Article
Clinical Neurology
Mateusz W. Kucharczyk, Francesca Di Domenico, Kirsty Bannister
Summary: Diffuse noxious inhibitory control is an endogenous pain modulation mechanism in the central nervous system that can inhibit the pain response to a noxious stimulus. The A5 noradrenergic cell group in the brainstem is identified as a critical relay in this pathway. Understanding this mechanism and identifying therapeutic targets are important for pain modulation.
Article
Clinical Neurology
Mateusz Wojciech Kucharczyk, Diego Valiente, Kirsty Bannister
Summary: This review discusses strategies for pharmacological manipulation of diffuse noxious inhibitory controls (DNIC) and the descending control of nociception (DCN), highlighting methodological limitations and the complexity of underlying circuitry, as well as the impact of drug modulation on noradrenergic, serotonergic, and opioidergic transmission systems.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Clinical Neurology
Caroline M. Kopruszinski, Joelle M. Turnes, Juliana Swiokla, Troy J. Weinstein, Todd J. Schwedt, David W. Dodick, Trent Anderson, Edita Navratilova, Frank Porreca
Summary: The study aimed to investigate the role of calcitonin-gene related peptide in promoting post-traumatic headache and dysregulation of central pain modulation induced by mild traumatic brain injury in mice. The results showed that mild traumatic brain injury led to cutaneous allodynia and loss of diffuse noxious inhibitory control in mice on day 2 post-injury. However, systemic treatment with fremanezumab was able to block mild traumatic brain injury-induced cutaneous allodynia and restore the loss of diffuse noxious inhibitory control.
Article
Neurosciences
Ling Shen, Hai-Bo Qiu, Hui-Hong Xu, Kai Wei, Liang Zhao, Cheng-Cheng Zhu, Cheng-Jian Li, Zhi-Jie Lu
Summary: Nicotine withdrawal in rats leads to hyperalgesia, which is associated with decreased serotonin levels in the raphe nucleus. Intrathecal injection of 5-HT or TPH-overexpression virus can alleviate hyperalgesia, while pharmacological blockade of 5-HT receptors exacerbates pain sensitivity.
Article
Neurosciences
Jason D. Bao, Morgan A. Rosser, Su Hyoun Park, Anne K. Baker, Katherine T. Martucci
Summary: The impact of long-term opioid therapy on central sensitization is investigated using temporal summation measurement. Hypersensitivity to heat pain in participants taking opioids may influence temporal summation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Kenjiro Matsumoto, Kana Takata, Daisuke Yamada, Haruki Usuda, Koichiro Wada, Maaya Tada, Yoshiyuki Mishima, Shunji Ishihara, Syunji Horie, Akiyoshi Saitoh, Shinichi Kato
Summary: Juvenile social defeat stress (SDS) exposure in mice leads to social avoidance, anxiety, depression, and visceral hypersensitivity. The number of 5-HT-containing cells and calcitonin gene-related peptide-positive neurons in the colon increases, while gut microbiota remains largely similar. Responses to stress are exacerbated in the juvenile SDS group, suggesting later onset of IBS-like symptoms.
SCIENTIFIC REPORTS
(2021)
Article
Integrative & Complementary Medicine
Shuai Han, Hua Mao, Tingting Jin, Rubing Yan, Ziyi Wang, Jie Zhang, Jianwen Shi, Yongxin Liang
Summary: This study evaluated the effect of berberine on morphine analgesia, tolerance, and hyperalgesia. The results showed that berberine can enhance and prolong the analgesic effect of morphine, as well as inhibit the development of morphine tolerance and hyperalgesia.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2023)
Article
Medicine, General & Internal
Bjorn Gerdle, Karin Wahlen, Torsten Gordh, Bijar Ghafouri
Summary: Chronic widespread pain, including fibromyalgia, is characterized by generalized musculoskeletal pain and increased pain sensitivity. A study found differences in correlation patterns between plasma/muscle proteins and thermal pain thresholds in patients compared to healthy controls, with immune system proteins playing important roles in pain thresholds.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Rong-Rong Ye, Shuang Jiang, Xu Xu, Yan Lu, Yu-Jun Wang, Jing-Gen Liu
Summary: Dezocine, a synthetic opioid, was reintroduced in China in 2009 for relieving moderate to severe pain and now holds a significant market share. Both preclinical and clinical studies have shown that dezocine is effective in managing various types of pain, can be used as a primary analgesic or in combination with other opioids for improved efficacy or reduced adverse effects.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Anesthesiology
Stijn Veldman, Maria van Beek, Steffie van Rijswijk, Hannah Ellerbroek, Hans Timmerman, Selina van der Wal, Monique Steegers, Arnt Schellekens
Summary: This study investigated the added value of buprenorphine or naloxone (BuNa) in patients with chronic noncancer pain (CNCP) and opioid use disorder (OUD). The results showed that conversion to BuNa led to decreased self-reported pain, increased pain thresholds and tolerance, and improved quality of life (QoL) in these patients.
Article
Multidisciplinary Sciences
Roland R. Reezigt, Geranda E. C. Slager, Michel W. Coppieters, Gwendolyne G. M. Scholten-Peeters
Summary: This study aimed to determine the within and between-session agreement and reliability of pressure pain threshold (PPT) measurements performed by novice assessors. The results showed that after 3 hours of training, novice assessors showed good reproducibility in determining PPTs.
Article
Medicine, General & Internal
Yung-Chi Hsu, Kuo-Hsing Ma, Shu-Lin Guo, Bo-Feng Lin, Chien-Sung Tsai, Chun-Chang Yeh
Summary: Inflammatory pain is less severe than neuropathic pain but can lead to more noticeable depression-like behavior. Neuroinflammation may be a crucial factor in influencing depression-like behavior in rats.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Antonella Comitato, Enza Lacivita, Marcello Leopoldo, Rita Bardoni
Summary: The 5-HT7 receptors play an important role in synaptic modulation, particularly in synaptic inhibition, in the dorsal horn of the spinal cord. The stronger impact on synaptic inhibition suggests that these receptors may have an anti-nociceptive role in the spinal cord of naive animals.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Kazuhiro Horii, Yuka Ehara, Takahiko Shiina, Kiyotada Naitou, Hiroyuki Nakamori, Yuuki Horii, Hiroki Shimaoka, Shouichiro Saito, Yasutake Shimizu
Summary: This study demonstrated a significant sex difference in the responses of colorectal motility to noxious stimuli in rats, with male rats showing enhanced motility in response to capsaicin compared to female rats. The activation of different types of neurons in the descending pathways after noxious stimulation may be responsible for this sex difference, with serotoninergic and dopaminergic neurons being dominant in males and GABAergic neurons in addition to serotoninergic neurons being activated in females. This provides valuable insights into the pathophysiological mechanisms underlying sex differences in functional defaecation disorders like irritable bowel syndrome.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Oncology
Nerijus Eimantas, Soneta Ivanove, Rima Solianik, Marius Brazaitis
Summary: This study investigated the acute shock response of the respiratory system to immersion in hot water. The findings showed that short-duration immersion in noxious 45 degrees C water resulted in higher body temperature, heart rate, and respiratory strain compared to immersion in harmless 37 degrees C water. The initial minute of immersion at 45 degrees C caused a cardiorespiratory shock response, which was later adjusted during the remaining immersion time. Breathing frequency, oxygen uptake, and carbon dioxide washout did not differ between immersion at 37 degrees C and 45 degrees C, but were higher than in control conditions.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Clinical Neurology
Guillaume Leonard, Philippe Chalaye, Philippe Goffaux, David Mathieu, Isabelle Gaumond, Serge Marchand
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2015)
Article
Anesthesiology
L. Devoize, P. Chalaye, S. Lafrenaye, S. Marchand, R. Dallel
EUROPEAN JOURNAL OF PAIN
(2016)
Article
Anesthesiology
Veronique Gougeon, Isabelle Gaumond, Philippe Goffaux, Stephane Potvin, Serge Marchand
CLINICAL JOURNAL OF PAIN
(2016)
Review
Neurosciences
Meggane Melchior, Pierrick Poisbeau, Isabelle Gaumond, Serge Marchand
Article
Anesthesiology
Stephane Potvin, Serge Marchand
Article
Psychiatry
Andras Tikasz, Valerie Tourjman, Philippe Chalaye, Serge Marchand, Stephane Potvin
PSYCHIATRY RESEARCH
(2016)
Review
Clinical Neurology
James A. Blackman, Camilla I. Svensson, Serge Marchand
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2018)
Article
Clinical Neurology
Nathalie Bitar, Serge Marchand, Stephane Potvin
PAIN RESEARCH & MANAGEMENT
(2018)
Article
Anesthesiology
Catherine E. Ferland, Alisson R. Teles, Pablo Ingelmo, Neil Saran, Serge Marchand, Jean A. Ouellet
EUROPEAN JOURNAL OF PAIN
(2019)
Article
Mechanics
M. Brouillette, M. Dore, C. Hebert, M. -F. Spooner, S. Marchand, J. Cote, F. Gobeil, M. Rivest, M. Lafrance, B. G. Talbot, J. -M. Moutquin
Article
Medicine, General & Internal
Anais Le Fur Bonnabesse, Mathilde Cabon, Gildas L'Heveder, Aurelie Kermarrec, Bertrand Quinio, Alain Woda, Serge Marchand, Amandine Dubois, Marie-Agnes Giroux-Metges, Fabrice Rannou, Laurent Misery, Celine Bodere
Article
Clinical Neurology
Nathalie Bitar, Jules R. Dugre, Serge Marchand, Stephane Potvin
JOURNAL OF PAIN RESEARCH
(2020)
Review
Behavioral Sciences
Elora Midavaine, Jerome Cote, Serge Marchand, Philippe Sarret
Summary: Chronic pain is a major global health issue with limited pharmacological treatment options available. Sex-specific differences in pain conditions are increasingly recognized, highlighting the importance of developing gender-specific pain medications. Research on sexually dimorphic pain responses is vital for advancing pain management strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Gael Villanueva-Charbonneau, Stephane Potvin, Serge Marchand, Alexander McIntyre, Diane McIntosh, Alain Bissonnette, Alain Gendron, Charles-edouard Giguere, Marie-eve Koue, Edouard Kouassi
Summary: This study found that mRNA expression of serotonin transporter (SERT) on the surface of peripheral blood mononuclear cells (PBMCs) was significantly reduced in subjects with major depression disorder (MDD), but not in those with fibromyalgia (FM) or FM + MDD. Although drug treatment improved symptoms, it had no significant effect on SERT mRNA expression.
Article
Psychology, Developmental
A. Dubois, M. Boudjarane, A. Le Fur-Bonnabesse, A. Dion, G. L'heveder, B. Quinio, M. Walter, S. Marchand, C. Bodere
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2020)