Article
Chemistry, Inorganic & Nuclear
Carolina Hahn da Silveira, Otavio A. Chaves, Amanda C. Marques, Nathalia M. P. Rosa, Luiz Antonio S. Costa, Bernardo Almeida Iglesias
Summary: A classical methodology was used to design a new type of free-base meso-tetra-(1-pyrenyl)porphyrin (H(2)TPyrP) and their corresponding metalloporphyrins. The structure, photophysical properties, and interactions with CT-DNA and BSA were characterized. The metalloporphyrins showed spectrum shifts according to the nature of the ion, and their fluorescence and singlet oxygen quantum yield decreased compared to H(2)TPyrP.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Jan Kuliga, Rodrigo Cezar de Campos Ferreirra, Rajan Adhikari, Stephen Massicot, Michael Lepper, Helen Hoelzel, Norbert Jux, Hubertus Marbach, Abner de Siervo, Hans-Peter Steinrueck
Summary: The study investigates the interaction and metalation reaction of 2HTCNPP with post-deposited Zn atoms on a Ag(111) surface, leading to the formation of three different 2D ordered island types. The presence of a bright new species on the surface, attributed to SAT complexes formed by Zn and the macrocycle, indicates an intermediate in the metalation reaction to ZnTCNPP, which occurs upon heating to 500 K.Interestingly, the activation barrier for the successive reaction of the SAT complex to the metalated ZnTCNPP species can also be overcome by a voltage pulse applied to the STM tip.
Article
Chemistry, Inorganic & Nuclear
Briana R. Schrage, Eugeny Ermilov, Victor N. Nemykin
Summary: The formation and deactivation of charge-separated state was investigated in a series of compounds using transient absorption spectra. The lifetime of the charge-separated state was nearly constant for all compounds and independent of the central ion and solvent. A minor long-lived component was observed in polar solvent.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ahmed M. Mansour
Summary: In this study, a series of mono- and binuclear triazolate complexes were synthesized through catalyst-free [3+2] cycloaddition coupling, with the isomerization process from the kinetically formed N(1) bound triazolate isomer to the N(2) analogue successfully evidenced. The solvatochromism properties of these complexes were assessed using UV/Vis spectroscopy and time dependent density functional theory calculations. Additionally, the potential antimicrobial activity of the free ligands and their tricarbonyl triazolato Re(i) complexes against various bacterial and fungal pathogens was preliminarily evaluated.
Article
Chemistry, Organic
Min-Sung Ko, Jung-Ho Hong, Adil S. Aslam, P. Sankara Rao, Pradeep P. Desale, Jonghoon Choi, Yunho Lee, Dong-Gyu Cho
Summary: o-Arene-connected porphyrinoids were synthesized using o-(2-thienyl)vinylarene motif as a new building block. This motif can replace meso-aryl-substituted dipyrromethene and control the connectivity of porphyrinoids. The experimental results showed that the rigidified Pd-6a had higher aromaticity than 6b.
Review
Chemistry, Multidisciplinary
Poornenth Pushpanandan, Mangalampalli Ravikanth
Summary: This review provides an overview of the development in the chemistry of 20π porphyrinoids, emphasizing on the synthesis, structure, and electronic properties of these macrocycles, which have great potential for various applications.
Article
Chemistry, Organic
Nicholas A. Clanton, Nicolas A. Wilson, Eliezer Ortiz, Shawn T. Blumberg, Doug E. Frantz
Summary: This study describes the site-selective functionalization of unactivated allylic C-H bonds via direct deprotonation using KTMP. It demonstrates the conversion of amorphadiene to artemisinic alcohol through a simple and highly regioselective deprotonation over four other possible allylic sites, with further extrapolation to the first large-scale chemical synthesis of artemisinic acid from amorphadiene. Additionally, it highlights the successful application of this method for site-selective functionalization of unactivated allylic C-H bonds in other terpene-based natural products.
Article
Chemistry, Multidisciplinary
Faeza Alkorbi, Alejandro Diaz-Moscoso, Jacob Gretton, Isabelle Chambrier, Graham J. Tizzard, Simon J. Coles, David L. Hughes, Andrew N. Cammidge
Summary: This study demonstrates a strategy for straightforward, controlled access to differentially substituted meso-aryl-tetrabenzotriazaporphyrins, allowing selective preparation of functionalized hybrids.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Inorganic & Nuclear
Juan Carlos Lopez-Lopez, Yennie H. Nguyen, Chenggang Jiang, Thomas S. Teets
Summary: This study presents a series of luminescent platinum acetylide complexes with electronically modified and/or pi-extended ligands. The photoluminescence properties of these complexes depend strongly on the substitution pattern and extent of pi conjugation on the acetylide ligands.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Narges Abdolhossein Rejali, Mohammad Dinari, Yong Wang
Summary: Covalent organic frameworks (COFs) are porous and crystalline organic polymers that can be tailored by introducing diverse functionalities. However, sometimes these functionalities are not compatible with reaction conditions or interfere with other monomers. To overcome these challenges, post-synthetic modification (PSM) approaches are helpful in adjusting the porous size and improving stability without affecting crystallite. Different PSM strategies, including post-functionalization, post-metalation, chemical locking, and host-guest post-modification, have been discussed in this review. The potential applications of post-modified COFs in various fields, such as energy storage and conversion, heterogeneous catalysts, food safety evaluation, gas separation, environmental domains, and biological applications, have also been explored.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Narges Abdolhossein Rejali, Mohammad Dinari, Yong Wang
Summary: Covalent organic frameworks (COFs) are porous and crystalline organic polymers that have found diverse applications in various fields. Post-synthetic modification (PSM) strategies, including post-functionalization, post-metalation, chemical locking, and host-guest post-modifications, offer a helpful approach to introduce functionalities into COFs. These modifications allow for tunable porous size, improved stability, and modification of features such as conductivity, hydrophobicity/hydrophilicity, and chirality. The potential applications of post-modified COFs include energy storage and conversion, heterogeneous catalysis, food safety evaluation, gas separation, environmental remediation, and biological applications.
CHEMICAL COMMUNICATIONS
(2023)
Review
Chemistry, Organic
Nuno M. M. Moura, Carlos J. P. Monteiro, Augusto C. Tome, M. Graca P. M. S. Neves, Jose A. S. Cavaleiro
Summary: This review highlights the procedures developed over the last 10 years to synthesize chlorins and bacteriochlorins, namely through Diels-Alder and 1,3-dipolar reactions using porphyrin macrocycles as templates.
Review
Chemistry, Inorganic & Nuclear
Hualin Yang, Yu Zhou, Juewen Liu
Summary: Metalloporphyrins are important in biology and materials science, with DNAzymes and nanozymes developed as enzyme mimics to accelerate metalation reactions. Additionally, nanomaterials and surfactants with catalytic activity have been found to enhance the metalation reaction of porphryins.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Philipp Schueler, Simon Sengupta, Alexander Koch, Helmar Goerls, Sven Krieck, Matthias Westerhausen
Summary: The in situ Grignard Metalation Method (iGMM) is a straightforward strategy to synthesize alkaline-earth metal amides in high yields. It offers advantages such as no need for calcium activation and the ability to prepare large amounts of reagents. However, steric factors limit its applicability, and bulky amidines cannot be converted directly using this method.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Organic
Rima Sengupta, Prosenjit Isar, Mangalampalli Ravikanthe
Summary: This study successfully synthesized N-fused dithia and dibenzi homoporphyrins using a [2 + 2] approach, and analyzed their structures and properties. The results revealed their non-aromatic nature.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Cesar Augusto Abreu-Pereira, Marlise Inez Klein, Carmelia Isabel Vitorino Lobo, Ana Luiza Gorayb Pereira, Claudia Carolina Jordao, Ana Claudia Pavarina
Summary: This study evaluated the effectiveness of DNase I combined with antimicrobial photodynamic therapy against biofilms formed by a fluconazole-resistant Candida albicans strain. The results showed that DNase treatment combined with aPDT could significantly reduce cell viability and the components of the biofilm.
Article
Biochemistry & Molecular Biology
Lucas M. O. S. Martins, Xuhui Wang, Gustavo T. M. Silva, Helena C. Junqueira, Barbara Fornaciari, Lohanna F. Lopes, Cassio P. Silva, Peng Zhou, Victor F. Cavalcante, Mauricio S. Baptista, Frank H. Quina
Summary: Hydroxypyranoflavylium (HPF) cations are synthetic analogs with excellent photophysical properties and can serve as sensitizers for photodynamic therapy (PDT). The study found that HPF cations have phototoxic effects on human cervical adenocarcinoma cells at lower concentrations, and even small structural differences can lead to significant variations in phototoxicity. Therefore, HPF cations are potential PDT sensitizers that deserve further evaluation.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lohanna de Faria Lopes, Jana Jandova, Rebecca Justiniano, Jessica Perer, Mauricio S. Baptista, Georg T. Wondrak
Summary: Cellular oxidative stress plays a significant role in solar ultraviolet radiation-induced skin photoaging and photocarcinogenesis. Methylglyoxal (MG), a metabolic byproduct, has been found to act as a UVA-photosensitizer, causing photooxidative stress and caspase-dependent cell death in human keratinocytes. Additionally, MG induces gene expression changes related to proteotoxic and oxidative stress response. Further investigation into the role of MG photosensitizer activity in human skin photodamage is crucial.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Orlando Chiarelli-Neto, Michelle Lima Garcez, Christiane Pavani, Waleska Martins, Fernanda Cristina de Abreu Quintela Castro, Roberta Passamani Ambrosio, Flavia Carla Meotti, Mauricio S. Baptista
Summary: This study evaluated the effects of UV-A exposure on J774 macrophage cells previously challenged with LPS in terms of oxidative distress, release of pro-inflammatory cytokines, and activation of regulated cell death pathways. The results showed that LPS potentiates the UV-A-induced oxidative distress and cell damage, indicating that a previous inflammatory stimulus intensifies UV-A-induced cell damage.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Aya Sakaya, Isabel O. L. Bacellar, Jose Luis Fonseca, Andres M. Durantini, Julia McCain, Laiyi Xu, Mariana Vignoni, Andres H. Thomas, Mauricio S. Baptista, Gonzalo Cosa
Summary: A sensitive fluorogenic probe is developed to quantify the arrival of singlet oxygen (1O2) on lipid membranes, allowing for the study of membrane dynamics. The probe shows remarkable intensity enhancement upon 1O2 trapping and enables the visualization of membrane expansion dynamics.
Review
Biochemistry & Molecular Biology
Mauricio S. Baptista, Jean Cadet, Alexander Greer, Andres H. Thomas
Summary: The interaction of light with natural matter can lead to either detrimental or beneficial photosensitized reactions in living organisms. These reactions can degrade biomolecules or be used in photomedicine for disease treatment. Different processes of photosensitization reactions, both oxygen-dependent and oxygen-independent, are discussed in this review, along with various approaches and techniques for investigation. The aim is to provide a general description of techniques and good practices, illustrated by key biomarkers measurement in DNA, and target students and beginners.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Oncology
Isabele Fattori Moretti, Antonio Marcondes Lerario, Paula Rodrigues Sola, Janaina Macedo-da-Silva, Mauricio da Silva Baptista, Giuseppe Palmisano, Sueli Mieko Oba-Shinjo, Suely Kazue Nagahashi Marie
Summary: This study analyzed the effects of MET combined with TMZ treatment in two GBM cell lines, U87MG and A172, stimulated with LPS. MET treatment led to mitochondrial respiration blunting and oxidative stress in both cell lines, with U87MG cells exhibiting increased apoptosis after MET + LPS + TMZ treatment and A172 cells showing cell cycle arrest after MET + TMZ treatment. The observed differential response was associated with the metabolic status of the cells. This study highlights the potential of MET as a treatment option for GPM-GBM cases with an activated TLR4 pathway and suggests the use of combination therapies, such as an IL8 inhibitor for cases with upregulated CXCL8 and an antioxidant inhibitor for MTC-GBM cases.
Article
Chemistry, Multidisciplinary
Rodrigo Ken Kawassaki, Mariana Romano, Mayara Klimuk Uchiyama, Roberta Mansini Cardoso, Mauriicio S. Baptista, Sandra H. P. Farsky, Khallil Taverna Chaim, Robson Raphael Guimaraes, Koiti Araki
Summary: A novel ultrasmall paramagnetic nanoparticle (UPN), decorated with iron oxide on 3 nm titanium dioxide nanoparticles, has been developed as a potential alternative blood-pool contrast agent to gadoteric acid (GA) for MR angiography. It exhibits comparable relaxometric parameters to GA and has strong and prolonged contrast enhancement before renal excretion.
Article
Oncology
Jose Marcelo Lacerda Alves Goncalves, Carolina Montovam Monteiro, Gabriela Benedito Machado, Christiane Pavani
Summary: The combination of MB and SDS has shown to increase the antimicrobial effect of aPDT. Higher values of irradiance and radiant exposure were found to be more effective in reducing CFU. It is recommended to use a radiant exposure above 18 J/cm2 and an irradiance above 26 mW/cm2.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Oncology
Gabriela Benedito Machado, Carolina Montovam Monteiro, Jose Marcelo Lacerda Alves Goncalves, Christiane Pavani
Summary: The study shows that photodynamic therapy (PDT) with phenothiazinium dyes and sodium dodecyl sulfate (SDS) can effectively eradicate C. albicans biofilms, especially in the adhesion stage. However, PDT has a limited effect on mature and dispersed biofilms.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Oncology
Claudio Teruo Kassa, Luciana Toledo Costa Salviatto, Ana Carolina A. C. Tortamano, Ketlyn Sthefany Rost-Lima, Carla Andreotti Damante, Christiane Pavani, Alessandro Deana, Ilka Tiemy Kato, Mark Wainwright, Renato Araujo Prates
Summary: The photodynamic effect of methylene blue in sodium dodecyl sulfate in periodontitis was evaluated in this study. The results showed no significant reduction in bacterial plaque or clinical parameters.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Review
Chemistry, Multidisciplinary
Erick L. Bastos, Frank H. Quina, Mauricio S. Baptista
Summary: Endogenous photosensitizers play a crucial role in light-induced transformations in biological systems. This comprehensive review focuses on their mode of action and its implications in various fields, such as photomedicine, photoredox catalysis, and the development of sun care products. The analysis reveals the potential causes of the increase in skin cancer cases and highlights the limitations of current sun protection approaches.
Letter
Surgery
Christiane Pavani
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2023)
Article
Surgery
Lidiane Rocha Mota, Ivone da Silva Duarte, Thais Rodrigues Galache, Katia Maria dos Santos Pretti, Orlando Chiarelli Neto, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Daniela de Fatima Teixeira da Silva, Christiane Pavani
Summary: This study aimed to evaluate the effectiveness of red and amber light-emitting diode protocols for facial rejuvenation at the same light dose. The results showed that both red and amber light can effectively reduce wrinkles and improve quality of life, indicating strong potential for clinical applications.
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2023)
Article
Physics, Multidisciplinary
Shangjie Guo, Sophia M. Koh, Amilson R. Fritsch, I. B. Spielman, Justyna P. Zwolak
Summary: This paper presents a framework that combines machine learning models with physics-based traditional analyses to identify and track solitonic excitations in images of Bose-Einstein condensates (BECs). The researchers use a machine learning-based object detector to locate the solitonic excitations and develop a physics-informed classifier to categorize them. This framework, called SOLDET, provides a useful tool for feature identification in cold-atom images.
PHYSICAL REVIEW RESEARCH
(2022)
