Diterpenes from European Euphorbia Species Serving as Prototypes for Natural-Product-Based Drug Discovery

Activation of Latent HIV-1 Expression by Protein Kinase C Agonists. A Novel Therapeutic Approach to Eradicate HIV-1 Reservoirs

(2012) Gonzalo Sanchez-Duffhues et al.   CURRENT DRUG TARGETS

Therapeutic Targeting of TRPV1 by Resiniferatoxin, from Preclinical Studies to Clinical Trials

(2011) Igor Kissin et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Unusual Tigliane Diterpenes fromEuphorbia grandicornis

(2011) Peter Forgo et al.   JOURNAL OF NATURAL PRODUCTS

Jatrophane Diterpenes fromEuphorbia esulaas Antiproliferative Agents and Potent Chemosensitizers to Overcome Multidrug Resistance

(2011) Andrea Vasas et al.   JOURNAL OF NATURAL PRODUCTS

Dual mechanism of action of ingenol mebutate gel for topical treatment of actinic keratoses: Rapid lesion necrosis followed by lesion-specific immune response

(2011) Robert H. Rosen et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

New premyrsinane-type diterpene polyesters from Euphorbia falcata

(2011) Edvárd Sulyok et al.   TETRAHEDRON

Cyclomyrsinane and premyrsinane diterpenes from Euphorbia falcata modulate resistance of cancer cells to doxorubicin

(2011) Andrea Vasas et al.   TETRAHEDRON

PEP005 (ingenol mebutate) gel for the topical treatment of superficial basal cell carcinoma: Results of a randomized phase IIa trial

(2010) Greg Siller et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

The Skin Cancer Chemotherapeutic Agent Ingenol-3-Angelate (PEP005) Is a Substrate for the Epidermal Multidrug Transporter (ABCB1) and Targets Tumor Vasculature

(2010) Luowei Li et al.   CANCER RESEARCH

New Myrsinol Diterpenes from Euphorbia prolifera

(2010) Wan-Jin Zhang et al.   CHINESE JOURNAL OF CHEMISTRY

Diterpenoid (poly)esters and a ring A-seco-phorboid from the aerial parts of Euphorbia macroclada Boiss

(2010) Yalda Shokoohinia et al.   FITOTERAPIA

Novel Antileukemic Compound Ingenol 3-Angelate Inhibits T Cell Apoptosis by Activating Protein Kinase Cθ

(2010) Wing-yiu Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Protein Kinase C Agonist PEP005 (Ingenol 3-Angelate) in the Treatment of Human Cancer: A Balance between Efficacy and Toxicity

(2010) Elisabeth Ersvaer et al.   Toxins

PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: Results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study

(2009) Greg Siller et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells

(2009) Sharon A. Mason et al.   INVESTIGATIONAL NEW DRUGS

Randomized, double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025% and 0.05% for actinic keratosis

(2009) Lawrence Anderson et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Jatrophane diterpenes from Euphorbia spp. as modulators of multidrug resistance in cancer therapy

(2009) G. Corea et al.   PHYTOCHEMISTRY REVIEWS

Isolation and structure determination of new 4,12-dideoxyphorbol esters from Euphorbia pannonica Host.

(2009) Edvárd Sulyok et al.   TETRAHEDRON

Immunostimulatory cancer chemotherapy using local ingenol-3-angelate and synergy with immunotherapies

(2009) Thuy T.T. Le et al.   VACCINE

Chemical and Pharmacological Research of the Plants in GenusEuphorbia

(2008) Qing-Wen Shi et al.   CHEMICAL REVIEWS

Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells

(2008) M. Serova et al.   MOLECULAR CANCER THERAPEUTICS