Review
Orthopedics
Michael McLarnon, Neil Heron
Summary: IA-PRP injections show superior outcomes compared to CS injections in symptomatic management of knee OA, with better pain management, less joint stiffness, and improved participation in exercise/sporting activity at 12 months follow-up. Triple IA-PRP injections, separated by a week, are more effective than a single IA-PRP injection.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Multidisciplinary Sciences
Nathalie Accart, Janet Dawson, Michael Obrecht, Christian Lambert, Manuela Flueckiger, Julie Kreider, Shinji Hatakeyama, Peter J. Richards, Nicolau Beckmann
Summary: This study aimed to assess the impact of repeated intra-articular injections of monosodium urate (MSU) crystals with inflammasome priming by lipopolysaccharide (LPS) on the development of gout in rats. Translational imaging was used to evaluate the extent of damage in different areas of the knee joint. The findings showed that MSU/LPS injections led to joint swelling, thickening of the synovial membrane, fibrosis of the infrapatellar fat pad, cartilage invasion by inflammatory cells, and increased sensitivity to mechanical stimulus. Magnetic resonance imaging (MRI) revealed changes in synovial fluid volume, decreased fat volume and fibrosis formation in the infrapatellar fat pad, and alterations in the femoral cartilage. These observations suggest that repeated intra-articular MSU/LPS injections can induce pathology in multiple tissues and may offer insights into the development of degenerative joint disease.
SCIENTIFIC REPORTS
(2022)
Article
Orthopedics
Laura Elisa Streck, Sebastian Braun, Kimi Spilo, Cosima Sue Boettner, Marco Brenneis, Friedrich Boettner
Summary: This retrospective study evaluated 682 cases of intra-articular corticosteroid injections (ICSI) for hip osteoarthritis. The results showed that 0.6% of patients developed rapidly progressive osteoarthritis (RPIO) following the injections, but there was minimal risk for septic arthritis or periprosthetic joint infections (PJI), even in patients with multiple injections or injections within 3 months prior to total hip arthroplasty (THA).
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Yunong Ao, Jiangjie Duan, Na Xiong, Nannan Qian, Rui Zhang, Liu Yang, Shicang Yu, Fuyou Wang
Summary: Repeated intra-articular injection of umbilical cord-derived mesenchymal stem cells (UC-MSCs) is safe and does not induce serious adverse events in the treatment of osteoarthritis (OA). This treatment may temporarily improve symptoms in patients with knee OA and may be a potential therapeutic option.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Rehabilitation
Terin T. Sytsma, Rozalina G. McCoy, Karen M. Fischer, Kelly R. Dean, Laura S. Greenlund
Summary: This study examined the odds of influenza in patients who received intra-articular corticosteroid (IACS) treatment compared to matched controls. The results showed that patients receiving IACS during influenza season had higher odds of influenza, but vaccination seemed to mitigate this risk.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2023)
Article
Orthopedics
Jiabao Chu, Weifeng Duan, Ziqiang Yu, Tao Tao, Jie Xu, Qianli Ma, Lingying Zhao, Jiong Jiong Guo
Summary: The study aims to compare the long-term clinical efficacy of intra-articular injections of P-PRP or sham saline for treating knee osteoarthritis. The results showed that P-PRP had better clinical outcomes in terms of pain, physical function, and overall efficacy compared to sham saline, and the effects were sustained for at least 24 months. The P-PRP group also had lower inflammation levels, improved cartilage volume, and comparable safety profiles.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Review
Medicine, General & Internal
Maciej Checinski, Kamila Checinska, Natalia Turosz, Anita Brzozowska, Dariusz Chlubek, Maciej Sikora
Summary: This mapping review aims to discuss the current research directions on intracavitary temporomandibular joints (TMJs) injections for patients with temporomandibular joint disorders (TMDs). A total of 152 qualified reports were identified from 2712 records, and the results showed that viscosupplementation with hyaluronic acid (HA) was the best-documented injectable administered into TMJ cavities, but there is a growing trend in the use of centrifuged blood preparations for injections.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Orthopedics
J. Samuels, M. H. Pillinger, D. Jevsevar, D. Felson, L. S. Simon
Summary: Intra-articular injections of glucocorticoids have been shown to be effective and relatively safe in patients with knee osteoarthritis, with few contraindications and rare injection-associated complications when delivered with proper technique. However, there are still important unanswered questions regarding the long-term effects and predictive factors of response to intra-articular glucocorticoids in knee osteoarthritis patients, highlighting the need for further research in this area.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Orthopedics
Nathan H. Varady, Troy B. Amen, Paul F. Abraham, Ahab Chopra, David M. Freccero, Eric L. Smith, Scott D. Martin
Summary: Intra-articular hip injections within 3 months before hip arthroscopy were not associated with an increased risk of postoperative infection, and there was no significant difference in infection rates between patients who received injections and those who did not. Additionally, the type of imaging modality used (FL or US) did not impact infection risk.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Geun Joo Choi, Hyun Kang, Oh Haeng Lee, Eun Jin Ahn, Fletcher A. White, Ye Jin Cho, Chong Wha Baek, Yong Hun Jung, Ji Wung Kwon
Summary: This study evaluated the efficacy of immature Rubus occidentalis extract (iROE) on acid-induced hyperalgesia and investigated the mechanism involved. The antihyperalgesic effect of immature and mature ROEs was compared.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Review
Medicine, General & Internal
Xingzhen Lin, Fang Zhi, Qin Lan, Weixiong Deng, Xinju Hou, Qing Wan
Summary: This study compared the efficacy of platelet-rich plasma, ozone, and hyaluronic acid in treating knee osteoarthritis through reticulated meta-analysis. The results showed that platelet-rich plasma injection was more effective than ozone and hyaluronic acid therapies. The combination of hyaluronic acid and ozone, as well as platelet-rich plasma and hyaluronic acid, were also more effective than monotherapy with ozone or hyaluronic acid. Additionally, platelet-rich plasma was found to be more effective than ozone and hyaluronic acid when used alone in the treatment of knee osteoarthritis.
Article
Orthopedics
Paul F. Abraham, Nathan H. Varady, Kirstin M. Small, Nehal Shah, Luis S. Beltran, Michael P. Kucharik, Scott D. Martin
Summary: This study compared complication rates in patients treated with hip corticosteroid/anesthetic injection (CSI) to those without, controlling for preexisting conditions. The results showed no significant difference in short-term osteoarthritis progression or femoral head collapse between the two groups, contrary to previous retrospective investigations. Further randomized trials are needed to determine the exact short-term risk profile of hip CSI.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Editorial Material
Orthopedics
Raveendhara R. Bannuru
Summary: For patients with knee osteoarthritis, intra-articular corticosteroids provide acute and short-term pain relief, while hyaluronic acid offers longer-term treatment effects. More research is needed before platelet-rich plasma and stem cell therapies can be widely recommended for knee osteoarthritis patients. Several new injectables, such as antienerve growth factor antibodies, Wnt pathway inhibitors, and capsaicin, are showing promise to enter the market soon.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Review
Clinical Neurology
Jose I. Acosta Julbe, Jacob C. Mandell, Joerg Ermann, Zacharia Isaac, Julia R. Gottreich, Jay M. Zampini, Miriam DeFilipp, Michael N. Andrew, Jeffrey N. Katz
Summary: This study aimed to identify and describe the factors associated with patient-reported response after lumbar intra-articular facet joint injections or medial branch blocks. Facet joint osteoarthritis is a common cause of chronic low back pain. The success of these approaches is variable, prompting interest in identifying patient characteristics associated with response.
Article
Orthopedics
Cristian Aletto, Lorenzo Giordano, Marco Quaranta, Arnaldo Zara, Donato Notarfrancesco, Nicola Maffulli
Summary: Intra-articular injection of stromal vascular fraction (SVF) is a safe and effective treatment for improving clinical and functional scores in patients with early knee osteoarthritis for up to 6 months.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)