Article
Endocrinology & Metabolism
Jingjing An, Junqi Wang, Li Guo, Yuan Xiao, Wenli Lu, Lin Li, Lifen Chen, Xinqiong Wang, Zhiya Dong
Summary: The study established an SGA rat model and found that Lactobacillus and short-chain fatty acids were associated with metabolic disorders during CUG in SGA. This suggests that gut microbiome may play a role in metabolic disorders during catch-up growth in small-for-gestational-age individuals.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Hwal Rim Jeong, Jae-A Han, Heeji Kim, Hye Jin Lee, Young Suk Shim, Min Jae Kang, Jong Seo Yoon, Seongho Ryu, Il Tae Hwang
Summary: This study investigated the exosomal miRNA signature associated with catch-up growth in small-for-gestational-age (SGA) children. The results showed that SGA children without catch-up growth have a distinct exosomal miRNA expression profile compared with SGA children with catch-up growth and appropriate-for-gestational-age (AGA) children. The study also identified certain miRNAs that may be associated with growth failure in SGA children.
Article
Nutrition & Dietetics
Laura E. Lach, Katherine E. Chetta, Amy L. Ruddy-Humphries, Myla D. Ebeling, Mathew J. Gregoski, Lakshmi D. Katikaneni
Summary: This study examined the growth and body composition of SGA and AGA VLBW infants, as well as their outpatient neurodevelopmental outcomes. The results showed significant differences in percentage of body fat, percentage of lean mass, and weight gain between SGA and AGA groups at the first ADP assessment. However, there was no difference in outpatient neurodevelopmental testing between the two groups. The study found that weight gain as catch-up body fat accrual is associated with normal neurodevelopment in SGA preterm infants compared to AGA preterm infants.
Article
Pediatrics
Hui Xiong, Wei Liu, Jie Song, Xia Gu, Shunchang Luo, Zhendong Lu, Hu Hao, Xin Xiao
Summary: Insulin resistance is associated with children born small for gestational age (SGA) with catch-up growth (CUG). This study found that miR-210-5p, highly expressed in adipose tissue macrophage-derived exosomes, promotes insulin resistance in SGA-CUG rats by targeting SIDT2. This suggests that targeting miR-210-5p or SIDT2 could be a potential therapeutic strategy for insulin resistance in children born SGA with CUG.
TRANSLATIONAL PEDIATRICS
(2023)
Article
Pediatrics
Giulia Vizzari, Daniela Morniroli, Valentina Tiraferri, Marta Macchi, Silvana Gangi, Alessandra Consales, Federica Ceroni, Jacopo Cerasani, Fabio Mosca, Maria Lorella Gianni
Summary: This study examined the growth outcomes of late preterm infants and identified factors associated with failure to recover growth. The results showed that 34% of children did not regain weight at 36 months. Infants who did not regain weight at 12 months were at a higher risk of not regaining weight at 36 months. The same risk factor was also associated with length catch-up growth. Additionally, infants fed any human milk at discharge were protected from failure to achieve weight and length catch-up growth at 36 months.
PEDIATRIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Bireshwar Sinha, Tarun Shankar Choudhary, Nitika Nitika, Mohan Kumar, Sarmila Mazumder, Sunita Taneja, Nita Bhandari
Summary: This study aims to describe the linear growth trajectories of low birthweight small-for-gestational-age (SGA-LBW) infants during the first 6 months of life compared with appropriate-for-gestational-age LBW (AGA-LBW) infants. The results showed that SGA-LBW infants had slower linear growth, lower attained length, and lower LAZ score compared to AGA-LBW infants. Factors associated with poor catch-up growth in SGA-LBW infants included lower wealth quintiles, high birth order, home birth, male child, term delivery, non-exclusive breastfeeding, and pneumonia.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Lihua Huang, Shiwei Jiang, Jian Xu, Xiaoping Lei, Jun Zhang
Summary: This study found that SGA children born to mothers with inadequate gestational weight gain or underweight prepregnancy tend to have a higher risk of poor weight catch-up growth.
MATERNAL AND CHILD NUTRITION
(2022)
Article
Multidisciplinary Sciences
Takafumi Yamauchi, Daisuke Ochi, Naomi Matsukawa, Daisuke Saigusa, Mami Ishikuro, Taku Obara, Yoshiki Tsunemoto, Satsuki Kumatani, Riu Yamashita, Osamu Tanabe, Naoko Minegishi, Seizo Koshiba, Hirohito Metoki, Shinichi Kuriyama, Nobuo Yaegashi, Masayuki Yamamoto, Masao Nagasaki, Satoshi Hiyama, Junichi Sugawara
Summary: This study introduced a model to predict gestational age using urinary metabolite information, identifying 184 urinary metabolites that exhibit dynamic systematic changes in healthy pregnant women according to gestational age. The model constructed showed a high correlation in predicting gestational age during normal pregnancy progression.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Fatima Crispi, Merida Rodriguez-Lopez, Gabriel Bernardino, Alvaro Sepulveda-Martinez, Susanna Prat-Gonzalez, Carolina Pajuelo, Rosario J. Perea, Maria T. Caralt, Giulia Casu, Kilian Vellve, Francesca Crovetto, Felip Burgos, Mathieu De Craene, Constantine Butakoff, Miguel A. Gonzalez Ballester, Isabel Blanco, Marta Sitges, Bart Bijnens, Eduard Gratacos
Summary: This study evaluated the baseline cardiac function and structure as well as exercise capacity in young adults born small for gestational age (SGA). The results showed that these young adults had markedly reduced exercise capacity, indicating potential association with increased cardiovascular mortality.
Article
Pediatrics
Rong Huang, Hua He, Anne Monique Nuyt, Pierre Julien, Isabelle Marc, Emile Levy, William D. Fraser, Zhong-Cheng Luo
Summary: This study aimed to explore whether small-for-gestational-age (SGA) infants would have differences in metabolic health biomarkers compared to optimal-for-gestational-age (OGA) infants at age 2 years. The results showed that SGA infants had similar insulin resistance and secretion, circulating leptin and adiponectin levels compared to OGA infants. However, in SGA infants, current BMI was positively associated with circulating adiponectin. This suggests the development of dysfunctional adiposity-adiponectin negative feedback loop in SGA infants during infancy.
Article
Pediatrics
Maria Sonsoles Galan Arevalo, Ignacio Mahillo-Fernandez, Miguel Saenz De Pipaon, Luis Mariano Esteban, Diego Hernandez Martin, Juan Rodriguez Delgado, Jose Carlos Estevez Munoz, Mercedes Andeyro-Garcia, Roi Pineiro Perez, Ricardo Saviron-Cornudella
Summary: Newborns with fetal growth deceleration (FGD) but appropriate-for-gestational-age (AGA) weight experience catch-up growth, especially in weight and BMI, in the first year of life.
PEDIATRIC RESEARCH
(2023)
Article
Acoustics
R. L. Deter, W. Lee, P. Dicker, E. C. Tully, F. Cody, F. D. Malone, K. M. Flood
Summary: This study found that there are seven growth restriction patterns in small fetuses with delayed growth in the third trimester. 37% of fetuses without evidence of growth restriction had vascular abnormalities. The distribution and types of normal growth and growth restriction patterns in the AGA cohort were different compared to the SGA cohort.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Nutrition & Dietetics
Jonas Ellerbrock, Benthe Spaanderman, Joris van Drongelen, Eva Mulder, Veronica Lopes van Balen, Veronique Schiffer, Laura Jorissen, Robert-Jan Alers, Jeanine Leenen, Chahinda Ghossein-Doha, Marc Spaanderman
Summary: This study found that both high insulin resistance and beta cell dysfunction increase the risk of gestational diabetes mellitus (GDM) in second-trimester pregnant women. Additionally, high insulin resistance is associated with the need for additional glucose lowering medication, especially in women diagnosed with GDM who do not respond well to a low carbohydrate diet. Therefore, insulin sensitizers may be the most targeted therapeutic modality for diet-insensitive GDM patients.
Article
Endocrinology & Metabolism
Ravi Retnakaran, Chang Ye, Anthony J. Hanley, Philip W. Connelly, Mathew Sermer, Bernard Zinman
Summary: This study compared postpartum glucose tolerance between women treated for gestational diabetes mellitus (GDM) and those not treated. The results showed that treating GDM lowers birth weight but does not disrupt the association between gestational glycemia and maternal prediabetes/diabetes after pregnancy. Insulin sensitivity and beta-cell function decreased, while fasting and 2-h glucose levels increased progressively across the five groups.
Article
Endocrinology & Metabolism
Mario Angulo, Diana Ramirez-Montano, Laura Torres-Canchala, Ximena Garcia, Rodrigo Lemus, Ana M. Aristizabal, Danielle Floyd-Aristizabal, Diana M. Davalos, Lorena Diaz-Ordonez, Harry Pachajoa
Summary: In small for gestational age (SGA) children, methylation of leptin and GLP2R genes were observed, while there was no association between IRS2 methylation and catch-up growth. Catch-up patients showed larger waist circumference and higher proportion of increased appetite, family history of dyslipidemia and diabetes.
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2021)