Article
Medicine, General & Internal
Oriane Aebischer, Marc Rene Suter, Peter Vollenweider, Pedro Marques-Vidal
Summary: In a Swiss population-based cohort, there was no consistent association found between chronic pain and physical activity. Overall, chronic pain does not significantly impact time spent in physical activity in the general population.
Article
Multidisciplinary Sciences
Sara Caxaria, Sabah Bharde, Alice M. Fuller, Romy Evans, Bethan Thomas, Petek Celik, Francesco Dell'Accio, Simon Yona, Derek Gilroy, Mathieu-Benoit Voisin, John N. Wood, Shafaq Sikandar
Summary: We demonstrated the role of neutrophils in fibromyalgia by using a back-translational approach in mice. Adoptive transfer of neutrophils from mice with chronic widespread pain or patients with fibromyalgia can induce mechanical pain in recipient mice, sensitize spinal cord neurons, and cause changes in the expression of neutrophil proteins that lead to neutrophil infiltration into dorsal root ganglia. These findings suggest an immunological basis for chronic widespread pain in fibromyalgia mediated by neutrophils.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Nancy Ho-A-Tham, Niels Struyf, Beverly Ting-A-Kee, Johanna de Almeida Mello, Yves Vanlandewijck, Wim Dankaerts
Summary: This study investigated the level of physical activity in women with chronic low back pain (CLBP) in Suriname and found that 43.3% of urban adult women with CLBP were physically inactive. Work-related physical activity was the major contributor to total physical activity, and fear avoidance beliefs, disability, and workload were associated with total physical activity.
Article
Rehabilitation
Marta Moreno-Ligero, Jose A. Moral-Munoz, Inmaculada Failde, Maria Duenas
Summary: The objective of this study was to identify and compare physical activity levels in Spanish individuals with chronic low back pain and their associated factors. The study found that 30% of participants had a low level of physical activity, 53% had a moderate level, and 17% had a high level. Females were more predominant in the low and moderate activity groups, while the high activity group consisted of younger individuals. Factors associated with higher levels of physical activity included being male, having a normal body mass index or being overweight, having better health status, experiencing less pain and physical/cognitive limitations, and having more social support.
JOURNAL OF REHABILITATION MEDICINE
(2023)
Article
Medicine, General & Internal
Caroline Feldthusen, Anna Bergenheim, Emmelie Barenfeld, Inger Gjertsson, Anette Larsson, Kaisa Mannerkorpi
Summary: This study found that collaborating with physiotherapists to create a health plan and utilizing digital platforms for support can provide hope for CWP patients, enabling them to develop a reasonable health plan based on their own goals and interests that actually works.
Article
Anesthesiology
Marina M. Finnern, Dieter Kleinboehl, Herta Flor, Justus Benrath, Rupert Hoelzl
Summary: This study examined the differentiation of chronic primary pain syndromes into those with widespread vs regional musculoskeletal pain, identifying four clusters of patients with chronic primary back pain and fibromyalgia syndrome based on pressure sensitivity markers and clinical pain characteristics. Discriminant analysis revealed that three discriminant functions of pressure sensitivity markers were sufficient to differentiate the clusters, highlighting the relevance of sensory testing in chronic primary pain syndromes.
Article
Rehabilitation
Sofia Juhlin, Anna Bergenheim, Inger Gjertsson, Anette Larsson, Kaisa Mannerkorpi
Summary: This study found no significant differences in pain intensity and physical activity improvement between chronic widespread pain patients receiving a person-centred intervention with digital eHealth support compared to standard telephone follow-up. However, the active control group showed a significant decrease in global fatigue. Future development of interventions to support individuals with chronic pain to maintain regular exercise is needed.
JOURNAL OF REHABILITATION MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Juan Antonio Valera-Calero, Umut Varol
Summary: This study investigated the correlation between routinary physical activity and chronic neck pain severity indicators and salivary cortisol. The results showed that female sex, sedentary behaviors, and pain sensitivity were associated with higher cortisol levels. Worse disability, pain intensity, and pain pressure thresholds were associated with lower physical activity levels.
Article
Rehabilitation
Matthias Poesl, Gabriela F. Carvalho, Waclaw M. Adamczyk, Beate Schuessler, Michael Richter, Kerstin Luedtke, Tibor M. Szikszay
Summary: This study aims to investigate whether proprioceptive accuracy measured with the Joint Position Sense (JPS) in patients with chronic neck and low back pain is impaired exclusively in affected areas or also in distant areas not affected by pain.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Review
Rehabilitation
Anette Larsson, Emmelie Barenfeld, Andreas Fors, Inger Gjertsson, Anna Bergenheim, Kaisa Mannerkorpi
Summary: This study described the content and perceptions of person-centred health plans, and evaluated patients' implementation of the health plan in their everyday life. The results showed that the person-centred approach enhanced motivation, increased self-efficacy in physical activity, and improved participants' level of physical activity and physical capacity.
DISABILITY AND REHABILITATION
(2023)
Article
Multidisciplinary Sciences
Anders Pedersen Arnes, Christopher Sievert Nielsen, Audun Stubhaug, Mats Kirkeby Fjeld, Aslak Johansen, Bente Morseth, Bjorn Heine Strand, Tom Wilsgaard, oloef Anna Steingrimsdottir
Summary: This study aimed to investigate the effect of habitual leisure-time physical activity (PA) level and PA change on pain tolerance. The results showed that participants with consistently high PA levels had significantly higher pain tolerance compared to sedentary individuals. Additionally, pain tolerance increased with higher total activity levels, and more for those who increased their activity level during follow-up.
Article
Medicine, General & Internal
Jing Tian, Graeme Jones, Xin Lin, Yuan Zhou, Anna King, James Vickers, Feng Pan
Summary: This study investigates the association between the number of chronic pain sites and the risk of dementia and its subtypes. The findings suggest that a greater number of chronic pain sites is associated with an increased risk of all-cause dementia and Alzheimer's disease, but not vascular and frontotemporal dementia.
Article
Rheumatology
Maxim B. Freidin, Maria A. Stalteri, Philippa M. Wells, Genevieve Lachance, Andrei-Florin Baleanu, Ruth C. E. Bowyer, Alexander Kurilshikov, Alexandra Zhernakova, Claire J. Steves, Frances M. K. Williams
Summary: The study found reduced diversity in the microbiome of CWP patients, with the species Coprococcus comes significantly depleted. A genome-wide association study identified a potential link between C. comes and CWP, but causal relationship was not supported. This suggests the involvement of gut microbiota in CWP and potential therapeutic opportunities in the microbiome for this condition.
Article
Orthopedics
Joshua J. Van Wyngaarden, Kristin R. Archer, Jacquelyn S. Pennings, Paul E. Matuszewski, Brian Noehren
Summary: This study aimed to evaluate the impact of psychosocial characteristics on pain outcomes after lower extremity fracture. The results showed that psychosocial scores at 6 weeks post-surgery were associated with pain outcomes at 12 months.
Article
Anesthesiology
Jami L. Saloman, Darwin L. Conwell, Evan Fogel, Santhi Swaroop Vege, Liang Li, Shuang Li, Dana K. Andersen, William E. Fisher, Christopher E. Forsmark, Phil A. Hart, Stephen J. Pandol, Walter G. Park, Anna Evans Phillips, Mark Topazian, Stephen K. Van den Eeden, Jose Serrano, Dhiraj Yadav
Summary: Pain is common and significantly reduces quality of life in patients with chronic pancreatitis. This study aimed to classify the pain types in these patients, finding that patients with multiple pain types have worse health and quality of life scores. Further research is needed to identify biomarkers associated with specific pain types and predict responses to interventions.
Article
Anesthesiology
Claire E. Hastie, Hamish M. E. Foster, Bhautesh D. Jani, Catherine A. O'Donnell, Frederick K. Ho, Jill P. Pell, Naveed Sattar, Srinivasa V. Katikireddi, Frances S. Mair, Barbara I. Nicholl
Summary: We investigated the association between self-reported chronic pain and COVID-19 hospitalization or mortality. The study found that chronic pain was associated with higher risk of hospitalization for COVID-19, even after adjusting for other variables, with a clear dose-response relationship. However, the association with COVID-19 mortality was unclear.
Article
Rheumatology
Gary J. Macfarlane, Renke Biallas, Linda E. Dean, Gareth T. Jones, Nicola J. Goodson, Ovidiu Rotariu
Summary: Among patients with axSpA, biologic therapies were associated with an increased risk of IBD compared to other therapies, based on observational studies. However, this association was not observed in placebo-controlled RCTs. Furthermore, the data did not suggest a higher risk of IBD with ETN compared to other anti-TNF therapies.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Anesthesiology
Rebecca Rachael Lee, Danielle Mountain, Mark Connelly, Tonya M. Palermo, Sarah Peters, Lis Cordingley, Janet E. McDonagh
Summary: This study explores the experiences of pain communication in children and adolescents during pediatric rheumatology consultations. The findings demonstrate that these patients expect and value being asked about their pain by healthcare professionals. They remember the processes, experiences, and outcomes of pain communication. The study provides insights for improving pain communication between healthcare professionals and children/adolescents and offers key recommendations.
EUROPEAN JOURNAL OF PAIN
(2023)
Letter
Rheumatology
Daniel J. Clauw, Ernest H. S. Choy, Vitaly Napadow, Anushka Soni, Kevin F. Boehnke, Bruce Naliboff, Afton L. Hassett, Anne Arewasikporn, Andrew Schrepf, Chelsea M. Kaplan, David Williams, Neil Basu, Rachel S. Bergmans, Richard E. Harris, Steven E. Harte, Andrea Chadwick, Gary J. Macfarlane
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
K. Walker-Bone, G. J. Macfarlane, K. Burton, A. M. McConnachie, R. Zhang, G. T. Jones
Summary: Arm pain is a common problem in the workplace. Advicing workers to keep using their arms as much as possible leads to less disability at 6 months, especially for those who lift heavy weights or believe work caused their symptoms. Early physiotherapy, however, made no difference to disability outcomes. Similar results were seen amongst workers diagnosed with lateral epicondylitis.
OCCUPATIONAL MEDICINE-OXFORD
(2023)
Review
Anesthesiology
Christopher Eccleston, Emma Begley, Hollie Birkinshaw, Ernest Choy, Geert Crombez, Emma Fisher, Anna Gibby, Rachael Gooberman-Hill, Sharon Grieve, Amber Guest, Abbie Jordan, Amanda Lilywhite, Gary J. Macfarlane, Candida McCabe, John McBeth, Anthony E. Pickering, Tamar Pincus, Hannah M. Sallis, Samantha Stone, Danielle Van der Windt, Diego Vitali, Elaine Wainwright, Colin Wilkinson, Amanda C. de C. Williams, Anica Zeyen, Edmund Keogh
Article
Rheumatology
Louise Linde, Lykke M. Ornbjerg, Stylianos Georgiadis, Simon H. Rasmussen, Ulf Lindstrom, Johan Askling, Brigitte Michelsen, Daniela Di Giuseppe, Johan K. Wallman, Bjorn Gudbjornsson, Thorvardur Jon Love, Dan C. Nordstrom, Timo Yli-Kerttula, Lucie Nekvindova, Jiri Vencovsky, Florenzo Iannone, Alberto Cauli, Anne Gitte Loft, Bente Glintborg, Karin Laas, Ziga Rotar, Matija Tomsic, Gary J. Macfarlane, Burkhard Moller, Marleen van de Sande, Catalin Codreanu, Michael J. Nissen, Merih Birlik, Sukran Erten, Maria J. Santos, Elsa Vieira-Sousa, Merete L. Hetland, Mikkel Ostergaard
Summary: In bio-naive patients with PsA initiating a TNF inhibitor (TNFi), baseline predictors of Disease Activity index for PsA in 28 joints (DAPSA28) remission and moderate response at 6 months, as well as drug retention at 12 months were identified, indicating potential generalizability from country to disease level.
Article
Rheumatology
Huey Yi Chong, Paul McNamee, Eva-Maria Bachmair, Kathryn Martin, Lorna Aucott, Neeraj Dhaun, Emma Dures, Richard Emsley, Stuart. R. Gray, Elizabeth Kidd, Vinod Kumar, Karina Lovell, Graeme MacLennan, John Norrie, Lorna Paul, Jonathan Packham, Stuart. H. Ralston, Stefan Siebert, Alison Wearden, Gary Macfarlane, Neil Basu
Summary: This study estimated the cost-effectiveness of combining cognitive behavioural approach (CBA) or personalized exercise programme (PEP) with usual care (UC) for patients with inflammatory rheumatic diseases and chronic, moderate to severe fatigue. The results showed that PEP was more expensive but significantly more effective than UC, while CBA was more expensive but not significantly more effective. Therefore, combining PEP with UC is likely to be a cost-effective use of healthcare resources.
Letter
Rheumatology
Burak Kundakci, Michelle Hall, Fabiola Atzeni, Jaime Branco, Dan Buskila, Daniel Clauw, Leslie J. Crofford, Mary-Ann Fitzcharles, Vasileios Georgopoulos, Robert D. Gerwin, Eva Kosek, Gary J. Macfarlane, Caroline Neal, Nathan J. Rudin, Sarah Ryan, Jose A. P. da Silva, Ann M. Taylor, Dennis C. Turk, Daniel Whibley, Michael Doherty, Weiya Zhang, Abhishek Abhishek
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Neurosciences
Georgios Baskozos, Harry L. Hebert, Mathilde M. V. Pascal, Andreas C. Themistocleous, Gary J. Macfarlane, David Wynick, David L. H. Bennett, Blair H. Smith
Summary: This study is the largest epidemiological investigation of neuropathic pain so far. The findings confirm that this disorder is common in middle- to older-aged individuals with various causes and has a greater impact on health compared to non-neuropathic pain.
Article
Health Care Sciences & Services
Syed Mustafa Ali, Rebecca R. Lee, John McBeth, Ben James, Sean McAlister, Alessandro Chiarotto, William G. Dixon, Sabine N. van der Veer
Summary: This study aimed to inform the development of cross-culturally acceptable digital pain self-report tools by understanding the similarities and differences between ethnic groups in pain experiences and self-reporting needs. The findings showed that participants from different ethnic groups faced similar challenges in communicating their pain to healthcare professionals, but had differences in beliefs about pain causes, attitudes toward pain medication, and experiences of stigma and gender norms influencing pain-reporting behavior. Future research and development should address these differences in pain perceptions and beliefs, factors influencing pain reporting behavior, and language requirements to improve cross-cultural acceptability and equity of digital pain self-report tools.
JMIR HUMAN FACTORS
(2023)
Article
Oncology
Johannes M. A. Kusters, Brenda Diergaarde, Andrew Ness, Maarten F. Schim van der Loeff, Janneke C. M. Heijne, Lea Schroeder, Katrina Hueniken, James D. McKay, Gary J. Macfarlane, Pagona Lagiou, Areti Lagiou, Jerry Polesel, Antonio Agudo, Laia Alemany, Wolfgang Ahrens, Claire M. Healy, David I. Conway, Max Robinson, Christina Canova, Ivana Holcatova, Lorenzo Richiardi, Ariana Znaor, Miranda Pring, Steve Thomas, D. Neil Hayes, Geoffrey Liu, Rayjean J. Hung, Paul Brennan, Andrew F. Olshan, Shama Virani, Tim Waterboer
Summary: An increasing proportion of head and neck cancer, particularly oropharyngeal cancer, is caused by HPV. This study examined the diagnostic accuracy of HPV serology and its performance across patient characteristics. The results showed that HPV serology is a robust biomarker for HPV-driven OPC, with consistent diagnostic accuracy across sex and different age groups.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Psychology, Developmental
Danielle C. Mountain, Syed Mustafa Ali, Daniela Ghio, Janet E. Mcdonagh, Lis Cordingley, Rebecca R. Lee
Summary: This scoping review examined beliefs about pain in children/young people with chronic musculoskeletal conditions. Similarities and differences in pain beliefs were found between those with inflammatory and noninflammatory conditions. Further research is needed to identify potential targets for improving pain outcomes in this population.
JOURNAL OF PEDIATRIC PSYCHOLOGY
(2023)
Article
Medicine, General & Internal
Hamish M. E. Foster, Jason M. R. Gill, Frances S. Mair, Carlos A. Celis-Morales, Bhautesh D. Jani, Barbara I. Nicholl, Duncan Lee, Catherine A. O'Donnell
Summary: This study found that both functional and structural components of social connection are independently associated with mortality. It also suggests that the beneficial associations for some types of social connection might not be felt when other types of social connection are absent. Additionally, individuals who live alone with additional structural markers of isolation may represent a high-risk population.