Article
Chemistry, Applied
J. H. F. de Jesus, I. M. Szilagyi, G. Regdon, E. T. G. Cavalheiro
Summary: Thermal analysis of sorbic acid and its salts revealed different thermal behaviors during heating and cooling processes, such as melting, decomposition, and phase transition.
Article
Biotechnology & Applied Microbiology
Najmeh Yazdanfar, Leila Mana, Boshra Ebrahiminejad, Yeganeh Mazaheri, Parisa Sadighara, Burhan Basaran, Sara Mohamadi
Summary: This study aimed to evaluate the concentrations of the common preservatives sodium benzoate and potassium sorbate in different sauce samples and compare them with the acceptable level of Codex standard. The results showed that the mean concentrations of sodium benzoate and potassium sorbate in the collected samples were lower than the general standard of Codex Alimentarius and European legislation. Therefore, regular and accurate evaluation of these preservatives in sauces is still recommended for consumer safety.
JOURNAL OF FOOD PROTECTION
(2023)
Article
Agronomy
Erica Benjamim da Silva, Limin Kung Jr
Summary: This study conducted a meta-analysis on the effects of a chemical additive on the fermentation and aerobic stability of maize silage. The results showed that the additive reduced the concentration of lactic acid, ammonia-N, and ethanol, while increasing the concentration of residual reducing sugars, dry matter recovery, and aerobic stability. The effectiveness of the additive was influenced by the dry matter content and length of ensiling, and it consistently improved the aerobic stability of maize silage under various conditions.
Article
Pharmacology & Pharmacy
Arun Kolanjiyil, Ross Walenga, Andrew Babiskin, Laleh Golshahi, Michael Hindle, Worth Longest
Summary: This study analyzed the effects of changes in spray cone angle, spray velocity, spray ovality, and droplet size distribution on regional nasal deposition using a computational fluid dynamics model. The results showed that spray cone angle had the greatest impact on nasal deposition, followed by plume ovality and characteristic droplet size. Spray velocity and droplet size distribution uniformity had only minimal influence. The study established quantitative relationships for predicting changes in nasal deposition.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Food Science & Technology
Micaela Alvarez, Felix Nunez, Josue Delgado, Maria J. Andrade, Paula Rodrigues
Summary: The effects of Debaryomyces hansenii, rosemary derivatives, and a commercial antifungal preparation were tested against Aspergillus westerdijkiae in dry-cured meat products. The results showed that using Debaryomyces hansenii alone or in combination with rosemary can significantly reduce the production of ochratoxin A, suggesting its potential as a preservative agent.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Chemistry, Physical
Zaklina Z. Tasic, Marija B. Petrovic Mihajlovic, Milan B. Radovanovic, Ana T. Simonovic, Milan M. Antonijevic
Summary: This study investigated the potential of expired paracetamol in preventing copper corrosion in a synthetic acid rain solution, showing that paracetamol can protect copper from dissolution. The binary system of paracetamol and potassium sorbate exhibited higher inhibition efficiency compared to paracetamol alone. Quantum chemical parameters and Gibbs free energy calculations confirmed the inhibitory ability of paracetamol by adsorption on the copper surface.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Food Science & Technology
Suman Kharb, Dilip Kumar Thompkinson, Harshita Kumari
Summary: This study examined the effects of storage time on the properties of low-fat spreads. The results showed that adding preservatives extended the shelf life of the spreads and protected their physicochemical and sensory properties. The growth of molds and yeasts was the main cause of spoilage.
FOOD QUALITY AND SAFETY
(2022)
Article
Food Science & Technology
Suman Kharb, Dilip Kumar Thompkinson, Harshita Kumari
Summary: The effects of storage time on the physicochemical, sensory, rheological, and microbiological properties of fortified low-fat spreads were examined. The addition of preservatives inhibited the formation of free fatty acids and thiobarbituric acid, influencing pH, acidity, and emulsion stability. Yeasts and molds were the main cause of spoilage, with lower preservative levels extending shelf life.
FOOD QUALITY AND SAFETY
(2022)
Article
Biotechnology & Applied Microbiology
Jiajia Li, Jie Yang, Weishan Xin, Sirui Wu, Xujuan Wang, Chuanfa Wang, Zhong Zhang
Summary: Combining High-pressure Thermal Treatment (HPTT) and Potassium Sorbate (PS) has a stronger spore inactivation effect. The combination treatment resulted in a higher inactivation rate of Bacillus subtilis spores compared to HPTT treatment alone. It also caused changes in spore permeability, size, inner membrane damage, and reduced enzyme activity. Consequently, the combination of HPTT and PS is proposed as a promising strategy for Bacillus subtilis spore inactivation.
Article
Pharmacology & Pharmacy
Katarina Jokicevic, Shari Kiekens, Eline Byl, Ilke De Boeck, Eline Cauwenberghs, Sarah Lebeer, Filip Kiekens
Summary: This study developed a probiotic nasal spray derived from URT with potential probiotic effects through spray drying, showing long-term stability and high cell survival rate. The spray demonstrated excellent cell adhesion and antimicrobial activity, indicating its potential as a health-promoting product for URT diseases control and prevention.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Multidisciplinary Sciences
Davide D'Angelo, Stefan Kooij, Frank Verhoeven, Fabio Sonvico, Cees van Rijn
Summary: This study optimized a method for evaluating the nasal deposition and coverage of innovative nasal spray nozzles. It was found that aerosol formulations with droplets of 15-25 μm in size could be uniformly deposited in the nasal cavity, with less than 10% passing beyond the nasopharyngeal region.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Multidisciplinary Sciences
Maliheh Akbarpour, Mir -Mohammad Jalali, Maryam Akbari, Sevil Nasirmohtaram, Soudabeh Haddadi, Ali Faghih Habibi, Fateme Azad
Summary: This study investigated the effects of nasal desmopressin on the quality of the surgical field and the volume of bleeding during rhinoplasty. The results showed that desmopressin could reduce bleeding in the surgical field. Further studies are recommended to generalize these results to other surgeries in the ENT field.
Article
Food Science & Technology
Enrico Maurizzi, Francesco Bigi, Luisa Antonella Volpelli, Andrea Pulvirenti
Summary: Fruits are prone to post-harvest decay, and bio-based coatings could be a useful solution. This study evaluated the efficacy of different coatings on tomatoes and oranges, finding that all coatings effectively preserved fruits against fungi but one ingredient caused significant fruit weight loss.
FOOD PACKAGING AND SHELF LIFE
(2023)
Article
Food Science & Technology
Alireza Haseli, Rezvan Pourahmad, Mohammad Reza Eshaghi, Peyman Rajaei, Behrouz Akbari-Adergani
Summary: This study aimed to nanoencapsulate Nepeta crispa essential oil and evaluate its application in yogurt drink. The highest nanoencapsulation efficiency was achieved with a pectin:whey protein concentrate ratio of 75:25. The nanoencapsulated essential oil exhibited a semi-spherical structure and a size of about 400 nm. The addition of nanoencapsulated essential oil positively influenced the sensory quality of the yogurt drink and showed inhibitory effects on Escherichia coli and Staphylococcus aureus. The sample containing 0.20 mg/mL of nanoencapsulated essential oil was selected as the best sample due to its acceptable sensory quality and antimicrobial activity.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Michele Dario Manniello, Sana Hosseini, Ali Alfaifi, Amir R. Esmaeili, Arun Kolanjiyil, Ross Walenga, Andrew Babiskin, Dennis Sandell, Reza Mohammadi, Theodore Schuman, Michael Hindle, Laleh Golshahi
Summary: This study investigated the in vitro deposition pattern of two different locally-acting nasal suspension sprays using anatomically accurate nasal replicas, revealing important implications for understanding the bioequivalence of these sprays.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Gustavo Vaz, Adryana Clementino, Evgenia Mitsou, Elena Ferrari, Francesca Buttini, Cristina Sissa, Aristotelis Xenakis, Fabio Sonvico, Cristiana Lima Dora
Summary: The nose-to-brain delivery of neuroprotective natural compounds is a promising approach for the treatment of neurodegenerative diseases. Nanoemulsions containing curcumin and quercetin were found to effectively protect and deliver these compounds, showing potential as an anti-inflammatory treatment.
Article
Pharmacology & Pharmacy
Franciele Aline Bruinsmann, Aline de Cristo Soares Alves, Amanda de Fraga Dias, Luiz Fernando Lopes Silva, Fernanda Visioli, Adriana Raffin Pohlmann, Fabricio Figueiro, Fabio Sonvico, Silvia Staniscuaski Guterres
Summary: In this study, chitosan-coated simvastatin-loaded lipid-core nanocapsules were prepared for nose-to-brain delivery and showed effective antitumor effects against glioblastoma both in vitro and in vivo.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Multidisciplinary Sciences
Davide D'Angelo, Stefan Kooij, Frank Verhoeven, Fabio Sonvico, Cees van Rijn
Summary: This study optimized a method for evaluating the nasal deposition and coverage of innovative nasal spray nozzles. It was found that aerosol formulations with droplets of 15-25 μm in size could be uniformly deposited in the nasal cavity, with less than 10% passing beyond the nasopharyngeal region.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Giovanni Falcone, Sonja Kuth, Aldo R. Boccaccini, Rita P. Aquino, Tiziana Esposito, Paola Russo
Summary: To fully utilize the potential of 3D printing, particularly in the case of semisolid extrusion (SSE), the technological challenges need to be addressed. This study focuses on investigating the physicochemical properties of natural polymers, specifically alginate hydrogel, for 3D printing tablets that are easy to swallow. By adding sorbitol as a plasticizer, the aim is to improve the swallowability of the tablets. Different concentrations of sorbitol solution are evaluated to determine the best composition in terms of printing and technological properties. The results highlight a predictable relationship between the amount of sorbitol loaded and the residual mass of the final platforms.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Davide 'Angelo, Veronica Chierici, Eride Quarta, Giada Varacca, Luca Cavalieri, Alessio Piraino, Andrea S. Melani, Fabio Sonvico, Francesca Buttini
Summary: This study investigates the effects of unshaken, shaken, and delayed use of suspension pressurized metered-dose inhalers (pMDIs) on Fine Particle Mass (<5 μm), Extra Fine Particle Mass (<2 μm), and MMAD. Most suspension pMDIs produce variable amounts of respirable size drug when subjected to shake-fire delays, with FPM ranging from -82% for Symbicort to 363% for Ventolin compared to the control values if not shaken. In terms of MMAD measurements, Seretide and Serzyl inhalers experience an increase from around 3 μm to 4.2-5.1 μm when not shaken. On the other hand, FPM and MMAD for solution aerosols remain unchanged regardless of being shaken or the delay in actuation after shaking.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Giada Varacca, Davide D'Angelo, Stefania Glieca, Luca Cavalieri, Alessio Piraino, Eride Quarta, Fabio Sonvico, Francesca Buttini
Summary: The correct use of dry powder inhalers is crucial for effective treatment and management of the disease. This study evaluated the impact of inhaler misuse on dose delivery and aerodynamic parameters. Two different inhaler devices, NEXThaler and Ellipta, were investigated. NEXThaler consistently delivered the correct dose, while Ellipta had reduced dose delivery when operated facing downward. NEXThaler's dose protector prevented powder loss during incorrect manipulations. Both devices proved reliable during double activation. Exhalation conditions had a slight effect on the aerodynamic profile of the inhalers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Davide D'Angelo, Eride Quarta, Stefania Glieca, Giada Varacca, Lisa Flammini, Simona Bertoni, Martina Brandolini, Vittorio Sambri, Laura Grumiro, Giulia Gatti, Giorgio Dirani, Francesca Taddei, Annalisa Bianchera, Fabio Sonvico, Ruggero Bettini, Francesca Buttini
Summary: This study developed a dry inhalation powder of cyclosporine-A for lung transplantation rejection prevention and COVID-19 treatment. The impact of excipients on the powder's critical quality attributes was investigated. The optimized powder exhibited faster dissolution, better respirability, and showed efficacy in reducing IL-6 and inhibiting SARS-CoV-2 replication, suggesting its potential as a therapeutic strategy for lung rejection prevention and COVID-19 treatment.
Article
Biology
Chiara Amante, Chiara De Soricellis, Gianni Luccheo, Luigi Luccheo, Paola Russo, Rita Patrizia Aquino, Pasquale Del Gaudio
Summary: The National Institute of Health has found that 80% of chronic infections are linked to biofilms, which contribute to bacterial resistance to antimicrobial agents. A novel mixture composed of N-acetylcysteine (NAC) and various natural ingredients has been developed to enhance NAC's activity against different bacteria and reduce biofilm formation. This mixture has shown increased NAC permeation, fibrinolytic activity, antibiofilm activity, and reduced bacterial adhesion.
Article
Polymer Science
Maria Rosaria Sellitto, Chiara Amante, Rita Patrizia Aquino, Paola Russo, Rosalia Rodriguez-Dorado, Monica Neagu, Carlos A. Garcia-Gonzalez, Renata Adami, Pasquale Del Gaudio
Summary: The use of polysaccharide-based aerogels as drug carriers for wound healing is being explored. Drug-loaded aerogel capsules were produced through prilling in tandem with supercritical extraction. The capsules had a hollow cavity and a thin alginate aerogel layer with good textural properties. These capsules effectively absorbed wound fluid and prolonged drug release due to a formed hydrogel barrier.
Article
Engineering, Biomedical
Eride Quarta, Michele Chiappi, Alessio Adamiano, Anna Tampieri, Weijie Wang, Teresa D. Tetley, Francesca Buttini, Fabio Sonvico, Daniele Catalucci, Paolo Colombo, Michele Iafisco, Lorenzo Degli Esposti
Summary: There has been a growing interest in developing biocompatible inhalable nanoparticle formulations for treating and diagnosing lung disease. In this study, superparamagnetic iron-doped calcium phosphate nanoparticles (FeCaP NPs) were found to be safe for inhalation administration to human lung cells. D-mannitol spray-dried microparticles embedding FeCaP NPs were formulated to achieve optimal particle size distribution for successful inhalation and deposition. This work demonstrates a spray drying method to provide a dry powder platform for the lung delivery of safe FeCaP NPs for magnetically driven applications.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Pharmacology & Pharmacy
Fabio Sonvico, Gaia Colombo, Eride Quarta, Fabiola Guareschi, Sabrina Banella, Francesca Buttini, Regina Scherliess
EXPERT OPINION ON DRUG DELIVERY
(2023)
Review
Pharmacology & Pharmacy
Francesca Buttini, Stefania Glieca, Fabio Sonvico, David A. Lewis
Summary: The urgency to replace propellants with sustainable alternatives has led to the need for investigation and reformulation of pMDIs.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Biochemistry & Molecular Biology
Sabrina Banella, Aishwarya Saraswat, Akanksha Patel, Abu T. M. Serajuddin, Paolo Colombo, Ketan Patel, Gaia Colombo
Summary: Loco-regional chemotherapy is an effective strategy to deliver anticancer drugs directly to tumor tissues, reducing systemic side effects. The complex of cisplatin and hyaluronan has shown improved efficacy and safety in pleural mesothelioma. The complex targets cancer cells locally and has the potential to prevent metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Md. Musfizur Hassan, Bilquis Romana, Guangzhao Mao, Naresh Kumar, Fabio Sonvico, Pall Thordarson, Paul Joyce, Kristen E. Bremmell, Timothy J. Barnes, Clive A. Prestidge
Summary: The study explores the potential of liposome-micelle-hybrid (LMH) carriers for co-formulation and delivery of PTX and 5-FU, aiming to enhance their chemotherapeutic performance. The optimized PTX-5FU-LMH carriers demonstrated increased drug loading and solubility, temperature-sensitive release, enhanced permeability, and cancer cell eradication.
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Vito Fodera, Per Larsson, Zarah Schaal, Christel A. S. Bergstrom, Korbinian Lobmann, Aleksei Kabedev
Summary: Our previous work demonstrated that beta-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin remains stable for over 12 months. We further investigated the stabilization mechanisms by testing five other drug molecules and using experimental techniques and molecular dynamics simulations. The results showed that steric confinement, hydrogen bonding, and the glass transition temperature of the drug molecule play important roles in stabilizing ASDs with high drug loadings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Sebastian Schmidt, Ulrike Holzgrabe
Summary: The binding of drugs to plasma proteins, such as human serum albumin (HSA), is crucial for determining pharmacokinetic parameters. This study investigated the enantioselective binding of S- and R-ketamine to HSA. It was found that ketamine has weak affinity to HSA, with no significant differences in binding behavior between the individual enantiomers and the racemate. The aromatic ring and N-methyl group were identified as the most strongly involved structural moieties in the binding of ketamine to HSA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Yuchen Zhao, Han Wang, Lin Jin, Ziwei Zhang, Lianghu Liu, Mengqi Zhou, Xianzheng Zhang, Lingling Zhang
Summary: Interleukins (ILs) are important for communication between immune cells and non-immune cells, but dysregulation of ILs expression is a characteristic of autoinflammatory diseases. Drugs targeting ILs have significant clinical benefits, but may also cause adverse reactions. Fusion protein technology, with its ability to enhance therapeutic efficacy, has been explored for developing anti-inflammatory drugs. This review discusses the efficacy of fusion protein drugs developed with ILs or their receptors in treating autoinflammatory diseases, highlighting the potential of this technology in future anti-inflammatory drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini, Nadia Passerini
Summary: This study investigated the correlation between the structure and release properties of solid lipid microparticles (MPs) with different liquid additives. The additives accelerated the conversion of the unstable alpha-form of tristearin to the stable beta-polymorph and caused structural modifications in the MPs. The presence of additives prolonged the drug release in water and resulted in higher release profiles in biorelevant media. The findings suggest that the release behavior can be influenced by the polymorphism and supramolecular-level structural modification of lipid formulations containing crystal modifiers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Juulia Jarvinen, Ahmed B. Montaser, Santosh Kumar Adla, Jukka Leppanen, Marko Lehtonen, Kati-Sisko Vellonen, Tuomo Laitinen, Aaro Jalkanen, William F. Elmquist, Juri Timonen, Kristiina M. Huttunen, Jarkko Rautio
Summary: This study attempted to alter the brain distribution pattern of Palbociclib by creating and assessing two novel prodrugs. Although the prodrug design did not significantly improve Palbociclib brain delivery, the study provides valuable insights for future prodrug development and drug delivery strategies targeting specific transporters.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Miao Wang, Xinyu Ma, Shiyu Zong, Yaqiong Su, Rui Su, Hong Zhang, Yang Liu, Chunliu Wang, Ye Li
Summary: This article discusses the potential and limitations of nasal administration in central nervous system drug delivery. Nasal gel viscosity can alleviate the impact of nasal mucociliary clearance on drug delivery, and materials such as gellan gum, chitosan, carbomer, cellulose, and poloxamer can be used to prepare nasal gels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Bjarke Strom Larsen, Eric Kissi, Liebert Parreiras Nogueira, Natalja Genina, Ingunn Tho
Summary: This study investigates the influence of drug load and polymer molecular weight on the structure of 3D printed tablets. The results show that drug load and polymer molecular weight have a significant impact on the porosity and size of the tablets, while the effect of drug load on the total porosity of the tablets is minimal.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Zhentao Qiao, Fuhang Wang, Dongjian Han, Yuansong Zhuang, Qingjiao Jiang, Yi Zhang, Miaomiao Liu, Quanxu An, Zhiwei Wang, Deliang Shen
Summary: In this study, it was demonstrated that periadventitial delivery of rapamycin-fibrin glue (RPM-FG) can inhibit intimal hyperplasia (IH) in a rat carotid artery injury model without compromising re-endothelialization. This provides a promising direction for the future development of a safe, effective, and minimally invasive perivascular drug delivery method to treat vascular disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
