Article
Nutrition & Dietetics
Neha Kajale, Anuradha Khadilkar, Chirantap Oza, Ketan Gondhalekar, Vaman Khadilkar
Summary: The study aimed to investigate the factors influencing resting metabolic rate (RMR) in Indian children and its relationships with anthropometry and body composition. The study found that overweight and obese children had lower RMR, and lower RMR was associated with girls and increasing age.
Article
Endocrinology & Metabolism
Yong Guo, Cui Liu, Yu-Hong Deng, Jing Ning, Li Yu, Jie-Ling Wu
Summary: A cross-sectional investigation conducted in Guangzhou, China, reveals that there is a positive correlation between Bisphenol A (BPA) exposure and body composition parameters in children aged 4 to 6 years, providing further evidence for this association.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Yun Hwan Oh, Seulggie Choi, Gyeongsil Lee, Joung Sik Son, Kyae Hyung Kim, Sang Min Park
Summary: The study found that increasing relative lean body mass and appendicular skeletal mass can reduce the risk of metabolic syndrome in both men and women, while increasing relative body fat mass index can increase the risk of metabolic syndrome. Particularly, the risk reduction of MetS is more significant in groups with higher baseline BMI and body fat mass index.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Food Science & Technology
Shuo Wang, Lingling Zhang, Di Wang, Meiqin Huang, Jingyu Zhao, Vasanti Malik, Xiaoran Liu, Liang Sun, Xu Lin, Yan Chen
Summary: This study suggests that peanut intervention in adults with MetS risk is associated with gut microbiota composition, and responsiveness data can predict improvements in MetS risk and various parameters.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Haobin Zhao, Han Jin, Junfang Xian, Zhifu Zhang, Junling Shi, Xiaosu Bai
Summary: A ketogenic diet can reduce body weight and fat mass in cancer patients and improve their mental health. However, more large-scale trials are needed to validate the long-term effects of ketogenic diets.
Article
Nutrition & Dietetics
Rafaela Catherine da Silva Cunha de Medeiros, Tatiane Andreza Lima da Silva, Anna Luiza Vasconcelos de Oliveira, Paulo Francisco de Almeida-Neto, Jason Azevedo de Medeiros, Alexandre Bulhoes-Correia, Francisco Americo Micussi, Marcela Abbott Galvao Ururahy, Breno Guilherme de Araujo Tinoco Cabral, Paulo Moreira Silva Dantas
Summary: Dietary counseling and physical activity can have a positive impact on biochemical and metabolic parameters in children and adolescents with HIV, leading to reduced blood glucose and triglycerides, maintained resting metabolic rate, increased fruit consumption, and decreased consumption of soft drinks. This contributes to improved health-related parameters and healthy habits.
Article
Nutrition & Dietetics
Justyna Paulina Wielgosz-Grochowska, Nicole Domanski, Malgorzata Ewa Drywien
Summary: Recent observations have shown that Small Intestinal Bacterial Overgrowth (SIBO) affects the host through various mechanisms. This study found that the methane-hydrogen dominant type of SIBO is inversely correlated with body weight, BMI, body fat, and mineral bone content.
Article
Endocrinology & Metabolism
Seung Shin Park, Chang Ho Ahn, Sang Wan Kim, Ji Won Yoon, Jung Hee Kim
Summary: Patients with bilateral primary aldosteronism (PA) are more obese and have higher visceral fat area (VFA) levels than those with lateralized PA. Despite a milder form of PA, this metabolically unfavorable visceral fat distribution may lead to a higher metabolic risk in patients with bilateral PA.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biotechnology & Applied Microbiology
Ezequiel Lacunza, Valeria Fink, Maria E. Salas, Romina Canzoneri, Julian Naipauer, Sion Williams, Omar Coso, Omar Sued, Pedro Cahn, Enrique A. Mesri, Martin C. Abba
Summary: Evidence indicates that the microbiome plays a significant role in HIV immunopathogenesis and associated complications. This study aimed to characterize the oral and anal microbiome of Men who have Sex with Men (MSM) and Transgender Women (TGW), with and without HIV. Significant differences in the microbiome composition were found among subjects associated with HIV infection, gender, sex behavior, CD4+ T-cell counts, antiretroviral therapy (ART), and the presence of HPV-associated precancerous anal lesions. The identified microbial features at accessible sites are potential biomarkers for predicting precancerous anal lesions and therapeutic targets for HIV immunopathogenesis.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Nutrition & Dietetics
Mariangela Rondanelli, Gabriella Peroni, Attilio Giacosa, Teresa Fazia, Luisa Bernardinelli, Maurizio Naso, Milena Anna Faliva, Alice Tartara, Clara Gasparri, Simone Perna
Summary: The study showed that rice germ supplementation may have beneficial effects on body composition, metabolic parameters, and satiety in obese postmenopausal women.
Article
Endocrinology & Metabolism
Yi Ying Ong, Jonathan Y. Huang, Navin Michael, Suresh Anand Sadananthan, Wen Lun Yuan, Ling-Wei Chen, Neerja Karnani, S. Sendhil Velan, Marielle Fortier, Kok Hian Tan, Peter D. Gluckman, Fabian Yap, Yap-Seng Chong, Keith M. Godfrey, Mary F-F Chong, Shiao-Yng Chan, Yung Seng Lee, Mya-Thway Tint, Johan G. Eriksson
Summary: In 6-year-old children, those with high fat mass had higher BMI z-scores and metabolic syndrome risk scores compared to those with high lean mass. Lean mass seemed to protect against cardiometabolic risk markers more in girls than in boys.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pediatrics
Priscila Custodio Martins, Luiz Rodrigo Augustemak de Lima, Analiza Monica Silva, Diego Augusto Santos Silva
Summary: The aim of the study was to investigate the association between phase angle (PhA) and bone mineral density (BMD), lean soft tissue mass (LSTM), total body fat mass, and android and gynoid in children and adolescents with HIV. The study found that PhA was directly associated with BMD, LSTM, and inversely with gynoid fat in boys with HIV. In girls, PhA was only directly associated with BMD.
Article
Agriculture, Dairy & Animal Science
Ahmad Shalaldeh, Shannon Page, Patricia Anthony, Stuart Charters, Majeed Safa, Chris Logan
Summary: Visual imaging combined with live weight and body parameters can be used to predict the body compositions of ewes. The correlation between the estimated values obtained from image processing and the results from computerized tomography indicates the potential usefulness of these measurements for farmers to improve their management practices.
Article
Endocrinology & Metabolism
F. N. U. Deepika, Elliot Ballato, Georgia Colleluori, Lina Aguirre, Rui Chen, Clifford Qualls, Dennis T. Villareal, Reina Armamento-Villareal
Summary: Male hypogonadism negatively affects body composition, bone mineral density, and metabolic health. This study found that men with a baseline testosterone level of <264 ng/dl showed greater improvement in fat-free mass with testosterone therapy, while men with a testosterone level of >=264 ng/dl showed better improvement in metabolic profile.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Microbiology
Michael J. Bale, Mary Grace Katusiime, Daria Wells, Xiaolin Wu, Jonathan Spindler, Elias K. Halvas, Joshua C. Cyktor, Ann Wiegand, Wei Shao, Mark F. Cotton, Stephen H. Hughes, John W. Mellors, John M. Coffin, Gert U. Van Zyl, Mary F. Kearney
Summary: Despite significant differences in T-cell composition and dynamics between children and adults, HIV-infected cell clones are established early in children, persist for up to 9 years on ART, and can be driven by proviral integration in proto-oncogenes. Selection for integration events in proto-oncogenes were observed in children despite early ART, indicating potential long-term consequences.
Article
Pharmacology & Pharmacy
Giulia Fiore, Martina Chiara Pascuzzi, Elisabetta Di Profio, Antonio Corsello, Marta Agostinelli, Alice La Mendola, Chiara Milanta, Cristina Campoy, Valeria Calcaterra, Gianvincenzo Zuccotti, Elvira Verduci
Summary: Obesity is a common chronic disease in children worldwide and has a significant burden on society. Metabolically unhealthy obesity (MUO) can occur in children from an early age, and new therapeutic strategies are being investigated. This review focuses on bioactive compounds and their potential benefits in treating obesity, including omega-3, docosahexaenoic acid, vitamin D, biotics, polysaccharide macromolecules, polyphenols, inositols, alpha lipoic acid, and bromelaine. The review highlights the most studied compounds, such as omega-3 and vitamin D, and explores the emerging interest in the gut-brain axis and its connection to metabolic health and microbiota. However, more research is needed to fully understand the efficacy and dosage requirements, especially in pediatric patients.
PHARMACOLOGICAL RESEARCH
(2023)
Editorial Material
Nutrition & Dietetics
Alessandro Leone, Simona Bertoli, Giorgio Bedogni, Laila Vignati, Marta Pellizzari, Alberto Battezzati
Review
Clinical Neurology
Antonio Corsello, Lorenzo Scatigno, Annalisa Govoni, Gianvincenzo Zuccotti, Frederic Gottrand, Claudio Romano, Elvira Verduci
Summary: Intestinal motility disorders are common in children with neurological impairment, characterized by abnormal gut movements and symptoms such as constipation, diarrhea, reflux, and vomiting. Nutritional management plays an important role in improving their quality of life.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Rossella Del Toro, Francesco Palmese, Francesco Feletti, Gianluca Zani, Maria Teresa Minguzzi, Ernesto Maddaloni, Nicola Napoli, Giorgio Bedogni, Marco Domenicali
Summary: Little is known about the changes in organs and tissues that may make elder patients more vulnerable to acute stressors such as SARS-CoV-2 infection. In this study of elderly patients with SARS-CoV-2 infection, the association between vascular calcifications, bone density, muscle density, and the odds of dying was evaluated. Age was found to be the strongest predictor of body composition and death, overshadowing the relationships between these factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Francesca Pennati, Stefano Calza, Antonio Di Biagio, Cristina Mussini, Stefano Rusconi, Stefano Bonora, Alberto Borghetti, Eugenia Quiros-Roldan, Giovanni Sarteschi, Marianna Menozzi, Micol Ferrara, Anna Celotti, Arturo Ciccullo, Vania Giacomet, Ilaria Izzo, Laura Dotta, Raffaele Badolato, Francesco Castelli, Emanuele Foca
Summary: This study evaluates the viro-immunological outcome of young adults with vertical transmission of HIV. The results show that having a CD4+/CD8+ ratio >= 1 at 18 years of age is associated with a better viro-immunological status, while an AIDS diagnosis reduces the probability of achieving optimal status. Patients who have not achieved optimal status at 18 years of age are more likely to discontinue antiretroviral therapy.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Review
Pediatrics
Valeria Calcaterra, Vittoria Carlotta Magenes, Francesca Destro, Paola Baldassarre, Giustino Simone Silvestro, Chiara Tricella, Alessandro Visioli, Elvira Verduci, Gloria Pelizzo, Gianvincenzo Zuccotti
Summary: Severe obesity is a major symptom of PWS, and controlling weight is crucial in the treatment of this syndrome. This article provides an overview of different patterns of weight control in PWS, discusses the mechanisms involved in obesity development and preventive strategies. Early diagnosis, controlled diet, regular physical activity, multidisciplinary follow-up, and hormonal treatment improve weight management. Surgery can be considered in some cases. Controlling weight in PWS is a challenge for pediatricians, and consulting different healthcare specialists from neonatal and pediatric age is important in preventing and managing obesity.
Editorial Material
Pediatrics
Valeria Calcaterra, Gianvincenzo Zuccotti
Article
Engineering, Biomedical
Bianca Barzaghini, Stephana Carelli, Letizia Messa, Federica Rey, Maria Antonietta Avanzini, Emanuela Jacchetti, Erika Maghraby, Clarissa Berardo, Gianvincenzo Zuccotti, Manuela Teresa Raimondi, Cristina Cereda, Valeria Calcaterra, Gloria Pelizzo
Summary: Mesenchymal stem cells (MSCs) show promise as a source for stem cell therapies in pediatric respiratory diseases. Using a 3D micro-scaffold called Nichoid, the anti-inflammatory potential of MSCs can be enhanced through mechanical stimulation, overcoming limitations of biochemical and xenogenic growth factors.
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2023)
Letter
Medical Laboratory Technology
Simona Ferraro, Elvira Verduci, Gianvincenzo Zuccotti, Camilla Sertori
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Enrico Pompili, Maurizio Baldassarre, Giorgio Bedogni, Giacomo Zaccherini, Giulia Iannone, Clara De Venuto, Dario Pratelli, Francesco Palmese, Marco Domenicali, Paolo Caraceni
Summary: The PREDICT study found that acutely decompensated patients with cirrhosis can have three different clinical trajectories: pre-ACLF, unstable decompensated cirrhosis (UDC), and stable decompensated cirrhosis (SDC). This study aimed to validate these trajectories and identify predictors for each trajectory.
LIVER INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Chiara Mameli, Taylor M. Triolo, Francesco Chiarelli, Marian Rewers, Gianvincenzo Zuccotti, Kimber M. Simmons
Summary: Type 1 diabetes is a serious autoimmune condition for which interventions can delay or prevent its onset. Primary prevention aims to prevent autoimmunity, secondary prevention aims to preserve beta cells, and tertiary prevention aims to initiate and extend remission. The approval of teplizumab marks a milestone in diabetes care and opens the door for new prevention strategies.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Rheumatology
Andrea Taddio, Sara Della Paolera, Luisa Abbagnato, Anna Agrusti, Raffaele Badolato, Francesca Biscaro, Roberta Caorsi, Alessandro Consolaro, Rosa Maria Dellepiane, Marianna Fabi, Ilenia Floretta, Marco Gattorno, Manuela Giangreco, Francesco La Torre, Maria Cristina Maggio, Lorenzo Mambelli, Angela Mauro, Maria Vincenza Mastrolia, Alessandra Meneghel, Davide Montin, Francesca Ricci, Gabriele Simonini, Andrea Smarrazzo, Rita Sottile, Sara Stucchi, Maria Tardi, Lucio Verdoni, Gianvincenzo Zuccotti, Fiammetta Zunica, Angelo Ravelli, Marco Cattalini
Summary: The study aimed to determine the best treatment option for multisystem inflammatory syndrome in children (MIS-C) and analyze the role of anakinra. The results showed that early treatment with anakinra can reduce the probability of developing persistent heart disease at the end of follow-up.
Article
Endocrinology & Metabolism
Domenico Corica, Maria Rosaria Licenziati, Valeria Calcaterra, Monica Curro, Claudia Di Mento, Selenia Curatola, Gianvincenzo Zuccotti, Angela Alibrandi, Riccardo Ientile, Tommaso Aversa, Malgorzata Wasniewska
Summary: This study aimed to evaluate the relationship between sensitivity to thyroid hormones, severity of overweight, and glyco-metabolic alterations in prepubertal euthyroid children with obesity. The results showed that sensitivity to thyroid hormones was significantly affected by the severity of overweight and the presence of insulin resistance in prepubertal children with obesity. This could potentially contribute to the pathogenesis of glucose metabolism impairment.
Article
Pediatrics
Antonella Amendola, Elisa Borghi, Silvia Bianchi, Maria Gori, Clara Fappani, Lucia Barcellini, Federica Forlanini, Nicolo Garancini, Chiara Nava, Alessandra Mari, Anna Sala, Chiara Gasparini, Emerenziana Ottaviano, Daniela Colzani, Elia Mario Biganzoli, Elisabetta Tanzi, Gian Vincenzo Zuccotti
Summary: This study describes the first school-located influenza vaccination campaign with quadrivalent live-attenuated influenza vaccine (LAIV) among pre-school children in Italy, coupled with an innovative school-centred influenza-like illnesses (ILIs) surveillance using a self-sampling non-invasive saliva collection method. The results show that the participation in the immunisation campaign was good, and the intranasal administration was well tolerated and helped to overcome parental hesitancy. Saliva sampling represented a useful tool to reduce children's stress and increase parents' compliance. The high participation of families with an immigrant background suggests that school-based interventions can represent an effective strategy to overcome socioeconomic and cultural barriers.
ITALIAN JOURNAL OF PEDIATRICS
(2023)
Article
Computer Science, Information Systems
Savina Mannarino, Valeria Calcaterra, Giulia Fini, Andrea Foppiani, Antonio Sanzo, Martina Pisarra, Gabriele Infante, Marta Marsilio, Irene Raso, Sara Santacesaria, Gianvincenzo Zuccotti
Summary: This study introduces an innovative pediatric telecardiology system, seamlessly integrated with a hospital telemedicine platform, which enhances patient management in the community. The results demonstrate the system's value as a diagnostic tool to facilitate the execution, transmission, and reporting of ECG data between primary care pediatrician clinics and the hospital.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2024)