Article
Pediatrics
Gil Vervloet, Antoine De Backer, Stijn Heyman, Paul Leyman, Sebastiaan Van Cauwenberge, Kim Vanderlinden, Charlotte Vercauteren, Dirk Vervloessem, Marc Miserez
Summary: Non-surgical biopsies are more likely to give inconclusive results due to smaller amounts of submucosa present in the specimen. Open biopsies are especially useful when previous non-surgical biopsies are inconclusive. An experienced pathologist is a key factor for the result.
Article
Pediatrics
Emma Fransson, Christina Graneli, Kristine Hagelsteen, Louise Tofft, Mette Hambraeus, Rodrigo Urdar Munoz Mitev, David Gisselsson, Pernilla Stenstroem
Summary: This study explored the influence of weight on the diagnostic efficacy of rectal suction biopsy (RSB) and found that RSB diagnostic efficacy was higher in children weighing less than 9.0 kg. The study also found lower diagnostic efficacy in aganglionic tissue compared to ganglionic tissue. Therefore, weight can be used to predict RSB diagnostic efficacy.
Article
Pediatrics
Emma Fransson, Emilia Gottberg, Rodrigo Munoz Mitev, David Gisselsson, Kristine Hagelsteen, Louise Tofft, Pernilla Stenstrom, Christina Graneli
Summary: Systematic orientation of fresh RSB specimens improves the quality and efficiency of Hirschsprung's disease diagnostics, especially in aganglionic specimens.
Article
Pediatrics
Maricarmen Olivos, Catalina Correa, Luis De la Torre
Summary: The study evaluated the current practice of rectal biopsy for Hirschsprung's disease among pediatric surgeons in Latin America. It found that rectal suction biopsy is not a standard procedure in the region, with limited access for surgeons. There is a lack of consensus on sample number, site of proximal biopsy, and antibiotic prophylaxis use. Complications associated with the procedure seem to be fewer than reported with rectal suction biopsy, indicating a need for standardized guidelines for the rectal biopsy procedure.
PEDIATRIC SURGERY INTERNATIONAL
(2021)
Article
Surgery
L. Hartford, N. Schonfeldt, R. Mohanlal, C. Bebington, J. Loveland, C. Westgarth-Taylor, G. Brisighelli
Summary: The aim of this study was to optimize cost-effectiveness by analyzing the actual situation. It was found that in low-resource settings, selecting the appropriate rectal suction biopsy system and obtaining a single specimen is sufficient to diagnose Hirschsprung's disease. For patients with inconclusive results, a repeat biopsy should be performed and two specimens should be obtained.
SOUTH AFRICAN JOURNAL OF SURGERY
(2023)
Article
Pediatrics
Yanan Zhang, Yongwei Chen, Shen Yang, Yichao Gu, Kaiyun Hua, Yong Zhao, Jinshi Huang
Summary: A retrospective study showed that suction rectal biopsy is safe and accurate for diagnosing Hirschsprung disease in late preterm infants, with high sensitivity and specificity. This method can have a positive impact on the treatment and recovery of patients.
FRONTIERS IN PEDIATRICS
(2021)
Article
Health Care Sciences & Services
Jiraporn Khorana, Phawinee Phiromkanchanasak, Jitthiwimon Kumsattra, Suparada Klinoun, Suthasinee Aksorn, Sireekarn Chantakhow, Kanokkan Tepmalai, Jesda Singhavejsakul
Summary: The study aimed to develop a clinical score model for diagnosing and early referrals of Hirschsprung's disease, especially in areas where investigations were not available. Patients with a clinical score of 4-7 had a high probability of having HSCR and should undergo further investigations, while those with a low probability still require clinical observation. This clinical scoring system can be used as a screening tool to prevent delayed diagnosis and complications.
Article
Pediatrics
Leise Elisabeth Hviid Korsager, Niels Bjorn, Mark Bremholm Ellebaek, Lene Gaardsmand Christensen, Niels Qvist
Summary: This study investigates the value of re-evaluation for initially inconclusive Hirschsprung's disease biopsies through stainings with HE and IHC. The results show that one patient was re-evaluated as positive and 11 patients were re-evaluated as negative, which were confirmed by the final diagnosis at a 5-year follow-up. This suggests that re-evaluation of inconclusive biopsies may help avoid re-biopsies.
Article
Gastroenterology & Hepatology
Emilie G. Jaroy, Ragnhild Emblem, Henrik M. Reims, The Tien Mai, Gabriel T. Risa, Rune Ougland
Summary: Factors most indicative of Hirschsprung's disease in children undergoing rectal biopsy include male sex, failure to thrive, gross abdominal distention plus vomiting, and meeting the Rome 4 criteria for functional constipation. The prevalence of Hirschsprung's disease decreases with increasing age of the children, and girls referred for a biopsy rarely have the disease, especially those older than 1 month.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Pediatrics
Yew-Wei Tan, Carmen Sofia Chacon, William Sherwood, Munther Haddad, Muhammad Choudhry
Summary: The study found a high rate of negative rectal biopsies for HD, with the majority requiring ORB. While red flags and gender, but not age, have strong predictive values, they are inadequate for excluding HD. This study supports the need for alternative strategies in excluding HD.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Multidisciplinary Sciences
Yuanyuan Liang, Ting An, Wenqiong Xin
Summary: Rectal anorectal manometry (ARM) has high sensitivity for the diagnosis of Hirschsprung's disease (HD) in children of all ages, but the specificity is lower in neonates.
Article
Pediatrics
Hong Yang, Yangyang Ma, Shaobo Yang, Yanlei Huang, Gong Chen
Summary: The article describes two cases of SS-HSCR, highlighting key issues in the diagnosis and treatment of this rare disease, including multipoint biopsy, laparoscopic identification of the transition zone, and multisegment biopsy as a preventative measure. Further research is needed to determine the optimal length and method of retention of segments.
PEDIATRIC SURGERY INTERNATIONAL
(2021)
Review
Surgery
Koichiro Yoshimaru, Yusuke Yanagi, Satoshi Obata, Yoshiaki Takahashi, Keiko Irie, Atsuko Omori, Toshiharu Matsuura, Tomoaki Taguchi
Summary: Hirschsprung's disease is a congenital condition resulting in functional bowel obstruction due to the absence of enteric ganglion cells in the colonic segment. Diagnostic methods evolved from full-thickness biopsy to rectal mucosal biopsy with rubeanic acid-amplificated AChE staining, significantly improving diagnosis rates in the 1980s. Early diagnosis is crucial to prevent serious complications.
Article
Medicine, General & Internal
Suellen Serafini, Maria Merces Santos, Ana Cristina Aoun Tannuri, Celso Di Loreto, Josiane de Oliveira Goncalves, Uenis Tannuri
Summary: By studying the distribution of ganglion cells in the submucosal plexus, we developed a simplified method for diagnosing Hirschsprung's Disease. The study showed that by examining the submucosal region, it is possible to accurately locate ganglionic plexuses, leading to a 93% accuracy in diagnosing Hirschsprung's Disease.
Article
Medicine, General & Internal
Maria Evertsson, Christina Graneli, Alvina Vernersson, Olivia Wiaczek, Kristine Hagelsteen, Tobias Erlov, Magnus Cinthio, Pernilla Stenstrom
Summary: It has been shown that using ultra-high frequency (UHF) ultrasound on the external bowel wall can accurately differentiate between normal bowel and aganglionosis, which could potentially eliminate the need for biopsies in diagnosing Hirschsprung's disease. However, there are currently no suitable rectal probes available for this purpose. This study aimed to define the specifications of a new UHF transrectal ultrasound probe that would be suitable for use in infants, and two prototypes were created and tested by pediatric surgeons, with the larger and straight probe being preferred.
Article
Orthopedics
Nicola Krahenbuhl, Travis L. Bailey, Maxwell W. Weinberg, Nathan P. Davidson, Beat Hintermann, Angela P. Presson, Chelsea McCarty Allen, Heath B. Henninger, Charles L. Saltzman, Alexej Barg
FOOT AND ANKLE SURGERY
(2020)
Article
Medicine, Research & Experimental
Richard K. Gurgel, Brandon R. Cardon, Chelsea McCarty Allen, Angela P. Presson, Brenna C. Kelly, Harriet W. Hopf, Sukgi S. Choi, Robert H. Miller
Article
Otorhinolaryngology
Vanessa Torrecillas, Chelsea M. Allen, Tom Greene, Albert Park, Winnie Chung, Tatiana M. Lanzieri, Gail Demmler-Harrison
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2020)
Article
Surgery
Shawn M. Purnell, Daniel J. Vargo, Michael Sarap, John J. Nguyen-Lee, Chelsea Allen, Brian J. Dunkin
Summary: The study surveyed rural surgeons on their requirements and preferences for a simulation model for rehearsing the endoscopic management of NVUGIB. Results showed that most rural surgeons lack experience with simulation models but are interested in further training.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Anesthesiology
Adam W. Meier, Michael J. Buys, Manasa Gill, Eric W. Piacenza, Linda Nguyen, Chelsea M. Allen, Ami R. Stuart, Jeremy Gililland, Ken B. Johnson
Summary: The study aimed to investigate whether AVD could reduce self-administered propofol consumption during total hip or total knee arthroplasty under spinal anesthesia. Results showed that there was no significant difference in propofol consumption between patients who used AVD or patient-controlled sedation during surgery.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2021)
Article
Orthopedics
Andrew R. Tyser, Chelsea M. Allen, Angela P. Presson, Andrew R. Stephens, David J. Petron, Wyatt Walsh, Nikolas H. Kazmers
Summary: The study highlights the limitations of QuickDASH and PROMIS UE CAT tools in assessing upper extremity function in Division I athletes due to large ceiling effects. However, PROMIS PF CAT was not significantly affected by this issue. Athlete scores were significantly better than normative values, except for males on QuickDASH.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2021)
Article
Pediatrics
Neha R. Malhotra, M. Chad Wallis, Chelsea M. Allen, Patrick C. Cartwright, Glen A. Lau
JOURNAL OF PEDIATRIC UROLOGY
(2020)
Article
Surgery
Marta L. McCrum, Austin R. Cannon, Chelsea M. Allen, Angela P. Presson, Lyen C. Huang, Benjamin S. Brooke
Article
Pediatrics
Liese C. C. Pruitt, Brian T. Bucher, Chelsea McCarty Allen, Scott S. Short
Summary: The study compared outcomes of early versus delayed pouch construction in children undergoing restorative proctocolectomy and IPAA, finding no significant differences in adverse events between the two groups despite increased exposure to steroids and immune suppressants in the early pouch creation group.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Editorial Material
Orthopedics
John T. Wilkinson, Jordan W. Clawson, Chelsea M. Allen, Angela P. Presson, Andrew R. Tyser, Nikolas H. Kazmers
Summary: The study aimed to assess the reliability of telephone administration for PROMIS UE CAT in a hand and upper extremity population compared to QuickDASH. Results showed that QuickDASH had significantly better reliability than PROMIS UE CAT, with some patients demonstrating clinically relevant score differences between telephone and computer-based administration.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2021)
Article
Otorhinolaryngology
Alana Aylward, Morganne Murphy-Meyers, Chelsea McCarty Allen, Neil S. Patel, Richard K. Gurgel
Summary: The study found that in older adults, there was no correlation between frailty index and hearing scores after cochlear implantation, but a lower frailty index and greater improvement in pure tone averages after cochlear implantation predicted better quality of life scores.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Urology & Nephrology
Austen D. Slade, James R. Cardinal, Christopher R. Martin, Angela P. Presson, Chelsea D. Allen, William T. Lowrance, Christopher B. Dechet, Brock B. O'Neil
Summary: The study found that monitoring postoperative heart rate and activity in cystectomy patients using wearables is feasible, with higher step counts associated with lower risk of adverse events. However, current wearables are not well-suited for this task.
Article
Clinical Neurology
Alana Aylward, Steven A. Gordon, Morganne Murphy-Meyers, Chelsea McCarty Allen, Neil S. Patel, Richard K. Gurgel
Summary: This study aimed to evaluate the factors influencing the quality of life (QOL) of caregivers of older cochlear implant recipients. The results showed that caregiver QOL was significantly influenced by patient gender and health status, but not by patient speech recognition scores.
OTOLOGY & NEUROTOLOGY
(2022)
Article
Neurosciences
William C. Walker, Jk Werner, Aa Agyemang, Cm Allen, Je Resch, M. Troyanskaya, K. Kenney
Summary: This study found no evidence that remote mild traumatic brain injury (mTBI) or related post-concussive clinical features are linked to growth hormone deficiency (GHD), hypothyroidism, or male hypogonadism. Further case-control studies with more definitive neuroendocrine disorder (NED) testing are needed to determine whether mTBI alone increases the risk for chronic NED and how to best select patients for comprehensive testing.
Article
Cardiac & Cardiovascular Systems
Jason P. Glotzbach, Heidi A. Hanson, Joseph E. Tonna, Joshua J. Horns, Chelsea McCarty Allen, Angela P. Presson, Claire L. Griffin, Megan Zak, Vikas Sharma, Martin Tristani-Firouzi, Craig H. Selzman
Summary: In this large-population study, familial associations of thoracic aortic disease and bicuspid aortic valve (BAV) were examined. The risk of developing the same disease was found to be higher in relatives of patients with BAV, as well as in those with thoracic aortic aneurysm or dissection. Additionally, relatives of individuals with these diagnoses had a higher risk of aortic-specific mortality compared to controls.