4.5 Article

Copper-Catalyzed Regioselective Synthesis of N-Aryl Amides from Aldoximes and Aryl Halides

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 8, Pages 1602-1605

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201301868

Keywords

Homogeneous catalysis; Rearrangement; Copper; Aldoximes; Amides

Funding

  1. Department of Science and Technology (DST), New Delhi [SR-S1/OC-60/2011]
  2. Board of Research in Nuclear Sciences (BRNS)
  3. Department of Atomic Energy (DAE)
  4. Government of India [2012/37C/3/BRNS]

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Ligand-assisted copper-catalyzed reaction of aldoximes with aryl halides is described for the regioselective synthesis of N-aryl amides. This protocol is simple and compatible with a wide range of functional groups attached to the aryl ring of the halides as well as aldoximes.

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