Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2012, Issue 9, Pages 1790-1799Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201101822
Keywords
Synthetic methods; Homogeneous catalysis; Gold; Cascade reactions; Nitrogen heterocycles; Antitumor agents; Privileged structures
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A robust library-based approach to new fused quinazolinones by the development of gold(I)-catalyzed cascade reactions between 2-aminobenzohydrazides and alkynoic acids is documented. Selected compounds were administered to lung (A549) and breast cancer cells (MDA-MB-231 and MCF-7) in vitro and it was found that some successfully inhibited cell proliferation.
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