Article
Neurosciences
Stacey Anne Gould, Matthew White, Anna L. Wilbrey, Erzsebet Por, Michael Philip Coleman, Robert Adalbert
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer treatment associated with sensory axon degeneration. While WLDS and SARM1 have been shown to protect against axon degeneration, SARM1 deletion can alleviate acute oxaliplatin-induced pain, suggesting an independent mechanism of pain hypersensitivity in early stages. Targeting SARM1 may be a potential therapeutic approach for preventing oxaliplatin-induced acute neuropathic pain.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Immunology
Thomas A. Szabo-Pardi, Luz R. Barron, Melissa E. Lenert, Michael D. Burton
Summary: Recent studies have highlighted the importance of identifying sex-specific differences in pain states and the cell-types involved. These studies have shown that neuroimmune interactions play a role in mediating pain states in a sex-specific manner. Specifically, females were found to use immune components of sensory neurons to modulate neuropathic pain development.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Multidisciplinary Sciences
Tadashi Tanioku, Masayuki Nishibata, Yasuyuki Tokinaga, Kohtaro Konno, Masahiko Watanabe, Hiroaki Hemmi, Yuri Fukuda-Ohta, Tsuneyasu Kaisho, Hidemasa Furue, Tomoyuki Kawamata
Summary: This study demonstrates the essential role of Tmem45b in inflammation- and tissue injury-induced mechanical pain hypersensitivity, highlighting it as a potential therapeutic target for future treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Endocrinology & Metabolism
Jun Fu, Fang Wang, Siyuan Ha
Summary: This study investigates the effect of propentofylline (PPF) on Vin-induced neuropathic pain and its underlying mechanism. The results demonstrate that PPF can alleviate pain hypersensitivity by suppressing neuroinflammation in rats.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Medicine, Research & Experimental
Bing Wang, Yingping Liang, Alex Bekker, Huijuan Hu, Yuan-Xiang Tao
Summary: This study found that downregulation of SSlncRNA in small non-peptidergic sensory neurons contributes to nerve injury-induced mechanical hypersensitivity. Through the involvement of the calcium-activated potassium channel KCNN1, the downregulation of SSlncRNA affects the expression of KCNN1 in injured DRG neurons, leading to an increased occurrence of mechanical hypersensitivity.
Review
Cell Biology
YanLing Hu, JinHong Liu, Renjie Zhuang, Chen Zhang, Fei Lin, Jun Wang, Sha Peng, Wenping Zhang
Summary: HIV-related neuropathic pain (HRNP) is a neurodegeneration that develops during the course of acquired immune deficiency syndrome (AIDS), causing abnormal pain and hyperalgesia in the extremities. The pathogenesis of HRNP is not fully understood and there is a lack of effective clinical treatment. This study provides a systematic review of recent research on HRNP, including etiology, pathology, therapeutic strategies, and future research directions.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Niina Jalava, Janne Kaskinoro, Hugh Chapman, Miguel Morales, Hanna Metsaenkylae, Heinonen Satu-Maarit, Koivisto Ari-Pekka
Summary: The study demonstrates that HC-070, a highly selective and potent TRPC4/C5 antagonist, can effectively alleviate or reverse colonic hypersensitivity and chronic neuropathic pain sensitivity in rats. This suggests that TRPC4/C5 antagonism could be a promising non-opioid treatment for chronic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Sabrina L. McIlwrath, Marlene E. Starr, Abigail E. High, Hiroshi Saito, Karin N. Westlund
Summary: The study aimed to investigate the effects of acetyl-L-carnitine on pain behaviors and brain microglial activation in a mouse model of CAE-induced pancreatitis. The results showed that ALC can alleviate mechanical and heat hypersensitivity induced by pancreatitis, but not hypersensitivity caused by abdominal wall injury from repeated injections.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Pharmacology & Pharmacy
Huan-Jun Lu, Yuan-Yuan Fu, Qian-Qi Wei, Zhi-Jun Zhang
Summary: Chronic pain is a common issue in HIV-infected patients, mainly neuropathic pain. The main mechanisms of neuropathic pain in HIV include injury caused by HIV proteins, nervous system sensitization, and neuroinflammation response, which still require further research for clarification.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hichem Bouchenaki, Aurore Danigo, Amandine Bernard, Flavien Bessaguet, Laurence Richard, Franck Sturtz, David Balayssac, Laurent Magy, Claire Demiot
Summary: The study evaluated the effect of the ACE inhibitor ramipril in a mouse model of oxaliplatin-induced acute pain syndrome, showing that ramipril can prevent cold sensitivity and improve tactile sensitivity in treated mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
George Sideris-Lampretsas, Silvia Oggero, Lynda Zeboudj, Rita Silva, Archana Bajpai, Gopuraja Dharmalingam, David A. Collier, Marzia Malcangio
Summary: This study suggests that pain attenuation in a mouse model of Alzheimer's disease may be due to the absence of TLR4 in microglia and the lack of Galectin-3 released by sensory neurons.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Kazue Hisaoka-Nakashima, Kodai Moriwaki, Natsuki Yoshimoto, Toshiki Yoshii, Yoki Nakamura, Yukio Ago, Norimitsu Morioka
Summary: Neuropathic pain causes severe pain and comorbidities such as cognitive impairment, which are not effectively treated with current analgesics. This study demonstrates the role of interleukin-6 (IL-6) in neuropathic pain and cognitive impairment. Blocking the IL-6 receptor improves cognitive impairment, while inhibiting IL-6 activity reduces allodynia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Behavioral Sciences
Nicholas R. Reed, William R. Reed, Michael Syrett, Madison L. Richey, Andrey Frolov, Joshua W. Little
Summary: The study illustrates the time-dependent development of mechanical hypersensitivity in adult male rats in an NGF-induced LBP model, showing that mechanical sensitivity changes primarily locally in the ipsilateral trunk following NGF injections.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Wisam Toma, Jason J. Paris, Urszula O. Warncke, Sara R. Nass, Martial Caillaud, Bryan McKiver, Olivia Ondo, Deniz Bagdas, John Bigbee, Pamela E. Knapp, Kurt F. Hauser, M. Imad Damaj
Summary: This study aims to investigate the role of chronic HIV-1 Tat exposure in the development of neuropathy in mice. The results show that Tat induces mechanical and cold hypersensitivity, with females exhibiting more severe hypersensitivity. Current therapeutics have limited effectiveness in alleviating symptoms in female mice.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Veronica Baron-Flores, Araceli Diaz-Ruiz, Jorge Manzanares, Camilo Rios, Masha Burelo, Gustavo Jardon-Guadarrama, Maria de los Angeles Martinez-Cardenas, Alfonso Mata-Bermudez
Summary: CBD has antinociceptive effects on neuropathic pain induced by spinal cord injury through reducing lipid peroxidation and increasing glutathione concentration.
NEUROSCIENCE LETTERS
(2022)
Article
Clinical Neurology
Denise A. Duricki, Svetlana Drndarski, Michel Bernanos, Tobias Wood, Karen Bosch, Qin Chen, H. David Shine, Camilla Simmons, Steven C. R. Williams, Stephen B. McMahon, David J. Begley, Diana Cash, Lawrence D. F. Moon
ANNALS OF NEUROLOGY
(2019)
Article
Orthopedics
S. M. Lockwood, D. M. Lopes, S. B. McMahon, A. H. Dickenson
OSTEOARTHRITIS AND CARTILAGE
(2019)
Article
Anesthesiology
Georgios Baskozos, John M. Dawes, Jean S. Austin, Ana Antunes-Martins, Lucy McDermott, Alex J. Clark, Teodora Trendafilova, Jon G. Lees, Stephen B. McMahon, Jeffrey S. Mogil, Christine Orengo, David L. Bennett
Review
Biochemistry & Molecular Biology
Cosmin I. Ciotu, Christoforos Tsantoulas, Jannis Meents, Angelika Lampert, Stephen B. McMahon, Andreas Ludwig, Michael J. M. Fischer
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Nickolai Vysokov, Stephen B. McMahon, Ramin Raouf
SCIENTIFIC REPORTS
(2019)
Letter
Respiratory System
Radu Rapiteanu, Tina Karagyozova, Natalie Zimmermann, Kuljit Singh, Gareth Wayne, Matteo Martufi, Nikolai N. Belyaev, Edith M. Hessel, David Michalovich, Ricardo Macarron, Wendy C. Rowan, William J. Cairns, Jan Roger, Joanna Betts, Soren Beinke, Klio Maratou
EUROPEAN RESPIRATORY JOURNAL
(2020)
Review
Neurosciences
George Goodwin, Stephen B. McMahon
Summary: Evidence from human genetic pain disorders shows that voltage-gated sodium channel alpha-subtypes Nav1.7, Nav1.8 and Nav1.9 play important roles in peripheral pain signaling. Drug development targeting these channels requires a better understanding of their involvement in pain signal transmission.
NATURE REVIEWS NEUROSCIENCE
(2021)
Article
Cell Biology
Martyn G. Jones, Evan R. Rogers, James P. Harris, Andrew Sullivan, D. Michael Ackermann, Marc Russo, Scott F. Lempka, Stephen B. McMahon
Summary: Research has shown that ultra-low frequency biphasic current can rapidly generate conduction block in animal models, holding promise as an effective treatment for chronic pain. In clinical trials, epidural spinal ULF neuromodulation significantly improved pain ratings, demonstrating high therapeutic potential.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Neurosciences
Elena Makovac, Alessandra Venezia, David Hohenschurz-Schmidt, Ottavia Dipasquale, Jade B. Jackson, Sonia Medina, Owen O'Daly, Steve C. R. Williams, Stephen B. McMahon, Matthew A. Howard
Summary: This study investigates the interaction between the autonomic nervous system (ANS) and descending pain control mechanisms, revealing the role of the periaqueductal grey (PAG) in mediating this relationship. The results show a negative correlation between heart rate variability (HRV) and descending pain modulation, with PAG-vmPFC functional connectivity mediating this association. This multi-modal approach provides new evidence of body-brain interactions in pain modulation.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Anesthesiology
George Goodwin, Sheridan McMurray, Edward B. Stevens, Franziska Denk, Stephen B. McMahon
Summary: Na(v)1.7 is a promising drug target for pain treatment, but there is a mismatch between the analgesia produced by Na(v)1.7 loss-of-function and the peripherally restricted Na(v)1.7 inhibitors. The function of Na(v)1.7 in axonal propagation in nociceptors is not clearly defined.
Article
Anesthesiology
Daniel Martins, Ottavia Dipasquale, Mattia Veronese, Federico Turkheimer, Marco L. Loggia, Stephen McMahon, Matthew A. Howard, Steven C. R. Williams
Summary: This study examines alterations in morphometric similarity in chronic pain patients and identifies genetic and cellular correlates of these changes. The findings suggest that cortical remodeling in chronic pain may be influenced by multiple elements of the brain's cellular architecture and highlight potential pathways for future genetic association or drug development studies.
Article
Neurosciences
Jade B. Jackson, Owen O'Daly, Elena Makovaca, Sonia Medina, Alfonso de Lara Rubio, Stephen B. McMahon, Steve C. R. Williams, Matthew A. Howard
Article
Neurosciences
Seth D. Holland, Leanne M. Ramer, Stephen B. McMahon, Franziska Denk, Matt S. Ramer
Article
Genetics & Heredity
Matteo Martufi, Robert B. Good, Radu Rabiteanu, Tobias Schmidt, Eleni Patili, Ketil Tvermosegaard, Maria New, Carmel B. Nanthakumar, Joanna Betts, Andy D. Blanchard, Klio Maratou
Article
Neurosciences
Kim I. Chisholm, Nikita Khovanov, Douglas M. Lopes, Federica La Russa, Stephen B. McMahon