Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 13, Pages 2682-2685Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201400108
Keywords
Synthetic methods; Domino reactions; Cleavage reactions; Nitrogen heterocycles; Copper
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Funding
- National Natural Science Foundation of China (NSFC) [21302188, 81072576, 91027033]
- Chinese Academy of Sciences [KJCX2-EW-N06-01, XDA09030307]
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A copper-catalyzed approach for the synthesis of 2-aryl-quinazolinones through a domino reaction involving C-C bond cleavage is described. This protocol involves intramolecular C-C bond cleavage to construct 2-aryl-quinazolinones, which may offer an alternative method to prepare medically important quinazolinone derivatives and a new strategy for C-C bond cleavage. Besides C-C bond cleavage, this domino reaction includes N-arylation and benzylic C-H amidation.
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