Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2013, Issue 21, Pages 4495-4498Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201300464
Keywords
Asymmetric catalysis; Amino alcohols; Organocatalysis; Anhydrides; Natural products; Thiolysis
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Asymmetric thiolysis of prochiral cyclic anhydrides was achieved with our developed chiral sulfonamide and squaramide bifunctional organocatalysts based on amino alcohol scaffolds. The corresponding thioesters were obtained in high yields with excellent enantioselectivities. The usefulness of this methodology was demonstrated in the enantioselective synthesis of pregabalin.
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