4.5 Article

Asymmetric Transfer Hydrogenation of Aromatic Ketones Using Rhodium Complexes of Chiral N-Heterocyclic Carbenes Derived from (S)-Pyroglutamic Acid

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2011, Issue 15, Pages 2772-2776

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201100100

Keywords

Asymmetric catalysis; Hydrogenation; Carbene ligands; Ketones; Rhodium

Funding

  1. Interchim Company
  2. Centre National de la Recherche Scientifique (CNRS-UMR) [8182]
  3. Universite Paris-Sud 11

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A new and flexible procedure for the preparation of chiral azolium salts derived from (S)-pyroglutamic acid has been developed. The efficiency of these ligands has been evaluated in the metal-catalyzed asymmetric transfer hydrogenation of aromatic ketones in isopropanol. Good enantioselectivities up to 90% ee were observed.

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