cancer cells. Hazelnut oil and Span 80 surfactant were added to minimize the nanocomposite size and increase its uniformity, and to enhance the stability and retention of CUR as an anticancer drug, respectively. The resulting drug delivery system exhibited high drug loading and encapsulation efficiency, pH-sensitivity, and sustained drug release. It also demonstrated strong toxicity against MCF-7 cancer cells and induced apoptosis. These results highlight the potential of PAA/CMC/HNT/CUR hydrogel nanocomposites as smart drug delivery vehicles for breast cancer treatment.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Fengjiao Zhang, Sufeng Zhang, Rui Lin, Shuyuan Cui, Xiaokai Jing, Sergiu Coseri
Summary: This study successfully synthesized an injectable and self-healing pH-responsive hydrogel that can be used as a carrier for drug delivery systems. The hydrogel exhibited notable mechanical properties, good self-healing ability, pH responsiveness, and excellent antibacterial properties. It also showed a high drug loading capacity and sustained drug release behavior, as well as good cytocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Reza Zare, Mohammad Khorram, Sajjad Barzegar, Bahador Sarkari, Qasem Asgari, Samad Ahadian, Kamiar Zomorodian
Summary: Cutaneous leishmaniasis is a significant public health problem caused by different species of Leishmania parasites. A dissolvable microneedle patch was developed for transdermal delivery of Amphotericin B, showing potential as an efficient and clinically translational approach for treating CL.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Polymer Science
Svetlana Morozkina, Ulyana Strekalovskaya, Anna Vanina, Petr Snetkov, Alexander Krasichkov, Victoriya Polyakova, Mayya Uspenskaya
Summary: Hydrogels based on natural water-soluble polysaccharides have gained attention for their favorable characteristics, including high water-holding capacity, lack of toxicity, and biodegradability. Sodium alginate and cellulose are commonly used polysaccharides in various industries, such as food processing, pharmaceuticals, and biomedical applications. This review collects various methods for preparing compositions using sodium alginate and cellulose, and analyzes the drug release profile from these polymer matrices.
Article
Polymer Science
Shaoning Cui, Congli Cui, Shengju Ge, Wei Xie, Mengting Yu, Ying Li, Qingjie Sun, Liu Xiong
Summary: The physical properties of hydrocolloids currently restrict their wide application in the food industry. By adding cellulose nanocrystals (CNCs) to sodium carboxymethyl cellulose (CMC) and sodium alginate (SA) solutions, their viscoelasticity can be improved and the non-Newtonian flow behaviors can be regulated under different conditions.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Chemistry, Physical
Chengdong Su, Guojie Liu, Min Wang, He Gao, Yulong Zou, Jun Gao
Summary: In this study, a simple approach for preparing a multifunctional drug delivery system was reported. The system utilized a novel structure modified cellulose to control drug release through pH-responsive carriers. The system showed great promise in the safe and effective treatment of cancer in the gastrointestinal tract.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Vito Fodera, Per Larsson, Zarah Schaal, Christel A. S. Bergstrom, Korbinian Lobmann, Aleksei Kabedev
Summary: Our previous work demonstrated that beta-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin remains stable for over 12 months. We further investigated the stabilization mechanisms by testing five other drug molecules and using experimental techniques and molecular dynamics simulations. The results showed that steric confinement, hydrogen bonding, and the glass transition temperature of the drug molecule play important roles in stabilizing ASDs with high drug loadings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Sebastian Schmidt, Ulrike Holzgrabe
Summary: The binding of drugs to plasma proteins, such as human serum albumin (HSA), is crucial for determining pharmacokinetic parameters. This study investigated the enantioselective binding of S- and R-ketamine to HSA. It was found that ketamine has weak affinity to HSA, with no significant differences in binding behavior between the individual enantiomers and the racemate. The aromatic ring and N-methyl group were identified as the most strongly involved structural moieties in the binding of ketamine to HSA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Yuchen Zhao, Han Wang, Lin Jin, Ziwei Zhang, Lianghu Liu, Mengqi Zhou, Xianzheng Zhang, Lingling Zhang
Summary: Interleukins (ILs) are important for communication between immune cells and non-immune cells, but dysregulation of ILs expression is a characteristic of autoinflammatory diseases. Drugs targeting ILs have significant clinical benefits, but may also cause adverse reactions. Fusion protein technology, with its ability to enhance therapeutic efficacy, has been explored for developing anti-inflammatory drugs. This review discusses the efficacy of fusion protein drugs developed with ILs or their receptors in treating autoinflammatory diseases, highlighting the potential of this technology in future anti-inflammatory drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini, Nadia Passerini
Summary: This study investigated the correlation between the structure and release properties of solid lipid microparticles (MPs) with different liquid additives. The additives accelerated the conversion of the unstable alpha-form of tristearin to the stable beta-polymorph and caused structural modifications in the MPs. The presence of additives prolonged the drug release in water and resulted in higher release profiles in biorelevant media. The findings suggest that the release behavior can be influenced by the polymorphism and supramolecular-level structural modification of lipid formulations containing crystal modifiers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Juulia Jarvinen, Ahmed B. Montaser, Santosh Kumar Adla, Jukka Leppanen, Marko Lehtonen, Kati-Sisko Vellonen, Tuomo Laitinen, Aaro Jalkanen, William F. Elmquist, Juri Timonen, Kristiina M. Huttunen, Jarkko Rautio
Summary: This study attempted to alter the brain distribution pattern of Palbociclib by creating and assessing two novel prodrugs. Although the prodrug design did not significantly improve Palbociclib brain delivery, the study provides valuable insights for future prodrug development and drug delivery strategies targeting specific transporters.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Miao Wang, Xinyu Ma, Shiyu Zong, Yaqiong Su, Rui Su, Hong Zhang, Yang Liu, Chunliu Wang, Ye Li
Summary: This article discusses the potential and limitations of nasal administration in central nervous system drug delivery. Nasal gel viscosity can alleviate the impact of nasal mucociliary clearance on drug delivery, and materials such as gellan gum, chitosan, carbomer, cellulose, and poloxamer can be used to prepare nasal gels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Bjarke Strom Larsen, Eric Kissi, Liebert Parreiras Nogueira, Natalja Genina, Ingunn Tho
Summary: This study investigates the influence of drug load and polymer molecular weight on the structure of 3D printed tablets. The results show that drug load and polymer molecular weight have a significant impact on the porosity and size of the tablets, while the effect of drug load on the total porosity of the tablets is minimal.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Zhentao Qiao, Fuhang Wang, Dongjian Han, Yuansong Zhuang, Qingjiao Jiang, Yi Zhang, Miaomiao Liu, Quanxu An, Zhiwei Wang, Deliang Shen
Summary: In this study, it was demonstrated that periadventitial delivery of rapamycin-fibrin glue (RPM-FG) can inhibit intimal hyperplasia (IH) in a rat carotid artery injury model without compromising re-endothelialization. This provides a promising direction for the future development of a safe, effective, and minimally invasive perivascular drug delivery method to treat vascular disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
