Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 36, Pages 8077-8084Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201403049
Keywords
Imaging agents; Radicals; EPR spectroscopy; Peptidomimetics; Density functional calculations
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Funding
- Universite catholique de Louvain (UCL)
- Fond de la Recherche Scientifique (FRS-FNRS, Belgium)
- Fond de la Recherche Scientifique (FRS-FNRS, Belgium) [2.5020.11]
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Tetrathiatriarylmethyl (TAM) radicals are favourite spin labels for electron paramagnetic resonance imaging (EPRI). In this work, we report a straightforward synthesis of new TAM radicals bound to an Arg-Gly-Asp (RGD)-peptido-mimetic known to be a cell-targeting agent. These new radicals are stable in solution, and sensitive to oxygen, and their experimental EPR data is consistent with density functional theory (DFT) calculations.
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