Article
Chemistry, Physical
Francisco Gaspar, Guilherme S. Caleffi, Paulo C. T. Costa-Junior, Paulo R. R. Costa
Summary: The Noyori-Ikariya Ru-II complexes were utilized to promote the reduction of C=C/C=O bonds in isoflavones, leading to selective formation of cis-3-phenylchroman-4-ols with different substituents at the 2' position of the B-ring in high yields and excellent enantioselectivities. New synthetic strategies for obtaining enantioenriched isoflavanones and pterocarpans were also demonstrated in this study, showcasing the versatility of the developed method.
Article
Chemistry, Multidisciplinary
Pep Rojo, Medea Molinari, Albert Cabre, Clara Garcia-Mateos, Antoni Riera, Xavier Verdaguer
Summary: Chiral compounds containing nitrogen heteroatoms are crucial for the chemical, pharmaceutical, and agrochemical industries. In this study, a series of P-stereogenic phosphinooxazoline iridium catalysts were synthesized and successfully used in the asymmetric hydrogenation of N-Boc-2,3-diarylallyl amines, achieving high enantioselectivity. The synthetic utility of the obtained 2,3-diarylpropyl amines was also demonstrated.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Minami Odagi, Taisei Matoba, Keisuke Hosoya, Kazuo Nagasawa
Summary: The first enantioselective total syntheses of hasubanan alkaloid (-)-metaphanine and norhasubanan alkaloid (+)-stephadiamine have been reported. These syntheses involve diastereoselective oxidative phenolic coupling reaction and subsequent regioselective intramolecular aza-Michael reaction to efficiently construct the hasubanan skeleton with a quaternary stereogenic center at C13. Furthermore, based on a hypothesis regarding the biosynthetic pathway of (+)-stephadiamine, it was found that (-)-metaphanine can easily be converted to (+)-stephadiamine via an aza-benzilic acid type rearrangement reaction.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Zhining Li, Shiqi Huang, Yuan Tao, Meifen Jiang, Dang Cheng, Li Wan, Fener Chen
Summary: A continuous flow synthesis of 2-(1-cyclohexenyl)ethylamine was developed starting from cyclohexanone via five chemical transformations. This method features an expeditious synthesis of 2-(1-cyclohexenyl)ethylamine in an integrated flow platform with in-line separation and without any intermediate purification. The overall yield of this multi-step flow method was up to 56% in a total residence time of 44.5 min, corresponding to a throughput of 32 mmol h(-1).
REACTION CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Organic
Yuta Takeuchi, Kengo Akagawa, Kazuaki Kudo
Summary: Solid-phase biomimetic polyketide synthesis has been developed, which involves specific steps for carbon chain elongation and transformation to synthesize natural products, with monitoring and confirmation through colorimetric tests and NMR.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Jorge Gonzalez-Rodriguez, Jesus Albarran-Velo, Raquel G. Soengas, Ivan Lavandera, Vicente Gotor-Fernandez, Humberto Rodriguez-Solla
Summary: In this study, a bienzymatic cascade was developed and optimized to efficiently synthesize enantiopure chlorohydrins. The reaction showed high conversion and selectivity under mild conditions.
Article
Chemistry, Organic
Yuxuan Zhang, Xiaotong Li, Limin Xu, Xiaomin Xie, Yan Lu, Zhaoguo Zhang
Summary: Asymmetric hydrogenation of diaryl 1,4-diketones was achieved using trans-RuCl2[(S)-BINAP)][(S)-Daipen] as the catalyst, affording excellent enantio- and diastereoselectivities (up to >99% ee and de). This procedure provides a convenient and efficient synthetic method for chiral 1,4diarylbutane-1,4-diols, which are important intermediates for a variety of chiral auxiliaries and ligands.
Article
Chemistry, Organic
Danielle L. J. Pinheiro, Martin Nielsen
Summary: The chemoselective reduction of enamides to alpha-amino acids using Ru pincer complexes as catalysts and iPrOH and EtOH as H-donors and solvents is demonstrated. A range of alpha-amino acids is synthesized with good to excellent yields. Applications, large-scale synthesis, and a one-pot experiment are also reported. Deuterium-labeling experiments show high regioselectivity between the alpha- and beta-positions of the alkene unit.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Johannes Fessler, Kathrin Junge, Matthias Beller
Summary: An efficient and general cascade synthesis of pyrroles from nitroarenes using an acid-tolerant homogeneous iron catalyst is presented. The method involves initial (transfer) hydrogenation using an iron-Tetraphos catalyst and subsequent acid catalysed Paal-Knorr condensation. It shows high functional group tolerance, complementing reactivity, and enhanced chemoselectivity.
Article
Chemistry, Organic
Yanping Xia, Sen Wang, Rui Miao, Jianhua Liao, Lu Ouyang, Renshi Luo
Summary: Cationic iridium complexes were demonstrated to catalyze the transfer hydrogenation of oximes, providing access to N-alkoxy amines and hydroxylamines. The reaction rate was accelerated by trifluoroacetic acid. The practical application of this method was demonstrated by the synthesis of a fungicide in high yields, and the asymmetric synthesis of chiral N-alkoxy amines showed potential for further development.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xin Liu, Thomas Werner
Summary: A manganese pincer complex is reported as a versatile catalyst for the transfer hydrogenation of amides, carbamates, urea derivatives, and polyurethanes, leading to the corresponding alcohols, amines, and methanol. This method represents an approach to the indirect reduction of CO2 and shows the first examples of reduction of carbamates and urea derivatives as well as C-N bond cleavage in amides by transfer hydrogenation. The general applicability of this methodology is demonstrated by successful reduction of various compounds with good to excellent yields.
Article
Chemistry, Multidisciplinary
Tiantian Chen, Yashi Zou, Yanhua Hu, Zhenfeng Zhang, Hao Wei, Liangming Wei, Wanbin Zhang
Summary: An efficient asymmetric hydrogenation of internal simple enamides has been achieved using the diphosphine-cobalt-zinc catalytic system. The Ph-BPE ligand can achieve convergent asymmetric hydrogenation of E/Z-substrates. High yields and excellent enantioselectivities were obtained for different types of enamides. The hydrogenated products can be used for the synthesis of useful chiral drugs. Reasonable catalytic mechanism and stereocontrol mode are proposed based on DFT calculations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Marina Garcia-Ramos, Ivan Lavandera
Summary: Transaminases have demonstrated the ability to catalyze the amination of α,α-difluorinated ketones, yielding β,β-difluoroamines with high yields and enantiomeric excess. This reaction can be quantitatively transformed by employing a small molar excess of the amine donor, and scaled up successfully.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Editorial Material
Chemistry, Multidisciplinary
Joakim B. Jakobsen, Magnus H. Ronne, Kim Daasbjerg, Troels Skrydstrup
Summary: The reduction of carbon dioxide is crucial for producing non-fossil-fuel-based feedstocks and mitigating greenhouse gas emissions. Amines play a critical role in these transformations, acting as CO2 trapping agents, proton shuttles, electron donors, and facilitators of CO2 reductions through formamide derivatives.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Tamara Dinhof, Thomas Kalina, Toda Stankovic, Kristof Braunsteiner, Philipp Rohrbach, Ertan Turhan, Andreas Gradwohl, Artur Koenigshofer, Jeannie Horak, Katharina Pallitsch
Summary: alpha-Aminophosphonic acids have a wide range of bioactivity and can serve as highly efficient transition state mimics. Although various methods for accessing enantiopure a-aminophosphonic acids have been reported, none of them can be applied universally for the synthesis of PaAAs. By using catalytic, stereoselective asymmetric transfer hydrogenation, phosphonic acid analogs of many alpha-amino acids can be obtained, which are important pharmaceutical building blocks and can be easily converted to a-aminophosphonic acids in most cases.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Multidisciplinary Sciences
Maria Jesus Garcia-Munoz, Ana Sirvent, Francisco Foubelo, Miguel Yus
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2018)
Review
Chemistry, Multidisciplinary
Irina P. Beletskaya, Carmen Najera, Miguel Yus
Article
Chemistry, Organic
Sofiane Ikhlef, Cherif Behloul, Alejandro Lahosa, Francisco Foubelo, Miguel Yus
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Chemistry, Organic
Meriem Benlahrech, Alejandro Lahosa, Cherif Behloul, Francisco Foubelo, Miguel Yus
Article
Chemistry, Organic
Joseane A. Mendes, Pedro Merino, Tatiana Soler, Eduardo J. Salustiano, Paulo R. R. Costa, Miguel Yus, Francisco Foubelo, Camilla D. Buarque
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Chemistry, Organic
Alejandro Lahosa, Miguel Yus, Francisco Foubelo
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Review
Chemistry, Multidisciplinary
Carmen Najera, Leiv K. Sydnes, Miguel Yus
Article
Chemistry, Organic
Ana Sirvent, M. Jesus Garcia-Munoz, Miguel Yus, Francisco Foubelo
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Organic
Sandra Hernandez-Ibanez, Olga Soares do Rego Barros, Alejandro Lahosa, Maria Jesus Garcia-Munoz, Meriem Benlahrech, Cherif Behloul, Francisco Foubelo, Miguel Yus
Article
Chemistry, Organic
Sarah-Jayne Burlingham, David Guijarro, Irene Bosque, Rafael Chinchilla, Jose C. Gonzalez-Gomez
Summary: Riboflavin tetraacetate efficiently catalyzes the decarboxylative alkenylation of aryl styryl sulfones, showing excellent stereoselectivity. This metal-free and environmentally friendly method also allows for the regioselective synthesis of internal alkynes.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Manel Estruch-Blasco, Irene Bosque, David Guijarro, Jose C. Gonzalez-Gomez
Summary: The ECDC method was utilized to synthesize 4'-alkoxyspirolactones and isomerize them into 4'-alkoxy-2-phenylbenzoic acids. This reaction is also suitable for axially chiral substrates, allowing for retention of configuration and enantiomeric purity.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Review
Chemistry, Organic
Irene Bosque, Rafael Chinchilla, Jose C. Gonzalez-Gomez, David Guijarro, Francisco Alonso
ORGANIC CHEMISTRY FRONTIERS
(2020)
Review
Chemistry, Multidisciplinary
Francisco Alonso, Irene Bosque, Rafael Chinchilla, Jose Carlos Gonzalez-Gomez, David Guijarro
CURRENT GREEN CHEMISTRY
(2019)
Review
Chemistry, Multidisciplinary
Carmen Najera, Irina P. Beletskaya, Miguel Yus
CHEMICAL SOCIETY REVIEWS
(2019)
Article
Chemistry, Organic
Edgar Macia, Francisco Foubelo, Miguel Yus