Synthesis and Characterization of β-Trifluoromethyl-Substituted Pyrrolidines

Mitigating Heterocycle Metabolism in Drug Discovery

(2012) David J. St. Jean et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Synthetic Route to a Dipeptidyl Peptidase-4 Inhibitor

(2012) Danny Lafrance et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Systematic Enumeration of Heteroaromatic Ring Systems as Reagents for Use in Medicinal Chemistry

(2011) Richard A. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorinated Amino-Derivatives of the Sesquiterpene Lactone, Parthenolide, as19F NMR Probes in Deuterium-Free Environments

(2011) James R. Woods et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

(2011) Stephen D. Roughley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Heterocycle Synthesis via Direct C–H/N–H Coupling

(2011) Enrico T. Nadres et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Efficient Syntheses of Azetidines, Pyrrolidines, and Indolines via Palladium Catalyzed Intramolecular Amination of C(sp3)–H and C(sp2)–H Bonds at γ and δ Positions

(2011) Gang He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of β-fluoro-β-proline

(2011) Vladimir S. Yarmolchuk et al.   TETRAHEDRON LETTERS

Oxetanes in Drug Discovery: Structural and Synthetic Insights

(2010) Georg Wuitschik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 2-Trifluoromethyl-1,3-oxazolidines as Hydrolytically Stable Pseudoprolines

(2010) Grégory Chaume et al.   JOURNAL OF ORGANIC CHEMISTRY

The reaction of cyclic imines with the Ruppert–Prakash reagent. Facile approach to α-trifluoromethylated nornicotine, anabazine, and homoanabazine

(2010) Nikolay E. Shevchenko et al.   TETRAHEDRON

Fluorine in medicinal chemistry: a century of progress and a 60-year retrospective of selected highlights

(2009) Robert Filler et al.   Future Medicinal Chemistry

Mitiglinide: a rapid- and short-acting non-sulfonylurea insulinotropic agent for the treatment of type 2 diabetic patients

(2008) Willy J Malaisse   EXPERT OPINION ON PHARMACOTHERAPY

A β-Fluoroamine Inhibitor of Purine Nucleoside Phosphorylase

(2008) Jennifer M. Mason et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

(2008) Kenneth L. Kirk   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Enzymatic Resolution ofN-Substituted-β-prolines

(2008) Javier Mendiola et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS