4.5 Article

Lewis Acid Catalyzed [3+2] Coupling of Indoles with Quinone Monoacetals or Quinone Imine Ketal

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 21, Pages 4467-4471

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201402490

Keywords

Nitrogen heterocycles; Fused-ring systems; C-C coupling; Lewis acids; Acetals

Funding

  1. National Basic Research Program of China (973 Program) [2010CB833300]
  2. National Sciences Foundation of China (NSFC) [21372218, 21172217]

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The one-pot synthesis of benzofuroindolines and tetrahydroindolo[ 2,3-b]indoles was accomplished through a mild and concise [3+2] coupling of indoles and quinone monoacetals or quinone imine ketal promoted by a Lewis acid. A wide variety of benzofuroindolines and tetrahydroindolo[2,3b]indoles were prepared in moderate to good yields.

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